Patents Assigned to The University of North Carolina at Chapel Hill
  • Publication number: 20200299309
    Abstract: The invention relates a compound of the formula: a pharmaceutically acceptable salt thereof, compositions thereof, and methods of therapeutic treatment using the same.
    Type: Application
    Filed: June 10, 2020
    Publication date: September 24, 2020
    Applicants: GlaxoSmithKline Intellectual Property Development Limited, The University of North Carolina at Chapel Hill, ViiV Healthcare Company
    Inventors: Richard M DUNHAM, David MARGOLIS, Vincent Wing-Fai TAI, Jun TANG
  • Patent number: 10772948
    Abstract: The present invention provides compositions directed to recombinant flavivirus E glycoprotein ectodomain dimers for use in diagnostic and immunotherapeutic methods.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: September 15, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Stefan Metz, Aravinda Desilva, Michael Miley
  • Patent number: 10774156
    Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: September 15, 2020
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Hector Aldaz, Shane Krummen Atwell, Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay
  • Patent number: 10759877
    Abstract: The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: September 1, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Yuan Lu
  • Patent number: 10755915
    Abstract: Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm2 to about 25 cm2 and the stack assembly has a thickness that is between about 0.1 mm to about 25 mm.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: August 25, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: John Michael Ramsey
  • Patent number: 10745447
    Abstract: The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: August 18, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Mavis Agbandje-McKenna, Long Ping Victor Tse, Brittney Gurda
  • Publication number: 20200248111
    Abstract: The present invention relates to a method, a system, and a kit of parts for cleaning a surface contaminated with a hazardous drug or a hazardous drug related product, which involves cleaning in succession with a quaternary ammonium solution followed by an isopropyl alcohol solution.
    Type: Application
    Filed: April 3, 2020
    Publication date: August 6, 2020
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: William Zamboni, Tom O'Neill, Stephen Eckel
  • Patent number: 10733745
    Abstract: Methods, systems, and computer readable media for deriving a three-dimensional (3D) textured surface from endoscopic video are disclosed. According to one method for deriving a 3D textured surface from endoscopic video, the method comprises: performing video frame preprocessing to identify a plurality of video frames of an endoscopic video, wherein the video frame preprocessing includes informative frame selection, specularity removal, and key-frame selection; generating, using a neural network or a shape-from-motion-and-shading (SfMS) approach, a 3D textured surface from the plurality of video frames; and optionally registering the 3D textured surface to at least one CT image.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: August 4, 2020
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Stephen Murray Pizer, Jan-Michael Frahm, Julian Gary Rosenman, Qingyu Zhao, Rui Wang, Ruibin Ma, James True Price, Miao Fan, Sarah Kelly McGill
  • Patent number: 10734216
    Abstract: A pneumatic method, and associated apparatus, for injecting a discrete sample plug into the separation channel of an electrophoresis microchip (100) is disclosed. In a first step, pressurized gas (90) is applied to the sample (30) and background electrolyte (20) reservoirs such that the pressure is higher there than at the sample waste reservoir (35) to create a focused sample stream at the junction between the sample and separation channels. In a second step, the pressure at the sample reservoir (30) is reduced in order to pneumatically inject the sample plug into the separation channel. The waste reservoir (35) may be connected to a pressure reducing device (91). The methods, systems and devices are particularly suitable for use with a mass spectrometer (200i).
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: August 4, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Scott Mellors, Erin Anne Redman, John Michael Ramsey
  • Patent number: 10709708
    Abstract: The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating disorders such as cancer.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: July 14, 2020
    Assignees: The University of North Carolina at Chapel Hill, Emory University
    Inventors: Dan Yan, H. Shelton Earp, III, Deborah Ann DeRyckere, Douglas Kim Graham, Jing Wan
  • Patent number: 10703746
    Abstract: Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 7, 2020
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Matthew Brian Boxer, Jason Matthew Rohde, Rajan Pragani, Li Liu, Mindy Irene Emily Davis, Kyle Ryan Brimacombe, Min Shen, Anton Simeonov, Surendra Karavadhi, Daniel Jason Urban, Ajit Jadhav, Xiaodong Wang, Andrew Louis McIver
  • Patent number: 10695562
    Abstract: A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: June 30, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Joseph DeSimone, Mary Napier, Jonathan Pillai, James Byrne, Lukas Miller Roush, Jen Jen Yeh, Matt Parrott
  • Publication number: 20200187910
    Abstract: Disclosed is a method and related systems comprising detecting a position of each of two or more targets in a volume to be imaged; generating and directing a single beam of ultrasound energy toward the volume by simultaneously focusing the single beam on each of the two or more the target positions; detecting the ultrasound energy from each of the two or more the target positions; and using the detected ultrasound energy to generate an image of the volume to be imaged. Such as generating a blood flow profile in a blood vessel.
    Type: Application
    Filed: May 9, 2018
    Publication date: June 18, 2020
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Gianmarco Francesco PINTON, Paul Alexander DAYTON, David Antonio ESPINDOLA ROJAS, Fanglue LIN
  • Publication number: 20200188540
    Abstract: Conformationally strained irans-cycloalkenes and derivatives thereof suitable for radiolabeling in a subject in need thereof.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 18, 2020
    Applicants: University of Delaware, The University of North Carolina at Chapel Hill, United Kingdom Research and Innovation
    Inventors: Joseph FOX, Zibo LI, Yu LIU, Michael Thompson TAYLOR, Dennis SVATUNEK, Katarina ROHLFING, Mengzhe WANG, Zhanhong WU, Raghu VANNAM, Jason W. CHIN, Stephen WALLACE
  • Patent number: 10682108
    Abstract: Methods, systems, and computer readable media for deriving a three-dimensional (3D) surface from colonoscopic video are disclosed. According to one method for deriving a 3D surface from colonoscopic video, the method comprises: performing video frame preprocessing to identify a plurality of keyframes of a colonoscopic video, wherein the video frame preprocessing includes informative frame selection and keyframe selection; generating, using a recurrent neural network and direct sparse odometry, camera poses and depth maps for the keyframes; and fusing, using SurfelMeshing and the camera poses, the depth maps into a three-dimensional (3D) surface of a colon portion, wherein the 3D surface indicates at least one region of the colon portion that was not visualized.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: June 16, 2020
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Ruibin Ma, Rui Wang, Stephen Murray Pizer, Jan-Michael Frahm, Julian Gary Rosenman, Sarah Kelly McGill
  • Patent number: 10679755
    Abstract: Methods, systems, and computer readable media for data analysis and inference of particle diffusion in mucus barriers and generic permeable biomaterials are disclosed. According to one aspect, the subject matter described herein includes a method for data analysis and inference of particle diffusion in target materials, such as mucus barriers, or their simulants. The method includes collecting experimental data of observed particle movement through samples of a target material or simulant (“the target”), analyzing the collected data to determine the stochastic diffusive process that is being observed for particular particles in the particular sample, using one or more of the observed stochastic diffusive processes to simulate the diffusion of particles through layers of the target of various thicknesses, using the simulation results to determine how passage time scales according to thickness of the target, and verifying the simulation results.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: June 9, 2020
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Mark Gregory Forest, John William Mellnik, Paula Andrea Vasquez, David Brooks Hill, Scott Alister McKinley
  • Patent number: 10679407
    Abstract: Methods, systems, and computer readable media for simulating sound propagation are disclosed. According to one method, the method includes decomposing a virtual environment scene including at least one object into a plurality of surface regions, wherein each of the surface regions includes a plurality of surface patches. The method further includes organizing sound rays generated by a sound source in the virtual environment scene into a plurality of path tracing groups, wherein each of the path tracing groups comprises a group of the rays that traverses a sequence of surface patches. The method also includes determining, for each of the path tracing groups, a sound intensity by combining a sound intensity computed for a current time with one or more previously computed sound intensities respectively associated with previous times and generating a simulated output sound at a listener position using the determined sound intensities.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: June 9, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Carl Henry Schissler, Ravish Mehra, Dinesh Manocha
  • Patent number: 10675306
    Abstract: The present invention relates to methods of improving blastocyst implantation by delivering adrenomedullin to the endometrium of a subject. The invention further relates to methods of performing in vitro fertilization.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: June 9, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kathleen M. Caron, Brooke C. Matson
  • Patent number: 10664978
    Abstract: A method for using a synthetically trained neural network for tracking particle movement in video microscopy data includes receiving, as input, video microscopy data representing images of particles that move between video frames. The method includes using a synthetically trained neural network to track movement of the particles between the video frames, wherein the synthetically trained neural network comprises a neural network that is trained on a plurality of different simulated video microscopy data sets. The method further includes outputting, by the synthetically trained neural network, an indication of movement of the particles between the video frames.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: May 26, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jay Mack Newby, M. Gregory Forest, Samuel Kit Bunn Lai
  • Patent number: 10640747
    Abstract: The present invention provides biomatrix scaffolds for industrial scale dispersal.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: May 5, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Marsha Lynn Roach, Richard Harold Malavarca, Yunfang Wang, Lola M. Reid