Patents Assigned to Thermo Finnigan LLC
  • Patent number: 11658017
    Abstract: A method of analyzing a sample, the method includes separating precursor ions from the sample into narrow mass range groups based on mass-to-charge ratio; fragmenting the ions from each group to create groups of fragment ions; and mass analyzing fragment ions from each group of fragment ions using a long transient time mass analyzer, wherein the separation and fragmentation are decoupled from the mass analyzing and the cycle time of the high transient mass analyzer is greater than about five times longer than the cycle time of a narrow mass range scan time, and wherein the separation and fragmentation has a high duty cycle and the mass analyzing has a high duty cycle.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: May 23, 2023
    Assignee: Thermo Finnigan LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 11651948
    Abstract: A mass selective ion trapping device includes a linear ion trap and a RF control circuitry. The ion trap includes a plurality of trap electrodes configured for generating a quadrupolar trapping field in a trap interior and for mass selective ejection of ions from the trap interior. The RF control circuitry is configured to apply a balanced AC voltage to the trap electrodes during a first period of time such that an AC voltage applied to a first pair of trap electrodes is of the same magnitude and of opposite sign to an AC voltage applied to a second pair of trap electrodes; apply unbalanced RF voltage to the second pair of trap electrodes during a second period of time; ramp the balanced AC voltage down and the unbalanced RF voltage up during a transition period; and eject ions from the linear ion trap after the second period of time.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: May 16, 2023
    Assignee: Thermo Finnigan LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 11640005
    Abstract: An ion detector that can detect either positive or negative ions comprises: an ion inlet comprising an ion focusing lens; a dynode having a surface configured to intercept, within a zone of interception, a stream of ions passing through the ion focusing lens, wherein a plane that is tangent to the dynode surface at the zone of interception is disposed at an angle to a line that passes through the center of the dynode surface and the center of the focusing lens; a scintillator having a surface that is configured to receive secondary electrons emitted from the zone of interception; a scintillator electrode affixed to the scintillator surface; a photodetector configured to receive photons emitted by the scintillator and to generate an electric signal in response thereto; and one or more power supplies electrically coupled to the focusing lens, the dynode, the scintillator electrode and the photodetector.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: May 2, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Linfan Li, Jae C. Schwartz, Oleg Silivra
  • Publication number: 20230105334
    Abstract: A dual polarity ion detector comprises: an entrance electrode disposed to receive ions and maintained at a reference voltage, V0; a first dynode maintained at a voltage, V1, that is negative relative to V0; a second dynode maintained at a voltage, V2, that is positive relative to V0; a shielding electrode disposed between the first and second dynodes and maintained at a voltage, V3; and an ion detector comprising an entrance aperture configured to receive first secondary particles from the first dynode and second secondary particles from the second dynode, the entrance aperture maintained at a voltage, Vaperture; that is intermediate between the voltage, V1, and the voltage, V2. In some instances, the voltage, V3, may be equal to or approximately equal to the voltage, V0.
    Type: Application
    Filed: September 28, 2022
    Publication date: April 6, 2023
    Applicant: Thermo Finnigan LLC
    Inventors: Oleg Silivra, Linfan Li, Jae C. Schwartz
  • Patent number: 11610768
    Abstract: A mass spectrometer system comprises: (a) an ion source; (b) a mass filter or a time-of-flight (TOF) ion separator configured to receive a stream of first-generation ions from the ion source; (c) an ion storage device having an ion inlet configured to receive a stream of filtered ions comprising a plurality of ion species from the mass filter or TOF separator and to accumulate the plurality of ion species therein; (d) an ion mobility cell having an ion inlet configured to receive an accumulated batch of ion species from the ion storage device and an ion outlet configured to release, one at a time, the individual ion species therefrom; and (e) a mass analyzer configured to receive and mass analyze each first-generation ion species or each fragment ion species generated by fragmentation or other reaction of the various first-generation ion species.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: March 21, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, Jae C. Schwartz, Alexander A. Makarov
  • Patent number: 11600480
    Abstract: A mass spectrometry method comprises: receiving a stream of ions at an inlet end of an ion transport device; accumulating a first portion of the ion stream at a first electrical potential well at a first position within the ion transport device between the inlet and outlet ends; creating a generally descending potential profile within the ion transport apparatus between a second position and the outlet end and, simultaneously, creating a second potential well at a third position within the ion transport apparatus, the second position disposed between the first position and the inlet end, the third position disposed between the second position and the inlet end; and transporting the accumulated first portion of the ion stream from the first position to the outlet end under the impetus of the generally descending potential profile and, simultaneously, accumulating a second portion of the ion stream at the second potential well.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: March 7, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Pablo Nieto Ramos, Mikhail V. Ugarov
  • Publication number: 20230062288
    Abstract: A method of performing mass spectrometry includes accumulating, over an accumulation time, ions produced from components eluting from a chromatography column and transferring the accumulated ions to a mass analyzer. During an acquisition, a mass spectrum of detected ions derived from the transferred ions is acquired. An elution profile is obtained from a series of acquired mass spectra including the acquired mass spectrum and a plurality of previously-acquired mass spectra. The elution profile includes a plurality of detection points representing intensity of the detected ions as a function of time. A current signal state of the elution profile is classified based on a subset of detection points included in the plurality of detection points. The accumulation time for a next acquisition of a mass spectrum is set based on the classified current signal state of the elution profile.
    Type: Application
    Filed: August 27, 2021
    Publication date: March 2, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventors: Philip M. REMES, Jesse D. CANTERBURY
  • Patent number: 11594404
    Abstract: A method of performing mass spectrometry includes accumulating, over an accumulation time, ions produced from components eluting from a chromatography column and transferring the accumulated ions to a mass analyzer. During an acquisition, a mass spectrum of detected ions derived from the transferred ions is acquired. An elution profile is obtained from a series of acquired mass spectra including the acquired mass spectrum and a plurality of previously-acquired mass spectra. The elution profile includes a plurality of detection points representing intensity of the detected ions as a function of time. A current signal state of the elution profile is classified based on a subset of detection points included in the plurality of detection points. The accumulation time for a next acquisition of a mass spectrum is set based on the classified current signal state of the elution profile.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: February 28, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, Jesse D. Canterbury
  • Patent number: 11587774
    Abstract: A method includes obtaining a first mass spectrum; selecting a first peak of the first mass spectrum; fragmenting and analyzing ions of the first peak to obtain a second mass spectrum; performing a real-time spectral search for compounds corresponding to peaks in the second mass spectrum; identifying fragments for the compounds identified based on the real-time spectral search; adding mass-to-charge ratios for the fragments to an exclusion list; selecting a second peak present in the first mass spectrum and not on the exclusion list; and fragmenting and analyzing ions of the second peak to obtain a third mass spectrum.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: February 21, 2023
    Assignee: Thermo Finnigan LLC
    Inventor: Graeme C. McAlister
  • Patent number: 11581179
    Abstract: A method of reducing fragmentation of ions generated from a sample during transport of the ions through an ion transport apparatus that comprises an ion funnel portion, comprises: applying a selected DC potential difference between an outlet end of the ion transport apparatus and an exit ion lens that is disposed adjacent to the outlet end, wherein a sign of the selected DC potential difference is chosen so as to accelerate the ions from the outlet end of the ion transport apparatus towards and through the exit ion lens.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: February 14, 2023
    Assignees: Thermo Finnigan LLC, Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Joshua A. Silveira, Eloy R. Wouters, Alexander A. Makarov, Mikhail G. Skoblin, Viacheslav I. Kozlovskiy, Christopher Mullen, Brian D. Adamson
  • Patent number: 11581180
    Abstract: A mass spectrometry method comprises: storing a first packet of ions within an ion storage apparatus; transferring the first ion packet into an electrostatic trap mass analyzer through a set of electrostatic lenses, wherein, during the transfer, either the lenses are operated in a first mode of operation or an injection voltage of a first pre-determined magnitude is applied to an electrode of the mass analyzer; mass analyzing the first ion packet using the mass analyzer; storing a second packet of ions within the ion storage apparatus; transferring the second ion packet into the mass analyzer through the set of lenses, wherein, during the transfer, either the lenses are operated in a second mode of operation or an injection voltage of a second pre-determined magnitude is applied to the electrode of the mass analyzer; and mass analyzing the second packet of ions using the electrostatic trap mass analyzer.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: February 14, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Jesse D. Canterbury, Michael W. Senko
  • Publication number: 20230029511
    Abstract: A compression fitting includes a nut with a threaded end for receiving a threaded tube and a receiving end for holding a plunger head; and a plunger with an inner bore for receiving a capillary tube and the plunger head for engaging a ferrule positioned within the receiving end between the plunger head and the threaded tube, the plunger slidingly engaged with the nut to force the ferrule from the nut.
    Type: Application
    Filed: July 27, 2021
    Publication date: February 2, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventors: George B. GUCKENBERGER, Adam D. BRYANT
  • Patent number: 11562893
    Abstract: A method for cleaning a first electrospray emitter of a mass spectrometer comprises: changing an operating mode of the first electrospray emitter from a stable jet mode of operation to a dripping or pulsating mode of operation by lowering a magnitude of a voltage applied between a counter electrode and the first electrospray emitter, |V1|; moving the first electrospray emitter from a first emitter position from which electrospray ions are delivered to a mass spectrometer inlet to a second emitter position and, simultaneously, moving a second electrospray emitter from a third emitter position to a fourth emitter position; causing a cleaning solvent to flow through the first electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the first electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and causing the droplet to dislodge from the emitter exterior.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: January 24, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua A. Silveira, Michael L. Poltash, Wei Wei, Eloy R. Wouters
  • Publication number: 20220415641
    Abstract: A mass spectrometry method comprises: storing a first packet of ions within an ion storage apparatus; transferring the first ion packet into an electrostatic trap mass analyzer through a set of electrostatic lenses, wherein, during the transfer, either the lenses are operated in a first mode of operation or an injection voltage of a first pre-determined magnitude is applied to an electrode of the mass analyzer; mass analyzing the first ion packet using the mass analyzer; storing a second packet of ions within the ion storage apparatus; transferring the second ion packet into the mass analyzer through the set of lenses, wherein, during the transfer, either the lenses are operated in a second mode of operation or an injection voltage of a second pre-determined magnitude is applied to the electrode of the mass analyzer; and mass analyzing the second packet of ions using the electrostatic trap mass analyzer.
    Type: Application
    Filed: June 23, 2021
    Publication date: December 29, 2022
    Applicant: THERMO FINNIGAN LLC
    Inventors: Jesse D. CANTERBURY, Michael W. SENKO
  • Patent number: 11538675
    Abstract: The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: December 27, 2022
    Assignees: University of Virginia Patent Foundation, Thermo Finnigan LLC
    Inventors: Donald F. Hunt, Ann M. English, Scott A. Ugrin, Dina L. Bai, Jeffrey Shabanowitz, John Edward Philip Syka
  • Publication number: 20220397560
    Abstract: A method for scientific instrument support includes obtaining a chromatographic data. The method includes one of (a) calculating an intensity score for the chromatographic data and identifying an injection miss when the intensity score is below a score threshold or (b) applying a machine learning model to classify the chromatographic data. The method further includes notifying a user of an injection miss or injection error.
    Type: Application
    Filed: June 10, 2021
    Publication date: December 15, 2022
    Applicant: THERMO FINNIGAN LLC
    Inventor: Xin ZHENG
  • Patent number: 11525772
    Abstract: A method comprises: aspirating a sample through a needle capillary into a chamber having first and second windows, the capillary and chamber both affixed to a moveable robotic arm; causing a light beam generated by a light source that is affixed to the robotic arm to pass through the sample between the windows; detecting, using a photodetector that is affixed to the robotic arm, a quantity of the light that passes through the sample and the windows; determining an optical absorbance of the sample and a concentration of an analyte in the sample from the detected quantity of light; determining a quantity of the sample to dispense into an analytical apparatus based on the determined concentration; moving the robotic arm so as to cause the needle capillary to mate with an inlet port of an analytical apparatus; and dispensing the determined quantity of the sample into the analytical apparatus.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: December 13, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Greg A. Foster, Daniel Lopez Ferrer
  • Patent number: 11501962
    Abstract: A mass spectrometer collision cell system, comprising: a gas containment vessel comprising an internal chamber having ion inlet and ion outlet ends and a cross-sectional area, Achamber; a gas inlet aperture; first and second gas outlet apertures that are disposed at or proximal to the ion inlet and outlet ends, respectively, and that have respective outlet aperture cross-sectional areas, Aaperture1 and Aaperture2, and an average outlet aperture cross-sectional area, Aapertureave; a longitudinal axis of the chamber extending from the ion inlet end to the ion outlet end and having a length, Lchamber; and a set of multipole rod electrodes, at least a portion of each multipole rod electrode being within the chamber, wherein the values of Achamber, Lchamber and Aapertureave are such that the combined gas conductance of the chamber and the gas outlet apertures is not greater than 95 percent of the gas conductance of the gas outlet apertures alone.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: November 15, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Scott T. Quarmby, Joshua T. Maze
  • Patent number: 11495323
    Abstract: Techniques for determining a microbial classification based on a mass spectrum are disclosed. A mass spectrometer generates a mass spectrum for a biological sample. A binning function is applied to the mass spectrum to generate a binned mass spectrum. As an example, a binned mass spectrum is associated with a set of bins having mass errors of the same value. A classification algorithm is applied to the binned mass spectrum to determine a microbial classification.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: November 8, 2022
    Assignee: Thermo Finnigan LLC
    Inventor: Michael J. Athanas
  • Patent number: 11493487
    Abstract: A method for determining a quantity of an analyte in a liquid sample, comprises: adding a known quantity of an internal standard comprising an isotopically labeled version of the analyte to the sample; (b) providing a continuous stream of the sample having the internal standard to an inlet of a Liquid Chromatography Mass Spectrometry (LCMS) system; and repeatedly performing the steps of: performing a data-independent analysis of the precursor ion species using a mass analyzer, whereby mass spectra of a plurality of fragment-ion species are acquired; calculating one or more degree-of-matching scores that relate to either a number of ions of the internal standard that overlap between results of the data-independent analysis and tabulated mass spectral data of the internal standard; and performing quantitative tandem mass spectrometric analyses of the internal standard and the analyte if each of the degree-of-matching scores meets a respective degree-of-matching condition.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: November 8, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, David A. Sarracino, Sebastien F. Gallien