Patents Assigned to The University of North Carolina at Chapel Hill
  • Patent number: 11504435
    Abstract: This invention relates to polynucleotides comprising a nucleotide sequence encoding a PPT1 polypeptide or a fragment thereof, vectors (viral or non-viral vectors) comprising the same, and methods of using the same for delivery of the open reading frame to a cell or a subject and to treat infantile neuronal lipofuscinosis (infantile Batten disease). The polynucleotides comprise an optimized CLN1 open reading frame.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: November 22, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Steven Gray
  • Patent number: 11492361
    Abstract: The invention relates to compounds of Formula (I), salts thereof, combinations, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: November 8, 2022
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, The University of North Carolina at Chapel Hill, ViiV Healthcare Company
    Inventors: Richard M. Dunham, David Margolis, Vincent Wing-Fai Tai, Jun Tang
  • Patent number: 11491241
    Abstract: This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: November 8, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Steven James Gray
  • Patent number: 11492379
    Abstract: This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: November 8, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Harold Kenneth Dinnon, III, Sarah Rebecca Leist, Yixuan Hou
  • Patent number: 11491242
    Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: November 8, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Steven Gray, Thomas McCown
  • Publication number: 20220347350
    Abstract: Compositions and methods of transplanting cells by grafting strategies into solid organs (especially internal organs) are provided. These methods and compositions can be used to repair diseased organs or to establish models of disease states in experimental hosts. The method involves attachment onto the surface of a tissue or organ, a patch graft, a “bandaid-like” covering, containing epithelial cells with supporting early lineage stage mesenchymal cells. The cells are incorporated into soft gel-forming biomaterials prepared under serum-free, defined conditions comprised of nutrients, lipids, vitamins, and regulatory signals that collectively support stemness of the donor cells. The graft is covered with a biodegradable, biocompatible, bioresorbable backing used to affix the graft to the target site. The cells in the graft migrate into and throughout the tissue such that within a couple of weeks they are uniformly dispersed within the recipient (host) tissue.
    Type: Application
    Filed: July 18, 2022
    Publication date: November 3, 2022
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Lola M. Reid, Wencheng Zhang, Eliane Wauthier
  • Patent number: 11484574
    Abstract: The present invention relates to compositions and methods for the delivery of agents to a subject, particularly to the central nervous system (CNS).
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: November 1, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Alexander V. Kabanov, Yuhang Jiang, Xing Yi
  • Patent number: 11485994
    Abstract: Methods and systems for using encapsulated microbubbles to process biological samples are disclosed. According to one aspect, a method for using encapsulated microbubbles to process a biological sample includes creating a mixture comprising encapsulated microbubbles mixed with a biological sample and adding activation energy to the mixture to cause at least some of the microbubbles to oscillate or burst and thereby process the sample, including effecting cell lysis, shearing DNA, and/or performing tissue dispersion.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: November 1, 2022
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: William Perry Janzen, Samantha Gail Pattenden, Chatura Nadisha Jayakody, Jason Eric Streeter, Paul Alexander Dayton, Cameron Champion Wood, Siddharth Kaup Shenoy
  • Patent number: 11479651
    Abstract: A process for chemically recycling polyethylene terephthalate (PET) which utilizes a microwave absorber to optimize glycolytic depolymerization of PET via microwave irradiation. The method of chemically degrading PET to its reactive intermediate, bis(2-hydroxyethyl) terephthalate (BHET), is carried out by: (a) combining PET with ethylene glycol and a catalytic system comprising a catalyst and a microwave absorber to produce a heterogeneous reaction mixture; and then (b) heating by microwave irradiating the reaction mixture to a temperature sufficient to produce a reaction product comprising BHET. The BHET monomer then can be purified and re-polymerized to form new, virgin PET.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: October 25, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Matthew Parrott
  • Patent number: 11471517
    Abstract: ILC2 cells play a role in the pathogenesis of graft versus host disease (GvHD) and idiopathic pneumonia syndrome (IPS), both conditions associated with allogeneic stem cell transplantation. Infusion of IL-33 activated ILC2 cells into patients with ongoing GvHD or IPS, or prior to onset of GvHD or IPS in susceptible patients, substantially ameliorates the disease and improves survival.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: October 18, 2022
    Assignees: The University of North Carolina at Chapel Hill, Regents of the University of Minnesota
    Inventors: Jonathan Serody, James Coghill, Danny Bruce, Bruce Blazar, Heather Stefanski, Benjamin Vincent
  • Patent number: 11474105
    Abstract: The present invention provides a method of diagnosing endometriosis and/or infertility in a subject, comprising: a) obtaining a sample from the subject; b) detecting a level of expression of a SIRT1 gene and/or protein in the sample; c) detecting a level of expression of a BCL6 gene and/or protein in the sample; d) comparing the level of expression detected in (b) with the level of expression of a SIRT1 gene and/or protein in a sample obtained from a control subject or a population of control subjects; e) comparing the level of expression detected in (c) with the level of expression of a BCL6 gene and/or protein in a sample obtained from a control subject or a population of control subjects; and f) diagnosing the subject as having infertility when the subject has a level of expression of the SIRT1 gene and/or protein greater than the level of expression of the SIRT1 gene and/or protein of the control subject or population of control subjects and also has a level of expression of the BCL6 gene and/or protein t
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: October 18, 2022
    Assignees: The University of North Carolina at Chapel Hill, Upstate Affiliate Organization, Board of Trustees of Michigan State University
    Inventors: Steven L. Young, Bruce Arthur Lessey, Jae Wook Jeong
  • Patent number: 11465146
    Abstract: A system, mixing-enhanced microfluidic container, and methods for small volume sample collection and/or analysis is disclosed. Namely, the invention is directed to a small volume sample collection system that includes a mixing-enhanced microfluidic container and a durable reusable actuation chuck. The mixing-enhanced microfluidic container is used to collect small volumes of sample fluid and includes a means for mixing the sample fluid with reagents disposed within the microfluidic container. The mixing means utilize an array of surface-attached structures (e.g., a micropost array). The application of an “actuation force,” such as a magnetic or electric field, actuates the surface-attached structures into movement, wherein the actuation chuck in close proximity to the mixing-enhanced microfluidic container provides the “actuation force.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: October 11, 2022
    Assignees: Redbud Labs, Inc., The University of North Carolina at Chapel Hill
    Inventors: Richard Chasen Spero, Jay Kenneth Fisher, Richard Superfine
  • Patent number: 11467240
    Abstract: A method for accelerating diffusion magnetic resonance imaging (MRI) acquisition via slice interleaved diffusion encoding (SIDE) includes conducting a plurality of simultaneous multislice (SMS) excitations for each of a plurality of SIDE diffusion-weighted volumes to obtain SMS images of an MRI subject at different diffusion orientations, regrouping the images into slice groups with different orientations, generating a plurality of slice-undersampled diffusion weighted volumetric images of the subject, wherein each of the plurality of slice-undersampled diffusion weighted volumetric images is produced by cyclically interleaving the slice groups, such that each slice group is associated with a different diffusion wavevector, and reconstructing a full diffusion-weighted volumetric image of the subject by providing the plurality of slice-undersampled diffusion weighted volumetric images to a neural network trained to produce full diffusion-weighted volumetric versions of diffusion magnetic resonance images from
    Type: Grant
    Filed: December 31, 2020
    Date of Patent: October 11, 2022
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Pew-Thian Yap, Yoonmi Hong, Wei-Tang Chang
  • Patent number: 11458097
    Abstract: The present invention relates to compositions comprising exosomes and biological agents and methods of using the compositions for the delivery of biological agents to cells and to subjects.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: October 4, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Elena V. Batrakova, Alexander V. Kabanov, Marina Sokolsky, Matthew J. Haney, Dongfen Yuan, Myung Soo Kim
  • Publication number: 20220306996
    Abstract: The present invention provides a mutant FAD-dependent glucose dehydrogenase comprising: a catalytic subunit; an electron transfer subunit; and a hitchhiker subunit; wherein each of the amino acid sequence of the catalytic subunit and the amino acid sequence of the electron transfer subunit comprises a cysteine residue introduced therein, the catalytic subunit and the electron transfer subunit being bound to each other through a disulfide bond between the cysteine residues to achieve improved thermal stability of the FAD-dependent glucose dehydrogenase.
    Type: Application
    Filed: October 21, 2021
    Publication date: September 29, 2022
    Applicants: The University of North Carolina at Chapel Hill, ARKRAY, Inc.
    Inventors: Koji Sode, Junko Shimazaki, Katsuhiro Kojima, Masashi Tsukada
  • Patent number: 11445914
    Abstract: Methods, systems, and computer readable media for taking measurements of a material, including determining material anisotropy, are provided. According to one aspect, a method for determining tissue anisotropy comprises: applying, to a tissue sample, a first force having a direction and having a coronal plane normal to the direction of the force, the first force having an oval or other profile with long and short axes within the coronal plane, the long axis being oriented in a first direction within the coronal plane, and measuring a first displacement of the tissue; applying, to the tissue sample, a second force, and measuring a second displacement of the tissue; and calculating a tissue elasticity anisotropy based on the measured first and second displacements. Furthermore, by applying the first and second forces multiple times, tissue viscosity, elasticity, or other anisotropy may be calculated from the multiple displacement measurements.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: September 20, 2022
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Caterina M. Gallippi, Christopher Joseph Moore, Md Murad Hossain, Tomasz Joseph Czernuszewicz
  • Patent number: 11446390
    Abstract: Disclosed herein are antigen-capturing nanoparticles. Specifically, the subject matter contained herein pertains to novel nanoparticles that can capture a multitude of tumor antigens that are released from tumor cells. Also, provided herein are methods for preparing the antigen-capturing nanoparticles and methods for the treatment of disease in a subject comprising administering the antigen-capturing nanoparticles.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 20, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Andrew Wang, Yuanzeng Min, Zach Rodgers
  • Patent number: 11446412
    Abstract: Compositions and methods of transplanting cells by grafting strategies into solid organs (especially internal organs) are provided. These methods and compositions can be used to repair diseased organs or to establish models of disease states in experimental hosts. The method involves attachment onto the surface of a tissue or organ, a patch graft, a “bandaid-like” covering, containing epithelial cells with supporting early lineage stage mesenchymal cells. The cells are incorporated into soft gel-forming biomaterials prepared under serum-free, defined conditions comprised of nutrients, lipids, vitamins, and regulatory signals that collectively support stemness of the donor cells. The graft is covered with a biodegradable, biocompatible, bioresorbable backing used to affix the graft to the target site. The cells in the graft migrate into and throughout the tissue such that within a couple of weeks they are uniformly dispersed within the recipient (host) tissue.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: September 20, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Lola M. Reid, Wencheng Zhang, Eliane Wauthier
  • Patent number: 11420986
    Abstract: Nitric oxide-releasing mesoporous silica nanoparticles (MSNs) were prepared using an aminosilane-template surfactant ion exchange reaction. Initially, bare silica particles were synthesized under basic conditions in the presence of cetyltrimethylammonium bromide (CTAB). These particles were functionalized with nitric oxide (NO) donor precursors via the addition of aminosilane directly to the particle sol, and a commensurate ion exchange reaction between the cationic aminosilanes and CTAB. N-diazeniumdiolate NO donors were formed at the secondary amines to yield NO-releasing silica MSNs. Tuning of the ion exchange-based MSN modification approach allowed for the preparation of monodisperse particles ranging from 30 to 1100 nm. Regardless of size, the MSNs stored appreciable levels of NO (0.4-1.5 ?mol/mg) with tunable NO-release durations (1-33 h) dependent on the aminosilane modification. The range of MSN sizes and NO release demonstrate the versatility of this strategy.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: August 23, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Robert J. Soto
  • Patent number: 11421044
    Abstract: Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 23, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Mona Jasmine R. Ahonen, Lei Yang, Haibao Jin, Evan Scott Feura, Sara Elizabeth Maloney