Patents Assigned to Tokyo Women's Medical University
  • Publication number: 20190120742
    Abstract: A device for measuring a tension of a sheet-like tissue containing cardiomyocytes includes a first gel adapter holder having a frame member and a first gel holding member protruding toward a part of an inside face of the frame member for fixing one end of a film-like gel; and a second gel adapter holder having a second gel holding member for fixing the other end of the gel and a connection member connected to the second gel holding member. A kit includes the tension measuring device; a substrate having a pair of gel molding protruding members fitted along the inside face of the frame member; and a gel forming lid body having a face parallel to a gel contact face of the substrate so as to form an upper face of the gel. Further, a system for measuring the tension includes the tension measuring device.
    Type: Application
    Filed: October 24, 2018
    Publication date: April 25, 2019
    Applicants: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Hirotsugu KUBO, Takahiro SHIOYAMA, Yuki KAGAWA, Tatsuya SHIMIZU, Daisuke SASAKI
  • Patent number: 10251916
    Abstract: An object of the present invention is to provide a cell composition for treatment of uterine tissue that heals damage occurring in uterine tissue, including intrauterine adhesion, to a state that enables pregnancy. In addition, an object of the present invention is to provide a method for producing this cell composition for treatment of uterine tissue, and a cell composition for treatment of uterine tissue produced according to that method. The cell composition, which has a first cell layer containing epithelial cells and a second cell layer containing stromal cells, and the first cell layer is laminated on the second cell layer, has the ability to heal damage occurring in uterine tissue, including intrauterine adhesion, and restore it to a state that enables pregnancy.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: April 9, 2019
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Goro Kuramoto, Soichi Takagi, Tatsuya Shimizu, Teruo Okano
  • Publication number: 20190054123
    Abstract: The present invention addresses the problem of providing a cell sheet composition for healing or preventing discharge from a wounded region of a luminal organ. The present invention also addresses the problem of providing a method in which the cell sheet composition is affixed to a wounded region of a luminal organ to heal or prevent discharge from the wounded region of the luminal organ. The present invention provides a cell sheet composition including mesenchymal stem cells which is characterized by being affixed to a wounded region of a luminal organ in order to heal or prevent discharge from the wounded region of the luminal organ. The present invention also provides a method in which the cell sheet composition including mesenchymal stem cells is affixed to a wounded region of a luminal organ to heal or prevent discharge from the wounded region of the luminal organ.
    Type: Application
    Filed: January 17, 2017
    Publication date: February 21, 2019
    Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Nobuo Kanai, Yasuhiro Maruya, Kurodo Koshino, Masanori Maeda, Teruo Okano
  • Patent number: 10094816
    Abstract: Provided is a means for evaluating the wetting characteristic of an object such as a cell sheet and a culture dish in a non-contact fashion. The wetting characteristic of an object is evaluated by a method comprising the steps of: (1) removing a liquid by jetting a gas at a surface of the object covered with the liquid, (2) measuring a dimension of a region in which the liquid is removed after the completion of the gas jetting and (3) evaluating the wetting characteristic of the object using the measured dimension as an index.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: October 9, 2018
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Nobuyuki Tanaka, Ryohei Uchida, Makoto Kondo, Masayuki Yamato, Teruo Okano, Makoto Kaneko
  • Patent number: 10064684
    Abstract: In an operation-mode indicating system, a first light emitting device is located within a peripheral visual field of an operator and is controllably connected to a controller. The peripheral visual field is defined around a center visual field of the operator while the operator is looking at a predetermined site. A body support apparatus is capable of performing an operation to the predetermined site. The controller controls the first light emitting device to emit first light in a first operation mode of the body support apparatus and second light in a second operation mode of the body support apparatus. The first light and the second light are visually distinguishable from each other.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: September 4, 2018
    Assignees: DENSO CORPORATION, SHINSHU UNIVERSITY, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Satoru Nakamura, Minoru Takahashi, Kazuhiro Hongo, Tetsuya Goto, Yosuke Hara, Jun Okamoto
  • Publication number: 20180245047
    Abstract: The present invention pertains to a method for culturing a cell population including pluripotent stem cells and differentiated cells derived from pluripotent stem cells at a temperature of 40.5° C. or higher and reducing the pluripotent stem cells included in the cell population. The present invention also pertains to a method for reducing pluripotent stem cells from a cell population including pluripotent stem cells and differentiated cells derived from pluripotent stem cells, wherein the method includes a step for activating the TRPV-1 expressed in the pluripotent stem cells included in the cell population. The present invention makes it possible to reduce the pluripotent stem cells remaining in an undifferentiated state when inducing the differentiation of a pluripotent stem cell population.
    Type: Application
    Filed: August 23, 2016
    Publication date: August 30, 2018
    Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Katsuhisa Matsuura, Tatsuya Shimizu, Hiroyoshi Seta
  • Publication number: 20180155673
    Abstract: An object of the present invention is to obtain a thicker animal cell composition by a simple and less expensive method. Namely, an object of the present invention is to provide a method for culturing a thicker animal cell composition by eliminating the hypoxia associated with animal cell compositions, a method for producing an animal cell composition containing unicellular algae, and an animal cell composition. The present invention provides a method for culturing an animal cell composition in a culture medium in the presence of unicellular algae and under exposure to light. According to the method of the present invention, oxygen can be continuously supplied in the culture medium, cell damage is alleviated, and a thicker cell composition can be obtained in the absence of a capillary network.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 7, 2018
    Applicant: Tokyo Women's Medical University
    Inventors: Tatsuya Shimizu, Yuji Haraguchi, Yuki Kagawa, Katsuhisa Sakaguchi
  • Publication number: 20180149597
    Abstract: Provided is a determination device including a determining section that determines a state of a cell, using information relating to uniformity of a detection target generated based on an optical intensity of radiation light from the detection target included in a biological cell irradiated with excitation light. In the determination device, the detection target may be proteins. The determination device may include an information generating section that generated information, and the information generating section may generate information that excludes information corresponding to a non-resonant background signal.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 31, 2018
    Applicants: NIKON CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Tadashi Umezaki, Naoki Fukutake, Shunji Watanabe, Yusuke Taki, Yuji Haraguchi, Tatsuya Shimizu
  • Patent number: 9950094
    Abstract: Provided are layered cell sheets, comprising a plurality of layered cell sheets containing myoblasts, in which each cell sheet comprises cell population containing myoblasts with controlled orientations. Preferably provided are the layered cell sheets comprising a region in which the orientations of the cell population containing the myoblasts in each cell sheet are identical to each other.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 24, 2018
    Assignee: Tokyo Women's Medical University
    Inventors: Hironobu Takahashi, Tatsuya Shimizu, Teruo Okano
  • Patent number: 9919139
    Abstract: With the present invention the sheet shaped therapeutic substance can be accurately and easily affixed to the inside of the human body. As shown in FIG. 6A, the sheet shaped substance can be mounted on the head with wrinkles being formed. When this takes place, the sheet shaped substance is held in contact with the outer periphery of the head. Then, by making the pressure of the fluid inside the vent apertures positive, the sheet shaped substance can be blown off. The surface of the head is closely parallel to an inner surface of the esophagus wall for the sheet shaped substance to be affixed. Therefore, this particularly makes it possible to perform such applying step (FIG. 6B) in a more reliable fashion.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: March 20, 2018
    Assignee: Tokyo Women's Medical University
    Inventors: Nobuyuki Tanaka, Nobuo Kanai, Masayuki Yamato, Teruo Okano
  • Patent number: 9810371
    Abstract: In an arm support apparatus, an weight attachment is provided for at least one specified link in links of a support member supporting a mount to be movable based on rotation of at least one of the links around a corresponding at least one of the joints. The at least one specified link is associated with at least one specified degree of freedom. The weight attachment is configured such that one or more weight members are attachable thereto. When the one or more weight members are attached to the weight attachment, the weight attachment is configured to substantially balance in weight with the mount on which the part of the arm is mounted while applying supporting force to the part of the arm mounted on the mount.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: November 7, 2017
    Assignees: DENSO CORPORATION, SHINSHU UNIVERSITY, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Satoru Nakamura, Kazuhiro Hongo, Tetsuya Goto, Yosuke Hara, Jun Okamoto
  • Patent number: 9783773
    Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: October 10, 2017
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda
  • Patent number: 9758766
    Abstract: The present invention provides an artificial kidney precursor containing a non-human mammalian metanephros separated out from a living body, wherein the metanephros has been subjected to freezing and thawing treatments outside a living body, and contains mammalian mesenchymal stem cells transferred outside a living body, and a method of production thereof.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: September 12, 2017
    Assignees: OTSUKA PHARMACEUTICAL FACTORY, INC., JICHI MEDICAL UNIVERSITY, THE JIKEI UNIVERSITY, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Eiji Kobayashi, Takashi Yokoo, Koutaro Kai
  • Publication number: 20170216362
    Abstract: The present invention provides a method of inhibiting progression of or preventing renal disorder, the method comprising applying a cell sheet composition for inhibiting progression of or preventing renal disorder to at least one part of the surface of a kidney, wherein the part of the surface is uncovered by a fibrous capsule of the kidney. The present invention also provides a cell sheet composition for inhibiting progression of or preventing renal disorder, the cell sheet composition comprising a cell that has a function of producing a hepatocyte growth factor (HGF). The present invention also provides a method of producing a cell sheet composition for inhibiting progression of or preventing renal disorder.
    Type: Application
    Filed: January 25, 2017
    Publication date: August 3, 2017
    Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Masatoshi Oka, Sachiko Sekiya, Tatsuya Shimizu, Kosaku Nitta, Teruo Okano
  • Patent number: 9708578
    Abstract: A measuring unit which is to be attached to a cell culture container configured to accommodate cells to be cultured and a culture solution, includes: a measurer which is configured to measure information related to the cells and the culture solution, in a non-contact manner; and a sensor which is configured to detect at least one of a position, a posture, an impact, an orientation, and vibration.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 18, 2017
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Katsuyoshi Suzuki, Katsuhide Tone, Teruo Okano, Tatsuya Shimizu
  • Publication number: 20170115297
    Abstract: Provided is a method for detecting the expression of SMN protein, said method comprises: a step for labeling SMN protein in a sample, said sample containing nucleated cells derived from blood; a step for labeling the nuclei of the nucleated cells in the sample; a step for selecting a cell population of the nucleated cells in which nuclei and SMN protein are labeled; and a step for detecting the expression of the SMN protein on the basis of the label for the SMN protein in the selected cell population.
    Type: Application
    Filed: April 3, 2015
    Publication date: April 27, 2017
    Applicant: Tokyo Women's Medical University
    Inventors: Kayoko SAITO, Reiko ARAKAWA, Masayuki ARAKAWA, Akio NOMOTO (Deceased)
  • Patent number: 9623052
    Abstract: The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 18, 2017
    Assignees: Tokyo Women's Medical University, Kyoto University
    Inventors: Teruo Okano, Tatsuya Shimizu, Jun Yamashita, Hidetoshi Masumoto
  • Patent number: 9615988
    Abstract: In arm support apparatus, a longitudinal mount has opposing first and second ends. An elbow locator is provided on the first end of the mount. The elbow locator locates an operator's elbow when the operator's forearm is mounted on the mount. A rotary joint of a multijoint arm has a rotary axis having a vertical component. The mount is rotatably joined to the rotary joint. While the forearm is mounted on the mount so that the elbow of the operator's arm is located by the elbow locator, the rotary axis is located with a distance with respect to the elbow to enable both the first and second ends of the mount to swing about the rotary axis. The distance is set to be equal to or longer than 50 mm.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: April 11, 2017
    Assignees: DENSO CORPORATION, SHINSHU UNIVERSITY, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Satoru Nakamura, Minoru Takahashi, Hideki Okuda, Kazuhiro Hongo, Tetsuya Goto, Yosuke Hara, Jun Okamoto
  • Patent number: 9617519
    Abstract: A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: April 11, 2017
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Katsuhisa Sakaguchi, Tatsuya Shimizu, Hidekazu Sekine, Mitsuo Umezu, Teruo Okano
  • Patent number: 9574165
    Abstract: Disclosed herein is a cell culture apparatus that can achieve appropriate culture conditions. The cell culture apparatus (1) includes: a cylindrical culture vessel (10) that holds a culture liquid containing cells; a supporting column (20) that stands upright in a center of an inner surface of a bottom (12) in the culture vessel; and a stirring device (30) that includes an attaching portion (32) that is attached to an upper portion of the supporting column so as to be rotatable relative to the supporting column and a stirring blade (34) whose upper portion is fixed to the attaching portion so as to rotate around the supporting column.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: February 21, 2017
    Assignees: ABLE CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Masanori Wada, Katsuhisa Matsuura, Tatsuya Shimizu, Teruo Okano, Hiroyuki Tsurii