Patents Assigned to The United States of America as represented by the Secretary of Commerce
  • Patent number: 10381107
    Abstract: A nucleic acid sequencer includes: an atomically thin membrane; a solid electrode spaced apart from the atomically thin membrane and arranged in a capacitive configuration with the atomically thin membrane; a spacer member; a complementary base covalently disposed on the atomically thin membrane and arranged to base pair with a nitrogenous base of the single stranded nucleic acid; a power source in electrical communication with the solid electrode and that provides electrical power to the solid electrode; and a resistor in electrical communication with the power source and that receives electric current from the power source and that also is in electrical communication with the atomically thin membrane such that an amount of the electric current changes in response to a change in the selected distance between the atomically thin membrane and the solid electrode.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: August 13, 2019
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventor: Alex Smolyanitsky
  • Patent number: 10379038
    Abstract: A process for measuring a size distribution of a plurality of nucleic acid molecules, the process comprising: labeling the nucleic acid molecules with a fluorescent dye comprising a plurality of fluorescent dye molecules to form labeled nucleic acid molecules, such that a number of fluorescent dyes molecules attached to each nucleic acid molecule is reliably proportional to the number of base pairs in the nucleic acid molecule, the fluorescent dye molecules having a first florescence spectrum; producing, by the labeled nucleic acid molecules, the first florescence spectrum in response to irradiating the labeled nucleic acid molecules at the first wavelength; and detecting the first florescence spectrum to measure the size distribution of the plurality of nucleic acid molecules.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: August 13, 2019
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Samuel Martin Stavis, Craig Robert Copeland
  • Patent number: 10378092
    Abstract: A coinage alloy for coinage includes nickel present in an amount from 4 wt. % to 11 wt. %, based on a total weight of the coinage alloy; zinc present in an amount from 20 wt. % to 35 wt. %, based on the total weight of the coinage alloy; manganese present in an amount from 3 wt. % to 6 wt. %, based on a total weight of the coinage alloy; copper; an electrical conductivity from 5% International Annealed Copper Standard (IACS) to 6% IACS measured in accordance with ASTM E1004-09 (2009); and a color comprising a yellowness vector b* that is from 6 to 11, based on a CIE L*a*b* color space and determined in accordance with ASTM Standard E308-15 (2015).
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: August 13, 2019
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Eric A. Lass, Mark R. Stoudt, Carelyn Campbell
  • Patent number: 10382141
    Abstract: A communication linker includes: a classical encoder; an optical transmitter; a receiver; a local oscillator in communication with the receiver and that: receives a feedback signal; and produces a displacement frequency, based on the feedback signal; a single photon detector in communication with the receiver and that: receives an optical signal from the receiver; and produces a single photon detector signal, based on the optical signal; a signal processor in communication with the single photon detector and that: receives the single photon detector signal from the single photon detector; produces the feedback signal, based on the single photon detector signal; and produces a decoded signal, based on the single photon detector signal, the decoded signal comprising a frequency of the feedback signal.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: August 13, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Sergey V. Polyakov, Ivan Burenkov
  • Patent number: 10352837
    Abstract: An optomechanical reference includes a basal member; a flexure that includes: a floating link; a first flexural member; and a second flexural member such that: the floating link is moveably disposed; a first stator; a second stator; a first cavity including: a first primary mirror; a first secondary mirror; a first optical coupler in optical communication with the first secondary mirror; and a first cavity length; and a second cavity including: a second primary mirror; a second secondary mirror; a second optical coupler; and a second cavity length.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: July 16, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Gordon Shaw, Jacob Taylor, Ryan Wagner, Felipe Guzman
  • Patent number: 10350312
    Abstract: The present invention relates to magnetic contrast structures for magnetic resonance imaging, and methods of their use. The contrast structures include magnetic materials arranged as a pair of disk-shaped magnetic components with a space between a circular surface of each disk shape, or a tubular magnetic structure, a substantially cylindrical magnetic structure, a substantially spherical shell-formed magnetic structure, or a substantially ellipsoidal shell-formed structure, each defining a hollow region therein. The space and/or hollow region in the contrast structure creates a spatially extended region contained within a near-field region of the contrast structure over which an applied magnetic field results in a homogeneous field, such that nuclear magnetic moments of a second material when arranged within the spatially extended region precess at a characteristic Larmor frequency, whereby the contrast structure is adapted to emit a characteristic magnetic resonance signal of the magnetic material.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: July 16, 2019
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Sectretary of Commerce
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Patent number: 10344366
    Abstract: A coinage alloy for coinage includes nickel present in an amount from 13 wt. % to 16 wt. %, based on a total weight of the coinage alloy; zinc present in an amount from 25 wt. % to 32 wt. %, based on the total weight of the coinage alloy; manganese present in an amount from 1 wt. % to 4 wt. %, based on a total weight of the coinage alloy; copper; an electrical conductivity from 5% International Annealed Copper Standard (IACS) to 6% IACS; and a color comprising a yellowness vector b* that is from 5 to 10, based on a CIE L*a*b* color space and determined in accordance with ASTM Standard E308-15 (2015).
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: July 9, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Eric A. Lass, Mark R. Stoudt, Carelyn Campbell, Tsineng Tony Ying
  • Patent number: 10345226
    Abstract: A spectrum adjuster produces a pure analyte spectrum and includes: a dynamic opacity optic that receives input light, receives an adjustment signal, produces primary adjusted light, and produces secondary adjusted light from the input light based on the adjustment signal; a light source in optical communication with the dynamic opacity optic; a detector in optical communication with the dynamic opacity optic and that receives transmitted light from the sample and produces a transmitted light signal based on an amount of transmitted light received; and an adjustment controller that receives the transmitted light signal, produces the adjustment signal, and communicates the adjustment signal to the dynamic opacity optic.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: July 9, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventor: Young Jong Lee
  • Patent number: 10345249
    Abstract: An x-ray spectrometer system includes: an excitation source that produces excitation particles and irradiates a sample with the excitation particles such that the sample produces x-rays; thermal detectors that: detect the x-rays from the sample; and produce digital x-ray data in response to detecting the x-rays from the sample, the x-ray data including x-ray pulses; and an analyzer that includes a multichannel receiver that receives, in parallel, the digital x-ray data from the thermal detectors and that: rejects pulse pileup in the digital x-ray data and produces pass data from the digital x-ray data; subjects the pass data to an optimal filter to produce filter data; determines a pulse height of x-ray pulses in the filter data to produce pulse data; combines the pulse data to produce combined data; and calibrates the combined data to produce calibrated data.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: July 9, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Terrence J. Jach, Stephen M. Thurgate
  • Patent number: 10312568
    Abstract: A process for making a self-aligned waveguide includes: disposing a central conductor layer on a substrate; disposing a mask layer on the central conductor layer; forming a mask from the mask layer; removing a portion of the central conductor layer; forming an undercut interposed between substrate and the mask; forming a central conductor; disposing a ground conductor layer on the mask and the substrate; removing a portion of the ground conductor layer disposed on the mask; forming a ground plane conductor from the ground conductor layer in response to removing the portion of the ground conductor layer; and removing the mask to make the self-aligned waveguide in which the undercut provides self-alignment of each of the inner walls of the ground plane conductor to each of the sidewalls of the central conductor, and the ground plane conductor is electrically isolated from the central conductor.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: June 4, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventor: David P. Pappas
  • Patent number: 10265699
    Abstract: A fluid sampler includes: a sample cell that includes: a substrate comprising: a first port; a second port in fluid communication with the first port; a viewing reservoir in fluid communication with the first port and the second port and that receives the fluid from the first port and communicates the fluid to the second port, the viewing reservoir including: a first view membrane; a second view membrane; and a pillar interposed between the first view membrane and second view membrane, the pillar separating the first view membrane from the second view membrane at a substantially constant separation distance such that a volume of the viewing reservoir is substantially constant and invariable with respect to a temperature and invariable with respect to a pressure to which the sample cell is subjected.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: April 23, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: J. Alexander Liddle, Samuel M. Stavis, Glenn E. Holland
  • Patent number: 10261106
    Abstract: A photonic probe for atomic force microscopy includes: a cantilever including: a tip; a wing in mechanical communication with the tip; an extension interposed between the tip and the wing to synchronously communicate motion of the tip with the wing; an optical resonator disposed proximate to the cantilever and that: receives input light; and produces output light, such that: the cantilever is spaced by a gap distance from the optical resonator, wherein the gap distance varies as the cantilever moves relative to the optical resonator, and the output light differs from the input light in response to movement of the cantilever relative to the optical resonator; an optical waveguide in optical communication with the optical resonator and that: provides the input light to the optical resonator; and receives the output light from the optical resonator.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: April 16, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Vladimir Aksyuk, Marcelo Davanco
  • Patent number: 10247536
    Abstract: A differential compensator reduces uncertainty in determination of movement of a structural member and includes: a first probe line to attach to the structural member and to provide a first combination of displacement of the structural member and a first expansion of the first probe line in response to movement of the structural member and expansion of the first probe line; and a second probe line having a coefficient of thermal expansion that is different than that of the first probe line, the second probe line to attach to the structural member at a position on the structural member proximate to a point of attachment of the first probe line to the structural member and to provide a second combination of displacement of the structural member and second expansion of the second probe line in response to movement of the structural member and expansion of the second probe line.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 2, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Christopher M. Smith, Matthew S. Hoehler
  • Patent number: 10246479
    Abstract: This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: April 2, 2019
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Jingyue Ju, Shiv Kumar, Chuanjuan Tao, Minchen Chien, James J. Russo, John J. Kasianowicz, Joseph W. F. Robertson
  • Patent number: 10247860
    Abstract: A localized gap plasmon resonator includes: a pad including: a first plasmonic material to support a surface plasmon; and a first plasmon surface; a nanoelectromechanical (NEM) member disposed opposing the first plasmon surface of the pad and spaced apart from the pad by a plasmon gap, the plasmon gap supporting a plasmon resonance; and a plasmonic nanoprism disposed on the NEM member and including: a second plasmonic material to support a surface plasmon; and a second plasmon surface, such that: the second plasmon surface of the plasmonic nanoprism opposes the first plasmon surface of the pad; and the pad, the plasmonic nanoprism, and the plasmon gap support a localized gap plasmon (LGP) mode.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: April 2, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Vladimir A. Aksyuk, Brian J. Roxworthy, J. Alexander Liddle
  • Patent number: 10240998
    Abstract: A process for determining a location and size of a gas source within an area with a spectrometer gas monitor includes: providing the spectrometer gas monitor; performing fence line monitoring of the area with the spectrometer gas monitor; collecting spectroscopic data over multiple open paths around the area with the spectrometer gas monitor; measuring atmospheric conditions along gas inflows and gas outflows of the area; subtracting a background for a selected gas from the spectroscopic data; applying a boundary constraint to the spectroscopic data; determining an atmospheric concentration of air entering the area; applying bootstrapping to the spectroscopic data; applying zero minimum elimination to the spectroscopic data; and producing inversion data from the spectroscopic data to determine the location and size of the gas source within the area.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: March 26, 2019
    Assignees: The United States of America, as represented by the Secretary of Commerce, The Regents of the University of Colorado, a body corporate
    Inventors: Kuldeep Prasad, Caroline Alden, Gregory Brian Rieker, Robert James Wright, Sean Coburn
  • Patent number: 10241149
    Abstract: A massively parallel wafer-level reliability system to test a reliability of wafers includes: a test platform; stations disposed on the test platform, wherein an individual test station receives a wafer and includes: a chuck disposed on the test platform; a probe including contactors that electrically contact the wafer; and a temperature controller to control a temperature of the wafer; a control platform disposed among the test stations; and a system controller to independently control the test stations and that is in electrical communication with the temperature controller, wherein the reliability of the wafers is tested in parallel by the test stations.
    Type: Grant
    Filed: September 24, 2016
    Date of Patent: March 26, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventor: Kin P. Cheung
  • Patent number: 10234309
    Abstract: A photon momentum sensor includes: a reflector plate that includes: a central disk including a mirror; an annular member; a plurality of spring legs interposed between the central disk and the annular member, such that: the spring legs are interleaved; neighboring spring legs are spaced apart; and the spring legs individually are arranged in an Archimedean spiral that provides orthogonal motion of the central disk relative to the plane of the annular member; and a bias plate disposed opposing the reflector plate such that: the central disk of the reflector plate moves orthogonally to a plane of the bias plate in response to reflection of laser light, and the central disk and the bias plate are arranged spaced apart as a capacitive structure.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: March 19, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Alexandra Artusio-Glimpse, John Lehman, Michelle Stephens, Nathan Tomlin, Paul Williams, Ivan Ryger
  • Patent number: 10236433
    Abstract: A thermal impedance amplifier includes: a resistive layer including: a resistance member; a first electrode in electrical communication with the resistance member; and a second electrode in electrical communication with the resistance member; a switch layer opposing the resistive layer and including: a switch member; a first switch electrode in electrical communication with the switch member; and a second switch electrode in electrical communication with the switch member, the switch member: switching from a first resistance to a second resistance in response to receiving phonons from the resistance member, being superconductive at the first resistance, and producing an amplified voltage in response to being at the second resistance; and a thermal conductor interposed between the resistance member and the switch member.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: March 19, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Adam McCaughan, Varun Verma, Sonia Buckley, Sae Woo Nam
  • Patent number: 10228490
    Abstract: A system for detecting gas leaks and determining their location and size. A data gathering portion of the system utilizes a hub and spoke configuration to collect path-integrated spectroscopic data over multiple open paths around an area. A processing portion of the system applies a high resolution transport model together with meteorological data of the area to generate an influence function of possible leak locations on gas detector measurement paths, and applies an inversion model to the influence function and the spectroscopic data to generate gas source size and location.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: March 12, 2019
    Assignees: The United States of America, As Represented by the Secretary of Commerce, The Regents of the University of Colorado, A Body Corporate
    Inventors: Gregory B Rieker, Ian Coddington, Nathan R Newbury, Kuldeep Prasad, Anna Karion