Patents Assigned to The United States Government as Represented by the Department of Veterans Affair
  • Patent number: 12127998
    Abstract: A guide system is provided that uses a plurality of sensors to identify and determine a clear path for an ambulatory vision impaired person. The system includes one or more wheels that rotate to propel the system, a platform supported by the one or more wheels and housing a processor, a rigid harness with a haptic feedback grip that is positioned to be grasped by an operator, and one or more sensors configured to sense information about the environment. In operation, the processor analyzes information sensed by the sensors to identify object in the path of the guide system and sends messages to the operator to allow the operator to avoid the identified objects. The messages may be sent to the operator via the haptic feedback grip or audibly via a speaker or via a wireless connection to a haptic or audio device being worn by the operator.
    Type: Grant
    Filed: November 17, 2023
    Date of Patent: October 29, 2024
    Assignee: United States Government as Represented by the Department of Veterans Affairs
    Inventor: Brian L. Higgins
  • Patent number: 12121526
    Abstract: The present invention concerns protection of an organ or tissue outside of the central nervous system following an ischemic episode. In particular aspects, the invention concerns organ preservation for transplantation, angina pectoris, kidney reperfusion injury, and so forth. In specific embodiments, the organ is subjected to an inhibitor of an NCCa-ATP channel that is regulated by SUR1. Exemplary inhibitors include sulfonylurea compounds, such as glibenclamide, for example.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: October 22, 2024
    Assignees: The United States Government as Represented by the Department of Veterans Affairs, University of Maryland, Baltimore
    Inventor: J. Marc Simard
  • Patent number: 12122853
    Abstract: Disclosed herein, are decoy peptides or polypeptides capable of inhibiting binding of 5-HT2A autoantibodies to a second extracellular loop region of the 5-HT2A receptor, and a pharmaceutical composition containing the decoy peptides or polypeptides and methods of use.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: October 22, 2024
    Assignee: The United States Government As Represented By The Department of Veterans Affairs
    Inventor: Mark B. Zimering
  • Patent number: 12116416
    Abstract: The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.
    Type: Grant
    Filed: October 6, 2023
    Date of Patent: October 15, 2024
    Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Richard H. Weisbart, Robert N. Nishimura
  • Patent number: 12115018
    Abstract: An assembly for receiving a transesophageal echocardiogram (TEE) probe comprising a probe shaft having a length can comprise a cover defining an opening at a proximal end and a receiving space in communication with the opening, the receiving space having a length in a longitudinal dimension that is sufficient to receive the length of the probe shaft. A gel capsule can be positioned within the receiving space of the cover. The gel capsule can define a proximal opening and an interior in communication with the proximal opening. The interior of the gel capsule can contain a quantity of gel. Within a plane that is perpendicular to the longitudinal dimension, the interior can have a cross sectional area that is sufficient to receive a distal end of the probe shaft with a clearance to permit contact between the gel within the capsule and an exterior surface of the probe shaft.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: October 15, 2024
    Assignee: United States Government As Represented By The Department Of Veterans Affairs
    Inventor: Gerardo Robles
  • Patent number: 12115383
    Abstract: Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: October 15, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Amit Etkin, Corey Keller, Wei Wu
  • Publication number: 20240335489
    Abstract: Disclosed are compositions, devices, kits, and methods for treatment of Enterobacteriaceae infection. Aspects of the present disclosure are directed to bacteriophage compositions comprising one or more of ES17, ES19, HP3, HP3.1, and HP3.2. Certain aspects of the disclosure are directed to compositions comprising (a) bacteriophage ES17 or bacteriophage ES19, (b) bacteriophage HP3, and (c) bacteriophage HP3.1. Also disclosed are compositions comprising bacteriophage HP 3.2. Further disclosed are devices and kits comprising such compositions and methods for use of such compositions in treatment and prevention of pathogenic E. coli infection.
    Type: Application
    Filed: June 24, 2024
    Publication date: October 10, 2024
    Applicants: Baylor College of Medicine, United States Government as Represented by the Department of Veterans Affairs
    Inventors: Anthony Maresso, Robert Ramig, Sabrina Green, Austen Terwilliger, Keiko Salazar, Justin R. Clark, Barbara Trautner
  • Patent number: 12110504
    Abstract: Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.
    Type: Grant
    Filed: November 3, 2023
    Date of Patent: October 8, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Zurab Siprashvili, Ngon T. Nguyen, M. Peter Marinkovich, Jean Tang, Alfred T. Lane, Paul A. Khavari
  • Patent number: 12102640
    Abstract: Disclosed herein are methods of treating disorders of the retina (e.g., macular degeneration, retinitis pigmentosa, etc.) comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound (for example, an antipsychotic drug) that blocks or diminishes agonist-mediated responses upon binding to either dopamine D2-like receptors or serotonin 5-HT2 receptors.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: October 1, 2024
    Assignee: United States Government as represented by the Department of Veterans Affairs
    Inventor: Ralph Jensen
  • Patent number: 12102456
    Abstract: Technologies are provided for remote neuropsychological assessments and other types of remote assessments (medical or otherwise).
    Type: Grant
    Filed: October 26, 2022
    Date of Patent: October 1, 2024
    Assignee: United States Government as Represented by the Department of Veterans Affairs
    Inventor: Jessica Alva
  • Patent number: 12097367
    Abstract: An iontophoresis system for positioning against skin of a subject is disclosed. The iontophoresis system can comprise at least one vessel having a solvent therein. An anode apparatus can couple to the at least one vessel. The anode apparatus can comprise a first reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a first electrode positioned above the first reservoir. A cathode apparatus can couple to the at least one vessel. The cathode apparatus can comprise a second reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a second electrode positioned above the second reservoir.
    Type: Grant
    Filed: May 4, 2022
    Date of Patent: September 24, 2024
    Assignee: United States Government As Represented By The Department Of Veterans Affairs
    Inventors: Anton Sabiev, William Bauman, Mark Korsten
  • Patent number: 12096863
    Abstract: An access system includes a laterally extending frame, a carriage in operative connection with the laterally extending frame and including a drive to move the carriage laterally on the frame, a seat support attached to the carriage including a seat assembly interface and a lift to raise and lower the seat assembly interface within a range of positions, a seat assembly attached to the seat assembly interface, a controller in operative connection with the drive of the carriage and the lift of the seat support via which the position of the seat support is controllable, and a controller interface in operative connection with the controller.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: September 24, 2024
    Assignees: University of Pittsburg—Of the Commonweath System of Higher Education, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Rory Alan Cooper, Michael A. Shulock, Joshua D. Brown, Garrett G. Grindle, Benjamin Todd Gebrosky, Sayeedur Rahman, Sivan Almosnino, Lisa Garamella, Daniel Robin
  • Patent number: 12090145
    Abstract: The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: September 17, 2024
    Assignees: YALE UNIVERSITY, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Chadi Abdallah, John Krystal, Ronald Duman, Gerard Sanacora
  • Patent number: 12077812
    Abstract: Disclosed herein, are methods of detecting multiple sclerosis in a subject by measuring relative abundances of multiple oral microbiota in sample. Also, disclosed herein are methods of treatment and prophylaxis of MS.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: September 3, 2024
    Assignees: The United States Government As Represented By The Department Of Veterans Affairs, The Board Of Trustees Of The University Of Illinois
    Inventors: Douglas Feinstein, Anne Boullerne
  • Publication number: 20240290473
    Abstract: A deep learning-based system and method is provided that uses a convolutional neural network to rapidly transform in vivo reflectance confocal microscopy (RCM) images of unstained skin into virtually-stained hematoxylin and eosin-like images with microscopic resolution, enabling visualization of epidermis, dermal-epidermal junction, and superficial dermis layers. The network is trained using ex vivo RCM images of excised unstained tissue and microscopic images of the same tissue labeled with acetic acid nuclear contrast staining as the ground truth. The trained neural network can be used to rapidly perform virtual histology of in vivo, label-free RCM images of normal skin structure, basal cell carcinoma and melanocytic nevi with pigmented melanocytes, demonstrating similar histological features of traditional histology from the same excised tissue. The system and method enables more rapid diagnosis of malignant skin neoplasms and reduces invasive skin biopsies.
    Type: Application
    Filed: June 29, 2022
    Publication date: August 29, 2024
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Aydogan Ozcan, Jingxi Li, Yair Rivenson, Xiaoran Zhang, Philip O. Scumpia, Jason Garfinkel, Gennady Rubinstein
  • Patent number: 12072889
    Abstract: An intermediate data object is described that bridges source data to analysis-ready variables (ARVs).
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: August 27, 2024
    Assignee: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Anne S Woods
  • Patent number: 12071668
    Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: August 27, 2024
    Assignees: Duke University, United States Government as Represented by the Department of Veterans Affairs
    Inventors: Ephraim L. Tsalik, Geoffrey S. Ginsburg, Christopher W. Woods, Ricardo Henao Giraldo, Rachel A. Myers
  • Patent number: 12070399
    Abstract: Disclosed herein are devices, systems, and methods for accommodating quick and easy exchange of footwear for lower limb amputees. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: August 27, 2024
    Assignee: United States Government As Represented By The Department Of Veterans Affairs
    Inventors: Andrew Hansen, Gregory Owen Voss, Eric Nickel, Emily Hein
  • Publication number: 20240269149
    Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).
    Type: Application
    Filed: August 22, 2023
    Publication date: August 15, 2024
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • Patent number: 12049486
    Abstract: In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: July 30, 2024
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Joseph R. Pisegna, Patrizia M. Germano, John P. Vu