Patents Assigned to The University of North Carolina at Chapel Hill
  • Patent number: 11124546
    Abstract: This invention relates to modified parvovirus capsid proteins with enhanced transduction efficiency, viral vectors comprising the same, and methods of using the same for delivery of nucleic acids to a cell or a subject.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: September 21, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard Jude Samulski, Jayme Warischalk
  • Patent number: 11124476
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: September 21, 2021
    Assignees: Novan, Inc., The University of North Carolina at Chapel Hill
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Patent number: 11123302
    Abstract: Acoustically activatable particles having low vaporization energy are disclosed. A particle of material includes a first substance that includes at least one component that has a boiling point below 25° C. at atmospheric pressure. A second substance, different from the first substance, encapsulates the first substance to create the particle. The particle has a core consisting of a liquid and is an activatable phase change agent. The second substance includes a polymeric brush layer to prevent aggregation and coalescence.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: September 21, 2021
    Assignees: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Paul A. Dayton, Paul S. Sheeran, Terry O. Matsunaga, Mark A. Borden
  • Patent number: 11116850
    Abstract: This invention relates to viral vectors for delivery of alpha-L-iduronidase to the cornea of a subject and methods of using the same for treatment and prevention of corneal clouding and blindness in a subject due to mucopolysaccharidosis I.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: September 14, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Matthew Louis Hirsch, Richard Jude Samulski
  • Patent number: 11116330
    Abstract: A bassinet includes a base, a column assembly rotatably connected to the base at a first end of the column assembly, an arm rotatably connected to a second end of the column assembly, a tub frame pivotably connected to the arm, an infant tub retained within the tub frame, the infant tub including a front wall, a back wall, and two side walls and having areas of reduced height along the front wall and at least one of the side walls to provide enhanced access to the infants located within the infant tub, and an insert configured to reversibly fit within an interior of the infant tub.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: September 14, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kristin Patricia Tully, Catherine Sullivan, Carl John Seashore, Alison Mann Stuebe, Ty Hagler, Patrick Murphy, Prasad Joshi, Charity Grace Kirk
  • Patent number: 11103603
    Abstract: The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: August 31, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Zibo Li, Zhanhong Wu, Ben Giglio, Stergios Moschos
  • Patent number: 11099370
    Abstract: This specification describes methods for imaging a sample using fluorescence microscopy, systems for imaging a sample using fluorescence microscopy, and illumination systems for fluorescence microscopes. In some examples, a system includes a cylindrical lens shaped to form a light sheet from a collimated light beam at a focal line of the cylindrical lens, a photomask shaped for elongating a diffraction limited length of the light sheet by creating an interference pattern at the cylindrical lens focal line, and a structure for tilting the cylindrical lens and the photomask relative to an imaging axis of objective lens so that a propagation axis of the collimated light beam is at an oblique angle relative to the imaging axis of the objective lens for tilted illumination of a sample.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: August 24, 2021
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Paul Samuel Maddox, Tanner Christian Fadero
  • Patent number: 11096583
    Abstract: Methods, systems, and computer readable media for utilizing functional connectivity brain imaging for diagnosis of a neurobehavioral disorder are disclosed. One method for utilizing functional connectivity brain imaging for diagnosis of a neurobehavioral disorder includes receiving brain imaging data for a human subject of a first age, wherein the brain imaging data includes functional connectivity magnetic resonance imaging (fcMRI) data, and predicting, using at least one functional connection between brain locations in the fcMRI data, a neurobehavioral disorder diagnosis for the subject at a second age greater than the first age.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: August 24, 2021
    Assignees: The University of North Carolina at Chapel Hill, Washington University
    Inventors: Robert Wayne Emerson, Joseph Piven, Bradley Schlaggar, John Pruett, Jr.
  • Patent number: 11085081
    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: August 10, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Luda B. Diatchenko, William Maixner, Gary D. Slade, Andrea Gail Neely
  • Patent number: 11078495
    Abstract: The present invention provides an integration-defective lentiviral vector based on a parental lentivirus and related methods, the integration-defective lentiviral vector including one or more of the following: (a) a mutation, deletion or other modification of one or more binding sites for a host factor involved in gene silencing; (b) an addition of one or more binding sites for a transcription activator, which can be natural (such as but not limited to ubiquitous and/or tissue/cell type specific) including but not limited to SP1 NFkB, or synthetic including but not limited to binding sites for tetracycline regulated trans activators tTA, rtTA, tT65, and/or rtT65; (c) one or more nucleic acid sequences from a SV40 genome, wherein the one or more sequences are obtained from a region of the SV40 genome upstream to the SV40 poly-adenylation signal; (d) a shRNA expression cassette, which encodes a shRNA directed to a host gene involved in epigenetic silencing and/or in DNA repair pathways; or (e) any combination o
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: August 3, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Tal Kafri
  • Patent number: 11073507
    Abstract: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 27, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 11072668
    Abstract: Large molecular weight alginates which are covalently modified to store and release nitric oxide, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both planktonic and biofilm-based bacteria.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: July 27, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Mona Jasmine R. Ahonen, Dakota J. Suchyta, Kaitlyn Rose Rouillard
  • Publication number: 20210220827
    Abstract: A flow cell is provided that includes surface-attached structures in a chamber. The structures are movable in response to an actuation force. The flow cell may be utilized to extract or isolate nucleic acids from a sample flowing through the flow cell, wherein some portion of the flow cell comprises nucleic acid adsorbent material (e.g. the outer surface of the surface-attached structures, an inside surface of the chamber of the flow cell, beads attached to the outer surface of the surface-attached structures, or beads integrated into the outer surface of the surface-attached structures). Further, systems and methods for extraction of nucleic acids using such flow cells are also provided.
    Type: Application
    Filed: May 6, 2019
    Publication date: July 22, 2021
    Applicants: Redbud Labs, Inc., THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Richard Chasen Spero, Jay Kenneth Fisher, Richard Superfine
  • Patent number: 11067537
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: July 20, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 11059862
    Abstract: The present invention provides methods and compositions comprising an adeno-associated virus (AAV) capsid protein, comprising one or more amino acids substitutions, wherein the substitutions introduce a new glycan binding site into the AAV capsid protein.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: July 13, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Richard Samulski
  • Patent number: 11058743
    Abstract: The present invention provides compositions and formulations comprising glutathione with or without thiocyanate and methods of use thereof to treat diseases and disorders in mucosal/epithelial tissue.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: July 13, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Roland R. Arnold, David C. Henke
  • Publication number: 20210205459
    Abstract: Provided herein are pharmaceutical compositions that include a pharmaceutically active agent, a cellulose nanocrystal or a cellulose nanofiber, a thermogelling biocompatible polymer, and a gelling agent. Such pharmaceutical compositions can be configured as a bioink suitable for 3D printing. Such pharmaceutical compositions are suitable for treating bone disorders, including osteoporosis. Methods of treating Paget's disease, treating or preventing cancer, treating or preventing an infectious disease, and treating or preventing a disorder through regenerative medicine are also provided.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 8, 2021
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Soumya Rahima Benhabbour, Panita Maturavongsadit
  • Publication number: 20210206715
    Abstract: Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.
    Type: Application
    Filed: March 19, 2021
    Publication date: July 8, 2021
    Applicants: Duke University, The University of North Carolina at Chapel Hill
    Inventors: Pei Zhou, Eric J. Toone, Robert A. Nicholas, Ramesh Gopalaswamy, Xiaofei Liang, Frank Navas, III
  • Patent number: 11053535
    Abstract: Devices, such as chips for DNA analysis, have at least one fluid transport nanochannel with at least one intersecting (e.g., transverse) sensing nanochannel that can be monitored for change in ionic current to determine characteristics or parameters of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: July 6, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Jean Pierre Alarie, Laurent Menard
  • Patent number: 11052149
    Abstract: The present invention provides a composition comprising a) a polyacetal polymer, a polyester polymer and/or a biodegradable polymer; b) a cyclic dinucleotide; and c) an antigen and/or an antibody, as well as methods of using same.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: July 6, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jenny P.-Y. Ting, Robert Junkins, Brandon Johnson, Kristy Ainslie, Eric Bachelder, Matthew Gallovic, Michael Collier, Ning Cheng