Patents Assigned to The Trustees of the University of Pennsylvania
  • Publication number: 20220145326
    Abstract: The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell. The lentiviral transfer vector may be characterized by the following features: (a) including a cytomegalovirus (CMV) promoter; (b) including a polynucleotide encoding a partial gag protein that includes a mutated INS1 inhibitory sequence that reduces restriction of nuclear export of RNA; (c) not including a polynucleotide encoding the INS2, INS3, and INS4 inhibitory sequences of gag; (d) not including an SV40 origin of replication and/or an f1 origin of replication; (e) including a cPPT sequence that contains splice site; (f) including an EF1alpha promoter with intact splice donor and acceptor sites; and (g) including hepatitis B PRE with mutation in start codon of X protein ORF.
    Type: Application
    Filed: November 23, 2021
    Publication date: May 12, 2022
    Applicants: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Vladimir SLEPUSHKIN, Dmitriy LUKASHEV
  • Patent number: 11325963
    Abstract: The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte, macrophage or dendritic cell, the modified cell is recruited to the tumor microenvironment where it acts as a potent immune effector by infiltrating the tumor and killing the target cells. One aspect includes a modified cell and pharmaceutical compositions comprising the modified cell for adoptive cell therapy and treating a disease or condition associated with immunosuppression.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: May 10, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Saar Gill, Michael Klichinsky, Carl H. June
  • Patent number: 11327041
    Abstract: Provided are devices and methods for a rapid, non-perturbative and energy-efficient technique for pH sensing based on a flexible graphene electrode. This technique does not require the application of gate voltage or source-drain bias, and demonstrates fast pH-characterization with precision. The disclosed technology is suitable for in vivo monitoring of tumor-induced pH variation in tissues and detection of pH changes as required in a DNA sequencing system.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: May 10, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Jinglei Ping
  • Patent number: 11324858
    Abstract: The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: May 10, 2022
    Assignees: The Trustees of the University of Pennsylvania, Massachusetts Institute of Technology
    Inventors: Christopher S. Chen, Jan D. Baranski, Ritika Chaturvedi, Michael T. Yang, Kelly R. Stevens, Sangeeta N. Bhatia
  • Publication number: 20220135931
    Abstract: The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.
    Type: Application
    Filed: October 15, 2021
    Publication date: May 5, 2022
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Fabio FACHIN, Rodney RIETZE, Michael R. GREENE, Lan CAO
  • Patent number: 11319358
    Abstract: The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte, macrophage or dendritic cell, the modified cell is recruited to the tumor microenvironment where it acts as a potent immune effector by infiltrating the tumor and killing the target cells. One aspect includes a modified cell and pharmaceutical compositions comprising the modified cell for adoptive cell therapy and treating a disease or condition associated with immunosuppression.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: May 3, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Saar Gill, Michael Klichinsky, Carl H. June
  • Publication number: 20220125493
    Abstract: Systems and methods for improved cranio-maxillo-facial distraction are provided. The disclosed subject matter can include a distraction device adapted for subcutaneous implantation in a patient, and a handheld device operationally coupled to the distraction device. The distraction device can include a distraction element, adapted to attach to opposing bony fragments of a bone and perform distraction osteogenesis on the bone, and a rotatable magnetic element, coupled to the distraction element such that rotation of the magnetic element controls the distraction element. The handheld device can include a magnetic element, operationally coupled to and magnetically aligned with the magnetic element of the distraction device, such that rotation of the magnetic element of the handheld device causes corresponding rotation of the magnetic element of the distraction device.
    Type: Application
    Filed: February 12, 2020
    Publication date: April 28, 2022
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Jesse Taylor, Ari Wes
  • Patent number: 11317204
    Abstract: Methods, systems, and computer readable media for a phase array directed speaker are disclosed. One system includes a phase array and a controller. The controller is configured to determine an area to send directed sound. The controller is also configured to generate input instructions for the phase array to send directed sound to the area. The input instructions indicate that at least one speaker in the phase array is to delay outputting an audio signal relative to at least one other speaker in the phase array. The phase array is configured to generate, using the input instructions and ultrasonic signals emitted by the speakers in the phase array, the directed sound.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: April 26, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Jia-En Marcus Pan, Alfred Charles Murabito, III, Daniel Dongyuel Lee
  • Patent number: 11312784
    Abstract: Disclosed herein are multifunctional antigen-binding proteins comprising at least one multifunctional recombinant protein scaffold and at least one antigen-specific binding domain. Polynucleotides encoding the multifunctional antigen-binding proteins, vectors containing the disclosed polynucleotides, and cells that have been genetically engineered to express the polynucleotide are also provided. Methods of using the multifunctional antigen-binding proteins are disclosed.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: April 26, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang, Zhiqiang Zhu, Lian Lam, Zheng Cai
  • Publication number: 20220117717
    Abstract: Techniques for mesh augmentation and prevention of incisional hernia, including systems and methods for affixing mesh to a fascial incision. A mesh strip can be integrated with one or more uni-directional fasteners. Each fastener can include an anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating interface. An applicator can include tension arms adapted to interface with the mating interfaces of the fasteners to maintain a vertical tension of the mesh strip and a handle coupled with the tension arms adapted to spread the tension arms and thereby control a horizontal tension of the mesh strip. The mesh strip can be configured to be aligned over a fascial incision using the applicator and affixed under tension to anterior abdominal wall fascia by tissue penetration of the anchoring mechanisms of the one or more fasteners.
    Type: Application
    Filed: December 28, 2021
    Publication date: April 21, 2022
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: John Patrick Fischer
  • Patent number: 11305280
    Abstract: A magnetic separation device has a membrane having a plurality of pores, a magnetically soft material layer disposed on the membrane, and a passivation layer disposed on the magnetically soft material layer. The magnetic separation device may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: April 19, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Aaron Issadore, Melaku Muluneh Woldemariam
  • Patent number: 11306133
    Abstract: The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte, macrophage or dendritic cell, the modified cell is recruited to the tumor microenvironment where it acts as a potent immune effector by infiltrating the tumor and killing the target cells. One aspect includes a modified cell and pharmaceutical compositions comprising the modified cell for adoptive cell therapy and treating a disease or condition associated with immunosuppression.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: April 19, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Saar Gill, Michael Klichinsky, Carl H. June
  • Patent number: 11306134
    Abstract: The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte, macrophage or dendritic cell, the modified cell is recruited to the tumor microenvironment where it acts as a potent immune effector by infiltrating the tumor and killing the target cells. One aspect includes a modified cell and pharmaceutical compositions comprising the modified cell for adoptive cell therapy and treating a disease or condition associated with immunosuppression.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: April 19, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Saar Gill, Michael Klichinsky, Carl H. June
  • Patent number: 11299536
    Abstract: The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: April 12, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew J. Frigault, Yangbing Zhao, John Scholler, Carl H. June
  • Patent number: 11300640
    Abstract: The present invention relates to compositions and methods using protein reporters as imaging agents in 129Xe NMR and MRI applications. It is described that bla and MBP are genetically-encoded proteins that induce a detectable chemical shift during 129Xe NMR, allowing for use as protein reporters in research and clinical applications.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: April 12, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ivan J. Dmochowski, Yanfei Wang, Benjamin W. Roose, Serge Zemerov, Zhuangyu Zhao
  • Patent number: 11298541
    Abstract: A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: April 12, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Michael Kahana, Daniel S. Rizzuto
  • Publication number: 20220104517
    Abstract: The presently disclosed subject matter relates to method, compositions and food products for improving intestinal health, treating intestinal dysbiosis and/or treating an intestinal disorder in a subject, e.g., a human or a companion animal.
    Type: Application
    Filed: January 23, 2020
    Publication date: April 7, 2022
    Applicants: MARS, INCORPORATED, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Sally Christine PEREA, Daniel P. BEITING
  • Publication number: 20220096459
    Abstract: Compositions and methods for treatment of viral skin disease, precancerous and cancerous skin disease, and other neoplasms are disclosed.
    Type: Application
    Filed: October 12, 2021
    Publication date: March 31, 2022
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Xiaowei Xu, Shujing Liu, Alain Rook, Pankaj Karande
  • Patent number: 11288818
    Abstract: A method for prediction of an indication of motion using input from an event-based camera includes receiving events captured by an event-based camera, wherein each of the events represents a location of a change in pixel intensity, a polarity of the change, and a time. The method further includes discretizing the events into time discretized event volumes, each of which contain events that occur within a specified time range. The method further includes providing the time discretized event volumes as input to an encoder-decoder neural network trained to predict an indication of motion using a loss function that measures quality of image deblurring; generating, using the neural network, a prediction of the indication of motion. The method further includes using the prediction of the indication of motion in a machine vision application.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: March 29, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Konstantinos Daniilidis, Alex Zihao Zhu
  • Patent number: 11278619
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 22, 2022
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai