Patents Assigned to Topera, Inc.
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Patent number: 9055877Abstract: An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient. The first cardiac signal and the second cardiac signal are processed to identify a point of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to a derivative of the second cardiac signal. An activation onset time is assigned in the first cardiac signal at the point of change to define a cardiac activation.Type: GrantFiled: November 12, 2013Date of Patent: June 16, 2015Assignees: The Regents of the University of California, Topera, Inc., The United States of America as represented by the Department of Veterans AffairsInventors: Sanjiv Narayan, Carey Robert Briggs
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Patent number: 9050006Abstract: An example system and method of reconstructing cardiac activation information are disclosed. An analysis signal and a reference signal are processed to determine whether there is a first point of change in a first selected-order derivative of the analysis signal with respect to a first selected-order derivative of the reference signal above a first threshold. The analysis signal and the reference signal are processed to determine whether there is a second point of change in a second selected-order derivative of the analysis cardiac signal with respect to a second selected-order derivative of the reference cardiac signal above a second threshold. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.Type: GrantFiled: March 15, 2013Date of Patent: June 9, 2015Assignees: The Regents of the University of California, Topera, Inc.Inventors: Sanjiv Narayan, Carey Robert Briggs, Ruchir Sehra
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Publication number: 20150133760Abstract: A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; and a basket assembly including a plurality of flexible splines; an anchor for securably affixing proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a tip for securably affixing the distal portions of the splines; where the tip is recessed within the basket assembly upon radial expansion of the basket assembly.Type: ApplicationFiled: January 13, 2015Publication date: May 14, 2015Applicant: Topera, Inc.Inventors: Thomas F. Kordis, Ruchir Sehra, Eric T. Johnson, Darrin J. Kent, Robert Ryan Ragland
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Patent number: 8868169Abstract: System, assembly and method are provided to facilitate reconstruction of cardiac information representing a complex rhythm disorder associated with a patient's heart to indicate a source of the heart rhythm disorder. The complex rhythm disorder can be treated by application of energy to modify the source of the rhythm disorder.Type: GrantFiled: December 20, 2013Date of Patent: October 21, 2014Assignees: The Regents of the University of California, Topera, Inc., The United States of America as represented by the Department of Veterans AffairsInventors: Sanjiv Narayan, Ruchir Sehra
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Publication number: 20140276157Abstract: An example system and method of determining a likely core of a rotational source associated with a heart rhythm disorder are disclosed. A plurality of relative diffusion shapes associated with wave fronts is calculated at a plurality of time points associated with the rotational source. The wave fronts associated with heart signals. A plurality of intersecting points of a smallest relative diffusion shape and other relative diffusion shapes is determined. A bounded polygon of the intersecting points is defined as the likely core.Type: ApplicationFiled: March 20, 2014Publication date: September 18, 2014Applicant: Topera, Inc.Inventors: William Robert Macneil, Ruchir Sehra
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Publication number: 20140276152Abstract: A system and method of identifying a driver of a source associated with a heart rhythm disorder are disclosed. Data is accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and that controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicants: The Regents of the University of California, Topera, Inc.Inventors: Sanjiv Narayan, Carey Robert Briggs, Ruchir Sehra
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Patent number: 8812074Abstract: A method for sensing multiple local electric voltages from endocardial surface of a heart, includes: providing a system for sensing multiple local electric voltages from endocardial surface of a heart, including: a first elongate tubular member having a lumen, a proximal end and a distal end; a basket assembly including: a plurality of flexible splines for guiding a plurality of exposed electrodes, the splines having proximal portions, distal portions and medial portions therein between, wherein the electrodes are substantially flat electrodes and are substantially unidirectionally oriented towards a direction outside of the basket.Type: GrantFiled: January 7, 2014Date of Patent: August 19, 2014Assignee: Topera, Inc.Inventors: Thomas F. Kordis, Ruchir Sehra
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Publication number: 20140228663Abstract: A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.Type: ApplicationFiled: April 8, 2014Publication date: August 14, 2014Applicant: Topera, Inc.Inventors: Thomas F. Kordis, Eric T. Johnson, Phillip C. Burke, Darrin J. Kent, Robert Ryan Ragland
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Publication number: 20140128709Abstract: A method for sensing multiple local electric voltages from endocardial surface of a heart, includes: providing a system for sensing multiple local electric voltages from endocardial surface of a heart, including: a first elongate tubular member having a lumen, a proximal end and a distal end; a basket assembly including: a plurality of flexible splines for guiding a plurality of exposed electrodes, the splines having proximal portions, distal portions and medial portions therein between, wherein the electrodes are substantially flat electrodes and are substantially unidirectionally oriented towards a direction outside of the basket.Type: ApplicationFiled: January 7, 2014Publication date: May 8, 2014Applicant: Topera, Inc.Inventors: Thomas F. Kordis, Ruchir Sehra
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Patent number: 8715199Abstract: An example system and method of defining a rotational source associated with a heart rhythm disorder are disclosed. A plurality of center locations of wave fronts are calculated at a plurality of time points associated with the heart rhythm disorder. A rotational path that connects the plurality of center locations is then determined. The system and method can also determine a likely core associated with the rotational path. A plurality of relative diffusion shapes associated with the plurality of the center locations is calculated. A plurality of intersecting points of a smallest relative diffusion shape and other relative diffusion shapes is determined within the rotational path. A bounded polygon of the intersecting points is defined as the likely core.Type: GrantFiled: March 15, 2013Date of Patent: May 6, 2014Assignee: Topera, Inc.Inventors: William Robert Macneil, Ruchir Sehra
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Publication number: 20140073981Abstract: An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient. The first cardiac signal and the second cardiac signal are processed to identify a point of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to a derivative of the second cardiac signal. An activation onset time is assigned in the first cardiac signal at the point of change to define a cardiac activation.Type: ApplicationFiled: November 12, 2013Publication date: March 13, 2014Applicants: Topera, Inc., The Regents of the University of CaliforniaInventors: Sanjiv Narayan, Carey Robert Briggs
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Publication number: 20140066787Abstract: An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient. The first cardiac signal and the second cardiac signal are processed to determine whether there is a point of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to a derivative of the second cardiac signal above a threshold. An activation onset time is assigned in the first cardiac signal at the point of change to define a cardiac activation if the point of change is in the first cardiac signal.Type: ApplicationFiled: November 7, 2013Publication date: March 6, 2014Applicants: Topera, Inc., The Regents of the University of CaliforniaInventors: Sanjiv Narayan, Carey Robert Briggs
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Patent number: 8644902Abstract: A method for sensing multiple local electric voltages from endocardial surface of a heart, includes: providing a system for sensing multiple local electric voltages from endocardial surface of a heart, including: a first elongate tubular member having a lumen, a proximal end and a distal end; a basket assembly including: a plurality of flexible splines for guiding a plurality of exposed electrodes, the splines having proximal portions, distal portions and medial portions therein between, wherein the electrodes are substantially flat electrodes and are substantially unidirectionally oriented towards a direction outside of the basket.Type: GrantFiled: March 1, 2012Date of Patent: February 4, 2014Assignee: Topera, Inc.Inventors: Thomas F. Kordis, Ruchir Sehra
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Publication number: 20130331677Abstract: A system for sensing monophasic action potentials from endocardial tissue of a heart, includes: a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines; a tip for securably affixing the distal portions of the splines; and a polymeric member including opposed a first open end and a second open end defining an open lumen therein between, where at least one of the plurality of flexible splines is at least partially disposed within the lumen of the polymeric member; a flexible electrode assembly strip with two or more exposed electrodes oppositely disposed on at least a portion of the outer surface of the polymeric member.Type: ApplicationFiled: June 28, 2013Publication date: December 12, 2013Applicant: Topera, Inc.Inventors: Thomas F. Kordis, Eric T. Johnson, Phillip C. Burke, Darrin J. Kent, Kevin M. Magrini, Jeff A. Burke, Robert Ryan Ragland
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Publication number: 20130226016Abstract: An example system and method of reconstructing cardiac activation information are disclosed. An analysis signal and a reference signal are processed to determine whether there is a first point of change in a first selected-order derivative of the analysis signal with respect to a first selected-order derivative of the reference signal above a first threshold. The analysis signal and the reference signal are processed to determine whether there is a second point of change in a second selected-order derivative of the analysis cardiac signal with respect to a second selected-order derivative of the reference cardiac signal above a second threshold. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.Type: ApplicationFiled: March 15, 2013Publication date: August 29, 2013Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, TOPERA, INC.Inventors: Topera, Inc., The Regents of the University of California
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Patent number: 8504133Abstract: A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member; a plurality of flexible splines having proximal portions, distal portions and medial portions therein between; an anchor for securably affixing the proximal portions of the splines; an atraumatic tip for securably affixing the distal portions of the splines; and a polymeric member including opposed a first open end and a second open end defining an open lumen therein between and an inner member surface and an outer member surface, wherein at least one of the plurality of flexible splines is at least partially disposed within the lumen of the polymeric member; a flexible electrode assembly strip with one or more exposed electrodes disposed on at least a portion of the outer surface of the polymeric member.Type: GrantFiled: November 28, 2012Date of Patent: August 6, 2013Assignee: Topera, Inc.Inventors: Thomas F. Kordis, Eric T. Johnson, Philip C. Burke, Darrin J. Kent, Kevin M. Magrini, Jeff A. Burke, Robert Ryan Ragland
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Publication number: 20130150740Abstract: An example system and method of locating a source of a heart rhythm disorder are disclosed. In accordance with the method, a first pair of cardiac signals is processed to define a first coefficient associated with variability of the first pair of signals at a first region of the heart. Further, a second pair of cardiac signals is processed to define a second coefficient associated with variability of the second pair of signals at a second region of the heart. Thereafter, the first coefficient of variability is compared to the second coefficient of variability to determine a direction towards the source of the rhythm disorder.Type: ApplicationFiled: July 27, 2012Publication date: June 13, 2013Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, TOPERA, INC.Inventors: Sanjiv Narayan, Carey Robert Briggs
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Publication number: 20130150742Abstract: An example system and method of determining regularity associated with a rhythm disorder of a heart are disclosed. In accordance with the method, a derivative of a first cardiac signal at a plurality of first time points is processed against a derivative of a second cardiac signal at a plurality of second time points to define a plurality of coordinate pairs of the first cardiac signal against the second cardiac signal. Thereafter, an index of regularity that exceeds a threshold is determined. The index of regularity indicates an approximate congruence of the plurality of coordinate pairs among the first cardiac signal and the second cardiac signal.Type: ApplicationFiled: May 14, 2012Publication date: June 13, 2013Applicants: The Regents of the University of California, Topera, Inc.Inventors: Carey Robert Briggs, Sanjiv Narayan
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Publication number: 20130102869Abstract: A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member; a plurality of flexible splines having proximal portions, distal portions and medial portions therein between; an anchor for securably affixing the proximal portions of the splines; an atraumatic tip for securably affixing the distal portions of the splines; and a polymeric member including opposed a first open end and a second open end defining an open lumen therein between and an inner member surface and an outer member surface, wherein at least one of the plurality of flexible splines is at least partially disposed within the lumen of the polymeric member; a flexible electrode assembly strip with one or more exposed electrodes disposed on at least a portion of the outer surface of the polymeric member.Type: ApplicationFiled: November 28, 2012Publication date: April 25, 2013Applicant: TOPERA, INC.Inventor: TOPERA, INC.
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Patent number: 8364236Abstract: A device for insertion into a body lumen, includes: an electrode assembly strip with exposed electrodes including: a polymeric substrate having an upper surface and an opposed lower surface; one or more electrodes disposed over a portion of the upper surface of the polymeric substrate; one or more electrical traces disposed over a portion of the lower surface of the polymeric substrate in electrical communication with the one or more electrodes by way of metal plated holes through the substrate; and a flexible polymeric substrate having a substrate surface and a substrate wall; wherein the electrode assembly strip is compressingly and thermally bonded to the substrate surface of the flexible polymeric substrate to define a flexible electrode assembly strip; and wherein the electrode assembly strip has a thickness from about 0.0005 inches to about 0.008 inches.Type: GrantFiled: March 1, 2012Date of Patent: January 29, 2013Assignee: Topera, Inc.Inventors: Jeff A. Burke, Eric T. Johnson, Thomas F. Kordis, Darrin J. Kent, Kevin M. Magrini