Patents Assigned to THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF
  • Patent number: 11131676
    Abstract: The present invention provides a method of using increased levels of one or more biomarkers to identify subjects having non-celiac gluten sensitivity or non-celiac wheat sensitivity. The identification would aid the physician or health professional to determine a specific treatment for the patient, for example, a diet that eliminates wheat, rye, and/or barley. In one embodiment, the biomarkers are one or more of soluble CD 14 (sCD14), lipopolysaccharide-binding protein (LBP), anti-lipopolysaccharide antibodies, anti-flagellin antibodies, anti-gliadin antibodies, and intestinal fatty acid-binding protein (FABP2). The present invention also provides a method of using the same markers to monitor the response to treatment for non-celiac wheat sensitivity in a subject.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: September 28, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Armin Alaedini
  • Publication number: 20210285041
    Abstract: Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.
    Type: Application
    Filed: March 28, 2018
    Publication date: September 16, 2021
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Xiaoxu Li, Xin Chen, Shiv Kumar, James Russo, Minchen Chien
  • Publication number: 20210283428
    Abstract: The present subject matter relates to techniques for simultaneous monitoring and modulating target tissue. The disclosed system can include a focused ultrasound (FUS) stimulation probe for stimulating the target tissue, an imaging probe for obtaining ultrasound images of displacement on target tissue, and a processor configured to provide an image of target tissue within about 2 seconds from the stimulating. The imaging probe and the FUS stimulation probe are coaligned and include different center frequencies.
    Type: Application
    Filed: October 7, 2020
    Publication date: September 16, 2021
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa Konofagou, Hermes Arytto Salles Kamimura, Stephen Alexander Lee
  • Patent number: 11119104
    Abstract: The present invention provides methods for treatment of volume-dependent Acute Kidney Injury (vAKI) and ischemic Acute Kidney Injury (iAKI), as well as methods for diagnosing vAKI and iAKI. The methods are based on determining the levels of PAPPA2, NGAL, KRT20, or TACSTD2 protein in a sample from a patient, such as a urine sample. The present invention also provides a device and a diagnostics kit for determining whether a sample from a subject contains PAPPA2, NGAL, KRT20, or TACSTD2 protein.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 14, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jonathan Barasch, Katherine Xu, Paul Rosenstiel, Paolo Guarnieri
  • Patent number: 11116754
    Abstract: This invention relates to methods and compositions for increasing immunity against, and survival of, a bacterial infection by inhibiting Target of Rapamycin (TOR) complex 2 or TORC 2. In particular, the current invention is useful in increasing immunity and survival after infection by Burkholderia cepacia as well as other bacteria since the agents that target TORC2 increase host tolerance of infection rather than target the clearance or containment of specific types of bacteria. This invention also relates to methods and compositions for increasing immunity against, survival of, and host tolerance to a bacterial infection by inhibiting the circadian regulator, Period protein.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: September 14, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michele Shirasu-Hiza, Julie Canman
  • Patent number: 11110199
    Abstract: Hydrogel-based scaffolds useful for promoting pulp cell growth and biosynthesis, regulating pulp cell migration and morphology, or both as well as methods for their production and use are provided.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: September 7, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Helen H. Lu, Sagaw Prateepchinda, Gunnar Hasselgren
  • Patent number: 11110111
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: September 7, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Patent number: 11112360
    Abstract: Systems and methods for performing non-destructive sensing of a cell or tissue, in vivo or in culture, are provided. The disclosed systems and methods include fabricating and powering one or more implantable integrated circuit (IC) chips that include a network of Photovoltaic (PV) cells for energy harvesting from an optical energy source, an optical modulator integrating Quantum Dot capacitors (QD-caps) for optical data transfer using fluorescence modulation, and sensing circuitry. The IC chip disclosed herein can measure a thickness of around 10 ?m, allowing injection into small cells and diffusion through tissue, it is powered and imaged under a microscope and communicates using fluorescence modulation imaged under a microscope.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: September 7, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Kenneth Shepard, Girish Ramakrishnan
  • Patent number: 11109758
    Abstract: Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: September 7, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Elizabeth Marjorie Clare Hillman, Sean A. Burgess
  • Patent number: 11110070
    Abstract: Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount, of an antagonist of the glutamate N-methyl-D-aspartate (NMDA) receptor, such as ketamine, or a pharmaceutically acceptable salt or derivative thereof, is administered to a subject prior to a stressor.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 7, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Rebecca Anne Brachman, Christine Ann Denny, René Hen
  • Patent number: 11111199
    Abstract: The present disclosure provides, inter alia, methods for preparing formaldehyde from carbon dioxide using bis(silyl)acetals, methods for incorporating carbon derived from carbon dioxide into a complex organic molecule derived from formaldehyde using bis(silyl)acetals, and methods for generating an isotopologue of a complex organic molecule derived from formaldehyde using bis(silyl)acetals.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: September 7, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gerard Parkin, Zack Strater, Michael Rauch
  • Patent number: 11106799
    Abstract: Methods, media, and systems for detecting an anomalous sequence of function calls are provided. The methods can include compressing a sequence of function calls made by the execution of a program using a compression model; and determining the presence of an anomalous sequence of function calls in the sequence of function calls based on the extent to which the sequence of function calls is compressed. The methods can further include executing at least one known program; observing at least one sequence of function calls made by the execution of the at least one known program; assigning each type of function call in the at least one sequence of function calls made by the at least one known program a unique identifier; and creating at least part of the compression model by recording at least one sequence of unique identifiers.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: August 31, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Angelos D. Keromytis, Salvatore J. Stolfo
  • Publication number: 20210264663
    Abstract: The present subject matter relates to a voxel and methods of organizing an object into a three-dimensional (3D) array using the voxel. The voxel can include a plurality of frames including at least one single stranded (ss) DNA motif with at least one free base, wherein the at least one ssDNA motif hybridizes with a complementary strand fragment of other frames.
    Type: Application
    Filed: October 14, 2020
    Publication date: August 26, 2021
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Oleg Gang, Ye Tian, Jason S. Kahn, Yan Xiong, Brian Minevich, Sanat K. Kumar
  • Publication number: 20210261009
    Abstract: A system may mitigate leakage currents in non-isolated charging stations for electric vehicles. The system may include a bank of one or more parallel capacitors per phase electrically coupled to an AC voltage source, wherein a neutral point of the one or more parallel capacitors is electrically coupled to a DC ground; a bank of one or more inductors per phase electrically coupled to the one or more parallel capacitors, wherein each inductor is in series with and downstream from one capacitor; a rectifier electrically coupled to and downstream from the one or more parallel inductors, wherein the rectifier converts the AC voltage source to a DC voltage for supply to a battery; a DC bus electrically coupled to the rectifier; and a controller, wherein the controller is configured to mitigate leakage currents by controlling a voltage of at least one of the bank of one or more parallel capacitors.
    Type: Application
    Filed: February 11, 2021
    Publication date: August 26, 2021
    Applicants: The Trustees of Columbia University in the City of New York, Longmax Corporation Ltd.
    Inventors: William-Michael Eull, Liwei Zhou, Weizhong Wang, Gangqi Cen, Matthias Preindl
  • Patent number: 11096660
    Abstract: Ultrasound methods, devices, and systems are described which support a useful compromise in terms of spatial resolution and temporal resolution for capturing motion in tissue structures. Tissue engineering articles, methods, systems, and devices which employ ultrasound to deliver biological agents to selected regions of a tissue scaffold, deliver mechanical stimulation to cells growing in a tissue scaffold, and enhance the perfusion of fluids through tissue scaffolds.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 24, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Elisa E. Konofagou, Jean Provost, Jianwen Luo, Stanley J. Okrasinski, Stéphane Thiébaut, Vu Thanh-Hieu Nguyen
  • Patent number: 11098353
    Abstract: This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: August 24, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • Patent number: 11098296
    Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 24, 2021
    Assignees: The Trustees of Columbia University in the City of New York, University of Kentucky Research Foundation
    Inventors: Donald Landry, Chang-Guo Zhan
  • Publication number: 20210254143
    Abstract: Described herein are devices, systems, and methods for trapping single-cell lysates in sealed, microwells capable of printing RNA on glass or capturing RNA on beads. These provide efficient, inexpensive manipulation of RNA from individual cells suitable for single-cell transcriptomics on a large scale. Also described are dual barcode capture beads and merged barcode capture beads.
    Type: Application
    Filed: November 27, 2018
    Publication date: August 19, 2021
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Peter A. SIMS, Sayantan BOSE, Jinzhou YUAN
  • Patent number: 11092424
    Abstract: A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: August 17, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Michal Lipson, Xingchen Ji, Alexander Klenner, Xinwen Yao, Yu Gan, Alexander L. Gaeta, Christine P Hendon
  • Patent number: 11085076
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: August 10, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Xiaoxu Li, Xin Chen, Zengmin Li, Shiv Kumar, Shundi Shi, Cheng Guo, Jianyi Ren, Min-Kang Hsieh, Minchen Chien, Chuanjuan Tao, Ece Erturk, Sergey Kalachikov, James J. Russo