Abstract: A molded pharmaceutical primary closure including a thermoplastic elastomer molded into the shape of a closure and having a compression set less than about forty percent, an oxygen transmission rate of less than 500 cc/m.sup.2 /day, a moisture vapor transmission rate of less than 2 gm/m.sup.2 /day, and a needle penetration force of less than 2000 grams.

Abstract: An elastomeric member for use with a container and in contact with pharmaceutically pure contents therein. The elastomeric member has an elastomeric base and a continuous polyparaxylylene coating on the base. The coating ranges from about 0.5 microns to about 2.0 microns in thickness. The closure member has a coefficient of friction of less than 1.0 and is capable of substantially preventing metal extraction from said elastomers.

Abstract: An apparatus for checking the fill level of a vial. The apparatus indicates the presence of a vial in a predetermined location. Light is sensed to measuring the amount of light which is able to pass through the vial at that location. A signal is produced which is porportional to the amount of material in said vial.

Abstract: A device for transferring small discrete objects such as pharmaceutical stoppers and caps including a frame movably positionable at a predetermined location for delivery of the objects and an angularly displaced conveyor on the frame having a discharge chute at the predetermined location for discharge of objects thereto. The conveyor includes a conveyor chain defining a path from a transfer path to the discharge chute. The chain has bucket flights for conveying the objects along the path. A delivery chute is also on the frame for transferring the objects to the transfer point. The delivery chute includes a first tray inclined with the horizontal and having an open terminal end adjacent the transfer point positioned to feed the objects to the conveyor chain. The delivery chute further includes a second tray located within the first tray at the same or greater angle with the horizontal and positioned to receive the objects.

Abstract: A thermoplastic elastomer composition produced by dynamic vulcanization of SBR has a dispersed phase of cross linked SBR, and a co-continuous matrix of SEBS and polypropylene.

Abstract: A method of making a tamper-evident closure cap including the steps of forming a one piece closure cap from a plastic material having a top, a skirt depending from the top and a tamper-evident band depending from the skirt. The band has a radially inward directed rib and an annular portion between the skirt and the tamper-evident band. The annular portion is engaged with a cutting blade which has a cutting edge and series of spaced notches. The blade and the cap are rotated to form a plurality of circumferentially spaced bridges with a series of angularly inwardly disposed tabs.

Abstract: A container for use with a closure and a glass container having an access opening for a closure. The container was a crush strength increasing polyparaxylylene coating on at least one side of the glass container at a thickness of at least 0.1 microns to give at least 40% increased crush strength.

Abstract: A composite medicament container including a vial to contain a dry powdered medicament, an outlet opening in the vial, a Lyo-stopper closing and sealing the outlet opening, and a flexible liquid container to contain a diluent for the dry medicament. The liquid container has a discharge port having an ellipsoidal shape. There is a closure plug in the discharge port. The closure plug has an ellipsoidal configuration and a size to mate with the interior of the discharge port and be secured therein. The configurations and sizes of the discharge port and said closure plug co-act to provide an enlarged, closely contacting extensive scaling area. The vial opening has a circular external configuration so that the vial outlet opening and the liquid container closure plug are mateable. Also included is a composite interengaging and sealing means which is operatively attaching and sealing the containers in mated relationship for intermixing the materials therein.

Abstract: A device for transferring small discrete objects such as pharmaceutical stoppers andn caps including a frame movably positionable at a predetermined location for delivery of the objects and an angularly displaced conveyor on the frame having a discharge chute at the predetermined location for discharge in objects thereto. The conveyor includes a conveyor chain apparatus defining a path from a transfer point to the discharge chute. The chain has bucket flight apparatus for conveying the objects along the path. A delivery chute is also on the frame for transferring the objects to the transfer point. The delivery chute includes a first tray inclined with the horizontal and having an open lower terminal end adjacent the transfer point positioned to feed the objects to the conveyor chain. The delivery chute further includes a second tray located within the first tray at the same or greater angle with the horizontal and positioned to receive the objects.

Abstract: A tamper-proof closure for a container having a discharge opening at one end and a wall member spanning the opening, inter-engaging locking between the skirt of the cap and the container opening, a tab projecting radially outwardly from the skirt registerable with a recess or gap in a radially outwardly directed flange of the container which it normally overlies, a fracturable tear band portion including inter-locking to prevent relative rotation of the closure and container.

Abstract: A tamper-proof ring for securing a closure over the open end of a container. The closure and container has a projection engageable by the ring which comprises an annular member which before application to a container-closure assembly has a generally cylindrical section of a diameter slightly greater than the greatest transverse dimension of the container. The closure projection and a radially inwardly directed flange at one end of the cylindrical section define a plurality of circumferentially spaced, generally axial score lines extending from the edge of the cylindrical section opposite the one end and terminates at the juncture of the flange and cylindrical section.

Abstract: A soft, high strength thermoplastic elastomeric composition for use in medical and pharmaceutical products, comprising an ethylene butylene block copolymer having terminal polystyrene units, a platicizer in an amount sufficient to soften the ethylene butylene phase of the copolymer, and a thermoplastic acrylic resin in an amount ranging from 15 to 65 parts per 100 parts of the copolymer.

Abstract: A thermoplastic elastomer composition is disclosed, comprising a halobutyl rubber cured by dynamic vulcanization with a multifunctional amine curing agent. The cure is effected in the presence of at least 20 parts of a mixture formed from 10 to 60 parts of a polyolefin and 1 to 90 parts of a thermoplastic elastomer. The parts based on 100 parts by weight of said rubber.

Abstract: A tamper-proof seal for a container having at least one circumferentially extending flange adjacent the discharge opening therein comprising an annular top and a circumferentially extending skirt depending from the top adapted to be crimped at its lower terminal edge to engage under the flange to hold it on the container. A pull ring connects to the annular portion by a throat portion and partial score lines extend across the annular top portion on either side of the pull ring and define a plurality of circumferentially spaced score lines extending from the lower edge of the skirt upwardly in an axial direction to a point closely adjacent the juncture of the skirt and annular top portion. The axial score lines are spaced closely about the skirt.

Abstract: A child-resistant dropper closure container combination comprising a container having a finish at its discharge end including a plurality of locking fingers spaced apart to define a series of circumferentially spaced channels and having keeper slots, a cap having an annular top and a depending skirt and a plurality of locking lugs circumferentially spaced on the interior of the skirt and a dropper assembly mounted in the cap including a flexible biasing flange engageable with the container finish and the interior of the cap to normally bias the cap in a direction to retain it in a locked position wherein the lugs engage in the keeper slots and permitting axial and rotational movement of the cap relative to the container to align the locking lugs with the channels for removal purposes.

Abstract: A stopper device for use on a pharmaceutical closure, comprising an elastomeric stopper sized to function as a closure; and a polyurethane coating on the stopper. The coating has a modulus sufficient to decrease the coefficient of friction of the stopper to less than 0.6.

Abstract: A holder for cartridges or containers for medicaments in injectable form comprising an elongated housing having a pocket for the cartridge, a head assembly including an elongated plunger rod adapted to be attached to the cartridge plunger for actuating the same to effect discharge of medicament from the cartridge and means operatively connecting the head assembly to one end of the housing for actuating a shank portion of the head assembly axially (longitudinally) in the housing. The head assembly and housing is made of dissimilar materials to facilitate relative rotation of the head assembly and housing and resist slippage when the shank exerts an axial force on the cartridge to seat it in the housing.

Abstract: A container and tamper evident closure. The container has a threaded neck, first and second beads spaced below the threads and a groove between the beads. A threaded closure has a tamper-evident band connected to the lower terminal edge of the closure by a series of spaced, facturable bridges and retaining means cooperating with one bead to fracture the bridges when the closure is unscrewed. The band has a series of angularly disposed tabs which cooperate with the lower edge of the closure to limit lateral displacement and telescoping of the band when initially applied to the container.

Abstract: A needle shield comprising an elongated tubular housing having a central bore, means at one end for detachably mounting the shield to the hub of a syringe assembly, and means defining an elongated generally cylindrical chamber in the end of the housing opposite the mounting means. An inner end communicates with the bore and an insert made of resilient impermeable pierceable material is snugly supported in the chamber. The chamber is of a diameter slightly greater than the diameter of the insert and includes a tapered wall portion at the inner end and has a section of smaller diameter than the insert to provide a tight generally hermetic sealing relation therewith. The wall of the chamber opposite the inner end is deformable to permit ease of assembly and deformation after insertion of the plug to firmly seat the plug in the chamber.

Abstract: A method of producing a molded rubber product for use in the pharmaceutical industry comprising the steps of mixing a rubber formulation including a halogenated butyl rubber and a curing system of from 0.5 to 2.0 parts by weight of zinc oxide and from 0.5 to 1.5 parts by weight of m-PBM. The parts are based upon the weight of the formulation. A sheet is formed from the mixture by feeding the mixture through a calender means. The calender sheet is molded into a molded rubber product at a pressure of at least 500 psi and at a temperature of up to 375.degree. F. for up to 5 minutes. The formed product is then removed.