Patents Assigned to The United States of America, as represented by the Secretary, Department of Human Services
  • Substituted phenylpyrrolecarboxamides with therapeutic activity in HIV
    Patent number: 10576059
    Abstract: Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: March 3, 2020
    Assignees: New York Blood Center, Inc., The United States of America, as Represented by the Secretary, Department of Human Services
    Inventors: Asim Kumar Debnath, Francesca Curreli, Peter D. Kwong, Young Do Kwon
  • Survival predictor for diffuse large B cell lymphoma
    Patent number: 9970059
    Abstract: The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: May 15, 2018
    Assignees: The United States of America, as represented by the Secretary, Department of Human Services, Arizona Board of Regents on behalf of the University of Arizona, Queen Mary University of London, Board of Regents of the University of Nebraska, Oslo University Hospital HF, Oregon Health & Science University, University of Rochester, Hospital Clinic de Barcelona, Universitat de Barcelona, British Columbia Cancer Agency Branch, Julius-Maximilians-University of Würzburg
    Inventors: Lisa Rimsza, Andrew T. Lister, Wing C. Chan, Dennis Weisenburger, Jan Delabie, Erlend B. Smeland, Harald Holte, Stein Kvaloy, Rita M. Braziel, Richard I. Fisher, Pedro Jares, Armando Lopez-Guillermo, Elias Campo Guerri, Elaine S. Jaffe, Georg Lenz, Wyndham H. Wilson, George Wright, Sandeep S. Dave, Louis M. Staudt, Randy D. Gascoyne, Joseph M. Connors, Hans-Konrad Muller-Hermelink, Andreas Rosenwald, German Ott
  • Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist
    Patent number: 8338457
    Abstract: The present invention provides methods and kits for the selective ablation of pain-sensing neurons. The methods comprise administration of a vanilloid receptor agonist to a ganglion in an amount that causes death of vanilloid receptor-bearing neurons. Accordingly, the present invention provides methods of controlling pain and inflammatory disorders that involve activation of vanilloid receptor-bearing neurons.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: December 25, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Human Services
    Inventors: Michael J. Iadarola, Zoltan Olah, Laszlo Karai
  • Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
    Patent number: 8318425
    Abstract: Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to the Gag proteolytic cleavage site rather than to the protease enzyme.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: November 27, 2012
    Assignees: The United States of America, as represented by the Secretary, Department & Human Services, Myrexis, Inc.
    Inventors: Karl Salzwedel, Feng Li, Carl T. Wild, Graham P. Allaway, Eric O. Freed
  • Fibroblast growth factor receptor activating gene 1 and related compositions and methods
    Patent number: 6323316
    Abstract: A novel gene designated as FRAG 1 and its encoded protein are disclosed. A fusion protein called FGFR2-ROS, which is formed by chromosomal rearrangement of rat FRAG1 with FGFR2, is also disclosed. Methods of producing FRAG1 protein, related fusion proteins, and antibodies against FRAG1 are disclosed, as are related pharmaceuticals and methods of using such nucleic acids, polypeptides, and antibodies.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: November 27, 2001
    Assignee: The United States of America as represented by the Secretary of the Department of and Human Services
    Inventors: Matthew V. Lorenzi, Toru Miki
  • System and method for separating a multi-unit signal into single-unit signals
    Patent number: 5420787
    Abstract: An improved multi-unit analyzer is provided by virtue of the present invention. An analog-to-digital converter (A/D) digitizes a multi-unit signal, a pulse detector triggers when the multi-unit signal reaches a specified threshold, and a pulse sampler outputs a packet of samples of the signal around the point where the signal passes the threshold. The packet is then transformed into a point on a plane, the P-plane. The transformed point is compared to one or more rectangles in the P-plane, to determine if the point falls within any rectangle. If a point falls within a rectangle, a pulse is output on a line corresponding to the rectangle. This compare and output process is given a high priority. A low priority process displays the packet of samples in a window corresponding to the rectangle which encloses the point in the P-plane which results from the transformation of the packet of samples.
    Type: Grant
    Filed: October 26, 1992
    Date of Patent: May 30, 1995
    Assignee: The United States of America as represented by the Secretary of the Department of Human Services
    Inventors: Timothy J. Gawne, Barry J. Richmond