Patents Assigned to Therapeutic Proteins International, LLC
  • Publication number: 20170191015
    Abstract: The present invention relates to an apparatus comprising a single-use circular bag having a sealed edge, capable of holding a nutrient media and designed to deliver heated or cooled air/gas into the media thereby aerating and maintaining the appropriate temperature for growth of a cell culture. In addition mixing is provided by the use of acoustic radiation devices located below a support structure.
    Type: Application
    Filed: January 4, 2016
    Publication date: July 6, 2017
    Applicant: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20170101435
    Abstract: The present invention relates to an apparatus capable of harvesting a recombinant protein from a bioreactor having a porous container comprised of a chromatography medium capable of binding the recombinant protein and a method of use thereof.
    Type: Application
    Filed: October 13, 2015
    Publication date: April 13, 2017
    Applicant: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20170051243
    Abstract: A recirculating bioreactor exhaust apparatus designed to remove a gaseous element from the bioreactor exhaust, such as carbon dioxide, by freezing the gaseous element and then returning the remaining exhaust gas to the bioreactor and a method of use.
    Type: Application
    Filed: August 20, 2015
    Publication date: February 23, 2017
    Applicant: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9550971
    Abstract: Bioreactors suitable for housing a predetermined volume of culture medium comprising a plurality of containers of approximately equal internal volume in which the culture medium resides, wherein the predetermined volume of culture medium is retained in approximately equal amounts within each of the plurality of containers during operation of the bioreactor, and wherein the internal volume of each container is selected so that the amount of culture medium in each container exceeds 50 vol. % of the container internal volume during operation of the bioreactor, and related methods of use.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: January 24, 2017
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9500381
    Abstract: A septum is positioned within a disposable vessel and defines a lower chamber and an upper chamber. The septum includes a plurality of apertures that provide fluid communication between the upper chamber and lower chamber. Compressed gas is introduced in the lower chamber to produce fine bubbles rising up throughout the vessel to produce a mixing and gasification needed for the growth of a biological culture and manufacture of a biological product in a nutrient medium. Adding a binding resin to the upper chamber allows harvesting, separation and purification of biological products in the reactor as a single unit operation.
    Type: Grant
    Filed: September 3, 2011
    Date of Patent: November 22, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9499290
    Abstract: Reactors that allow mixing and gasification by converting the entire floor of the reactor vessel to a sparge filter is described.
    Type: Grant
    Filed: July 31, 2011
    Date of Patent: November 22, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9469671
    Abstract: Single-use closed bioreactors with recirculating exhaust gas that can be operated in an uncontrolled environment are reported for the manufacturing of biological products using genetically modified biological cultures that produces carbon dioxide or that requires carbon dioxide in their metabolic process.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: October 18, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9469834
    Abstract: A pair or receptacles capable of housing an emitter probe and a detector probe installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: October 18, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9469426
    Abstract: Stationary bioreactors and mixing vessels fitted with single-use flexible bags utilizing wave hydrodynamic principle are described for use in every type of biological process and products.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: October 18, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20160264930
    Abstract: A method and an apparatus for separating suspended matter from liquid includes a concentrator filter that draws the liquid out of the suspension while the filter kept unblocked by a sparging filter that allows scrubbing of the concentrator filter by gas bubbles. This invention can be used to replace cross-flow filtration and centrifugation in the bioprocess industry and to reduce the volume of suspensions to concentrate the yield of the end product in the chemical industry.
    Type: Application
    Filed: May 18, 2016
    Publication date: September 15, 2016
    Applicant: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20160200761
    Abstract: A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 14, 2016
    Applicant: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20160177248
    Abstract: Pressurized hermetically sealed bags disposed inside a cylindrical support and containing a septum with variable density of porosity and dividing the bag into two chambers are used to provide optimal mixing and gasification of nutrient media to grow a variety of biological cultures, particularly the cell cultures to produce a multitude of pharmaceutical and biotechnology products in a disposable system.
    Type: Application
    Filed: February 25, 2016
    Publication date: June 23, 2016
    Applicant: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20160166949
    Abstract: A chromatography column that captures components in a process liquid in a free flow state and allows elution in steps is described.
    Type: Application
    Filed: February 23, 2016
    Publication date: June 16, 2016
    Applicant: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9339026
    Abstract: A single-use round flexible mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element comprising a radial flow impeller driven by an internal pneumatic vane motor is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: May 17, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9321805
    Abstract: Large-scale downstream processing of secreted recombinant proteins is provided in a single device, wherein the contents of a plurality of bioreactors are combined simultaneous to their harvesting and purification resulting in significant savings of time and the cost of manufacturing.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: April 26, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20160097073
    Abstract: An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biological products in a bioreactor; the invention additionally provides means of removing undesirable metabolic products as well as provides for efficient loading of chromatography columns.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 7, 2016
    Applicant: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Publication number: 20160083685
    Abstract: A modular device comprising one or more porous substrate subunits comprising a binding substrate that is capable of interacting with a target biological product, either during, or at the end of a manufacturing cycle; and methods of using the device to harvest or purify a biological product.
    Type: Application
    Filed: September 19, 2014
    Publication date: March 24, 2016
    Applicant: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9290732
    Abstract: A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: March 22, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9284346
    Abstract: A chromatography column that captures components in a process liquid in a free flow state and allows elution in steps is described.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 15, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9284521
    Abstract: Pressurized hermetically sealed bags disposed inside a cylindrical support and containing a septum with variable density of porosity and dividing the bag into two chambers are used to provide optimal mixing and gasification of nutrient media to grow a variety of biological cultures, particularly the cell cultures to produce a multitude of pharmaceutical and biotechnology products in a disposable system.
    Type: Grant
    Filed: March 24, 2012
    Date of Patent: March 15, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi