Patents Assigned to The University of Alabama at Birmingham
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Patent number: 10946090Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.Type: GrantFiled: November 15, 2017Date of Patent: March 16, 2021Assignees: Duke University, The University of Alabama at Birmingham Research Foundation, Triad National Security, LLCInventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise L. Monti, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Publication number: 20210060101Abstract: In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.Type: ApplicationFiled: July 13, 2020Publication date: March 4, 2021Applicants: CITY OF HOPE, UNIVERSITY OF CHICAGO, UNIVERSITY OF ALABAMA AT BIRMINGHAMInventors: Karen S. ABOODY, Alexander J. ANNALA, David CURIEL, Maciej LESNIAK
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Patent number: 10709745Abstract: In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.Type: GrantFiled: March 21, 2019Date of Patent: July 14, 2020Assignees: CITY OF HOPE, UNIVERSITY OF ALABAMA AT BIRMINGHAM, UNIVERSITY OF CHICAGOInventors: Karen S. Aboody, Alexander J. Annala, David Curiel, Maciej Lesniak
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Patent number: 10238699Abstract: In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.Type: GrantFiled: September 11, 2015Date of Patent: March 26, 2019Assignees: CITY OF HOPE, UNIVERSITY OF CHICAGO, UNIVERSITY OF ALABAMA AT BIRMINGHAMInventors: Karen S. Aboody, Alexander J. Annala, David Curiel, Maciej Lesniak
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Patent number: 9844589Abstract: The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.Type: GrantFiled: August 23, 2011Date of Patent: December 19, 2017Assignees: DUKE UNIVERSITY, THE UNIVERSITY OF ALABAMA BIRMINGHAM RESEARCH FOUNDATION, LOS ALAMOS NATIONAL SECURITY, LLCInventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Patent number: 9011875Abstract: The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.Type: GrantFiled: February 17, 2012Date of Patent: April 21, 2015Assignees: Los Alamos National Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research FoundationInventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
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Patent number: 9011873Abstract: The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.Type: GrantFiled: April 26, 2011Date of Patent: April 21, 2015Assignees: Los Alamos National Security, LLC, Duke University, Beth Israel Deaconess Medical Center, The University of Alabama at Birmingham Research FoundationInventors: Bette T. Korber, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
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Publication number: 20140017342Abstract: This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to treat, prevent, or ameliorate diseases of the blood in a subject, or as a blood replacement in a subject.Type: ApplicationFiled: September 17, 2013Publication date: January 16, 2014Applicants: The Government of the United States of America as represented by the Secretary of the Department of, Wake Forest University, University of Alabama at BirminghamInventors: Mark T. Gladwin, Daniel B. Kim-Shapiro, Rakesh P. Patel, Jeffrey Kerby
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Patent number: 8551536Abstract: This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to treat, prevent, or ameliorate diseases of the blood in a subject, or as a blood replacement in a subject.Type: GrantFiled: August 29, 2008Date of Patent: October 8, 2013Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Alabama at Birmingham, Wake Forest UniversityInventors: Mark T. Gladwin, Daniel B. Kim-Shapiro, Rakesh P. Patel, Jeffrey Kerby
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Publication number: 20120231028Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.Type: ApplicationFiled: February 17, 2012Publication date: September 13, 2012Applicants: Los Alamos National Security, LLC, The University of Alabama at Birmingham Research Foundation, Duke University, Beth Israel Deaconess Medical CenterInventors: Bette T. KORBER, Simon PERKINS, Tanmoy BHATTACHARYA, William M. FISCHER, James THEILER, Norman LETVIN, Barton F. HAYNES, Beatrice H. HAHN, Karina YUSIM, Carla KUIKEN
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Patent number: 8257814Abstract: Composite structures and methods of fabrication thereof are disclosed. An embodiment of a composite structure, among others, includes: a backing substrate; a layer of structures distributed over the backing substrate; and a thermoplastic disposed onto the structures and the backing substrate, wherein the thermoplastic substantially binds the backing substrate and layer of structures together.Type: GrantFiled: June 23, 2006Date of Patent: September 4, 2012Assignee: University of Alabama at BirminghamInventors: Shane Bartus, George Husman, Uday Vaidya
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Publication number: 20120087938Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.Type: ApplicationFiled: August 23, 2011Publication date: April 12, 2012Applicants: DUKE UNIVERSITY, THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Patent number: 8119140Abstract: The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.Type: GrantFiled: August 23, 2006Date of Patent: February 21, 2012Assignees: Los Alamos Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research FoundationInventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
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Publication number: 20110301328Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.Type: ApplicationFiled: April 26, 2011Publication date: December 8, 2011Applicants: Los Alamos National Security, LLC, The University of Alabama at Birmingham Research Foundation, Beth Israel Deaconess Medical Center, Duke UniversityInventors: Bette T. KORBER, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
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Patent number: 8071107Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.Type: GrantFiled: September 17, 2004Date of Patent: December 6, 2011Assignees: Duke University, The Regents of the University of California, The University of Alabama at Birmingham Research FoundationInventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Publication number: 20110150915Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.Type: ApplicationFiled: December 3, 2010Publication date: June 23, 2011Applicants: Los Alamos National Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research FoundationInventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
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Publication number: 20100104596Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.Type: ApplicationFiled: March 27, 2008Publication date: April 29, 2010Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, DUKE UNIVERSITY, THE UNIVERSITY OF ALABAMA AT BIRMINGHAM, UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILLInventors: Barton F. Haynes, Betle T. Korber, Beatrice H. Hahn, Tanmoy Bhattacharya, Gnana Ganakaram, Feng Gao, Ron Swanstrom, George Shaw, Barton F. Uaynes, Betle T Korber
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Publication number: 20090176776Abstract: The present invention provides novel methods of treating HIV infections employing small molecule inhibitors identified by chemical library (DIVERSetâ„¢ library). These small molecule inhibitors may specifically bind to HIV-1 capsid protein thereby interfering with capsid assembly. The small molecule inhibitors of the present invention can be potential drug targets in the treatment of HIV infection.Type: ApplicationFiled: October 23, 2006Publication date: July 9, 2009Applicant: UNIVERSITY OF ALABAMA AT BIRMINGHAMInventor: Peter Prevelige
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Publication number: 20040019031Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: June 9, 2003Publication date: January 29, 2004Applicants: DUKE UNIVERSITY, UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, AEOLUS PHARMACEUTICALS, INC.Inventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Patent number: 6583132Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: November 30, 1998Date of Patent: June 24, 2003Assignees: Duke University, University of Alabama at Birmingham Research Foundation, Aeolus Pharmaceuticals, Inc.Inventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle