Patents Assigned to The University of Sydney
  • Patent number: 10238667
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: March 26, 2019
    Assignees: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ning Ding, Michael Downes, Christopher Liddle, Ronald M. Evans, Nanthakumar Subramaniam
  • Publication number: 20190084939
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Application
    Filed: November 27, 2018
    Publication date: March 21, 2019
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle
  • Publication number: 20190070220
    Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.
    Type: Application
    Filed: July 7, 2016
    Publication date: March 7, 2019
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: David Gottlieb, Leighton Clancy
  • Patent number: 10196335
    Abstract: Prenylated stilbene compounds and the use of such compounds in the treatment of diseases and medical disorders, for example cancer, skin ageing, inflammation, bacterial or fungal infection and immunosuppression.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: February 5, 2019
    Assignee: The University of Sydney
    Inventors: Colin Charles Duke, Van Hoan Tran, Rujee Kyokajee Duke
  • Publication number: 20180273478
    Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).
    Type: Application
    Filed: January 29, 2016
    Publication date: September 27, 2018
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Lenka Munoz, Fadi Maged Shokry Gurgis, Mia Akerfeldt, Michael Kassiou
  • Patent number: 10084542
    Abstract: A microwave photonic notch filter comprising: a modulator to modulate an optical signal with an electrical signal to generate a first sideband and a second sideband; a configurable optical processor to generate a modified optical signal by adjusting the power of the sidebands to achieve a power difference between first sideband and second sideband and by producing an antiphase relationship between light within two sidebands corresponding to the selected frequency band; an optical resonance to adjust the power of the first sideband of the modified optical signal corresponding to the selected frequency band by a resonance power adjustment to generate a resonance output signal; an optical-to-electrical converter to generate a copy of the electrical signal with suppressed frequency components within the selected frequency band; and a control unit to re-configure the configurable optical processor to adjust the power difference between two sidebands towards the resonance power adjustment.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 25, 2018
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: David Albert Immanuel Marpaung, Mattia Pagani, Shayan Shahnia
  • Publication number: 20180243469
    Abstract: Disclosed herein are biocompatible materials useful for tissue regeneration and repair, wherein the bioactive polymer may be in the form of a hydrogel, for example a thermoresponsive hydrogel. This bioactive polymer and a resulting hydrogel, may be used for the regeneration of bone tissue. Accordingly, also disclosed herein are methods of treating a bone defect in a mammal, the methods comprising administering a therapeutically effective amount of a hydrogel formed by the bioactive polymer to the mammal to treat the bone defect.
    Type: Application
    Filed: August 31, 2016
    Publication date: August 30, 2018
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Ali Fathi, Fariba Dehghani, Anthony Weiss, Suzannne Mithieux
  • Publication number: 20180244590
    Abstract: The present invention provides a method of stabilizing a nitrate-based explosive through the use of a NOx scavenger. The present invention further provides a blasting agent including ammonium nitrate and a NOx scavenger. The present invention further provides for a method of blasting adapted for use in reactive and/or elevated temperature ground.
    Type: Application
    Filed: September 1, 2016
    Publication date: August 30, 2018
    Applicant: The University of Sydney
    Inventors: James Kenneth Beattie, Alex Masato Djerdjev, Brian Stanley Hawkett, Chiara Neto, Pramith Priyananda
  • Publication number: 20180221089
    Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.
    Type: Application
    Filed: June 10, 2016
    Publication date: August 9, 2018
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20180163457
    Abstract: A pump-out tube for evacuating a space between two sheets of glass, the pump out tube being receivable in a hole formed in at least one of the sheets of glass, the pump out tube formed as a separate element comprising a tubular member and a seal formed around the tube.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 14, 2018
    Applicant: The University of Sydney
    Inventors: Cenk Kocer, Tom Vu, Clara Thao Hoang Tran
  • Publication number: 20180161502
    Abstract: A needle insertion device configured to insert a needle into a lumen of a vessel of a subject, the insertion device comprising an insertion mechanism configured to insert the needle into the lumen of the vessel at high speed, in accordance with one or more predetermined parameters.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 14, 2018
    Applicant: The University of Sydney
    Inventors: Ralph NANAN, Philip BOUGHTON, Jinman KIM, Alistair MCEWAN, Graham BROOKER, Jonathan BRUCK
  • Patent number: 9977268
    Abstract: An optical processing system providing a rapid optical response, the system including: a first optical material sensitive to an effective refractive index change under photon absorption; a first optical pump for optically pumping the first optical material at a first frequency so as to cause the first optical material to undergo an effective refractive index change by means of photon absorption; a second optical pump for optically pumping the first optical material at a second frequency so as to cause the first optical material to undergo a rapid second refractive index change by means of stimulated emission.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: May 22, 2018
    Assignee: The University of Sydney
    Inventors: Jeffrey Mandryk, Xiaoke Yi, Anish Lamichhane
  • Patent number: 9946973
    Abstract: This disclosure relates to preserving a quantum state in a quantum memory. A controller of the quantum memory determines based on a characteristic of noise that causes deterioration of the quantum state a dynamical decoupling base sequence. The duration of the base sequence is shorter than or equal to an access latency time of the quantum memory to allow access to the quantum state within the access latency time. Further, the deterioration of the quantum state is bounded to an upper deterioration limit when the base sequence is repeatedly applied to the quantum system. This provides acceptable access times while simultaneously allowing long term storage of data in the quantum state with low error rates. Repeatedly applying the base sequence to the quantum system will first yield an increasing deterioration but that deterioration will eventually reach the upper limit. As a result, over time the error rates will not exceed that upper limit and the quantum state is stable.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: April 17, 2018
    Assignees: The University of Sydney, Trustees of Dartmouth College
    Inventors: Michael J. Biercuk, Kaveh Khodjasteh, Lorenza Viola
  • Patent number: 9931391
    Abstract: The invention relates to the identification of antigens, including Mycobacterium sulphate assimilation pathway components such as CysD, for preventing and treating Mycobacterium infection, especially but not exclusively Mycobacterium tuberculosis infection; to expression systems including live Mycobacterium for expression of said antigens for prevention and treatment of said infection; and to use of said antigens and expression systems for prevention and treatment of said infection.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: April 3, 2018
    Assignees: The University of Sydney, Centenary Institute of Cancer Medicine and Cell Biology
    Inventors: James Anthony Triccas, Rachel Pinto-Nadanachandran, Warwick John Britton
  • Publication number: 20180071318
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
    Type: Application
    Filed: November 8, 2017
    Publication date: March 15, 2018
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ning Ding, Michael Downes, Christopher Liddle, Ronald M. Evans
  • Patent number: 9916539
    Abstract: Described herein is a computer implemented method for generating a probabilistic model usable to identify instances of a target feature in geophysical data sets stored on a memory device.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: March 13, 2018
    Assignee: The University of Sydney
    Inventors: Katherine Lee Silversides, Arman Melkumyan, Derek Wyman, Peter James Hatherly
  • Patent number: 9890578
    Abstract: In a gap retention member to be disposed between a pair of glass plates when a circumference of a gap formed between the pair of glass plates with their plate faces opposing each other is to be sealed to maintain the gap under a depressurized state, the gap retention member includes hard portions to contact the pair of glass plates respectively and a soft portion disposed between the hard portions and having a lower hardness than the hard portions, the soft portion being more susceptible to deformation based on a shearing force effective in the direction along the opposing faces of the glass plates than deformation based on a compressive force effective in a thickness direction perpendicular to the opposing faces of the glass plates.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: February 13, 2018
    Assignees: Nippon Sheet Glass Company, Limited, The University of Sydney
    Inventors: Yumi Kawashima, Osamu Asano, Cenk Kocer
  • Patent number: 9872866
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: January 23, 2018
    Assignees: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ning Ding, Michael Downes, Christopher Liddle, Ronald M. Evans
  • Patent number: 9805316
    Abstract: A planning system (201) for scheduling the operation of autonomous entities within a defined geographical region. The planning system operates at a region plan level (301) for strategic planning across the geographical region, at an operation plan level (302) for operations to be performed by autonomous entities in localized zones having operation-defined geographical boundaries, and at a task plan level (303) in which processing is undertaken in respect of specific tasks to be performed by the autonomous entities, in undertaking the operations.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: October 31, 2017
    Assignee: The University of Sydney
    Inventors: Eric Nettleton, Ross Hennessy, Hugh Durrant-Whyte, Ali Haydar Göktogan
  • Patent number: 9731321
    Abstract: A method of polymerizing monomer to form polymer at the surface of particulate material, said method comprising: providing a dispersion of said particulate material in a continuous liquid phase, said dispersion comprising a RAFT agent as a stabilizer for said particulate material, and said continuous liquid phase comprising one or more ethylenically unsaturated monomers; and polymerizing said one or more ethylenically unsaturated monomers under the control of said RAFT agent to thereby form polymer at the surface of said particulate material.
    Type: Grant
    Filed: October 4, 2005
    Date of Patent: August 15, 2017
    Assignee: The University of Sydney
    Inventors: Brian Stanley Hawkett, Christopher Henry Such, Duc Ngoc Nguyen, Jason Michael Farrugia, Olga Maree Mackinnon