Patents Assigned to The University of North Carolina at Chapel Hill
  • Patent number: 10314474
    Abstract: Methods, systems, and computer readable media for predicting early onset glaucoma via structural parameters obtained via time and spectral-domain optical coherence tomography (SD-OCT) are disclosed. SD-OCT technology measures the thicknesses of the layers of the retina that contain the cells that die in glaucoma before there is any functional loss. A multivariable predictive model may be used for the diagnosis of early glaucoma using a combination of optic nerve head (ONH), peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell-inner plexiform layer (GCIPL) parameters measured via SD-OCT. The model generates a glaucoma probability score for individual patient, which is valuable information in assisting clinicians in glaucoma diagnosis and treatment.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: June 11, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jean-Claude Kasongo Mwanza, Donald Lyle Budenz, Joshua Lindsey Warren
  • Patent number: 10319154
    Abstract: A system for providing auto-focus augmented reality (AR) viewing of real and virtual objects includes a frame for holding AR viewing components on a user's head and optically in front of the user's eyes. The AR viewing components include an internal virtual objects display for displaying virtual objects to a user. Internal and external focus correction modules respectively adjust focal distances of virtual and real objects, are respectively configurable to adjust the focal distances of the virtual and real objects differently based on the different user vision types, and operate to respectively adjust the focal distances of the virtual and real objects such that the virtual and real objects are simultaneously in focus based on the vision type of the user.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: June 11, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Praneeth Kumar Chakravarthula, Henry Fuchs
  • Patent number: 10321107
    Abstract: A system for illuminating a spatial augmented reality object includes an augmented reality object including a projection surface having a plurality of apertures formed through the projection surface. The system further includes a lenslets layer including a plurality of lenslets and conforming to curved regions of the of the projection surface for directing light through the apertures. The system further includes a camera for measuring ambient illumination in an environment of the projection surface. The system further includes a projected image illumination adjustment module for adjusting illumination of a captured video image. The system further includes a projector for projecting the illumination adjusted captured video image onto the projection surface via the lenslets layer and the apertures.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 11, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Henry Fuchs, Gregory Welch
  • Patent number: 10308705
    Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: June 4, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiao Xiao, Juan Li, Zhenhua Yuan
  • Patent number: 10312070
    Abstract: Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: June 4, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Scott Mellors, John Michael Ramsey, Nicholas George Batz
  • Patent number: 10309218
    Abstract: Contrast agents and methods for use in geological applications are provided. Contrast agents can be a nanopolymorph material, such as titania nanotubes, and have a low-frequency dielectric permittivity. Methods of identifying one or more subterranean features during geological exploration are provided. Methods of identifying a ganglion of bypassed oil are provided. Methods of illuminating subterranean fractures in hydraulic fracturing are provided.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: June 4, 2019
    Assignees: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Pabitra Sen, Alfred Kleinhammes, Yue Wu, Mohsen Ahmadian-Tehrani
  • Publication number: 20190161735
    Abstract: The present disclosure provides a model of human fibrolamellar hepatocellular carcinoma (FL-HCC) cells maintained as a transplantable tumor line in a host and a method to establish a transplantable human FL-HCC tumor line. Methods of ex vivo cultures of the FL-HCC are provided. Methods of diagnosing and treating FL-HCC tumors are also provided.
    Type: Application
    Filed: June 18, 2018
    Publication date: May 30, 2019
    Applicant: University of North Carolina at Chapel Hill
    Inventors: Eliane Wauthier, Tsunekazu OIKAWA, Timothy Anh-Hieu DINH, Praveen SETHUPATHY, Lola M. REID
  • Patent number: 10303923
    Abstract: Methods and systems for characterization of NETosis (Neutrophil Extracellular Traps) in neutrophils. In some examples, a method includes acquiring an image of a sample of neutrophils. The method includes classifying each neutrophil depicted in the image as having either a NETotic or non-NETotic nucleus using one or more processors executing a convolutional neural network (CNN) trained on training images of NETotic and non-NETotic neutrophil nuclei. The method includes generating output indicative of a number of neutrophils classified as having a NETotic nucleus and a number of neutrophil classified as having a non-NETotic nucleus.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: May 28, 2019
    Assignees: The University of North Carolina at Chapel Hill, The University of South Carolina
    Inventors: Leslie Victoria Parise, Noah Sciaky, Laila Elsherif, Joshua Nathan Cooper
  • Patent number: 10301630
    Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: May 28, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang
  • Patent number: 10296555
    Abstract: Methods, systems, and computer readable media for non-parametric dependence detection using bitwise operations in a computing system are disclosed. One method for non-parametric dependence detection using bitwise operations in a computing system includes receiving a set of p variables, wherein p represents an integer greater than or equal to two. The method also includes generating a set of binary interaction designs (BIDs) using a depth value d and bitwise operations, wherein each of the set of BIDs indicates a dependence structure based on arrangement of partitions in the respective BID. The method further includes determining, using the BIDs generated using bitwise operations in a computing system, non-parametric dependence between the set of p variables. The method also includes performing data analysis involving the set of p variables using the non-parametric dependence between the set of p variables. The method further includes generating output related to the data analysis.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: May 21, 2019
    Assignees: The University of North Carolina at Chapel Hill, The Board of Trustees of the Leland Stanford Junior University, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Kai Zhang, Michael Thomas Max Baiocchi, Zhigen Zhao
  • Patent number: 10294307
    Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: May 21, 2019
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Stephen J Demarest, Xiufeng Wu, Raheleh Toughiri, Brian Arthur Kuhlman, Steven Morgan Lewis
  • Patent number: 10292909
    Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 21, 2019
    Assignees: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, RESEARCH TRIANGLE INSTITUTE
    Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
  • Patent number: 10283341
    Abstract: Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm2 to about 25 cm2 and the stack assembly has a thickness that is between about 0.1 mm to about 25 mm.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: May 7, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: John Michael Ramsey
  • Patent number: 10274731
    Abstract: According to one aspect, the subject matter described herein includes a near-eye optical see-through display. The display includes a backlight layer including a plurality of point light sources. The display further includes a spatial light modulator (SLM) layer for modulating light from the point light sources. The spatial light modulator is located in the optical path between the point light sources and a user's eye. The spatial light modulator layer includes pixels that are controllable to modulate light from the point light sources such that the light that impacts the user's eye has a desired intensity and color to display a synthetic image. At least a portion of the backlight layer and the spatial light modulator layer are optically transparent to allow a user to view a real scene through the spatial light modulator layer and the backlight layer such that the synthetic image appears to be overlaid on a view of the real scene.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 30, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Andrew Stephen Maimone
  • Patent number: 10266823
    Abstract: Methods of administering an oligonucleotide of interest into a cell in vitro or in vivo are described. In the methods, a small organic compound active agent is concurrently administered to the cell in an amount effective to increase the delivery of the oligonucleotide into the cell, and/or increase the activity of said oligonucleotide in the cell. Compositions useful for carrying out the method are also described.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: April 23, 2019
    Assignees: The University of North Carolina at Chapel Hill, Southern Research Institute
    Inventors: Rudolph Juliano, William P. Janzen, Joseph A. Maddry, Canhong Cao, Xin Ming, Bing Yang
  • Patent number: 10261065
    Abstract: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: April 16, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 10246678
    Abstract: The present invention provides biomatrix scaffolds, a tissue extract enriched for extracellular matrix components and bound growth factors, cytokines and hormones, and methods of making and using same.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 2, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Yunfang Wang, Lola Cynthia McAdams Reid, Mitsuo Yamauchi, Cai-Bin Cui, Andrew Zhuang Wang, Michael Edward Werner
  • Patent number: 10250824
    Abstract: The subject matter described herein includes a camera sensor with event token based image capture and reconstruction. The sensor includes a photodetector for capturing light from a portion of a scene and for producing a signal indicative of the light. An integrator is coupled to the photodetector for accumulating charge resulting from the signal output by the photodetector and can be reset each time the charge reaches a predetermined level. An in-pixel processor is coupled to the integrator for resetting the integrator and generating an event token each time the predetermined level of charge is accumulated. A communication pipeline communicates the event tokens for downstream processing. A postprocessor is coupled to the pipeline for receiving the event tokens and for determining output intensity for the portion of the scene being reconstructed based on a number of reset events and a time between at least two of the event tokens.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 2, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Montek Singh, Leandra Vicci
  • Patent number: 10249484
    Abstract: An electrospray ionization (ESI)-mass spectrometer analysis systems include an ESI device with at least one emitter configured to electrospray ions and a mass spectrometer in fluid communication with the at least one emitter of the ESI device. The mass spectrometer includes a mass analyzer held in a vacuum chamber. The vacuum chamber is configured to have a high (background/gas) pressure of about 50 mTorr or greater during operation. During operation, the ESI device is configured to either; (a) electrospray ions into a spatial region external to the vacuum chamber and at atmospheric pressure, the spatial extent being adjacent to an inlet device attached to the vacuum chamber, the inlet device intakes the electrosprayed ions external to the vacuum chamber with the mass analyzer and discharges the ions into the vacuum chamber with the mass analyzer; or (b) electrospray ions directly into the vacuum chamber with the mass analyzer.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: April 2, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, William McKay Gilliland, Jr.
  • Patent number: 10248744
    Abstract: Methods, systems, and computer readable media for acoustic classification and optimization for multi-modal rendering of real-world scenes are disclosed. According to one method for determining acoustic material properties associated with a real-world scene, the method comprises obtaining an acoustic response in a real-world scene. The method also includes generating a three-dimensional (3D) virtual model of the real-world scene. The method further includes determining acoustic material properties of surfaces in the 3D virtual model using a visual material classification algorithm to identify materials in the real-world scene that make up the surfaces and known acoustic material properties of the materials. The method also includes using the acoustic response in the real-world scene to adjust the acoustic material properties.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: April 2, 2019
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Carl Henry Schissler, Dinesh Manocha