Patents Assigned to The United States Government as Represented by the Department of Veterans Affair
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Patent number: 12127998Abstract: A guide system is provided that uses a plurality of sensors to identify and determine a clear path for an ambulatory vision impaired person. The system includes one or more wheels that rotate to propel the system, a platform supported by the one or more wheels and housing a processor, a rigid harness with a haptic feedback grip that is positioned to be grasped by an operator, and one or more sensors configured to sense information about the environment. In operation, the processor analyzes information sensed by the sensors to identify object in the path of the guide system and sends messages to the operator to allow the operator to avoid the identified objects. The messages may be sent to the operator via the haptic feedback grip or audibly via a speaker or via a wireless connection to a haptic or audio device being worn by the operator.Type: GrantFiled: November 17, 2023Date of Patent: October 29, 2024Assignee: United States Government as Represented by the Department of Veterans AffairsInventor: Brian L. Higgins
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Patent number: 12121526Abstract: The present invention concerns protection of an organ or tissue outside of the central nervous system following an ischemic episode. In particular aspects, the invention concerns organ preservation for transplantation, angina pectoris, kidney reperfusion injury, and so forth. In specific embodiments, the organ is subjected to an inhibitor of an NCCa-ATP channel that is regulated by SUR1. Exemplary inhibitors include sulfonylurea compounds, such as glibenclamide, for example.Type: GrantFiled: December 21, 2020Date of Patent: October 22, 2024Assignees: The United States Government as Represented by the Department of Veterans Affairs, University of Maryland, BaltimoreInventor: J. Marc Simard
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Patent number: 12122853Abstract: Disclosed herein, are decoy peptides or polypeptides capable of inhibiting binding of 5-HT2A autoantibodies to a second extracellular loop region of the 5-HT2A receptor, and a pharmaceutical composition containing the decoy peptides or polypeptides and methods of use.Type: GrantFiled: March 4, 2022Date of Patent: October 22, 2024Assignee: The United States Government As Represented By The Department of Veterans AffairsInventor: Mark B. Zimering
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Patent number: 12116416Abstract: The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.Type: GrantFiled: October 6, 2023Date of Patent: October 15, 2024Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Richard H. Weisbart, Robert N. Nishimura
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Patent number: 12115018Abstract: An assembly for receiving a transesophageal echocardiogram (TEE) probe comprising a probe shaft having a length can comprise a cover defining an opening at a proximal end and a receiving space in communication with the opening, the receiving space having a length in a longitudinal dimension that is sufficient to receive the length of the probe shaft. A gel capsule can be positioned within the receiving space of the cover. The gel capsule can define a proximal opening and an interior in communication with the proximal opening. The interior of the gel capsule can contain a quantity of gel. Within a plane that is perpendicular to the longitudinal dimension, the interior can have a cross sectional area that is sufficient to receive a distal end of the probe shaft with a clearance to permit contact between the gel within the capsule and an exterior surface of the probe shaft.Type: GrantFiled: May 8, 2020Date of Patent: October 15, 2024Assignee: United States Government As Represented By The Department Of Veterans AffairsInventor: Gerardo Robles
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Patent number: 12115383Abstract: Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.Type: GrantFiled: March 24, 2022Date of Patent: October 15, 2024Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Amit Etkin, Corey Keller, Wei Wu
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Publication number: 20240335489Abstract: Disclosed are compositions, devices, kits, and methods for treatment of Enterobacteriaceae infection. Aspects of the present disclosure are directed to bacteriophage compositions comprising one or more of ES17, ES19, HP3, HP3.1, and HP3.2. Certain aspects of the disclosure are directed to compositions comprising (a) bacteriophage ES17 or bacteriophage ES19, (b) bacteriophage HP3, and (c) bacteriophage HP3.1. Also disclosed are compositions comprising bacteriophage HP 3.2. Further disclosed are devices and kits comprising such compositions and methods for use of such compositions in treatment and prevention of pathogenic E. coli infection.Type: ApplicationFiled: June 24, 2024Publication date: October 10, 2024Applicants: Baylor College of Medicine, United States Government as Represented by the Department of Veterans AffairsInventors: Anthony Maresso, Robert Ramig, Sabrina Green, Austen Terwilliger, Keiko Salazar, Justin R. Clark, Barbara Trautner
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Patent number: 12110504Abstract: Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.Type: GrantFiled: November 3, 2023Date of Patent: October 8, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Zurab Siprashvili, Ngon T. Nguyen, M. Peter Marinkovich, Jean Tang, Alfred T. Lane, Paul A. Khavari
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Patent number: 12102640Abstract: Disclosed herein are methods of treating disorders of the retina (e.g., macular degeneration, retinitis pigmentosa, etc.) comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound (for example, an antipsychotic drug) that blocks or diminishes agonist-mediated responses upon binding to either dopamine D2-like receptors or serotonin 5-HT2 receptors.Type: GrantFiled: May 17, 2021Date of Patent: October 1, 2024Assignee: United States Government as represented by the Department of Veterans AffairsInventor: Ralph Jensen
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Patent number: 12102456Abstract: Technologies are provided for remote neuropsychological assessments and other types of remote assessments (medical or otherwise).Type: GrantFiled: October 26, 2022Date of Patent: October 1, 2024Assignee: United States Government as Represented by the Department of Veterans AffairsInventor: Jessica Alva
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Patent number: 12097367Abstract: An iontophoresis system for positioning against skin of a subject is disclosed. The iontophoresis system can comprise at least one vessel having a solvent therein. An anode apparatus can couple to the at least one vessel. The anode apparatus can comprise a first reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a first electrode positioned above the first reservoir. A cathode apparatus can couple to the at least one vessel. The cathode apparatus can comprise a second reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a second electrode positioned above the second reservoir.Type: GrantFiled: May 4, 2022Date of Patent: September 24, 2024Assignee: United States Government As Represented By The Department Of Veterans AffairsInventors: Anton Sabiev, William Bauman, Mark Korsten
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Patent number: 12096863Abstract: An access system includes a laterally extending frame, a carriage in operative connection with the laterally extending frame and including a drive to move the carriage laterally on the frame, a seat support attached to the carriage including a seat assembly interface and a lift to raise and lower the seat assembly interface within a range of positions, a seat assembly attached to the seat assembly interface, a controller in operative connection with the drive of the carriage and the lift of the seat support via which the position of the seat support is controllable, and a controller interface in operative connection with the controller.Type: GrantFiled: August 31, 2021Date of Patent: September 24, 2024Assignees: University of Pittsburg—Of the Commonweath System of Higher Education, The United States Government as represented by the Department of Veterans AffairsInventors: Rory Alan Cooper, Michael A. Shulock, Joshua D. Brown, Garrett G. Grindle, Benjamin Todd Gebrosky, Sayeedur Rahman, Sivan Almosnino, Lisa Garamella, Daniel Robin
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Patent number: 12090145Abstract: The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition.Type: GrantFiled: August 20, 2019Date of Patent: September 17, 2024Assignees: YALE UNIVERSITY, The United States Government as represented by the Department of Veterans AffairsInventors: Chadi Abdallah, John Krystal, Ronald Duman, Gerard Sanacora
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Patent number: 12077812Abstract: Disclosed herein, are methods of detecting multiple sclerosis in a subject by measuring relative abundances of multiple oral microbiota in sample. Also, disclosed herein are methods of treatment and prophylaxis of MS.Type: GrantFiled: April 7, 2022Date of Patent: September 3, 2024Assignees: The United States Government As Represented By The Department Of Veterans Affairs, The Board Of Trustees Of The University Of IllinoisInventors: Douglas Feinstein, Anne Boullerne
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Publication number: 20240290473Abstract: A deep learning-based system and method is provided that uses a convolutional neural network to rapidly transform in vivo reflectance confocal microscopy (RCM) images of unstained skin into virtually-stained hematoxylin and eosin-like images with microscopic resolution, enabling visualization of epidermis, dermal-epidermal junction, and superficial dermis layers. The network is trained using ex vivo RCM images of excised unstained tissue and microscopic images of the same tissue labeled with acetic acid nuclear contrast staining as the ground truth. The trained neural network can be used to rapidly perform virtual histology of in vivo, label-free RCM images of normal skin structure, basal cell carcinoma and melanocytic nevi with pigmented melanocytes, demonstrating similar histological features of traditional histology from the same excised tissue. The system and method enables more rapid diagnosis of malignant skin neoplasms and reduces invasive skin biopsies.Type: ApplicationFiled: June 29, 2022Publication date: August 29, 2024Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Aydogan Ozcan, Jingxi Li, Yair Rivenson, Xiaoran Zhang, Philip O. Scumpia, Jason Garfinkel, Gennady Rubinstein
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Patent number: 12072889Abstract: An intermediate data object is described that bridges source data to analysis-ready variables (ARVs).Type: GrantFiled: November 4, 2019Date of Patent: August 27, 2024Assignee: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventor: Anne S Woods
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Patent number: 12071668Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.Type: GrantFiled: February 18, 2022Date of Patent: August 27, 2024Assignees: Duke University, United States Government as Represented by the Department of Veterans AffairsInventors: Ephraim L. Tsalik, Geoffrey S. Ginsburg, Christopher W. Woods, Ricardo Henao Giraldo, Rachel A. Myers
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Patent number: 12070399Abstract: Disclosed herein are devices, systems, and methods for accommodating quick and easy exchange of footwear for lower limb amputees. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: June 17, 2019Date of Patent: August 27, 2024Assignee: United States Government As Represented By The Department Of Veterans AffairsInventors: Andrew Hansen, Gregory Owen Voss, Eric Nickel, Emily Hein
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Publication number: 20240269149Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).Type: ApplicationFiled: August 22, 2023Publication date: August 15, 2024Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
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Patent number: 12049486Abstract: In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.Type: GrantFiled: October 25, 2021Date of Patent: July 30, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Joseph R. Pisegna, Patrizia M. Germano, John P. Vu