Patents Assigned to The University of Utah Research Foundation
  • Patent number: 10465242
    Abstract: Systems, devices, and methods for capturing single source-specific biological material from a multi-source aggregate of biological material are disclosed and discussed. A capture system is generated using reversible chain-blocking to make capture substrates having substrate-linked populations of capture molecules specific for molecules of interest. Incubating such capture substrates in the presence of only a single source of biological material facilitates the association of molecules of interest from the same source. Capture substrate-specific barcode sequences coupled to the capture molecules allow multisource aggregate processing and subsequent grouping to retain the source-specific information following downstream processing.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: November 5, 2019
    Assignee: University of Utah Research Foundation
    Inventors: John Phillips, William M. Hanson, Jennifer M. Heemstra
  • Publication number: 20190321510
    Abstract: Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
    Type: Application
    Filed: June 24, 2019
    Publication date: October 24, 2019
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Russell J. STEWART
  • Patent number: 10448895
    Abstract: A sensor sheath for a catheter. The sensor sheath includes a substrate having at least one sensor associated therewith; and an electronics unit in communication with at the at least one sensor, wherein the substrate is configured to attach to a catheter.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: October 22, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Prashant Tathireddy, Carlos Mastrangelo, Florian Solzbacher, Nassir Marrouche, Jules Magda
  • Patent number: 10453988
    Abstract: A method of creating cadmium telluride films is presented. The method demonstrates heterogeneous nucleation of CdTe directly on a substrate through sequential deposition of aqueous precursor solutions containing cadmium and telluride ions, respectively. The method can include (i) applying a cadmium precursor solution to the substrate to form a cadmium precursor film on the substrate, (ii) applying a telluride precursor solution to the cadmium precursor film. The telluride precursor solution includes Te2? in solution such that a CdTe film is adherently formed directly on the substrate.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: October 22, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Carina Hahn, Dennis Pruzan, Michael Scarpulla
  • Patent number: 10451628
    Abstract: The present invention provides biomarker compositions and methods for the diagnosis and prognosis of PDAC. In a particular embodiment, the invention provides methods and compositions for screening, diagnosis and prognosis of early stage, asymptomatic PDAC.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 22, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Sean J. Mulvihill, Matthew A. Firpo
  • Patent number: 10448875
    Abstract: A substance measurement device includes: a container portion configured to receive a substance; a sensing device configured to measure a property of the substance related to at least one of a flow rate of the substance into the container portion, a level of the substance within the container portion, and a volume of the substance within the container portion; and at least one shield positioned within the container portion and configured to provide at least one of: a mechanical buffer between the substance entering the container portion and the sensing device; and an electrical shield between the substance entering the container portion and the sensing device.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: October 22, 2019
    Assignees: Stream Dx, Inc, University of Utah Research Foundation
    Inventors: Brian D. Holt, Scott B. McClellan, Alvin Y. Le, Kent James Ogden
  • Patent number: 10450748
    Abstract: A structural device includes a first deformable member configured to absorb at least a portion of a load resulting from relative displacement between structural members of a building. The first deformable member exhibits elastic deformation when subjected to tensile and/or compressive forces within a first range of forces, and exhibits plastic deformation when subjected to tensile and/or compressive forces within a second range of forces. A second deformable member is affixed to a portion of the first deformable member, and is configured to absorb at least another portion of the load resulting from the relative displacement between the structural members of the building. The second deformable member exhibits elastic deformation when subjected to tensile and/or compressive forces within a third range of forces, and exhibits plastic deformation when subjected to tensile and/or compressive forces within a fourth range of forces. Methods relate to forming structural devices.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: October 22, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Lawrence D. Reaveley, Tyler J. Ross
  • Patent number: 10450602
    Abstract: Disclosed herein are methods and compositions for determining the copy number of a first target nucleic acid as compared to the copy number of a second target nucleic acid in a single well with a single detection label. For example, disclosed herein are methods and compositions for determining the copy number of a first target nucleic acid as compared to the copy number of a second target nucleic acid by a monochrome multiplex quantitative PCR (MMQPCR) in a single well with a single detection label.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: October 22, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Richard M. Cawthon
  • Patent number: 10440955
    Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 15, 2019
    Assignees: CURZA GLOBAL, LLC, UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Ryan Looper, Dustin Williams, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hariprasada R. Kanna Reddy
  • Patent number: 10434515
    Abstract: A microfluidic device can include a temperature regulator positioned to generate a temperature gradient across a thermally controlled portion of the microfluidic device from a high temperature region to a low temperature region. Additionally, the microfluidic device can include a bi-directional microfluidic serpentine pathway having a first terminus and a second terminus. The bi-directional microfluidic serpentine pathway can be oriented along a longitudinal direction transverse to the temperature gradient. Further, the bi-directional microfluidic serpentine pathway can include a plurality of oscillation segments fluidly coupling the first terminus to the second terminus and forming a flow path adapted to oscillate a fluid between the high temperature region and the low temperature region. The bi-directional microfluidic serpentine pathway can have a uniform cross section to facilitate bi-directional flow.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: October 8, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Raheel Samuel, Bruce Gale, Alex Jafek, James Trauba, Kenneth Aston
  • Patent number: 10429627
    Abstract: An imaging system can include an optical fiber and a light source for providing optical stimulation to a region of interest along the optical fiber. A camera can capture emission such as fluorescence resulting from the optical stimulation. A cannula configured for implantation into a subject can be configured to direct the emission from the subject. A mating sleeve coupling the cannula to the optical fiber, and configured to support the camera, can include a dichroic mirror to allow the optical stimulation to pass from the optical fiber to the cannula and to redirect the emission from the cannula to the camera.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: October 1, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Rajesh Menon, Ganghun Kim
  • Patent number: 10427183
    Abstract: Discrete magnetic nanoparticles synthesized using a layer-by-layer technique are disclosed. The nanoparticles contain a magnetic core having a large magnetic moment, a plurality of layers and an exterior coating. The nanoparticles have utility in a wide range of biological and bioanalytical applications.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: October 1, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Michael C. Granger, Jooneon Park, Marc D. Porter
  • Patent number: 10421991
    Abstract: Methods for typing a strain of an organism are provided, the methods comprising the steps of amplifying, in a single reaction mixture containing nucleic acid from the organism, dividing the reaction mixture into a plurality of sets of second-stage reaction wells, each set of second-stage reaction wells containing a different pair of second-stage primers, subjecting each of the second-stage reaction wells to amplification conditions to generate a plurality of second-stage amplicons, melting the second-stage amplicons to generate a melting curve for each second-stage amplicon, and identifying the strain of the organism from the melting curves.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: September 24, 2019
    Assignees: BioFire Diagnostics, LLC, University of Utah Research Foundation
    Inventors: Anne Jeannette Blaschke-Bonkowsky, Mark Aaron Poritz
  • Patent number: 10422630
    Abstract: Devices, systems, and methods for determining a distance between at least two points are disclosed and described, wherein interferometry technology is utilized to determine such distances.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: September 24, 2019
    Assignee: University of Utah Research Foundation
    Inventor: Clayton C. Williams
  • Patent number: 10408896
    Abstract: A monolithic reusable microwire assembly can include a substrate and an electrically conductive thin-film wire formed on the substrate. The conductive thin-film wire can include a narrow segment forming an active area. A thermally and electrically insulating barrier can be formed on the electrically conductive thin-film wire. A roughness-reducing layer can be formed on the thermally and electrically insulating barrier and can have minimal surface roughness.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: September 10, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Shirin Jamali, Christoph Boehme
  • Patent number: 10406229
    Abstract: Disclosed herein are compositions and methods for inhibiting viral entry.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: September 10, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: J. Nicholas Francis, Joseph S. Redman, Michael S. Kay
  • Patent number: 10395134
    Abstract: A spectral distribution of incident light can be determined to increase collected spectral information. The spectral distribution of the incident light can be represented as a sum of spectral components after the incident light passes through a spectrum selective element. A signal at each color pixel of the spectrum selective element can be determined using, in part, the sum of the spectral components, where the spectral components are represented by a set of preliminary values. An error associated with the signal at each color pixel of the spectrum selective element is calculated. One or more perturbations are performed on each of the preliminary values and the error associated with the signal at each color pixel of the spectrum selective element is recalculated. The perturbations on each of the preliminary values is repeated until the error stabilizes within a predetermined range in order to assign the stabilized preliminary values as the spectral components in the incident light.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: August 27, 2019
    Assignee: University of Utah Research Foundation
    Inventor: Rajesh Menon
  • Patent number: 10376602
    Abstract: Disclosed are compositions and methods for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for monitoring the course of eosinophilic esophagitis in a subject before, during, and after treatment. In another aspect, disclosed is a method of diagnosing eosinophilic esophagitis or eosinophilic diseases in a subject, comprising detecting an eosinophil granule protein in the mucosal tissue of the esophagitis or other organs in a subject.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Leonard F. Pease, Hedieh Saffari, Gerald J. Gleich, Kristin M. Leiferman, Kathryn A. Peterson, Russell Morris Condie
  • Patent number: 10369249
    Abstract: Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: August 6, 2019
    Assignee: University of Utah Research Foundation
    Inventor: Russell J. Stewart
  • Patent number: 10369125
    Abstract: Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: August 6, 2019
    Assignee: The University of Utah Research Foundation
    Inventor: Tianxin Yang