Abstract: According to one or more embodiments, a computer implemented method for implementing a convolutional neural network (CNN) using a crosspoint array includes configuring the crosspoint array corresponding to a convolution layer in the CNN by storing one or more convolution kernels of the convolution layer in one or more crosspoint devices of the crosspoint array. The method further includes performing computations for the CNN via the crosspoint array by transmitting voltage pulses corresponding to a vector of input data of the convolution layer to the crosspoint array. Performing the CNN computations further includes outputting an electric current representative of performing a multiplication operation at a crosspoint device in the crosspoint array based on a weight value stored by the crosspoint device and the voltage pulses from the input data. Performing the CNN computations further includes passing the output electric current from the crosspoint device to a selected integrator.

Abstract: Example embodiments allow for networks of hybrid controllers that can be computed efficiently and that can adapt to changes in the system(s) under control. Such a network includes at least one hybrid controller that includes a dynamic sub-controller and a learned system sub-controller. Information about the ongoing performance of the system under control is provided to both the hybrid controller and to an over-controller, which provides one or more control inputs to the hybrid controller in order to modify the ongoing operation of the hybrid controller. These inputs can include the set-point of the hybrid controller, one or more parameters of the dynamic controller, and an update rate or other parameter of the learned system controller. The over-controller can control multiple hybrid controllers (e.g., controlling respective sub-systems of an overall system) and can, itself, be a hybrid controller.

Abstract: This disclosure includes microfluidic devices, systems, and methods for investigating three-dimensional (3D) cell structures (e.g., organoids, spheroids, scaffolds, hydrogels, and the like). Some examples of the present microfluidic devices comprise: a body having a first end, a second end, to lateral edges, an upper side, a lower side, a first layer region between a medial plane of the body and the lower side, and a second layer region between the medial plane and the upper side. In some such examples, the first layer region defines one or more rows of wells, with each well open at the medial plane and having a bottom between the medial plane and the lower side.

Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.

Abstract: Aspects of the present disclosure are directed to methods and compositions for PKC-delta inhibition and cancer immunotherapy. Disclosed are methods for treatment of cancer comprising administration of a PKC-delta inhibitor and an immunotherapy. Also disclosed are compositions comprising a PKC-delta inhibitor and an immunotherapeutic (e.g., an immune checkpoint inhibitor). Further described herein are methods for treating a subject for cancer using an immunotherapy, where the subject was determined to have reduced PKC-delta expression.

Abstract: The sequential infiltration synthesis (SIS) of group 13 indium and gallium oxides (In2O3 and Ga2O3) into polymethyl methacrylate (PMMA) thin films is demonstrated. Examples highlight the an SIS process using trimethylindium (TMIn) and trimethylgallium (TMGa), respectively, with water. In situ Fourier transform infrared (FTIR) spectroscopy reveals that these metal alkyl precursors reversibly associate with the carbonyl groups of PMMA in analogy to trimethylaluminum (TMAl), however with significantly lower affinity. SIS with TMIn and water enables the growth of In2O3 at 80° C., well below the onset temperature of atomic layer deposition (ALD) using these precursors.

Abstract: Some aspects of the present disclosures includes catheters and methods of operating catheters having an elongated body that defines one or more first ports extending through a peripheral surface of the body, a plurality of interior lumens extending longitudinally through the catheter, and one or more tubes each having a sidewall defining a tube lumen in fluid communication with one of the first ports, the one or more tubes configured to shift between a collapsed configuration and an expanded configuration in which the one or more tubes define a cage shape having an unconstrained maximum transverse dimension that larger than a corresponding maximum transverse dimension of the catheter body, where in the collapsed configuration, at least part of tube(s) is radially closer to the catheter body than when in the expanded configuration.

Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

Abstract: The present invention relates to peptides and protein mimetics and their therapeutic and research use. In particular, the present invention provides synthetic, stabilized DNA binding domain peptides and methods of using such peptides as therapeutic agents.

Abstract: Provided are a semiconductor device including a two-dimensional material and a method of manufacturing the semiconductor device. The semiconductor device may include a substrate, first and second two-dimensional material layers on the substrate and junctioned to each other in a lateral direction to form a coherent interface, a first source electrode and a first drain electrode on the first two-dimensional material layer, a first gate electrode between the first source electrode and the first drain electrode, a second source electrode and a second drain electrode on the second two-dimensional material layer, and a second gate electrode between the second source electrode and the second drain electrode.

Abstract: Cavity resonators are promising resources for quantum technology, while native nonlinear interactions for cavities are typically too weak to provide the level of quan-turn control required to deliver complex targeted operations. Here we investigate a scheme to engineer a target Hamiltonian for photonic cavities using ancilla qubits. By off-resonantly driving dispersively coupled ancilla qubits, we develop an optimized approach to engineering an arbitrary photon-number dependent (PND) Hamiltonian for the cavities while minimizing the operation errors. The engineered Hamiltonian admits various applications including canceling unwanted cavity self-Kerr interac-tions, creating higher-order nonlinearities for quantum simulations, and designing quantum gates resilient to noise. Our scheme can be implemented with coupled microwave cavities and transmon qubits in superconducting circuit systems.

Abstract: Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.

Abstract: In aspects, the present disclosure provides a method of treating or preventing uterine fibroids (UF) or polycystic ovary syndrome (PCOS) in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of doxercalciferol. In aspects, the present disclosure provides a method of treating insulin resistance, infertility, obesity, and/or hyperandrogenism related to PCOS in a female mammal.

Abstract: Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith.

Abstract: Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith.

Abstract: Embodiments are directed to kits and methods of treating a breast cancer patient with a glucocorticoid receptor antagonist with or without an anticancer agent or compound after the patient has been determined to be susceptible to treatment with the glucocorticoid receptor antagonist.

Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.

Abstract: Embodiments are directed to a series of novel small molecule activators of NRF2 dependent gene expression that are evaluated in an effort to develop therapeutic methods against diseases with deregulated KEAP1-NRF2 signaling.

Abstract: Lewis acidic metal-organic framework (MOF) materials comprising triflate-coordinated metal nodes are described. The materials can be used as heterogenous catalysts in a wide range of organic group transformations, including Diels-Alder reactions, epoxide-ring opening reactions, Friedel-Crafts acylation reactions and alkene hydroalkoxylation reactions. The MOFs can also be prepared with metallated organic bridging ligands to provide heterogenous catalysts for tandem reactions and/or prepared as composites with support particles for use in columns of continuous flow reactor systems. Methods of preparing and using the MOF materials and their composites are also described.

Abstract: Provided are freeze-dried (FD) products of biological materials that have improved stability and reduced risk of collapse. The FD products include nanoparticles that are added to formulations including the biological materials prior to freeze-drying. Also described herein are methods of freeze-drying (FD).