Patents Assigned to The Trustees of the University of Pennsylvania
  • Patent number: 10881698
    Abstract: The invention provides methods and compositions for the diagnosis, prognosis and treatment of respiratory tract diseases. Specifically, the invention provides diagnosis, prognosis and treatment of respiratory infections using bitter and sweet taste signal transduction pathways. In one aspect, the invention relates to a method for treating a respiratory infection by administering a composition to the respiratory tract of a subject in an amount capable of activating bitter taste signaling and/or inhibiting sweet taste signaling. The composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract. In another aspect, the invention relates to a composition for treatment of a respiratory infection. Such composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: January 5, 2021
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, MONELL CHEMICAL SENSES CENTER, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Noam A. Cohen, Robert J. Lee, Danielle R. Reed
  • Patent number: 10881321
    Abstract: Method and apparatus for processing diffusion data for identification of white matter tracts in the brain of a patient is provided herein. The method involves, with a processor: generating a connectivity based representation of white matter fibers for multiple different subjects from the connectivity signatures of the fibers from a diffusion magnetic resonance imaging (dMRI) without using the physical coordinates of the fibers; generating a fiber bundle atlas from the connectivity based fiber representation of (a) which define a model of the human brain; adaptively clustering fibers of a new patient utilizing the fiber bundle atlas of (b) to extract white matter tracts without manual intervention in the form of drawing regions of interest; and presenting the selected white matter tracts and diffusion data in a report or on a display device. This method and apparatus can be used even for patients having edema or brain perturbations.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 5, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ragini Verma, Birkan Tunc
  • Patent number: 10883082
    Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: January 5, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James Eberwine, Jai-Yoon Sul, Chia-Wen Wu, Fanyi Zeng, Junhyong Kim
  • Patent number: 10883145
    Abstract: The present invention provides compositions and methods for the multiplex detection of biomarkers in an environmental, non-biological or biological sample. Compositions and methods are provided for simultaneously detecting and identifying multiple pathogens, including viruses, bacteria, fungi, protozoa and helminths, present in a sample.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: January 5, 2021
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Erle S. Robertson, James Alwine
  • Patent number: 10884430
    Abstract: The present subject matter relates to systems and methods for generating trajectories for a plurality of vehicles in a multi-vehicle system. An optimal motion plan is determined for moving each of the plurality of vehicles between a respective starting position and an assigned goal position, possible collisions are identified among the optimal motion plans of the plurality of vehicles, and, for a subset of the plurality of vehicles identified as being associated with a possible collision, the optimal motion plan of each vehicle in the subset is modified to define modified trajectories that each include a common circular holding pattern such that the possible collision is avoided.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: January 5, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: R. Vijay Kumar, Sarah Yifang Tang
  • Publication number: 20200405165
    Abstract: Provided are electrodes that comprise MXene materials as well as related methods of using the disclosure electrodes in neural and other monitoring applications.
    Type: Application
    Filed: September 14, 2018
    Publication date: December 31, 2020
    Applicants: The Trustees Of The University Of Pennsylvania, Drexel University
    Inventors: Flavia VITALE, Brian LITT, Nicolette DRISCOLL, Yury GOGOTSI, Babak ANASORI, Kathleen MALESKI
  • Patent number: 10874727
    Abstract: The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: December 29, 2020
    Assignees: The Trustees of the University of Pennsylvania, Regents of the University of Minnesota
    Inventors: James L. Riley, Carl H. June, Bruce R. Blazar, Keli Hippen
  • Patent number: 10874728
    Abstract: The present invention provides methods of immunizing a subject against a tumor, inhibiting tumor growth, inhibiting tumor recurrence, treating, suppressing the growth of, or decreasing the incidence of a tumor, overcoming tolerance to a tumor vasculature marker (TVM) in a subject comprising the step of administering a vaccine comprising a TVM or a nucleic acid encoding a TVM and related vaccines. The present invention also provides a method of targeting a tumor vasculature in a subject having a tumor comprising the step of contacting said subject with a labeled compound that binds a) a tumor vasculature marker (TVM) or b) a nucleic acid molecule encoding said TVM.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: December 29, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: George Coukos, Andrea Facciabene
  • Patent number: 10876157
    Abstract: Disclosed are insulated nanoelectrode associated with nanopores, useful in macromolecular analysis devices. Also disclosed are related methods of fabrication and use.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: December 29, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Marija Drndic, Ken Healy, Vishva Ray, Lauren J. Willis, Neil Peterman, John Bartel
  • Patent number: 10870670
    Abstract: The invention relates to processes for preparing (S,S)-secoisolariciresinol diglucoside and (R,R)-secoisolariciresinol diglucoside and compositions comprising the same.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: December 22, 2020
    Assignees: THE SCRIPPS RESEARCH INSTITUTE, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Melpo Christofidou-Solomidou, Kyriacos C. Nicolaou, Roman A. Valiulin, Nicholas Simmons, Philipp M. Heretsch
  • Patent number: 10865419
    Abstract: Disclosed herein are compositions and methods for treating Type II diabetes. The compositions comprise plant expressed Exendin 4. Particularly exemplified are plant derived compositions that include a CTB-EX4 conjugate that is bioencapsulated in chloroplasts.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: December 15, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Henry Daniell
  • Publication number: 20200386977
    Abstract: Systems and methods for passive multi-directional illumination in light-sheet fluorescence imaging and microscopy are disclosed herein. An elliptical light shaping diffuser is placed in the illumination path between the source of a light-sheet and the illuminated sample. The light-sheet is diffused anisotropically along two directions perpendicular to its propagation direction, eliminating stripe artifacts in obtained images. The method includes converting a light-sheet into an elliptically diffuse light-sheet by passing it through an elliptical light shaping diffuser, illuminating a sample with the elliptically diffuse light-sheet. The system includes a light-sheet source, an elliptical light shaping diffuser adapted to convert the light-sheet into an elliptically diffuse light-sheet to illuminate the sample, typical microscopy optics and lenses, and image capturing elements.
    Type: Application
    Filed: November 6, 2018
    Publication date: December 10, 2020
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Seyyed Salili, Douglas Durian, Matthew Harrington
  • Patent number: 10857240
    Abstract: Codon optimized nucleic acid sequences for the long form and short form of RdCVF are provided, as well as recombinant viral vectors, such as AAV, expression cassettes, proviral plasmids or other plasmids containing the codon optimized sequences. Recombinant vectors are provided that express the codon optimized RdCVFL and RdCVF individually, or express two copies of a codon optimized RdCVF or RdCVFL nucleic acid sequence, or both RdCVFL and RdCVF in a single vector or virus. Compositions containing these codon optimized sequences are useful in methods for treating, retarding or halting certain blinding diseases resulting from the absence or inappropriate expression of RdCVF and RdCVFL.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: December 8, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jeannette Bennicelli, Jean Bennett, Junwei Sun
  • Patent number: 10851149
    Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the Glycosyl-phosphatidylinositol (GPI)-linked GDNF family ?-receptor 4 (GFR?4).
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: December 1, 2020
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, NOVARTIS AG, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Donald L. Siegel, Michael C. Milone, Vijay Bhoj, Christoph Rader
  • Patent number: 10851166
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: December 1, 2020
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Hilmar Erhard Ebersbach, Thomas Huber, Julia Jascur, Celeste Richardson, Reshma Singh, Huijuan Song, Qilong Wu, Jiquan Zhang
  • Patent number: 10849970
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 1, 2020
    Assignees: Duke University, Triad National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The Government of The United States of America as Represented by the Secretary of the Department of Health and Human Services, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John R. Mascola
  • Patent number: 10849841
    Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: December 1, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: George Cotsarelis, Luis Garza
  • Publication number: 20200368358
    Abstract: The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 26, 2020
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Steven Siegel, Karen WINEY
  • Patent number: 10844117
    Abstract: The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having ?-folate receptor (FR?) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FR? binding domain is fully human, thereby preventing a host immune response.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: November 24, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Daniel J. Powell, Jr.
  • Patent number: 10842832
    Abstract: The invention features the use of a defined microbial consortia for the replacement of a gut microbiome associated with disease. In particular, the invention provides for the treatment of hyperammonemia, Clostridium difficile colitis, hepatic encephalopathy associated with cirrhosis, and inflammatory bowel disease.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: November 24, 2020
    Assignee: The Trustees of The University Of Pennsylvania
    Inventors: Frederic Bushman, Gary Wu, James Lewis, Mark Goulian