Patents Assigned to The Royal Institution of the Advancement of Learning/McGill University
  • Patent number: 9828399
    Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 28, 2017
    Assignee: The Royal Institution For The Advancement Of Learning/McGill University
    Inventors: Michel L. Tremblay, Claudia Penafuerte, Matthew Feldhammer, George Zogopoulos, Cameron Black, Brian Kennedy
  • Patent number: 9822890
    Abstract: A major challenge for the general use of “lab-on-a-chip” (LOAC) systems and point-of-care (POC) devices has been the generally complex and need for sophisticated peripheral equipment, such that it is more difficult than anticipated to implement low cost, robust and portable LOAC/POC solutions. It would be beneficial for chemical, medical, healthcare, and environmental applications to provide designs for inexpensive LOAC/POC solutions compatible with miniaturization and mass production, and are potentially portable, using compact possibly hand-held instruments, using reusable or disposable detectors. Embodiments of the invention address improved circuit elements for self-powered self-regulating microfluidic circuits including programmable retention valves, programmable trigger valves, enhanced capillary pumps, and flow resonators.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: November 21, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: David Juncker, Hosseinali Safavieh
  • Publication number: 20170291826
    Abstract: The present relates to a method for producing calcium sulfate solid crystals and hydrochloric acid (HCl) from a calcium chloride solution comprising the steps of feeding a continuous stirred-tank reactor with a calcium chloride solution, sulfuric acid and water; mixing the calcium chloride solution, sulfuric acid and water in the reactor; and maintaining the reactor a temperature of less than about 70° C., converting the calcium chloride solution, sulfuric acid and water into HCl and calcium sulfate solid crystals. The method described herein can be incorporated as a means for regenerating HCl from CaCl2 solutions which are generated in the metallurgical industry when processing calcium-bearing ores for recovering metals like rare earth elements.
    Type: Application
    Filed: April 6, 2016
    Publication date: October 12, 2017
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: George DEMOPOULOS, Thomas FELDMANN
  • Patent number: 9764060
    Abstract: There is provided a method for preparing a dense hydrogel comprising providing an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: September 19, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Showan Nazhat, Benedetto Marelli, Chiara Ghezzi, Neysan Nejat Oliver Kamranpour
  • Patent number: 9750200
    Abstract: A flue gas treatment apparatus has a flue gas inlet, a treated gas outlet downstream of the flue gas inlet, and a gas flow path therebetween. The flue gas treatment apparatus comprises a particulate removal device. A first heater is downstream of the particulate removal device. The first heater heats the flue gas to a first treatment temperature. A first catalytic converter is downstream of the first heater for eliminating at least some CO and SO2 from the flue gas. A second heater is downstream of the first catalytic converter for heating the flue gas to a second treatment temperature. A second catalytic converter is downstream of the second heater for eliminating at least some NOx from the flue gas. At least a first fan forces the flue gas from the flue gas inlet to the treated gas outlet.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: September 5, 2017
    Assignee: Royal Institution for the Advancement of Learning/McGill University
    Inventors: Mark Lefsrud, Yves Roy, Francis Filion, Julien Bouchard, Quoc Nguyen, Louis-Martin Dion, Antony Glover
  • Patent number: 9746236
    Abstract: The present disclosure relates to a process for reducing particle agglomeration and/or increasing porosity of agglomerated particles, a method for enhancing dispersion of nanoparticles in a polymer matrix, and thermoplastic or thermoset nanocomposites comprising nanoparticles.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: August 29, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Musa Kamal, Vahid Khoshkava
  • Publication number: 20170197873
    Abstract: Natural materials often boast unusual combinations of stiffness, strength and toughness currently unmatched by today's engineering materials. Beneficially, according to the embodiments of the invention, these unusual combinations can be introduced into ceramics, glasses, and crystal materials, for example by the introduction of patterns of weaker interfaces with simple or intricate architectures. Two-dimensional surface modifications and three-dimensional arrays of effects within these materials allow for the deformation of these materials for increased flexure, impact resistance, etc. Further, the addition of interlocking substrate blocks in isolation or with additional flexible materials provide for improved energy dissipation and toughening. Such modified materials, based on carefully architectured interfaces, provide a new pathway to toughening hard and brittle materials.
    Type: Application
    Filed: June 8, 2015
    Publication date: July 13, 2017
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: François BARTHELAT, Seyed Mohammad Mirkhalaf VALASHANI, Ahmad Khayer DASTJERDI
  • Patent number: 9702438
    Abstract: Multi-speed transmission for electric vehicles (EVs) can reduce the size of the electric motor and provide an appropriate balance between efficiency and dynamic performance. Currently used multi-speed transmissions for EVs were initially designed for internal combustion engine (ICE) vehicles. Since ICEs cannot operate below certain speeds and their speed control during gear changes is not an easy task, the presence of clutches or torque convertors is inevitable for start-ups, idle running and gear changing. This, however, is not the case for EVs as electric motors are speed controllable in a wide range of operating speeds. Accordingly, transmissions without clutches or torque converters are established for EVs.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: July 11, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Benoit Boulet, Mir Saman Rahimi Mousavi, Hossein Vahid Alizadeh, Ali Pakniyat
  • Patent number: 9705630
    Abstract: Optical solutions to address and overcome the issues of superseding/replacing electrical interconnection networks have generally exploited some form of optical space switching. Such optical space switching architectures required multiple switching elements, leading to increased power consumption and footprint issues. Accordingly, it would be beneficial for new optical, e.g. fiber optic or integrated optical, interconnection architectures to address the traditional hierarchal time-division multiplexed (TDM) space based routing and interconnection to provide reduced latency, increased flexibility, lower cost, and lower power consumption. Accordingly, it would be beneficial to exploit networks operating in multiple domains by overlaying mode division multiplexing to provide increased throughput in bus, point-to-point networks, and multi-cast networks, for example, discretely or in combination with wavelength division multiplexing.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: July 11, 2017
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, SCUOLA SUPERIORE SANT'ANNA
    Inventors: Odile Liboiron-Ladouceur, Nicola Andriolli, Isabella Cerutti, Philippe Velha
  • Patent number: 9671424
    Abstract: Energy dissipation measurements in Frequency Modulation-Atomic Force Microscopy (FM-AFM) should provide additional information for dynamic force measurements as well as energy dissipation maps for robust material properties imaging as they should not be dependent directly upon the cantilever surface interaction regime. However, unexplained variabilities in experimental data have prevented progress in utilizing such energy dissipation studies. The inventors have demonstrated that the frequency response of the piezoacoustic cantilever excitation system, traditionally assumed flat, can actually lead to surprisingly large apparent damping by the coupling of the frequency shift to the drive-amplitude signal. Accordingly, means for correcting this source of apparent damping are presented allowing dissipation measurements to be reliably obtained and quantitatively compared to theoretical models.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: June 6, 2017
    Assignee: The Royal Institution of the Advancement of Learning/McGill University
    Inventors: Aleksander Labuda, Peter Grutter, Yoichi Miyahara, William Paul, Antoine Roy-Gobeil
  • Patent number: 9663755
    Abstract: Various embodiments of methods and apparatuses for separating sperm, including apparatus having an inlet and an outlet reservoir, and either: i) a radial array of microchannels disposed between the inlet and outlet reservoirs to provide fluid communication therebetween and to direct motile sperm inwardly from the inlet reservoir to the outlet reservoir; or ii) at least one microchannel path disposed between the inlet and outlet reservoirs to provide fluid communication therebetween, the at least one microchannel path having a path inlet adjacent the inlet reservoir, a path outlet adjacent the outlet reservoir, and a junction located between the path inlet and the path outlet for directing a portion of sperm that enter the path inlet towards the outlet reservoir based on wall-swimming behavior of sperm. Methods include filling an apparatus with buffer fluid, introducing semen into an inlet reservoir, and retrieving sperm separated from the semen from the outlet reservoir.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: May 30, 2017
    Assignees: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Reza Nosrati, Lise Marie Eamer, Marion Vollmer, David Allan Sinton, Armand Zini
  • Publication number: 20170072097
    Abstract: It is provided a chitosan sponge for bone regeneration in a subject, comprising chitosan; a purine compound such as guanosine 5?-diphosphate (GDP); and at least one of a growth factor and a pyrophosphatase. Preferably the growth factor is BMP-7. The sponge is formed when the chitosan and the growth factor and/or pyrophosphatase is mixed with the purine compound such as guanosine 5?-diphosphate.
    Type: Application
    Filed: September 8, 2016
    Publication date: March 16, 2017
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Lamees NAYEF, Mina MEKHAIL, Maryam TABRIZIAN
  • Patent number: 9586060
    Abstract: Radiotherapy is one of the most effective treatments for cancer and its success depends critically on accurate targeting and delivery of the correct radiation dose. Accurate dosimetry is therefore essential to maintain and improve patient survival rates. However, size and long wait times currently limit water and graphite based calorimeters to standards laboratories leaving field-based dosimetry to ionization chamber measurements which depend upon a reference field-specified calibration factor. It would therefore be beneficial to provide radiotherapy equipment operators a direct approach of clinical reference dosimetry wherein the dosimeter provides increased independence on dose, dose rate, radiation energy, and energy type, etc. It would be further beneficial for such novel clinical dosimeters to be compact, function as secondary standards used routinely for measurements and allow radiotherapy doses to be measured directly and in an absolute manner.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: March 7, 2017
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Jan Seuntjens, Arman Sarfehnia, James Renaud
  • Patent number: 9573117
    Abstract: A catalyst precursor comprising (A) a microporous support; (B) a non-noble metal precursor; and (C) a pore-filler, wherein the micropores of the microporous support are filled with the pore-filler and the non-noble metal precursor so that the micropore surface area of the catalyst precursor is substantially smaller than the micropore surface area of the support when the pore-filler and the non-noble metal precursor are absent is provided. Also, a catalyst comprising the above catalyst precursor, wherein the catalyst precursor has been pyrolysed so that the micropore surface area of the catalyst is substantially larger than the micropore surface area of catalyst precursor, with the proviso that the pyrolysis is performed in the presence of a gas that is a nitrogen precursor when the microporous support, the non-noble metal precursor and the pore-filler are not nitrogen precursors is also provided. Methods of producing the catalyst precursor and the catalyst are provided.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: February 21, 2017
    Assignees: INSTITUTE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Michel Lefevre, Eric Proietti, Frederic Jaouen, Jean-Pol Dodelet, Allan S. Hay
  • Patent number: 9569887
    Abstract: The identification and determination of aspects of the construction of a patient's heart is important for cardiologists and cardiac surgeons in the diagnosis, analysis, treatment, and management of cardiac patients. For example minimally invasive heart surgery demands knowledge of heart geometry, heart fiber orientation, etc. While medical imaging has advanced significantly the accurate three dimensional (3D) rendering from a series of imaging slices remains a critical step in the planning and execution of patient treatment. Embodiments of the invention construct using diffuse MRI data 3D renderings from iterating connections forms derived from arbitrary smooth frame fields to not only corroborate biological measurements of heart fiber orientation but also provide novel biological views in respect of heart fiber orientation etc.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 14, 2017
    Assignee: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Kaleem Siddiqi, Emmanuel Piuze-Phaneuf, Jon Sporring
  • Publication number: 20170020460
    Abstract: A method for assessing a cancer status of biological tissue includes the steps of: obtaining a Raman spectrum indicating a Raman spectroscopy response of the biological tissue, the Raman spectrum captured using a fiber-optic probe of a fiber-optic Raman spectroscopy system; inputting the Raman spectrum into a boosted tree classification algorithm of a computer program, and using the boosted tree classification algorithm for comparing, in real-time, the captured Raman spectrum to reference data and assessing the cancer status of the biological tissue based on said comparison, the reference data being previously determined based on a set of reference Raman spectra indicating Raman spectroscopy responses of reference biological tissues wherein each of the reference biological tissues is associated with a known cancer status; and generating a real-time output indicating the assessed cancer status of the biological tissue.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicants: POLYVALOR, LIMITED PARTNERSHIP, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Frédéric LEBLOND, Kevin PETRECCA, Michael JERMYN
  • Patent number: 9551718
    Abstract: Assays for selecting a candidate modulator of a TMEM120A ion channel and/or a candidate modulator of chronic pain, the steps comprising contacting a lipid membrane comprising contacting a lipid membrane comprising TMEM120A polypeptide with a test compound; quantitating the TMEM120A ion channel activity; comparing the ion channel activity of the TMEM120A polypeptide with a control; and selecting the test compound that modulates the ion channel activity compared to the control; and methods and compositions for treating chronic pain including osteoarthritic pain.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: January 24, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventor: Reza Sharif-Naeini
  • Publication number: 20170000846
    Abstract: The present invention provides a new drug to treat malignant glioma, which is the most prevalent type of primary tumor of the central nervous system (CNS). The present invention indeed shows that the isolated NFL-TBS40-63 peptide is highly specific for glioma cells, in which it triggers apoptosis. It is therefore presented here for use in a method for treating malignant glioma. The present invention further relates to the use of the NFL-TBS40-63 peptide for detecting specifically glioma cells either in vivo, or in vitro, or for addressing chemical compounds to said tumor cells.
    Type: Application
    Filed: August 5, 2016
    Publication date: January 5, 2017
    Applicants: UNIVERSITE D'ANGERS, INSTITU NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Joel Eyer, Alan Peterson, Julien Balzeau, Raphael Berges
  • Patent number: 9523698
    Abstract: A method for diagnosing the presence of hereditary spastic paraplegia (HSP) or predicting the risk of developing HSP in a human subject, comprising detecting the presence or absence of a defect in a gene encoding a polypeptide comprising the sequence of FIG. 9 (SEQ ID NO: 19), in a nucleic acid sample of the subject, whereby the detection of the defect is indicative that the subject has or is at risk of developing HSP.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: December 20, 2016
    Assignees: Val-Chum L.P., The Royal Institution for the Advancement of Learning/McGill University, Universite de Montreal
    Inventors: Guy A. Rouleau, Paul Valdmanis, Inge Meijer, Pierre Drapeau, Patrick Dion
  • Publication number: 20160340590
    Abstract: A method for processing non-lignocellulosic waste comprises pre-treating the non-lignocellulosic waste by enzymatic hydrolysis to yield a pre-treated non-lignocellulosic waste subjecting the pre-treated non-lignocellulosic waste to microwave hydrothermal carbonization to yield at least one of a hydrochar and a biocrude liquor. A system for processing non-lignocellulosic waste includes an enzymatic hydrolysis station for receiving non-lignocellulosic waste and generating a treated non-lignocellulosic waste, and a microwave hydrothermal carbonization station downstream of the enzymatic hydrolysis station for receiving the treated non-lignocellulosic waste from the enzymatic hydrolysis station and generating at least one of a hydrochar and a biocrude liquor.
    Type: Application
    Filed: May 20, 2016
    Publication date: November 24, 2016
    Applicant: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Vijaya Raghavan, Shrikalaa Kannan, Yvan Gariepy