Patents Assigned to Theranos IP Company, LLC
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Patent number: 10466178Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.Type: GrantFiled: May 18, 2018Date of Patent: November 5, 2019Assignee: Theranos IP Company, LLCInventors: Chinmay Pangarkar, Karan Mohan
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Patent number: 10450595Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: GrantFiled: October 12, 2015Date of Patent: October 22, 2019Assignee: Theranos IP Company, LLCInventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Patent number: 10441204Abstract: Provided herein are methods for extracting blood from a subject's digit, such as a finger. Methods provided herein may release relatively large quantities of blood from a pierced finger. Pressure can be applied at selected locations on the subject's digit to increase blood flow released from the subject.Type: GrantFiled: March 19, 2014Date of Patent: October 15, 2019Assignee: Theranos IP Company, LLCInventors: Daniel Edlin, Nicholas Menchel
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Patent number: 10436687Abstract: Devices, systems and methods for holding and transferring small volume fluid samples are disclosed. Holding vessels, including holding vessels having two or more internal compartments for holding small volume fluid samples, are disclosed. Transfer vessels for receiving small volume fluid samples from such holding vessels are disclosed. Transfer vessels for combining small volume fluid samples from such holding vessels are disclosed. Methods for providing small volume fluid samples for analysis with small loss of sample are disclosed. Methods for providing small volume fluid samples for analysis using automated sample analysis devices and systems, with small loss of sample, are disclosed.Type: GrantFiled: February 2, 2018Date of Patent: October 8, 2019Assignee: Theranos IP Company, LLCInventors: Clarissa Lui, Priyanshu Gupta
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Patent number: 10425304Abstract: Methods and systems are provided for connecting an electronic device to a network. In some situations, the electronic device connects to a first network provider and pings a first server having a static internet protocol address and a second server having a dedicated uniform resource locator. If the electronic device receives a response from the first and second server, the electronic device maintains its connection to the first network provider. Otherwise, the electronic device connects to a second network provider and pings the first and second servers.Type: GrantFiled: October 10, 2014Date of Patent: September 24, 2019Assignee: Theranos IP Company, LLCInventor: Sunny Balwani
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Patent number: 10422806Abstract: Methods for improving assays of biological samples are provided, including assays of small volume biological samples, such as blood samples obtained from a fingerstick. The methods include steps of selecting a baseline assay; providing a first revised assay by altering an aspect, a reagent, or a step of the baseline assay; comparing the results of the baseline assay and first revised assay; and identifying the first revised assay as an improved assay if the results of the first revised assay are similar to, are substantially the same as, or are better than, the results of the baseline assay. The methods may be iterated. Alterations include reducing sample volume; setting temperature; reducing step number and duration; altering reagent composition and number; and altering detection. Improved assays may reduce the duration, cost, or complexity of the assay, may improve assay sensitivity, accuracy, or reliability, and may provide synergistic improvements.Type: GrantFiled: July 25, 2014Date of Patent: September 24, 2019Assignee: Theranos IP Company, LLCInventors: Paul Patel, Ian Gibbons, Elizabeth A. Holmes
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Patent number: 10416178Abstract: Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge from at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.Type: GrantFiled: September 15, 2015Date of Patent: September 17, 2019Assignee: Theranos IP Company, LLCInventors: Elizabeth A. Holmes, Adrit Lath
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Patent number: 10401373Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.Type: GrantFiled: May 2, 2017Date of Patent: September 3, 2019Assignee: Theranos IP Company, LLCInventors: Elizabeth A. Holmes, Timothy Smith, Alexander Loo, Daniel Young
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Patent number: 10392650Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: GrantFiled: November 30, 2016Date of Patent: August 27, 2019Assignee: Theranos IP Company, LLCInventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Patent number: 10391496Abstract: Methods, devices, systems, and kits useful for the collection and analysis of samples obtained by swabs are disclosed. Swab containers configured for receiving a swab containing a sample; cartridges for holding one or more of: a swab container, a swab, assay units, pipette tips, vessels, transport units, and implements; systems (which may include a sample processing device); kits; and methods for their use are disclosed. A swab container may include an entry port; an assay chamber having an assay port; a conduit comprising an interior channel connecting the entry port; and an interior channel providing fluidic communication between the entry port and assay chamber. An interior channel may be configured to squeeze a portion of a swab placed in or through the conduit. A cartridge may include a cartridge frame configured to receive one or more of swab containers, assay units, transport units, pipette tips, vessels or implements.Type: GrantFiled: February 11, 2016Date of Patent: August 27, 2019Assignee: Theranos IP Company, LLCInventors: Clarissa Lui, Elizabeth A. Holmes
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Patent number: 10391497Abstract: Devices, methods and systems are provided for reducing the sample volume required for analysis. Inserts placed within a sample container, and substitute sample containers having smaller volume sample chambers are provided. Methods are provided for detection and quantification of target substances in reduced volume samples. Methods include placing a small-volume of sample in a small-volume insert. Methods include diluting a small-volume sample, and placing the diluted sample in a small-volume insert.Type: GrantFiled: May 23, 2016Date of Patent: August 27, 2019Assignee: Theranos IP Company, LLCInventors: Xinwei Sam Gong, Daniel Young, William Westrick
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Patent number: 10371710Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: October 30, 2015Date of Patent: August 6, 2019Assignee: Theranos IP Company, LLCInventors: James R. Wasson, John Kent Frankovich, Elizabeth A. Holmes, Timothy Smith, Michael Chen, Daniel Young
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Patent number: 10345303Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.Type: GrantFiled: June 16, 2016Date of Patent: July 9, 2019Assignee: Theranos IP Company, LLCInventors: Elizabeth A. Holmes, Chinmay Pangarkar, Timothy Smith, Karan Mohan, Samartha Anekal, Daniel Young, James Wasson
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Patent number: 10328395Abstract: In one embodiment described herein, a bodily fluid separation material is provided comprising a formed component capture region and a bodily fluid pass-through region. The pass-through region has structures with a reduced liquid leaching quality relative to than the capture region, wherein during separation material use, bodily fluid enters the capture region prior to entering the pass-through region. Optionally, a bodily fluid pass-through region has a reduced amount of liquid leaching material relative to than the capture region.Type: GrantFiled: September 25, 2017Date of Patent: June 25, 2019Assignee: Theranos IP Company, LLCInventors: Samartha Anekal, Deborah Sloan
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Patent number: 10301689Abstract: Applicant discloses herein kits for identifying the presence of Zika virus in a sample. In embodiments, these kits comprise reagents disclosed herein. Applicant further provides kits for use in detecting ZIKV in a sample, the kits comprising reagents disclosed herein. In embodiments, kits include primers directed to Zika virus (ZIKV) nucleic acid sequences, the primers capable of hybridizing to ZIKV nucleic acids and to copies of ZIKV nucleic acids (including to cDNA copies of ZIKV nucleic acids). Applicant discloses herein reagents for detecting Zika virus (ZIKV) in a sample, the reagents including one or more nucleic acid primers that are capable of hybridizing to a ZIKV nucleic acid (including to cDNA copies of ZIKV nucleic acids).Type: GrantFiled: July 31, 2017Date of Patent: May 28, 2019Assignee: Theranos IP Company, LLCInventors: Chandan Shee, Jerzy Majka, Bernardo Araujo, Ushati Das Chakravarty, Katrina Sullivan-Bibee, Jerald Sapida, Kristine Salazar
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Patent number: 10302643Abstract: Methods, devices, apparatus, and systems are provided for image analysis. Methods of image analysis may include observation, measurement, and analysis of images of biological and other samples; devices, apparatus, and systems provided herein are useful for observation, measurement, and analysis of images of such samples. The methods, devices, apparatus, and systems disclosed herein provide advantages over other methods, devices, apparatus, and systems.Type: GrantFiled: October 7, 2014Date of Patent: May 28, 2019Assignee: Theranos IP Company, LLCInventors: Karan Mohan, Chinmay Pangarkar, James R. Wasson
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Patent number: 10281479Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.Type: GrantFiled: January 16, 2015Date of Patent: May 7, 2019Assignee: Theranos IP Company, LLCInventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes, Swapna Joshi
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Patent number: 10283217Abstract: Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.Type: GrantFiled: July 1, 2015Date of Patent: May 7, 2019Assignee: Theranos IP Company, LLCInventors: Clarissa Lui, Elizabeth A. Holmes, Pranav Patel, Scott Tabakman, Kamila Belhocine, Aaron Richardson, Josephine Lee
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Patent number: 10248765Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample vessel for receiving the bodily fluid sample collected in the sample collection channel, the sample vessel operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the vessel and/or another source provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the vessel.Type: GrantFiled: June 11, 2015Date of Patent: April 2, 2019Assignee: Theranos IP Company, LLCInventors: Elizabeth A. Holmes, Clarissa Lui, Michael Chen, Daniel Young, Adrit Lath, Zachary Morrison, Brian Argyres, William Westrick
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Patent number: 10244973Abstract: Bodily fluid sample transport systems, devices, and method are provided. In at least one embodiment described herein, methods are provided for the physical transport of small volumes of bodily fluid in liquid form from one location to another location. By way of nonlimiting example, the samples are collected in liquid form at a collection site, transported in liquid form, and arrive at an analysis site in liquid form. In many embodiments, the liquid form during transport is not held in a porous matrix, wicking material, webbing, or similar material that prevents sample for being extracted in liquid form at the destination site. In one embodiment, small volume of sample in each sample vessel is in the range of about 1 ml to about 1 microliter.Type: GrantFiled: May 20, 2016Date of Patent: April 2, 2019Assignee: Theranos IP Company, LLCInventors: Elizabeth A. Holmes, Clarissa Lui, Michael Chen, Daniel Young