Patents Assigned to The United States of America as reprsented by the Department of Health and Human Services
  • Patent number: 5827658
    Abstract: A method of analyzing an amplified gene, including determining its copy number, involves subtractive hybridization of two cDNA libraries, one from the tissue of interest and the other containing biotinylated cDNA from normal tissue, where the annealed cDNA is removed by means of magnetic beads coated with streptavidin or avidin. The cDNA isolated after subtractive hybridization represents amplified DNA, and it is analyzed to determine what gene(s) were amplified. Furthermore, the copy number of the gene(s) can be estimated. The copy number thus determined can be correlated to the severity of a pathogenic state, to its prognosis, or to treatment efficacy.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: October 27, 1998
    Assignee: The United States of America as reprsented by the Department of Health and Human Services
    Inventor: Bertrand C. Liang
  • Patent number: 4889137
    Abstract: Long term closed chest partial and total cardiopulmonary bypass by peripheral cannulation for severe right and/or left ventricular failure is achieved by the use of a percutaneous coil positioned in the pulmonary artery across the pulmonary artery valve to decompress the left heart.
    Type: Grant
    Filed: May 5, 1988
    Date of Patent: December 26, 1989
    Assignee: The United States of America as reprsented by the Department of Health and Human Services
    Inventor: Theodor Kolobow
  • Patent number: 4882346
    Abstract: Several analogues of hexamethylene bis[acetamide] were found to be effective differentiating agents. The most effective of these compounds was 3,3'-(1,6-hexandiyl)bis[5,5-dimethyl-2,4-imidazolinedione].
    Type: Grant
    Filed: June 16, 1987
    Date of Patent: November 21, 1989
    Assignee: The United States of America as reprsented by the Department of Health and Human Services
    Inventors: John S. Driscoll, Alberto Haces, Theodore Breitman