Abstract: The disclosure is directed to compositions and methods of treating or preventing headaches, including migraines. The compositions comprise a nitrate anion source, an elemental metal (uncharged), and an acid. The compositions are preferably administered orally. In some aspects, the product of a reaction of the nitrate anion source, the elemental metal (uncharged), and the acid are administered to the subject via inhalation.

Abstract: The disclosure is directed to methods related to creatinine, for example, a method for its safe administration to a human, a method for using creatinine to improve the bioavailability of creatine, and a metn.

Abstract: Salts of hexylamine, for example, hexylamine succinate and tri-hexylamine citrate and their method of production are described. The disclosure also relates to compositions comprising hexyalmine, for example, for reducing appetite in a human subject, treating obesity in a human subject, preventing obesity in a human subject, preventing weight gain in a human subject, increasing fat loss in a human subject, treating an overweight human subject, increasing athletic performance in a human subject, increasing endurance in a human subject, increasing muscle strength in a human subject, improving cognitive function in a human subject, treating ADHD in a human subject, increasing sweating in a human subject, reducing reaction time of a human subject, increasing psychomotor vigilance of a human subject, enhancing memory in a human subject, increasing central nervous system activity in a human subject, and enhancing alertness, attention, concentration, and/or memory in a human subject.

Abstract: Method for preventing paresthesia in a human is disclosed. The method includes administering to the human an effective amount of N-Acetyl Beta Alanine or an N-Acetyl Beta Alanine composition.

Abstract: Disclosed herein are methods for creatine supplementation for human subjects, particularly creatine non-responders.

Abstract: Improved methods of causing vasodilation in a human subject are disclosed. In one implementation, the human subject is administered a dose of a nitrate salt of arginine, norvaline, or ornithine, wherein the dose of the nitrate salt of the amino acid in moles of the amino acid is less than a molar amount of the amino acid needed to cause vasodilation in the human subject. In another implementation, the human subject is administered a composition comprising a dose of a nitrate salt and an amount of an amino acid, wherein the dose of the nitrate salt in the composition in moles of the nitrate salt is less than a molar amount of the nitrate salt that needs be administered alone in order to induce vasodilation in the human subject. The amino acid in the composition is selected from the group consisting of: arginine, citrulline, creatine, glutamine, leucine, norvaline, and ornithine.

Abstract: Methods of improving athletic performance in a human, increasing the bioabsorption of the compound in a human, or of increasing the vasodilative characteristics in a human comprise administering to the human compositions and supplement formulations comprising a compound selected from the group consisting of Carnitine, Taurine, and derivative forms thereof; and a Nitrate are disclosed.

Abstract: The present invention provides methods of producing decolorized beet products and compositions produced therefrom. In some implementations, the decolorized beet product is decolorized beetroot juice.

Abstract: The disclosure is directed to methods related to creatinine, for example, a method for its safe administration to a human, a method for using creatinine to improve the bioavailability of creatine, and a metn.

Abstract: Methods of producing an amino acid nitrate supplement drink suitable for human consumption are provided. The methods comprise providing a solid nitrate salt of an amino acid and adding an amount of water to the solid nitrate salt of the amino acid to produce the amino acid and nitrate drink, wherein the amount of water is sufficient to dissolve the solid nitrate salt of the amino acid. In particular implementations, the solid nitrate salt of an amino acid is selected from the group consisting of: creatine nitrate, arginine nitrate, leucine nitrate, isoleucine nitrate, valine nitrate, cysteine nitrate, glycine nitrate, agmatine nitrate, beta-alanine nitrate, N-acetyl cysteine nitrate, aspartic acid nitrate, lysine nitrate, histidine nitrate, norvaline nitrate, ornithine nitrate, glutamine nitrate, citrulline nitrate, and betaine nitrate.

Abstract: The present disclosure relates to methods of enriching beetroot products to increase the nitrate content of the beetroot powder product. The disclosure also relates to beetroot powder products with increased with at least 4% nitrate.

Abstract: Compositions comprising the nitrate of arginine are disclosed. In some aspects, the nitrate of arginine is a salt of a nitric acid (NO3?) or a mixed salt of a nitric acid (NO3?). The compositions further comprise one or more additional components selected from the group consisting of a carrier, an excipient, a binder, a colorant, a flavoring agent, a preservative, a buffer, and a dilutant. In one aspects, the composition is in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a powder, a granule, a pellet, a bead, a particle, a troche, and a lozenge. In other aspects, the composition is for human ingestion. In some embodiments, the composition, for example the composition for human ingestion, is a human dietary supplement.

Abstract: A method for improving athletic or physical performance in a human includes administering to the human a composition or supplement formulation including a single administration of inorganic nitrate (NO3?), a single administration of inorganic nitrite (NO2?), or a combination thereof; and an additive. A method for increasing endurance in a human includes administering to the human a composition or supplement formulation including a single administration of inorganic nitrate (NO3?), a single administration of inorganic nitrite (NO2?), or a combination thereof; and an additive.

Abstract: A composition and a supplement formulation includes: at least one constituent selected from the group consisting of a vegetable nitrate source; and at least one constituent amino acid selected from the group consisting of Arginine, Agmatine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, Ornithine, Valine, Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine.

Abstract: The disclosure is directed to methods related to creatinine, for example, a method for its safe administration to a human, a method for using creatinine to improve the bioavailability of creatine, and a metn.

Abstract: The present disclosure relates to methods of enriching root powder products, for example beetroot powder. In particular, the methods relates to increasing the nitrate content and/or reducing the sugar content of the root powder product. The disclosure also relates to root powder products with increased with at least 3% nitrate.

Abstract: The present invention provides methods of producing decolorized beet products and compositions produced therefrom. In some implementations, the decolorized beet product is decolorized beetroot juice.

Abstract: A method of making a composition or a dietary supplement is provided, the method comprising combining a quantity of a Nitrate with a quantity of an Amino Acid Compound, wherein the combining of the Nitrate with the Amino Acid Compound reduces a side effect or toxicity of the Nitrate. Also provided is a method of safely administering to a subject a Nitrate with a reduced side effect or toxicity, the method comprising: combining a quantity of the Nitrate with a quantity of an Amino Acid Compound in a composition or a dietary supplement, wherein the combining of the Nitrate with the Amino Acid Compound reduces the side effect or toxicity of the Nitrate; and safely administering to the subject the composition or dietary supplement comprising the Nitrate with the reduced side effect or toxicity.

Abstract: A composition and a supplement formulation includes: at least one constituent selected from the group consisting of a nitrate salt; and at least one constituent amino acid selected from the group consisting of Arginine, Agmatine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, Ornithine, Valine, Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine.

Abstract: A composition comprising a Nitrate or a Nitrite of an Amino Acid Compound selected from the group consisting of Arginine, Agmatine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, Ornithine, Valine, Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine is provided. The composition may be in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a powder, a granule, a pellet, a bead, a particle, a troche, a lozenge, a gel, a liquid, a suspension, a solution, an elixir, and a syrup.