Abstract: The invention provides a method for effecting a photocatalytic or photoelectrocatalytic reaction of a reactant comprising contacting a metallic material having an electrical conductivity of 105 to 106 S/m with the reactant and exposing the metallic material and the reactant to visible light so as to catalyze the reaction of the reactant.

Abstract: Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(?OH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclization of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3? rearrangement of allylic acetates, cyclization of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.

Abstract: The present invention relates to a photosensitive composition comprising synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion, the use of the composition in restorative or cosmetic dentistry, a process for preparing the composition and a method of generating an image of an exposed dentinal surface of a tooth.

Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.

Abstract: The invention provides a method for producing a modified surface (5) comprising: patterning a surface (7) by forming thereon a porous molecular network (9) defined by non-covalent interactions between constituent molecules; and depositing in said porous network (9) and on said patterned surface (11) molecules (13) so as to form a self-assembled monolayer (15), wherein both said patterning and said depositing are effected by contact with liquids.

Abstract: There is described zeolites containing releasably adsorbed nitric oxide, methods of preparing the zeolites, methods of releasing the nitric oxide into a solution or into air and uses of the zeolites in therapy.

Abstract: The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar? are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.

Abstract: The invention relates to an ophthalmoscope comprising a camera and an associated illumination device; the invention further concerns a novel method for processing a plurality of images of the eye taken by said device; and software, typically included in said ophthalmoscope, for executing said method.

Abstract: An optical device including: a waveguide of refractive index na for carrying at least one mode of at least one wavelength, and at least one resonator with a resonant wavelength. The resonator has a mode volume of less than ten cubic resonant wavelengths. In use light in the waveguide is vertically coupled into the at least one resonator, and the waveguide and resonator(s) are arranged to provide wave-vector matching between at least one mode of the resonator and at least one mode of the waveguide.

Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.

Abstract: The invention provides a method for chemically modifying a surface of a substrate, preferably a silicon substrate, including the steps of providing a substrate having at least a portion of a surface thereof coated with an organic coating composition including unsaturated moieties forming a surface coating, and introducing a vapor phase reactive intermediate species based on a Group 14 or Group 15 element from the Periodic Table of Elements to the substrate whereupon the reactive intermediate species is able to react with a number of the unsaturated moieties in the coating composition thereby chemically modifying the surface coating. Also disclosed is a surface-modified substrate obtained or obtainable by the method, and uses thereof in the fabrication of MEMS and IC devices.

Abstract: The present invention relates to a bifunctional material which comprises copper and which is capable of storing nitric oxide (NO), as well as catalytically producing nitric oxide from a suitable precursor. The material typically includes a zeolite and the copper may be part of, or separate from the zeolite. In this manner the material may include a single bifunctional material; that is, a material which is capable of both storing NO and catalytically producing NO, such as Cu-MFI or Cu-X. Alternatively the material may include at least two components, a first component to store NO, such as a zeolite Zn-LTA, and a further component including Cu(I), such as Cu2O, to catalytically produce NO from a suitable precursor. The bifunctional material may be used in a pharmaceutical, neutraceutical or cosmetic preparation, or comprised in a medical article, a cosmetic and/or personal hygiene product.

Abstract: Methods for controlling light transmission through a medium by transmitting light from a single spatial portion of an input optical field through the medium creating an output optical field, superposing the output optical field with a reference optical field creating an optical interference field, detecting an intensity of a spatial portion of a polarization component of the optical interference field and using the detected intensity to determine a value of an optical field amplitude and of an optical field phase for each of a plurality of spatial portions of the input optical field and for each of first and second orthogonal input polarization states of transmitted light entering the medium. The method may be used in the control of the transmission of light 1) through a medium, which is randomizing in amplitude, phase and/or polarization or 2) through a multi-mode fiber or for beam shaping, optical trapping and/or optical manipulation.

Abstract: Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(?OH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3? rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.

Abstract: Cis ruthenium complexes that can be used as catalysts are described. The complexes are generally square pyramidal in nature, having two anionic ligands X adjacent to each other. The complexes can be used as catalysts, for example in olefin metathesis reactions. Corresponding trans ruthenium complexes are also described, together with cationic complexes where one or both of the anionic ligands X are replaced by a non-co-ordinating anionic ligand.

Abstract: The present invention relates to novel micro or mesoporous metal organic frameworks (MOFs) which contain as ligands piperidine based phosphonic acids, as well as a method of synthesizing such MOFs and uses of the MOFs themselves.

Abstract: A communications system comprising at least one light source, a side-emitting fiber light rope into which light emitted from the light source is coupled, and means for sending at least one data carrying optical signal along the light rope.

Abstract: This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclases, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

Abstract: A method for manipulating one or more particles comprising exposing the particle(s) to a beam of radiation that is able to lift and or impart an acceleration to the particle(s) to cause it to move in a curved trajectory.

Abstract: A pulse generator is disclosed. The pulse generator can include a pulsed switch, such as a diode. The pulsed switched can be connected between an input source, such as an oscillator and a frequency multiplier.