Patents Assigned to The University of Kentucky Research Foundation
  • Patent number: 10433544
    Abstract: Provided herein are SDH substrates that have use as herbicides in treating pre-emergent and post-emergent weed control. The presently-disclosed subject matter includes an herbicide including SDH substrates such as ribitol and a growth inhibitive effective amount of another adjuvant SDH substrate and/or adjuvant. Methods of treating pre-emergent and post-emergent weeds comprising applying the herbicides disclosed herein in an effective amount to suppress weed growth are also provided.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: October 8, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Douglas Archbold, Marta Nosarzewski
  • Patent number: 10430942
    Abstract: Systems and methods for determining body weight predictions and human conditions are disclosed. A body weight may be predicted by capturing at least one image of a human, and determining, from the image, a body weight prediction of the human by processing the at least one image with a data processor. The body weight prediction may further be based on an age-based weight factor. A model such as a neural network model may be used to predict body weight.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: October 1, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Jeffrey S. Barrett, Chee Ng
  • Patent number: 10396175
    Abstract: The present invention relates to the presence of nanogaps across a metal dispersed over an atomically-thin material, such that the nanogap exposes the atomically-thin material. The resulting device offers an ultra-short gap with ballistic transport and demonstrated switching in the presence of a gate or dielectric material in close proximity to the channel.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: August 27, 2019
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Douglas Robert Strachan, Abhishek Sundararajan, Mathias Joseph Boland
  • Publication number: 20190255114
    Abstract: The present disclosure describes platelet compositions for storage and methods of storing platelet compositions in the cold and room temperature. The platelet compositions including platelets and one or more Ca++ chelators can be stored in the cold for longer than three days. The platelet compositions can be used to treat subjects with a platelet disease or disorder.
    Type: Application
    Filed: February 12, 2019
    Publication date: August 22, 2019
    Applicant: University of Kentucky Research Foundation
    Inventors: Zhenyu Li, Binggang Xiang, Guoying Zhang
  • Patent number: 10378018
    Abstract: The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an immune response in a subject, or a combination thereof.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Peixuan Guo, Hui Li, Emil Khisamutdinov, Daniel Jasinski
  • Patent number: 10358535
    Abstract: A flexible sheet of aligned carbon nanotubes includes an array of aligned nanotubes in a free standing film form not adhered to the synthesis substrate, with a matrix infiltrated interstitially into the nanotube array with access to the nanotube tips from both the top and bottom. That is, the infiltrant is purposely limited from over-filling or coating one or both exterior top and/or bottom surfaces of the array, blocking access to the tips. A typical matrix is a polymer material.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: July 23, 2019
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Matthew Collins Weisenberger, John Davis Craddock
  • Patent number: 10344095
    Abstract: Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: July 9, 2019
    Assignee: University of Kentucky Research Foundation
    Inventor: Jayakrishna Ambati
  • Patent number: 10335296
    Abstract: A segmented endograft includes at least one positioning segment and at least one main body segment which are separately deployable. The at least one positioning segment and at least one main body segment may be connected one to another. For example, the at least one positioning segment and at least one main body segment may be connected along a portion of a circumference thereof, but unconnected along a remainder of the circumference thereof. The at least one positioning segment overlaps a portion of the at least one main body segment. Deployment systems may include the segmented endograft and the segmented endograft may be deployed according to various methods.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: July 2, 2019
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventor: David J. Minion
  • Patent number: 10322367
    Abstract: The present invention relates to methods for improving carbon capture using entrained catalytic-particles within an amine solvent. The particles are functionalized and appended with a CO2 hydration catalyst to enhance the kinetics of CO2 hydration and improve overall mass transfer of CO2 from an acid gas.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: June 18, 2019
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Leland R. Widger, Cameron A. Lippert, Kunlei Liu
  • Patent number: 10312081
    Abstract: The present invention provides integrated nanostructures comprising a single-crystalline matrix of a material A containing aligned, single-crystalline nanowires of a material B, with well-defined crystallographic interfaces are disclosed. The nanocomposite is fabricated by utilizing metal nanodroplets in two subsequent catalytic steps: solid-liquid-vapor etching, followed by vapor-liquid-solid growth. The first etching step produces pores, or “negative nanowires” within a single-crystalline matrix, which share a unique crystallographic direction, and are therefore aligned with respect to one another. Further, since they are contained within a single, crystalline, matrix, their size and spacing can be controlled by their interacting strain fields, and the array is easily manipulated as a single entity—addressing a great challenge to the integration of freestanding nanowires into functional materials.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: June 4, 2019
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Beth S. Guiton, Lei Yu
  • Patent number: 10300057
    Abstract: The present disclosure relates to compositions and methods for treating retinal damage and/or retinal degradation. More specifically, this disclosure relates to methods for treating degradation of the retinal pigment epithelium by administering compositions comprising a nucleoside and/or a nucleoside or nucleotide reverse transcriptase inhibitor.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: May 28, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Jayakrishna Ambati, Benjamin Fowler
  • Patent number: 10301320
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: May 28, 2019
    Assignees: University of Kentucky Research Foundation, Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • Patent number: 10294220
    Abstract: The present disclosure relates to nucleosides, such as compositions, and methods useful for treating retinal damage and/or retinal degradation/retinal degeneration, for inhibiting inflammasome activation by Alu RNA associated with a cell, for reducing ATP-induced permeability of a cell, for reducing an amount of mitochondrial reactive oxygen species in a cell, and for reducing an amount of mitochondrial reactive oxygen species in a cell. The present disclosure further relates to nucleosides, such as compositions, and methods for use in protecting an RPE cell and/or for treating, including prophylactic and therapeutic treatment, of conditions associated with retinal damage and/or degradation including, but not limited to, dry age related macular degeneration (AMD) and wet AMD, Alzheimer disease, various forms of arthritis, atherosclerosis, diabetes mellitus, chronic obstructive pulmonary disease, inflammatory bowel disease, and Duchenne muscular dystrophy.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 21, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Jayakrishna Ambati, Benjamin Fowler, Kameshwari Ambati
  • Patent number: 10288626
    Abstract: Disclosed herein are methods for detecting Pgrmc1 in bodily fluids, e.g., blood, plasma and serum, wherein detection of Pgrmc1 is a biomarker for the presence of cancer, e.g., lung cancer or head or neck cancer. Pgrmc1 levels in bodily fluids may be used to predict patient prognosis, e.g., survival and response to therapy.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: May 14, 2019
    Assignee: University of Kentucky Research Foundation
    Inventor: Rolf Joseph Craven
  • Patent number: 10253035
    Abstract: Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: April 9, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov
  • Patent number: 10252216
    Abstract: The present invention includes a system and process to reduce amine mist emissions (or MEA) from carbon capture systems using colloidal gas aphrons (CGA), and includes a method for separating and recovering an amine solvent (e.g., in the form of entrained droplets/mist and/or fine aerosol particles) from a carbon dioxide scrubbed flue gas stream exiting a carbon capture system (e.g., oil-fired power plants, coal-fired power plants, and/or natural gas combined cycle plants).
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 9, 2019
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Xiaobing Li, Jesse G. Thompson, Kunlei Liu
  • Patent number: 10245558
    Abstract: A nanocomposite membrane includes a macroporous polymer membrane having a plurality of pores. A plurality of metal nanoparticles are synthesized and immobilized within those plurality of pores. The nanoparticles are reduced and capped with a green reducing and capping agent such as green tea extract.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: April 2, 2019
    Assignees: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, U.S. ENVIRONMENTAL PROTECTION AGENCY
    Inventors: Dibakar Bhattacharyya, Vasile Smuleac, Rajender S. Varma, Subhas K. Sikdar
  • Patent number: 10238436
    Abstract: A temporary fracture stabilization device includes a first intramedullary fixation rod, a second intramedullary fixation rod, a first extramedullary connector, a second extramedullary connector and a fastener. A field kit for temporary fracture stabilization is also disclosed.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: March 26, 2019
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventor: Steven J. Lawrence
  • Patent number: 10213734
    Abstract: A method of increasing the overall mass transfer rate of acid gas scrubbing solids is disclosed. Various catalyst compounds for that purpose are also disclosed.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: February 26, 2019
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joseph E. Remias, Cameron A. Lippert, Kunlei Liu
  • Patent number: 10208000
    Abstract: Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 19, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey