Patents Assigned to The University of Virginia Alumni Patents Foundation
  • Patent number: 4563768
    Abstract: A mammographic device comprises an X-ray source for emitting X-rays along a predetermined path, a film holder disposed in the predetermined path of the X-rays for holding film to be exposed to the X-rays, a compression plate disposed in the predetermined path of the X-rays, and positionable for compressing, and holding in position, against the film holder a woman's breast to be X-rayed, and a suspension arrangement disposed between the X-ray source and the compression plate for holding the X-ray source and the compression plate in a fixed relative mutual position so that the distance between the X-ray source and the compression plate remains constant. In a preferred embodiment of the invention, the compression plate holder and compression plate are formed into an integral structure made of plexiglass. Preferably, the compression plate contains a matrix pattern of holes or perforations for facilitating biopsy guidance and needle aspiration cytology.
    Type: Grant
    Filed: July 11, 1983
    Date of Patent: January 7, 1986
    Assignee: University of Virginia Alumni Patents Foundations
    Inventors: Mark E. Read, Ronald L. Boswell
  • Patent number: 4528207
    Abstract: Dental alloy particles having a coating of a silver-tin alloy are prepared by a process comprising codepositing silver and tin from a cyanide based plating solution containing silver and tin ions on a particulate metal substrate having a particle size sufficient to allow integral bonding between the alloy layer and the particulate substrate.
    Type: Grant
    Filed: December 12, 1983
    Date of Patent: July 9, 1985
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventor: Lewis B. Johnson
  • Patent number: 4446064
    Abstract: An insulin mediator substance produced by the process comprising: contacting muscle tissue with insulin; deproteinizing the muscle tissue; removing the major nucleotides from the deproteinized muscle tissue; chromatographing the so-treated product on a Sephadex G-25 column using 0.05 N formic acid; and recovering the fraction wherein the major 230-nm absorbance peak corresponds with the ninhydrin-positive peak.
    Type: Grant
    Filed: December 19, 1980
    Date of Patent: May 1, 1984
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventors: Joseph Larner, Kang Cheng, Gail Galasko
  • Patent number: 4438771
    Abstract: An apparatus and method is disclosed for detecting the cessation of movement of a body by detecting the voltage produced by the movement of the charge on said body because of the body's movement. This is accomplished by a passive contactless conductive pad which is spaced from the body and in which a potential is induced by the movement of the body through the movement of the charge on the body. This potential is amplified and an alarm indication device responds to the amplified potential to produce an alarm when the output of the amplifier is below a predetermined value or for a predetermined period of time. This device enables the unattended monitoring of breathing and heart functioning for long periods of time.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: March 27, 1984
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: W. Otto Friesen, Gene D. Block
  • Patent number: 4407800
    Abstract: A method of treating or protecting against parasitic diseases caused by members of the protozoan family Trypanosomatidae comprising administering to a mammal a phenothiazine drug. This represents a new use of the phenothiazine compounds.
    Type: Grant
    Filed: November 2, 1981
    Date of Patent: October 4, 1983
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: Richard D. Pearson, Erik L. Hewlett
  • Patent number: 4384943
    Abstract: Methods and apparatus for electrochemically disinfecting or treating contaminated aqueous liquids by contact disinfection and/or the generation of a biocidally active chemical agent in the liquid being treated. Rapid polarization of reactor electrodes after polarity reversal and out-of-phase operation of paired reactors can be employed to promote efficient disinfection, reduce the bulk of the apparatus, and protect the reactor electrodes against damage.
    Type: Grant
    Filed: September 11, 1980
    Date of Patent: May 24, 1983
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventors: Glenn E. Stoner, Louie L. Scribner, Jr., George L. Cahen, Jr.
  • Patent number: 4376125
    Abstract: 1-(p-Amino-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-propan ol, 1-(p-hydroxy-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-pro panol, 1-(p-methyl-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-prop anol, 1-(p-methoxy-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-pro panol and the pharmaceutically acceptable acid addition salts thereof are effective, long lasting .beta.-adrenergic blocking agents and areas of indication are hypertension, angina pectoris, cardiac arrythmia, and the like.
    Type: Grant
    Filed: November 5, 1980
    Date of Patent: March 8, 1983
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: Gary Brooker, Wesley L. Terasaki, Joel M. Linden
  • Patent number: 4364922
    Abstract: A method of relieving atrioventricular conduction block by administering to a human or animal an effective amount of an adenosine antagonist that competitively inhibits adenosine or that reduces the level of adenosine present in myocardial tissue and associated fluids. A method of diagnosing atrioventricular conduction block caused by ischemia of the heart by measuring the time delay between atrial and ventricular excitation before and after the administration of an adenosine antagonist. Specific antagonists disclosed include methylxanthines.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: December 21, 1982
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: Robert M. Berne, Luiz Belardinelli, Rafael Rubio
  • Patent number: 4358699
    Abstract: A versatile electrical fiber brush comprising the following components: Firstly a brush body, which is not necessarily equiaxed, non-porous, rigid or all in one piece, made of a matrix material, not necessarily electrically conductive, embedded in which is at least one set of similarly formed fibers, in which there may be embedded other, thinner fibers, and in these fibers still thinner fibers. Secondly, at least one fibrous part which is formed by removing from a part of the brush body most or all of the matrix material plus, as the conditions may make it advisable, some fibrous material. Third, at least one working surface, this being the macroscopic surface of a brush where it makes contact with the object(s) to which electrical connection shall be made. Fourth at least one set of electrically conductive fiber wires which form at least part of the working surface as well as of the fibrous part.
    Type: Grant
    Filed: June 5, 1980
    Date of Patent: November 9, 1982
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventor: Doris Wilsdorf
  • Patent number: 4324262
    Abstract: A catheter adapted to be introduced into a body cavity, such as a bronchial tube or lung, and a method of using the catheter. The catheter consists of inner and outer concentric tubes having a reflected cylindrical membrane attached adjacent their distal ends. Pressurized fluid may be introduced through the perfusate passage running between the tubes and thus between the walls of the reflected membrane in order to provide relative rigidity for the membrane and to seal the reflected end of the membrane, thereby creating a closed pristine chamber, defined by the walls of the reflected membrane about the end of the inner tube. A cage composed of balls mounted on resilient pins may be disposed within the reflected membrane to aid the reflection of the membrane. A portion of the reflected membrane may be perforate.
    Type: Grant
    Filed: January 2, 1979
    Date of Patent: April 13, 1982
    Assignee: University of Virginia Alumni Patents Foundation
    Inventor: John E. Hall
  • Patent number: 4319562
    Abstract: A method and apparatus for providing permanent epicardial pacing comparable to permanent transvenous pacing in the acutely ill or debilitated patient under local anesthesia and for drainage of pericardial fluid and pericardial biopsy. The apparatus includes a cylindrical member with first and second open end portions, an inner and outer wall portion and a connecting slot between the inner and outer wall portions, a guard member provided at the first end portion of the cylindrical member adjacent to the slot and a maneuvering member connected to the outer wall portion at the second end portion of the cylindrical member.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: March 16, 1982
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventor: Ivan K. Crosby
  • Patent number: 4310167
    Abstract: A center of gravity wheelchair with an articulated chassis front and rear caster wheels, in which the main wheels and front and rear caster wheels are arranged in a diamond pattern, and the main wheels and rear caster wheel are carried by a subframe to form a bogie system, with the seat and front caster wheel carried by a seat frame assembly articulated with respect to the subframe through a pivoted link arrangement, whereby the seat may be moved forward relative to the main wheels, with a spring and damper connected between the subframe and seat frame assembly to minimize the tendancy for the front caster wheel to lift off the ground when the main wheels are strongly propelled and to provide a shock absorbing structure for traversing rough ground. The diamond pattern provided by the wheels prevents lateral drift of the wheel chair when traversing sloping surfaces, and the articulated frame permits easier curb climbing.
    Type: Grant
    Filed: May 15, 1980
    Date of Patent: January 12, 1982
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventor: Colin A. McLaurin
  • Patent number: 4309187
    Abstract: A method and apparatus for analysis of atomic species which comprises directly forming metastable energy level nitrogen by processing a stream of nitrogen containing gas through a dielectric field wherein essentially no excited species above the 6th vibrational level of the B.sup.3 .pi..sub.g energy state nor nitrogen atoms nor ions are formed, admixing said excited nitrogen with a gas stream suspected of containing said atomic species to be analyzed whereby the energy level of said species is raised sufficiently to enable a fluorescent emission as the energy level of said excited species decays to its lower energy state, detecting and analyzing the spectrum of said flluroescent radiation to determine the identity and concentration of said element.
    Type: Grant
    Filed: October 25, 1979
    Date of Patent: January 5, 1982
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: William B. Dodge, III, Ralph O. Allen
  • Patent number: 4181123
    Abstract: A method and apparatus for providing permanent epicardial pacing comparable to permanent transvenous pacing in the acutely ill or debilitated patient under local anesthesia and for drainage of pericardial fluid and pericardial biopsy. The apparatus includes a cylindrical member with first and second open end portions, an inner and outer wall portion and a connecting slot between the inner and outer wall portions, a guard member provided at the first end portion of the cylindrical member adjacent to the slot and a maneuvering member connected to the outer wall portion at the second end portion of the cylindrical member.
    Type: Grant
    Filed: December 28, 1977
    Date of Patent: January 1, 1980
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventor: Ivan K. Crosby
  • Patent number: 4176179
    Abstract: Arthritis in mammals is treated by administering to said mammal an effective dose of a water soluble carotenoid.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: November 27, 1979
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventor: John L. Gainer
  • Patent number: 4161198
    Abstract: A portable machine for servicing small animal cage litter trays which is independent of water and waste connections.
    Type: Grant
    Filed: November 18, 1976
    Date of Patent: July 17, 1979
    Assignee: University of Virginia Alumni Patents Foundation
    Inventor: Nickolas J. Sojka
  • Patent number: 4141864
    Abstract: An osseous cement for orthopedic or dental application, which comprises the admixture of 10 to 40% weight of organic or inorganic particles wherein said particles are soluble in the extracellular fluid of the body, and are essentially non-toxic, 20 to 40% weight of an acrylic monomer and 35 to 65% weight of an insoluble particulate filler having a particle size of less than 100.mu..
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: February 27, 1979
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: Arie Rijke, Sue McCoy, Robert E. McLaughlin
  • Patent number: 4128628
    Abstract: An automated immunoassay apparatus which provides: time controlled incubation of a multiplicity of sample solutions, each of which comprise a mixture of (a) a sample, possibly containing an antigen or antibody intended to be assayed; (b) a solution of a known concentration of a tagged antigen or tagged antibody; and when assaying for antigen, optionally; (c) a solution of a known titer of an antibody reactable with said antigen;Isolation of incubated samples from additional sample solutions introduced into said apparatus for assay, whereby the system is isolated at a first predetermined signal from a timing device, and whereby the system is reconnected at a second predetermined signal from the timing device, wherein the second predetermined time period is set so as to enable sufficient time to complete a measurement of the amount of tagged material before the next incubated sample arrives in the detector for the next sequential measurement.
    Type: Grant
    Filed: February 3, 1977
    Date of Patent: December 5, 1978
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: Gary L. Brooker, Wesley L. Terasaki, Michael G. Price