Patents Assigned to The University of Liverpool
  • Patent number: 10449198
    Abstract: The present invention relates to a method of treating pain in a patient in need of such treatment, said method comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate: wherein Q is as defined herein.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: October 22, 2019
    Assignee: The University of Liverpool
    Inventors: Martin Leuwer, Paul O'Neill, Neil Berry, Chandrakala Pidathala
  • Patent number: 10442814
    Abstract: The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 15, 2019
    Assignee: University of Liverpool
    Inventors: Martin Leuwer, Paul M. O'Neill, Neil Berry, Chandrakala Pidathala
  • Patent number: 10398559
    Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: September 3, 2019
    Assignees: Howmedica Osteonics Corp., The University Of Liverpool
    Inventors: Eric Jones, Christopher J. Sutcliffe, Robin Stamp
  • Patent number: 10370422
    Abstract: Provided are compositions comprising fusion proteins, polynucleotides and/or expression vectors with therapeutic utility for suppressing and/or treating cancer, as well as medical uses of these agents, and methods of treatment in which they are used. A fusion protein of the invention comprises an amino acid sequence that provides the apoptosis-inducing activity of TRAIL, and a membrane-anchoring amino acid sequence. The amino acid sequence that provides the apoptosis-inducing activity of TRAIL comprises the extracellular domain of TRAIL, or a fragment or variant thereof. A fusion protein comprising an amino acid sequence from TRAIL that is able to induce apoptosis, and a second sequence that anchors the first sequence to the cell membrane, is markedly more effective at reducing viability of TRAIL receptor positive cells than the naturally occurring (“wild type”) TRAIL protein itself.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: August 6, 2019
    Assignee: The University of Liverpool
    Inventors: Daniel Palmer, Taha Elmitwalli
  • Patent number: 10363315
    Abstract: The present invention relates to a composition for use in the treatment of a detached retina, comprising an oil and an additive capable of increasing the extensional viscosity of the oil. The present invention also relates to a method and kit of parts for producing the composition.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: July 30, 2019
    Assignee: University of Liverpool
    Inventors: Michael Joseph Garvey, Rachel Lucinda Williams, Michael Day
  • Publication number: 20190218323
    Abstract: The present invention relates to a branched amphiphilic polymer, suitable for stabilizing an emulsion, comprising a plurality of polymer chains comprising hydrophobic chain ends; a plurality of polymer chains comprising functional chain ends capable of associating to a biological substrate; and a plurality of branching units. The present invention also relates to pharmaceutical compositions containing said branched amphiphilic polymers, their methods of use, and methods for their preparation.
    Type: Application
    Filed: August 8, 2017
    Publication date: July 18, 2019
    Applicant: The University of Liverpool
    Inventors: Stephanie Edwards, Steve Rannard, Andrew Owen
  • Publication number: 20190175497
    Abstract: A composition comprises: a base oil; an additive comprising a copolymer comprising hydrophobic and hydrophilic units; and a drug. The copolymer may for example have a comb structure in which the hydrophobic units and hydrophilic units are pendant chains on a backbone of the copolymer. The hydrophobic units and hydrophilic units may for example comprise polydimethylsiloxane moieties and ethylene glycol residues respectively. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye. The invention is useful for solubilising and/or releasing drugs.
    Type: Application
    Filed: August 9, 2017
    Publication date: June 13, 2019
    Applicant: The University of Liverpool
    Inventors: Victoria Kearns, Helen Cauldbeck, Steve Rannard, Rachel Williams, Maude Le Hellaye
  • Publication number: 20190175742
    Abstract: A composition comprises: a base oil; an additive; and a drug. The additive has segments which are conjugated, e.g. covalently linked, together. A first segment facilitates solubility in the base oil, whereas a second segment facilitates drug solubility and/or modifies drug release or other behaviour. The first segment may for example comprise a poly(dimethylsiloxane)-containing moiety. The second segment may for example resemble a drug molecule. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye.
    Type: Application
    Filed: August 9, 2017
    Publication date: June 13, 2019
    Applicant: The University of Liverpool
    Inventors: Victoria Kearns, Helen Cauldbeck, Steve Rannard, Rachel Williams, Maude Le Hellaye
  • Publication number: 20190134014
    Abstract: The invention provides anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopathy, as well as a method for promoting muscle regeneration in a subject with a myopathy, the method comprising providing the subject with a therapeutically effective amount of an elastase inhibitor. Further provided is a pharmaceutical composition comprising anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopathy. Elastase inhibitors may have a protective effect on muscle progenitor cells and their regenerative potential, which aids muscle cell regeneration. By protecting regenerative potential of muscle progenitor cells, elastase inhibitors enable or enhance the grown of new or existing muscle fibres.
    Type: Application
    Filed: May 15, 2017
    Publication date: May 9, 2019
    Applicant: THE UNIVERSITY OF LIVERPOOL
    Inventor: Addolorata PISCONTI
  • Publication number: 20190084993
    Abstract: The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: April 13, 2018
    Publication date: March 21, 2019
    Applicant: The University of Liverpool
    Inventors: Martin Leuwer, Paul M. O'Neill, Neil Berry, Chandrakala Pidathala
  • Patent number: 10181618
    Abstract: A method of preparing a porous carbon material is provided. The method comprises a) freezing a liquid mixture comprising a polymer suspended or dissolved in a solvent to form a frozen mixture; b) removing the solvent from the frozen mixture to form a porous frozen mixture; and c) pyrolyzing the porous frozen mixture to obtain the porous carbon material. A porous carbon material prepared using the method, and uses of the porous carbon material are also provided.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: January 15, 2019
    Assignees: Agency for Science, Technology and Research, The University of Liverpool
    Inventors: Aled Deakin Roberts, Suxi Wang, Haifei Zhang, Xu Li
  • Patent number: 9994624
    Abstract: The present invention relates to vaccines comprising a ShK domain of a filarial nematode protein. These vaccines may be used for the prevention and/or treatment of filarial nematode infections. The invention also relates to novel proteins comprising a ShK domain of a filarial nematode protein and pharmaceutical compositions. The invention may be used for the prevention and/or treatment of filarial nematode infections in canine subjects, and also in human subjects.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: June 12, 2018
    Assignees: THE UNIVERSITY OF LIVERPOOL, EDINBURGH UNIVERSITY
    Inventors: Ben Makepeace, David Taylor, Simon Babayon, Stuart Armstrong, Mark Blaxter
  • Patent number: 9981243
    Abstract: The present invention relates to compounds capable of forming metal-organic frameworks (MOFs), particularly f-block metal MOFs which selectively sorb one component (e.g. para-xylene) from a mixture of components (e.g. m-/p-xylene mixture). The invention also relates to methods of producing and using said compounds.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: May 29, 2018
    Assignee: The University of Liverpool
    Inventors: Matthew J. Rosseinsky, Catherine G. Perkins, John Edward Warren, Kim Elizabeth Jelfs, Paul Boldrin
  • Patent number: 9981957
    Abstract: The present invention relates to a process for preparing substituted piperidine compounds and especially chiral substituted piperidine compounds. The process involves reacting a substituted pyridinium ion with an amine as defined herein, in the presence of a hydrogen donor, a catalysts and a suitable solvent.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 29, 2018
    Assignee: THE UNIVERSITY OF LIVERPOOL
    Inventors: Jianliang Xiao, Jianjun Wu
  • Patent number: 9944653
    Abstract: The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: April 17, 2018
    Assignee: THE UNIVERSITY OF LIVERPOOL
    Inventors: Martin Leuwer, Paul O'Neill, Neil Berry, Chandrakala Pidathala
  • Patent number: 9889150
    Abstract: The present invention relates to the use of agents (including heparin derivatives) for the prevention and/or treatment of CNS damage.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: February 13, 2018
    Assignees: The University Of Liverpool, The University Court of the University of Glasgow
    Inventors: Jeremy Ewan Turnbull, Scott Ernest Guimond, Sophie Marie Thompson, Susan Carol Barnett, Jennifer Rosemary Higginson
  • Publication number: 20180038839
    Abstract: An embodiment of the present invention provides a method of creating a classifier indicative of a presence of a medical condition in a subject, comprising receiving chromatogram data indicative of a profile of volatile organic compounds in a sample from each of a first plurality of subjects having the medical condition and a second plurality of subjects without the medical condition, selecting one of the chromatogram data as reference chromatogram data, aligning the remaining chromatogram data in relation to the reference chromatogram data, extracting one or more features from the chromatogram data using a Mexican hat wavelet transform of one or more scales, selecting one or more features of the chromatogram data indicative of the medical condition, and constructing a classifier for determining a boundary between chromatogram data indicative of the medical condition and chromatogram data indicative of an absence of the medical condition.
    Type: Application
    Filed: February 12, 2016
    Publication date: February 8, 2018
    Applicant: University of Liverpool, Inst. Translation Medic
    Inventors: Christopher Simon John Probert, Raphael Bastos Mareschi Aggio
  • Patent number: 9879041
    Abstract: The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical compositions containing the compounds, processes for preparing the compounds, and methods of treating diseases or conditions in which it is desirable to inhibit ?-secretase.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: January 30, 2018
    Assignees: Victoria Link Limited, University of Liverpool
    Inventors: Peter Charles Tyler, Olga Vladimirovna Zubkova, Jeremy E. Turnbull
  • Publication number: 20180021261
    Abstract: An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm.
    Type: Application
    Filed: February 3, 2016
    Publication date: January 25, 2018
    Applicant: The University of Liverpool
    Inventors: Steve Rannard, Andrew Owen, James Hobson, Neill Liptrott, Pierre Chambon
  • Patent number: 9820939
    Abstract: The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: November 21, 2017
    Assignee: The University of Liverpool
    Inventors: Alison J. Foster, James Long, Steven P. Rannard, Dong Wang, David J. Duncalf, Andrew Owen