Patents Assigned to The United States of America
  • Publication number: 20240209059
    Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
    Type: Application
    Filed: January 25, 2024
    Publication date: June 27, 2024
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Eric Tran, Yong-Chen Lu, Anna Pasetto, Paul F. Robbins, Steven A. Rosenberg, Zhili Zheng
  • Patent number: 12021829
    Abstract: The invention relates to discovering and clustering Internet protocol addresses. For example, the invention can include discovering an IPv6 address of an Internet-facing device on a network, where the IPv6 address is associated with a wide area network (WAN) media access control (MAC) address and a WiFi basic service set identifier (BSSID), identifying an associated BSSID in WiFi geolocation databases based on the WAN and WiFi BSSID, and geolocating the Internet-facing device by retrieving a location record in the WiFi geolocation databases for the associated BSSID.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: June 25, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Eric Charles Rye, Robert Edward Beverly, IV
  • Patent number: 12018922
    Abstract: A cap for an explosive water charge may be fixed to a collapsible water bottle by threading internal threads of the cap onto external threads of the water bottle. The cap also may be fixed to a water bottle by engaging a lip on the water bottle with lip grabbers on the cap. The cap is configured to hold a blasting cap and two different sizes of tubes of energetic material.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: June 25, 2024
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Keith Chamberlain, Lee Foltz, Angel Diaz
  • Patent number: 12019205
    Abstract: Examples are directed toward systems and methods relating to security screening. For example, a screening system includes a sensor array to sense a gravitational field caused by an item, and a conveyor to convey the item through sensing positions for scanning by the sensor array. A controller acquires weight measurement information from sensor elements, and gravitational measurement information from the sensor array. The conveyor incrementally advances the item through additional sensing positions to acquire weight measurement information and gravitational measurement information. The controller performs tomographic reconstruction to generate a tomographic image of the item, using a generated weight map as a static weight input vector and using a generated mass map as a static mass input vector for the tomographic reconstruction.
    Type: Grant
    Filed: November 24, 2023
    Date of Patent: June 25, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: James Henry Remer
  • Patent number: 12022172
    Abstract: A multi-spectral imaging system utilizing tunable optics is disclosed. Various disclosed systems include a tunable optical filter coupled to a broadband imaging system. The tunable optical filter allows discrete infrared wavelengths to pass to the broadband imaging system so that monochromatic infrared images of a scene may be captured. An image processing system may process selected monochromatic infrared images by using a ratio technique to generate an emissivity-independent thermal image of the scene. The tunable optical filter may also be used to adjust a quality factor and control an amount of radiated energy that is passed to an image sensor of the broadband imaging system thereby acting as an aperture to account for both low and high radiance portions of the scene.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: June 25, 2024
    Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA
    Inventors: Stephen E. Borg, Hyun Jung Kim
  • Patent number: 12018045
    Abstract: Disclosed are compounds suitable for enhancing cancer treatment, for example, a compound of formula (I): (I) wherein R1 is as defined herein. Also disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, a method of inducing apoptosis in cancer cells in a mammal, and a method of treating prostate cancer in mammal in need thereof comprising administration of a compound described herein.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: June 25, 2024
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Thomas J. Sayers, Poonam Tewary, Leslie Gunatilaka, Alan D. Brooks, Kithsiri Wijeratne, Yaming Xu
  • Patent number: 12017832
    Abstract: The present application is directed to a packaging for a powdered explosive-detection training aid which may include first and second opposing flexible sheets heat sealed together along less than a periphery thereof and defining a storage compartment therebetween, wherein an unsealed portion of the periphery defines an opening to the storage compartment, wherein at least a portion of the first opposing flexible sheet is a semipermeable material permeable to a vapor emitted from the powdered explosive-detection training aid, with the second opposing flexible sheet being impermeable to the powdered explosive-detection training aid vapor; and a sealing member, wherein the sealing member is secured to the first opposing flexible sheet and, in a closing position, covers the semipermeable portion of the first opposing flexible sheet.
    Type: Grant
    Filed: September 21, 2023
    Date of Patent: June 25, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: Darren Jay Steed
  • Patent number: 12017972
    Abstract: A family of low-molecular-weight, main-chain thermotropic liquid-crystalline polyimides (TLC-PI) that are crosslinkable is disclosed. These all-aromatic TLC-PI are derived from (i) wholly aromatic and flexible diamine monomers, in which the linkage between the two aniline-ends contains a relatively high heat-tolerant but flexible chain constituted by two or more units of 1,4-phenoxy or 1,3-phenoxy or in combinations of both. Processes of making and using such all-aromatic TLC-PI is also provided.
    Type: Grant
    Filed: April 12, 2023
    Date of Patent: June 25, 2024
    Assignee: The Government of the United States of America as Represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, Zhenning Yu
  • Patent number: 12018320
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: June 25, 2024
    Assignees: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Services
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • Patent number: 12018613
    Abstract: A disk engine and system configured to provide high power at a reduced axial length is disclosed herein. The disk engine includes a radial compressor, a compressor discharge manifold positioned circumferentially about compressor, a combustion chamber positioned within the discharge manifold and a radial turbine positioned radially inward of the combustion chamber.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: June 25, 2024
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Brian Bohan, Marc Polanka, Bennett Staton
  • Patent number: 12017771
    Abstract: Methods, systems and devices of the various embodiments may provide slat-cove fillers configured to reduce leading-edge slat noise on aircraft, such as transport aircraft.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: June 25, 2024
    Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA
    Inventors: Travis L Turner, Scott E Brynildsen, John W. Mulvaney, Albert R. Allen, David P Lockard, Craig L. Streett, Mehdi R Khorrami
  • Patent number: 12020985
    Abstract: Methods for obtaining a free-standing thick (>5 ?m) epitaxial material layer or heterostructure stack and for transferring the thick epitaxial layer or stack to an arbitrary substrate. A thick epitaxial layer or heterostructure stack is formed on an engineered substrate, with a sacrificial layer disposed between the epitaxial layer and the engineered substrate. When the sacrificial layer is removed, the epitaxial layer becomes a thick freestanding layer that can be transferred to an arbitrary substrate, with the remaining engineered substrate being reusable for subsequent material layer growth. In an exemplary case, the material layer is a GaN layer and can be selectively bonded to an arbitrary substrate to selectively produce a Ga-polar or an N-polar GaN layer.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: June 25, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Travis J. Anderson, Marko J. Tadjer, Karl D. Hobart
  • Patent number: 12020494
    Abstract: A method is provided for non-invasively predicting characteristics of one or more cells and cell derivatives. The method includes training a machine learning model using at least one of a plurality of training cell images representing a plurality of cells and data identifying characteristics for the plurality of cells. The method further includes receiving at least one test cell image representing at least one test cell being evaluated, the at least one test cell image being acquired noninvasively and based on absorbance as an absolute measure of light, and providing the at least one test cell image to the trained machine learning model. Using machine learning based on the trained machine learning model, characteristics of the at least one test cell are predicted. The method further includes generating, by the trained machine learning model, release criteria for clinical preparations of cells based on the predicted characteristics of the at least one test cell.
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: June 25, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Kapil Bharti, Nathan A. Hotaling, Nicholas J. Schaub, Carl G. Simon
  • Publication number: 20240200894
    Abstract: A firearm with a real-time cartridge counter display function, comprising a firearm body, a cartridge clip, a scope, and ammunition cartridge or cartridges loaded within the cartridge clip.
    Type: Application
    Filed: December 16, 2022
    Publication date: June 20, 2024
    Applicant: the United States of America as represented by the Secretary of the Army
    Inventors: REBECCA T. OPPENHEIM, Brian J. Smith, Kevin D. Kennedy
  • Patent number: 12011151
    Abstract: Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: June 18, 2024
    Assignees: Muffin Incorporated, THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Shaun Davis Gittard, Gregory James Hardy, John C. Sigmon, Jr., Jeremy T. Newkirk, William J. Havel, Neal E. Fearnot, Toby Rogers, Kanishka Ratnayaka, Robert L. Lederman
  • Patent number: 12011282
    Abstract: An instrumented trail-making task (iTMT) platform includes a wearable sensor and interactive interface technology configured to identify cognitive-cognitive impairment in individuals such as older adults. The iTMT platform may be programmed with neuropsychological tests for assessing individuals. The iTMT may provide information on visual search, scanning, speed of processing, mental flexibility, and/or executive functions as well as physical biomarkers of motor performance including slowness, weakness, exclusion, and/or motor planning error. Results of tests administered by the iTMT system may be reported to a patient or caregiver and used in identifying cogni-tive-motor impairment among individuals suffering from cognitive impairment, dementia, and/or those with frailty status, and/or cognitive frailty, and/or high risk of falling, and/or high likelihood of decline in cognitive-motor over time.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: June 18, 2024
    Assignees: Baylor College of Medicine, Arizona Board of Regents on behalf of Arizona State University, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Bijan Najafi, Javad Razjouyan, He Zhou, Mark Kunik
  • Patent number: 12011857
    Abstract: A method for the design, manufacture, and assembly of modular lattice structures composed of cuboctahedron unit cells.
    Type: Grant
    Filed: November 14, 2022
    Date of Patent: June 18, 2024
    Assignees: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Benjamin Jenett, Neil Gershenfeld, Kenneth Cheung, Christine Gregg
  • Patent number: 12012369
    Abstract: Compositions containing at least one compound of formula I where R1 is a phenolic compound (e.g., simple phenol, creosote, thymol, or carvacrol), and where R2 is a polyamine (e.g., ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA), tetraethylenepentamine (TEPA), hexamethylenediamine (HDA)); and optionally a carrier; the compositions may additionally contain at least one epoxy resin. Methods for killing microorganisms involving contacting the microorganisms with an effective microorganism killing amount of the above composition. Compositions containing at least one compound produced by a method involving reacting phenolic-branched chain fatty acid methyl ester with at least one polyamine.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: June 18, 2024
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Kun Huang, Richard D. Ashby, Xuetong Fan, Helen N. Lew, Robert A. Moreau
  • Patent number: 12013202
    Abstract: An instrumentation article is provided for removably attaching to an ammunition round in a gun chamber and connecting to a cable that extends through the chamber. The cable provides tensile pull and signal communication through the chamber. The article has a longitudinal axis that corresponds to the chamber. The article includes a cap structure, an electronics package, a grip assembly, a lock mechanism and a release device. The cap structure connects to the cable. The electronics package provides electrical power and attaches to the cap structure for communication with the round. The grip assembly attaches to the round. The release device connects the electronics package to the lock mechanism. The lock mechanism is disposed between the release device and the grip assembly and rotates in first and second directions along the axis. The lock mechanism latches the claw assembly to the round by manual rotation in the first direction.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: June 18, 2024
    Assignee: United States of America, as represented by the Secretary of the Navy
    Inventor: Richard E. Main
  • Patent number: 12012438
    Abstract: The invention provides Brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids, non-yeast cells, and methods of use.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: June 18, 2024
    Assignee: The United States of America, as represented by the Secretary, Health and Human Services
    Inventors: Jeffrey Schlom, Claudia M. Palena