Patents Assigned to Thermo Finnigan LLC
  • Patent number: 11232936
    Abstract: A targeted quantitation system for mass spectrometry may acquire, while operating in a watch mode, a watch mode mass spectrum including mass peaks for ions produced from a plurality of internal standard variants added to a sample comprising a target analyte. Each internal standard variant included in the plurality of internal standard variants includes a unique isotopologue of the target analyte and is added to the sample in a unique amount. The targeted quantitation system may generate a calibration curve based on the watch mode mass spectrum. The targeted quantitation system may acquire, while operating in a quantitation mode, a quantitation mode mass spectrum including mass peaks for ions produced from the target analyte included in the sample. The targeted quantitation system may determine a concentration of the target analyte included in the sample based on the calibration curve and the second mass spectrum.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: January 25, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Aaron Gajadhar, Sebastien F. Gallien
  • Patent number: 11222778
    Abstract: An electrospray ion source for a mass spectrometer comprises: (i) a plurality of N electrospray emitters within an ionization compartment, wherein N?2; (ii) a mixing chamber; (iii) a plurality of N inlets, each inlet comprising a conduit configured to receive charged particles from a respective one of the electrospray emitters and to emit the charged particles into the mixing chamber; (iv) an outlet port either facing or within an intermediate-vacuum compartment; and (v) a heater in thermal contact with at least a portion of the mixing chamber.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: January 11, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Viatcheslav V. Kovtoun, Eloy R. Wouters
  • Patent number: 11211236
    Abstract: Real-time search (RTS) for mass spectrometry is described. In one aspect, a mass spectrometer can identify a candidate peptide for a product ion spectrum by searching a mass spectral database. While executing the search of the mass spectral database, a candidate peptide score representing a confidence of a match between the product ion spectrum and a theoretical mass spectrum stored in the mass spectral database is generated. A failing score can be promoted to a passing result based on attributes of the candidate peptide.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: December 28, 2021
    Assignee: Thermo Finnigan LLC
    Inventor: Derek J. Bailey
  • Patent number: 11201044
    Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: December 14, 2021
    Assignee: Thermo Finnigan LLC
    Inventors: Harald Oser, Raman Mathur
  • Publication number: 20210384026
    Abstract: A space-time buffer includes a plurality of discrete trapping regions and a controller. The plurality of discrete trapping regions is configured to trap ions as individual trapping regions or as combinations of trapping regions. The controller is configured to combine at least a portion of the plurality of trapping regions into a larger trap region; fill the larger trap region with a plurality of ions; split the larger trap region into individual trapping regions each containing a portion of the plurality of ions; and eject ions from the trapping regions.
    Type: Application
    Filed: August 19, 2021
    Publication date: December 9, 2021
    Applicant: THERMO FINNIGAN LLC
    Inventors: Philip M. REMES, Michael W. SENKO
  • Publication number: 20210343516
    Abstract: A method for cleaning a first electrospray emitter of a mass spectrometer comprises: changing an operating mode of the first electrospray emitter from a stable jet mode of operation to a dripping or pulsating mode of operation by lowering a magnitude of a voltage applied between a counter electrode and the first electrospray emitter, |V1|; moving the first electrospray emitter from a first emitter position from which electrospray ions are delivered to a mass spectrometer inlet to a second emitter position and, simultaneously, moving a second electrospray emitter from a third emitter position to a fourth emitter position; causing a cleaning solvent to flow through the first electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the first electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and causing the droplet to dislodge from the emitter exterior.
    Type: Application
    Filed: July 9, 2021
    Publication date: November 4, 2021
    Applicant: Thermo Finnigan LLC
    Inventors: Joshua A. SILVEIRA, Michael L. POLTASH, Wei WEI, Eloy R. WOUTERS
  • Patent number: 11145502
    Abstract: An ion source assembly is described that includes an electron source configured to inject electrons into an ion volume to ionize an atom or molecule in the ion volume, wherein the electron source includes a filament. A lens electrode is positioned adjacent the electron source and includes an opening configured to pass electrons therethrough from the electron source into the ion volume. A supply voltage source is coupled to the filament and configured to supply a first voltage to the filament, wherein the first voltage is operable to ionize the molecules in the ion volume. Further, a bias voltage source is coupled to the supply voltage source and configured to supply a bias voltage to the lens electrode. Electrons striking the lens electrode are thereafter returned to the filament.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 12, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventors: Lawrence G. Baldwin, Johnathan Wayne Smith, Edward B. McCauley
  • Publication number: 20210310935
    Abstract: A method comprises: aspirating a sample through a needle capillary into a chamber having first and second windows, the capillary and chamber both affixed to a moveable robotic arm; causing a light beam generated by a light source that is affixed to the robotic arm to pass through the sample between the windows; detecting, using a photodetector that is affixed to the robotic arm, a quantity of the light that passes through the sample and the windows; determining an optical absorbance of the sample and a concentration of an analyte in the sample from the detected quantity of light; determining a quantity of the sample to dispense into an analytical apparatus based on the determined concentration; moving the robotic arm so as to cause the needle capillary to mate with an inlet port of an analytical apparatus; and dispensing the determined quantity of the sample into the analytical apparatus.
    Type: Application
    Filed: June 21, 2021
    Publication date: October 7, 2021
    Applicant: THERMO FINNIGAN LLC
    Inventors: Greg A. FOSTER, Daniel LOPEZ FERRER
  • Patent number: 11133160
    Abstract: Systems, methods, and devices to dissociate ions using one or more light emitting diodes (LEDs). A mass spectrometer for ion dissociation includes an ion source for providing ions for dissociation, a mass analyzer, and a photodissociation (PD) device. The PD device includes an ion transport device. The ion transport device is configured perform one or more of: transporting the ions through the PD device, and trapping the ions within a region of the PD device. The PD device also includes one or more LEDs positioned to irradiate the ions in the PD device, resulting in fragmentation of the ions.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: September 28, 2021
    Assignees: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM, THERMO FISHER SCIENTIFIC (BREMEN) GMBH, THERMO FINNIGAN LLC
    Inventors: Dustin D. Holden, Jens Griep-Raming, Alexander A. Makarov, Jennifer S. Brodbelt, Yevgeniy Zhuk, Jae C. Schwartz
  • Patent number: 11125738
    Abstract: A system includes an optical measurement unit that measures an optical property of a whole blood sample deposited on a surface of a substrate, an ion source that causes ions derived from the whole blood sample, including ions formed from an analyte of interest present in the whole blood sample, to be emitted from the substrate, a mass analyzer that receives the ions emitted from the substrate and measures an abundance of at least one ion species corresponding to the analyte of interest, and at least one computing device that determines, based on the measured optical property, a hematocrit of the whole blood sample, and determines, based on the determined hematocrit of the whole blood sample and the measured abundance of the at least one ion species, a concentration of the analyte of interest per unit volume of blood plasma.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: September 21, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventors: John Glazier, Jae C. Schwartz, Berg A. Tehlirian
  • Publication number: 20210285913
    Abstract: An ion mobility separation apparatus comprises: a compartment having a gas therein; an electrode structure comprising a first plurality of electrodes within the compartment, the electrode structure defining a longitudinal axis; one or more power supplies electrically coupled to the electrodes, wherein the plurality of electrodes and the power supply are configured to maintain an electrical pseudopotential well encompassing and disposed parallel to the longitudinal axis and to maintain an electric field directed parallel to the longitudinal axis; an entrance ion gate disposed at a first end of the longitudinal axis; an exit ion gate disposed at a second end of the longitudinal axis; and at least one additional ion gate disposed between the entrance and exit ion gates.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 16, 2021
    Applicant: THERMO FINNIGAN LLC
    Inventors: Michael L. POLTASH, Joshua A. SILVEIRA
  • Patent number: 11119070
    Abstract: A system for analyzing a sample includes a source; a mobility separator configured to separate ions based on a mobility in a gas; a plurality of ion channels; and a mass analyzer. The mobility separator includes a two-dimensional grid of electrodes spanning a passage between first and second walls. The first and second walls include an inlet aperture and a plurality of exit apertures, respectively. The two-dimensional grid of electrodes configured to generate an electric field within the passage. The plurality of ion channels arranged adjacent to the plurality of exit apertures. Movement of ions between the inlet aperture and the plurality of exit apertures are governed by the electric field and a gas flow through the passage between to the first and second walls such that the ions are sorted and directed to different channels based on their respective mobility.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: September 14, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventor: Mikhail V. Ugarov
  • Patent number: 11114290
    Abstract: An ion transport system comprises: (I) an ion transfer tube extending between an atmospheric-pressure ionization chamber and a partially evacuated chamber; and (II) an ion funnel within the chamber comprising: (1) an exit electrode that has an exit aperture configured to deliver the gas and charged particles to a high-vacuum chamber; and (2) a funnel portion comprising a plurality of plate electrodes configured as a stack, each electrode comprising a respective aperture, wherein an aperture diameter of each of the plurality of electrodes is greater than or equal to three times an inter-electrode pitch and wherein no DC electrical potential gradient is applied between the exit electrode and an adjacent one of the plurality of plate electrodes.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: September 7, 2021
    Assignees: THERMO FINNIGAN LLC, Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Joshua A. Silveira, Eloy R. Wouters, Alexander A. Makarov, Mikhail G. Skoblin, Viacheslav I. Kozlovskiy
  • Patent number: 11114293
    Abstract: A space-time buffer includes a plurality of discrete trapping regions and a controller. The plurality of discrete trapping regions is configured to trap ions as individual trapping regions or as combinations of trapping regions. The controller is configured to combine at least a portion of the plurality of trapping regions into a larger trap region; fill the larger trap region with a plurality of ions; split the larger trap region into individual trapping regions each containing a portion of the plurality of ions; and eject ions from the trapping regions.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: September 7, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventors: Philip M. Remes, Michael W. Senko
  • Patent number: 11099153
    Abstract: An ion mobility device includes a plurality of electrodes and a current source. The plurality of electrodes arranged along an axis extending from a first end to a second end. The plurality of electrodes configured to receive a gas flow at the second end and provide for an expansion of the gas flow from the second end to the first end such that a first gas velocity at the second end is greater than a second gas velocity at the first end. The current source is configured to apply a first potential to the plurality of electrodes to generate a first electric field during a trapping and equilibration time period; and apply a second potential to the electrodes during an ejection time period to generate a second electric field, the second electric field being greater than the first electric field.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: August 24, 2021
    Assignee: Thermo Finnigan LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 11087968
    Abstract: A traveling wave multipole comprising two or more pairs of segmented electrodes arranged around a central axis; and a voltage supply. The voltage supply configured to supply the segments of each pair of electrodes with a different RF and DC potential; and match RF and DC potentials with a location of an ion of target m/z moving through the traveling wave multipole such that as the ion travels along the multipole the ion experiences the same RF and DC potentials while another ion of a second target m/z concurrently experiences a different RF and DC potentials at another location within the traveling wave multipole.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 10, 2021
    Assignee: THERMO FINNIGAN LLC.
    Inventors: David A. Schell, Joshua T. Maze
  • Patent number: 11085856
    Abstract: A method for preparing a protein-containing sample for analysis by mass spectrometry includes introducing the sample into a reaction vessel. The reaction vessel contains a reagent mixture including pre-measured quantities of an immobilized proteolytic enzyme, a reducing agent and an alkylating agent. The contents of the reaction vessel are activated by heating or by sonication.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: August 10, 2021
    Assignee: Thermo Finnigan LLC
    Inventors: Daniel Lopez Ferrer, Aaron M. Robitaille, Michael O. Krawitzky, Greg A. Foster
  • Patent number: 11087964
    Abstract: A method for cleaning an electrospray emitter of a mass spectrometer, comprises: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude of a voltage applied between an counter electrode and the electrospray emitter; (b) causing a cleaning solvent to flow through the electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and (c) causing the droplet to dislodge from the electrospray emitter exterior.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: August 10, 2021
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua A. Silveira, Michael L. Poltash, Wei Wei, Eloy R. Wouters
  • Patent number: 11069519
    Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes a quadrupole mass analyzer and a resonant circuit to generate a radio frequency (RF) signal applied to rods of the quadrupole mass analyzer. An amplitude control circuit can be inductively coupled with inductors of the resonant circuit to selectively discharge energy from the resonant circuit and, therefore, adjust the amplitude of the signal in particular situations.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: July 20, 2021
    Assignee: Thermo Finnigan LLC
    Inventor: Johnathan Wayne Smith
  • Patent number: 11069518
    Abstract: A mass spectrometer includes a vacuum manifold having an interior space, a vacuum pump configured to maintain the interior space at a pressure below 5×10-5 torr, a heated component, such as an ion source, located within the interior space, and a multilayer insulator located within the interior space. The multilayer insulator including an inner layer with a first surface oriented towards the heated component and a second surface oriented away from the heated component; and an outer layer with a third surface oriented towards away from the heated component and a fourth surface oriented towards the heated component.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: July 20, 2021
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley