Patents Assigned to The University of Vermont and State Agricultural College
  • Patent number: 10967047
    Abstract: The invention relates, in part, to compounds, compositions, and methods to assess characteristics of mitochondrial antiviral-signaling (MAVS) polypeptides and also to methods of modulating MAVS polypeptide characteristics. In addition, the invention relates, in part, to assays to assess characteristics of polypeptides.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: April 6, 2021
    Assignee: University of Vermont and State Agricultural College
    Inventors: Iwona A. Buskiewicz, Andreas Koenig
  • Patent number: 10954260
    Abstract: Organometallic compounds comprising a chloroquinoline moiety and uses of the compounds. The compounds are, for example, manganese or rhenium complexes of a ligand comprising a chloroquinoline moiety. The compounds can be used in, for example, methods of inhibiting cell growth.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: March 23, 2021
    Assignee: University of Vermont and State Agricultural College
    Inventors: William E. Geiger, Kevin Lam, Jon E. Ramsey, Claire F. Verschraegen
  • Publication number: 20210054055
    Abstract: Provided herein, in some embodiments, are compositions of Zika-specific antibodies and antigen-binding fragments thereof and methods of using said antibodies and antigen-binding fragments.
    Type: Application
    Filed: November 21, 2018
    Publication date: February 25, 2021
    Applicants: The University of Vermont and State Agricultural College, The University of North Carolina at Chapel Hill
    Inventors: Sean Diehl, Aravinda de Silva, Matthew Collins, Ben McElvany, Huy Tu
  • Patent number: 10918765
    Abstract: The present invention provides systems and methods for the decellularization and recellularization of tissue segments. In certain instances the invention comprises coating or sealing decellularized tissue segments with a cross-linked alginate hydrogel. The present invention also provides a decellularization kit, which may be used to generate decellularized tissue segments for high throughput studies. Also included are compositions and methods of tissue sealants comprising methacrylated alginate.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: February 16, 2021
    Assignee: University of Vermont and State Agricultural College
    Inventors: Darcy Wagner, Daniel J. Weiss, Nicholas Bonenfant, Rachael Oldinski, Spencer Fenn
  • Publication number: 20210033611
    Abstract: The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.
    Type: Application
    Filed: October 11, 2020
    Publication date: February 4, 2021
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Tamara Williams
  • Publication number: 20210023172
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 28, 2021
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • Patent number: 10897091
    Abstract: In various embodiments, a three-dimensional (3D) printed tripolar antenna fabricated through additive manufacturing techniques to match the geometries of various commercial wireless node packages is provided. The antenna systems are designed to mitigate harsh channel conditions by implementing polarization diversity between three mutually orthogonal monopoles.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: January 19, 2021
    Assignees: University of South Florida, The University of Vermont and State Agricultural College
    Inventors: Ramiro A. Ramirez, Marcia Golmohamadi, Thomas M. Weller, Jeffrey Frolik
  • Patent number: 10842843
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: November 24, 2020
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Ralph C. Budd, Cheryl Collins
  • Patent number: 10794332
    Abstract: Systems, apparatuses, and methods for generating hot gases based on catalyzation involving flowing catalyst. Catalysis occurs in a flow-type mixing catalyzation channel in which a liquid catalyst mixes with a liquid reactant flowing in a desired flow regime, such as a striated (laminar) flow regime or a slug flow regime. Devices such as micro-thrusters for satellite and other applications and hot gas generators for powering another device, such as an electrical generator, can be made using one or more flow-type mixing catalyzation channels.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: October 6, 2020
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Kevin R. Gagne, Darren L. Hitt, Michael Ryan McDevitt
  • Patent number: 10792330
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: October 6, 2020
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • Publication number: 20200283770
    Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 10, 2020
    Applicants: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNE
    Inventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
  • Patent number: 10765654
    Abstract: The invention includes, in part, methods and compounds for treating cancer including, but not limited to gliomas, melanomas, and neuroblastomas. In some embodiments of the invention, a glyceryltriacetate compound is administered to a subject in an amount effective to treat or prevent a cancer in the subject.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 8, 2020
    Assignee: University of Vermont and State Agricultural College
    Inventor: Diane M. Jaworski
  • Patent number: 10771116
    Abstract: A vibrating magnetic antenna for generating reversable magnetic dipoles is provided. Soft magnetic materials are used to project the magnetic field as the magnet moves linearly between soft magnetic stators arranged in a “Y” configuration. The soft magnetic stators include a nickel-iron alloy, having high magnetic permeability. Also provided is a magnetic coupling circuit for upshifting the frequency of the magnetic field.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: September 8, 2020
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Dryver R Huston, Tian Xia, Dylan Burns, Dan Orfeo
  • Publication number: 20200276263
    Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.
    Type: Application
    Filed: May 14, 2020
    Publication date: September 3, 2020
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Yvonne M. Janssen-Heininger, Vikas Anathy
  • Patent number: 10655126
    Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
    Type: Grant
    Filed: July 9, 2016
    Date of Patent: May 19, 2020
    Assignees: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGune
    Inventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
  • Publication number: 20200123619
    Abstract: Methods and kits for detecting cancer-associated miRNA are disclosed herein. Methods of identifying and treating a human patient at risk for cancer are also disclosed herein.
    Type: Application
    Filed: April 6, 2018
    Publication date: April 23, 2020
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Marie E. Wood, Jane B. Lian, Nicholas Farina, Janet L. Stein
  • Patent number: 10585270
    Abstract: A multi-plane imaging system for imaging multiple reflection planes of a regular or irregular shaped three-dimensional (3D) specimen having top, side and bottom views simultaneously. The system includes an inverted watertight pyramid well having at least four reflective side surfaces for reflecting the specimen side views, wherein each of the at least four reflective sides surfaces define an angle, ?, relative to the base horizontal plane, and wherein each reflective side surface comprises a plurality of reflective zones; A specimen is positioned horizontally equidistant from the at least four reflective side surfaces and positioned vertically from the base horizontal plane a predetermined vertical distance; wherein the predetermined vertical distance, the at least four reflective side surfaces, and the angle ? comprise a reflection image plane for reflecting the specimen bottom views.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: March 10, 2020
    Assignee: University of Vermont and State Agricultural College
    Inventors: Nathan R Tykocki, Grant Hennig
  • Patent number: 10583169
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: March 10, 2020
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • Publication number: 20200038663
    Abstract: According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 6, 2020
    Applicant: The University of Vermont and State Agricultural College
    Inventor: Markus Meyer
  • Publication number: 20200000869
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Application
    Filed: September 17, 2019
    Publication date: January 2, 2020
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Ralph C. Budd, Cheryl Collins