Patents Assigned to The University of Michigan
  • Publication number: 20230404427
    Abstract: A method is presented for tracking an ingestible device in a gastrointestinal tract of a subject. The method includes: measuring acceleration of the ingestible device as it traverses through the gastrointestinal tract, for example using an accelerometer disposed in the ingestible device; computing a metric from the acceleration measurements obtained by the accelerometer over a given period of time; and identifying a location in the gastrointestinal tract based in part on the metric.
    Type: Application
    Filed: June 16, 2023
    Publication date: December 21, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Duxin SUN, Yogesh GIANCHANDANI, Tao LI, Jeremy FELTON, Hsueh-Tsung LU, Alexander BENKEN, Partha DUTTA, Xiangyu ZHAO, Manjunath PAI
  • Patent number: 11844615
    Abstract: Techniques are provided that identify and localize on to reentrant and ectopic patterns of electrical activation in the heart wall. These patterns may correspond to atrial fibrillation, ventricular fibrillation, or other heart arrhythmia conditions. The techniques detect these patterns of electrical activity using a multi-lead an intra-cavitary catheter that, along with a controller, is able to track, over a multi-dimensional cubic space, reentrant activity and identify filaments in the heart cavity. The intra-cavitary catheter includes multiple conducting poles positioned in a configuration relative to each other and functioning as either or both sensing and active poles for measuring electrical pathways in the heart wall and over the multi-dimensional space.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: December 19, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Omer Berenfeld
  • Patent number: 11845993
    Abstract: Provided herein are compositions and methods for diagnosing and characterizing cancer. In particular, provided herein are compositions and methods for selecting MRI imaging methods for prostate tumors.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: December 19, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Simpa Salami, Ganesh Palapattu
  • Publication number: 20230403225
    Abstract: A computer-implemented method is presented for scanning a computer network. The method includes: a) sending a particular network probe to a network address in a computer network; b) receiving a response to the network probe from the network address; c) appending the response to a set of features forming a feature vector; d) determining a next network probe to conduct at the network address; and e) predicting, by the computer processor, the response from the next network probe using the feature vector and a model, where the model is trained using a machine learning method and outputs a probability that a given network address will respond to a network probe.
    Type: Application
    Filed: October 25, 2021
    Publication date: December 14, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Armin SARABI, Mingyan LIU, Kun JIN, Tongxin YIN
  • Patent number: 11833196
    Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: December 5, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: James J. Moon, Rui Kuai, Anna A. Schwendeman, Jutaek Nam
  • Patent number: 11833210
    Abstract: Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: December 5, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jolanta Grembecka, Szymon Klossowski, Jing Deng, Tomasz Cierpicki, Hao Li, Hongzhi Miao, Trupta Purohit, EunGi Kim
  • Publication number: 20230383228
    Abstract: An apparatus (e.g., for cell culture for in vitro growth of tissues and/or organs) includes a base, a plate on the base, and a removable barrier component on the plate. The removable barrier component is configured to at least partially define a first region. The removable barrier component includes a bottom surface and a top surface. The bottom surface configured to be in contact with the plate. The top surface is opposite the bottom surface. The press is configured to engage the top surface of the removable barrier component to apply a predetermined pressure to the removable barrier component. The removable barrier component is between the press and the plate. A joint between the plate and the removable barrier component may be substantially impermeable to live cells. The apparatus may further include a removable cover that engages the base to enclose the plate, the removable barrier component, and the press.
    Type: Application
    Filed: May 26, 2023
    Publication date: November 30, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Stephen E. FEINBERG, James Brian WASHINGTON, Roger W. MULDER, Allen SAMUELS, Cynthia L. MARCELO
  • Patent number: 11832504
    Abstract: A method for fabricating an organic electronic device comprises providing a plurality of photoresist structures on a substrate, the substrate having a first electrode layer, the photoresist structures having a bottom surface attached to the substrate and a top surface opposite the bottom surface, the top surface having a dimension greater than a dimension of the bottom surface, positioning a mask over the structures, the mask having a plurality of openings, and depositing an emissive material over the substrate through at least one of the plurality of openings to form at least one emissive element. An organic electronic device and a method of fabricating an organic electronic component are also described.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: November 28, 2023
    Assignee: The Regents of the University of Michigan
    Inventor: Stephen R. Forrest
  • Patent number: 11832475
    Abstract: A method of fabricating a light emitting device comprises providing a mold having an unpolished surface with an arithmetic mean roughness Ra in a range from 0.1 ?m to 10 ?m, depositing a thin polymer film over the surface of the mold, wherein the film has a thickness in a range from 1 ?m to 100 ?m, positioning a light emitting body onto the thin polymer film, wherein the light emitting body includes an anode, a cathode, and a light emitting layer positioned between the anode and the cathode, and separating the thin polymer film with the light emitting body from the mold. A light emitting device is also described.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: November 28, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Yue Qu, Xiaheng Huang, Stephen R. Forrest
  • Patent number: 11826469
    Abstract: Provided herein are methods of treatment, compositions, systems and kits using polymer particles as restraints of neutrophil function. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which neutrophils may be implicated. In some embodiments, polymer particles are useful for diagnosing neutrophil related diseases or conditions.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: November 28, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Omolola Eniola-Adefeso, William Kelley, Theodore Standiford
  • Patent number: 11831272
    Abstract: A device includes a support structure having a plurality of concentric cuts through the support structure that define a set of structure sections. The device also includes an insert assembly supported by the support structure at an inner structure section of the set of structure sections. The inner structure section is configured to tilt the insert assembly at a tilt angle in accordance with a displacement of a first outer structure section of the set of structure sections.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: November 28, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Max Shtein, Erin Evke, Michael Arwashan, Chao Huang
  • Patent number: 11819516
    Abstract: Provided herein is technology relating to immunotherapy and particularly, but not exclusively, to compositions, methods, and kits for immunotherapy and activation of T cells using a peptide-major histocompatibility complex (pMHC) assembled on a protein scaffold for patterned signal presentation of T cell activating ligands to T cells.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: November 21, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Fei Wen, Mason Smith
  • Patent number: 11819712
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: November 21, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Charles A. Cain, Adam Maxwell, Zhen Xu, Kuang-Wei Lin
  • Patent number: 11825687
    Abstract: An OLED device comprises a substrate, a first electrode positioned over the substrate, a second electrode positioned over the first electrode, at least one emissive layer positioned between the first and second electrodes in a first region of the OLED device, and a multilayer dielectric reflector stack, comprising a plurality of dielectric reflector layers positioned between the substrate and the first electrode, wherein the multilayer dielectric reflector stack is configured to form an optical cavity with the emissive layer having a Purcell Factor of at least 3.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: November 21, 2023
    Assignees: The Regents of the University of Michigan, The University of Southern California
    Inventors: Stephen R. Forrest, Yue Qu, Haonan Zhao, Mark E. Thompson
  • Patent number: 11819310
    Abstract: An optical probe assembly as a confocal endomicroscope includes an optical focusing stage that focuses an output beam onto a sample and a mirror scanning stage that is movable for scanning the output beam in both a lateral two dimensional plane and an axial direction, using a side-view configuration. The side-view configuration allows for output beam illumination and fluorescent imaging of the sample with greater imaging resolution and improved access to hard to reach tissue within a subject.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: November 21, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Thomas D. Wang, Xiyu Duan, Haijun Li
  • Patent number: 11813485
    Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: November 14, 2023
    Assignees: The Regents of the University of Michigan, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Zhen Xu, Clifford Suhyun Cho
  • Patent number: 11813358
    Abstract: The disclosure generally relates to lipid nanodiscs, in particular to lipid nanodiscs formed from polymers. A lipid nanodisc according to the disclosure includes a lipid bilayer having a first hydrophilic face and a second hydrophilic face opposing the first hydrophilic face, and a hydrophobic edge between the opposing hydrophilic faces, and a polymer encircling the hydrophobic edge of the lipid bilayer. The polymer includes a first monomeric unit having a pendant hydrophobic group and a second monomeric unit having a backbone hydrophilic group. Methods of making and characterizing the lipid nanodiscs are also disclosed.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: November 14, 2023
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ayyalusamy Ramamoorthy, Thirupathi Ravula, Nathaniel Z. Hardin
  • Patent number: 11814009
    Abstract: A driving authentication system is presented for a vehicle. The system includes: a dongle interfaced with a battery of the vehicle and an authenticator configured to receive a discharge current from the battery. The dongle operates to modulate discharge current from the battery with an input code; and the authenticator demodulate the input code from the discharge current, compares the input code to the one or more known authentication codes and, in response to the input code matching one of the one or more known authentication codes, controls power capacity of the battery.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: November 14, 2023
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE UNIVERSITY OF COLORADO
    Inventors: Kang G. Shin, Liang He
  • Publication number: 20230357710
    Abstract: Synthetic cellular support systems in the form of engineered extracellular matrices are provided. The cellular support system may include a three-dimensional scaffold structure comprising at least one void. At least one suspended fibril spans across the at least one void in the three-dimensional scaffold structure. The suspended fibril comprises at least one extracellular matrix protein, such as fibronectin, and at least one glycan, such as a hyaluronic acid. The suspended fibril is capable of supporting cells and promoting three-dimensional cellular growth. In various aspects, a plurality of suspended fibrils may span the void to form a three-dimensional suspended fibrillar network.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 9, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joerg LAHANN, Mirella WAWRYSZYN, Dylan B. NEALE
  • Publication number: 20230358205
    Abstract: A VIVACE converter to harness energy from currents as well as from waves— that is, the present teachings provide a method and apparatus to collect energy from both currents and waves—using the same physical components. The present teachings are particularly useful in that either currents and/or waves may exist on their own nearly everywhere in the oceans and frequently coexist.
    Type: Application
    Filed: March 30, 2023
    Publication date: November 9, 2023
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Vortex Hydro Power LLC
    Inventors: Michael M. BERNITSAS, Stergios I. LIAPIS