Abstract: A multi-plane imaging system for imaging multiple reflection planes of a regular or irregular shaped three-dimensional (3D) specimen having top, side and bottom views simultaneously. The system includes an inverted watertight pyramid well having at least four reflective side surfaces for reflecting the specimen side views, wherein each of the at least four reflective sides surfaces define an angle, ?, relative to the base horizontal plane, and wherein each reflective side surface comprises a plurality of reflective zones; A specimen is positioned horizontally equidistant from the at least four reflective side surfaces and positioned vertically from the base horizontal plane a predetermined vertical distance; wherein the predetermined vertical distance, the at least four reflective side surfaces, and the angle ? comprise a reflection image plane for reflecting the specimen bottom views.
Type:
Application
Filed:
October 25, 2018
Publication date:
April 25, 2019
Applicant:
The University of Vermont and State Agricultural College
Abstract: The invention relates, in part, to compounds, compositions, and methods to assess characteristics of mitochondrial antiviral-signaling (MAVS) polypeptides and also to methods of modulating MAVS polypeptide characteristics. In addition, the invention relates, in part, to assays to assess characteristics of polypeptides.
Type:
Application
Filed:
April 21, 2017
Publication date:
April 4, 2019
Applicant:
University of Vermont and State Agricultural College
Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
Type:
Application
Filed:
July 9, 2016
Publication date:
March 14, 2019
Applicants:
University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNE
Inventors:
Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
Type:
Grant
Filed:
June 5, 2017
Date of Patent:
March 12, 2019
Assignees:
The University of Vermont and State Agricultural College, Emory University
Inventors:
Victor May, Kerry J. Ressler, Sayamwong E. Hammack, Donna Toufexis, Karen M. Braas
Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
Type:
Application
Filed:
September 18, 2018
Publication date:
February 28, 2019
Applicant:
University of Vermont and State Agricultural College
Inventors:
Christopher Francklyn, Karen M. Lounsbury, Jason Botten
Abstract: The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.
Type:
Grant
Filed:
July 24, 2013
Date of Patent:
January 8, 2019
Assignee:
University of Vermont and State Agricultural College
Inventors:
Christopher Francklyn, Karen M. Lounsbury, Tamara Williams
Abstract: The present invention generally relates to inhibitors of DUOX1. In some aspects, an inhibitor may be applied to a subject having or being at risk for asthma or other conditions. The inhibitor may be applied by various techniques, such as pulmonary or topical delivery. In some embodiments, the inhibitor may include a peptide or other moiety having a reactive electrophile. The reactive electrophile can target cysteine or other residues within DUOX1 to inhibit its activity, e.g., by covalently binding to the residue. Other non-limiting examples of suitable inhibitors include hydroxynonenal, curcumin, sulforaphane, cinnamaldehyde, dimethyl fumarate, or phenyl vinyl sulfonate. Other aspects of the invention are generally directed to methods of making or using such inhibitors, kits involving such inhibitors, devices or formulations containing such inhibitors, or the like.
Type:
Grant
Filed:
October 21, 2016
Date of Patent:
December 4, 2018
Assignee:
The University of Vermont and State Agricultural College
Inventors:
Albert van der Vliet, David Earl Heppner, Karamatullah Danyal
Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by reduced threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is reduced as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by reduced TARS activity.
Type:
Grant
Filed:
July 24, 2013
Date of Patent:
November 13, 2018
Assignee:
University of Vermont and State Agricultural College
Inventors:
Christopher Francklyn, Karen M. Lounsbury, Jason Botten
Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
Type:
Grant
Filed:
July 24, 2013
Date of Patent:
October 2, 2018
Assignee:
University of Vermont and State Agricultural College
Inventors:
Christopher Francklyn, Karen M. Lounsbury, Jason Botten
Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
Type:
Grant
Filed:
December 5, 2014
Date of Patent:
August 21, 2018
Assignee:
University of Vermont and State Agricultural College
Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.
Type:
Application
Filed:
January 18, 2018
Publication date:
August 9, 2018
Applicant:
The University of Vermont and State Agricultural College
Inventors:
Yvonne M. Janssen-Heininger, Vikas Anathy
Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.
Type:
Application
Filed:
February 1, 2018
Publication date:
August 9, 2018
Applicants:
The University of Vermont and State Agricultural College, Universiteit Maastricht
Inventors:
Yvonne M. Janssen-Heininger, Niki Reynaert
Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
Type:
Application
Filed:
February 8, 2018
Publication date:
June 21, 2018
Applicant:
The University of Vermont and State Agricultural College
Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
Type:
Application
Filed:
November 7, 2017
Publication date:
May 10, 2018
Applicant:
University of Vermont and State Agricultural College
Abstract: The invention relates, in part, to compounds, compositions, and methods to assess molecular characteristics papillary microcarcinoma (PMC) of the thyroid and indicators of indolent compared to aggressive PMC of the thyroid. In addition, the invention relates, in part, to methods of assessing characteristics of microRNAs associated with PMC of the thyroid.
Type:
Application
Filed:
October 19, 2017
Publication date:
April 19, 2018
Applicant:
University of Vermont and State Agricultural College
Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
Type:
Grant
Filed:
February 1, 2012
Date of Patent:
April 10, 2018
Assignee:
The University of Vermont and State Agricultural College
Inventors:
Victor May, Kerry J. Ressler, Sayamwong E. Hammack, Donna Toufexis, Karen M. Braas
Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
Type:
Grant
Filed:
July 22, 2015
Date of Patent:
March 27, 2018
Assignee:
The University of Vermont and State Agricultural College
Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.
Type:
Grant
Filed:
June 20, 2013
Date of Patent:
March 6, 2018
Assignee:
The University of Vermont and State Agricultural College
Inventors:
Yvonne M. Janssen-Heininger, Vikas Anathy
Abstract: The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. In some aspects the invention includes compounds and methods that increase chemo-sensitivity and/or reduce chemo-resistance in a cancer cell. In certain aspects the invention includes compounds and methods useful to kill cancer cells.
Type:
Application
Filed:
February 18, 2016
Publication date:
February 1, 2018
Applicant:
University of Vermont and State Agricultural College
Inventors:
Mercedes Rincon, Thomas Roberts, Tina Thornton
Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
Type:
Application
Filed:
June 5, 2017
Publication date:
November 30, 2017
Applicants:
The University of Vermont and State Agricultural College, Emory University
Inventors:
Victor May, Kerry J. Ressler, Sayamwong E. Hammack, Donna Toufexis, Karen M. Braas