Patents Assigned to Toyo Boseki Kabushiki Kaisha
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Patent number: 8728771Abstract: The present invention provides a L-succinylacylase consisting of: (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; or (d) a protein which consists of an amino acid sequence where one or several amino acid(s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity. This enzyme is able to produce a sterically bulky unnatural amino acid such as L-tert-leucine etc. which is useful as an intermediate for pharmaceuticals.Type: GrantFiled: December 10, 2009Date of Patent: May 20, 2014Assignees: Toyo Boseki Kabushiki Kaisha, Sekisui Medical Co., Ltd.Inventors: Atsushi Toda, Sachio Iwai, Yoshiaki Nishiya, Shinya Kumagai
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Patent number: 8722161Abstract: Disclosed is a heat shrinkable polyester film formed from a polyester resin that is mainly composed of ethylene terephthalate and contains 3-12% by mole (inclusive) of one or more monomer components, which can be amorphous components, relative to all the polyester resin components, in which the heat shrinkable polyester film has a main shrinkage direction which is the width direction. The heat shrinkable polyester film is characterized in that the shrinkage in 80° C. glycerin, the shrinkage in 130° C. glycerin and the tensile breaking strength in the longitudinal direction are controlled within specific ranges.Type: GrantFiled: March 16, 2011Date of Patent: May 13, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Masayuki Haruta, Yukinobu Mukoyama, Katsuya Ito
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Patent number: 8708161Abstract: This disclosure relates to an anisotropic polyvinylidene fluoride hollow fiber microporous membrane containing a polyvinylidene fluoride resin. The hollow fiber microporous membrane does not include macrovoids, and has mainly a net-like structure. In addition, the hollow fiber microporous membrane has a dense outer layer on an outer surface, and a homogeneous bulk layer that is internally adjacent to the outer layer and has a coarser structure than the outer layer. The porosity of the bulk layer is at least 1.5 times the membrane surface porosity of the outer layer. The dense structure of the outer layer changes substantially discontinuously into the coarse structure of the bulk layer.Type: GrantFiled: January 10, 2007Date of Patent: April 29, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Akihiro Ariji, Hideki Yamada
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Patent number: 8703443Abstract: There are provided a microorganism characterized by producing poly-?-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-?-L-glutamate having large molecular weight by using the microorganism, and poly-?-L-glutamate having an average molecular weight of 1,300,000 or greater. In addition, usages of these are provided.Type: GrantFiled: March 12, 2007Date of Patent: April 22, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Shuhei Yamamoto, Masaru Kitagawa, Michiko Suzuki, Atsushi Sogabe, Makoto Ashiuchi
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Patent number: 8697207Abstract: The inventive heat-shrinkable polyolefin film is high in shrinkability in the longitudinal direction that is its main shrinkage direction and excellent in finish properties after shrinkage, perforated line openability, and thermal blocking resistance. The heat-shrinkable polyolefin film is characterized by particular values with respect to hot-water heat shrinkage ratio in the longitudinal and width directions, right angle tear strength in the width direction, and heat-resistant peel strength.Type: GrantFiled: December 19, 2007Date of Patent: April 15, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Shigetomo Yamamoto, Yukinobu Mukoyama, Kyoko Inagaki, Kenji Kawai, Masatoshi Hashimoto, Katsuhiko Nose
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Publication number: 20140100591Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.Type: ApplicationFiled: December 13, 2013Publication date: April 10, 2014Applicant: TOYO BOSEKI KABUSHIKI KAISHAInventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
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Publication number: 20140099427Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.Type: ApplicationFiled: December 13, 2013Publication date: April 10, 2014Applicant: TOYO BOSEKI KABUSHIKI KAISHAInventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
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Patent number: 8685305Abstract: The invention aims at providing a heat-shrinkable polyester film which is excellent in tearability along perforations and in break resistance after storage when used as labels of beverage bottles. The invention relates to a heat-shrinkable polyester film which is made of a polyester resin comprising ethylene terephthalate as the main constituent and containing at least 13 mol % of at least one monomer capable of forming an amorphous component in the whole polyester resin component and which has specific heat shrinkage characteristics and exhibits specific mechanical characteristics after heat shrinking treatment. The film can be produced by a sequential biaxial orientation process comprising longitudinal orientation step, intermediate heat treatment step, positive cooling step, transverse orientation step, and final heat treatment step.Type: GrantFiled: September 24, 2008Date of Patent: April 1, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Masayuki Haruta, Masatoshi Hashimoto, Masakazu Iwasaki, Katsuhiko Nose
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Patent number: 8673414Abstract: The present invention provides a heat-shrinkable polyester film with very good perforation-tear property and also very high productivity. A heat-shrinkable polyester film made of a polyester resin including ethylene terephthalate as a main constituent and containing 15% by mole or more of at least one monomer capable of forming an amorphous component in the whole components of the polyester resin, which exhibits specific heat shrinkage properties and specific mechanical properties after the heat shrinkage.Type: GrantFiled: August 27, 2007Date of Patent: March 18, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Masayuki Haruta, Norimi Tabota, Katsuhiko Nose
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Patent number: 8669310Abstract: There is provided a polyamide resin composition reinforced with glass fiber produced by the melt kneading of a mixture where 60 to 80 parts by weight of glass fiber bundles (B) comprising a glass fiber having a flat cross section whose flatness degree is 1.5 to 8 and having an ignition loss at 625° C. for 0.5 hour of not more than 0.8% by weight are added to 40 to 20 parts by weight of polyamide (A), characterized in that, during the above melt kneading, a polyamide-reactive silane coupling agent (C) is added to the above mixture in a rate of 0.1 to 1.0% by weight of the above glass fiber bundles (B). The polyamide resin composition of the present invention has high bending strength, bending elastic modulus and Charpy impact strength (at 23° C. and ?40° C.) by a specific fracture mode which have been never achieved before, and it is excellent in productivity.Type: GrantFiled: January 29, 2010Date of Patent: March 11, 2014Assignee: Toyo Boseki Kabushiki KaishaInventor: Tomohide Nakagawa
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Patent number: 8663808Abstract: The present invention provides a flexographic printing original plate having no wrinkle on the plate surface and having no plate surface abnormality due to laser in spite of the fact that it is a flexible water-developable plate. A photosensitive flexographic printing original plate developable by water in which at least a supporting member, a photosensitive resin layer, a protective layer and a heat-sensitive mask layer are successively laminated, characterized in that, the protective layer contains (A) polyvinyl alcohol, (B) plasticizer and (C) water-dispersible latex in the following rate. Polyvinyl alcohol (A): 25 to 80 parts by weight Plasticizer (B): 15 to 60 parts by weight Water-dispersible latex (C): 5 to 40 parts by weight.Type: GrantFiled: July 26, 2010Date of Patent: March 4, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Kazuya Yoshimoto, Tetsuma Kawakami, Yukimi Yawata
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Patent number: 8642717Abstract: The present invention is an aliphatic polyester resin in which a polyhydroxy acid skeleton is a main component, manufactured using a polymerization catalyst, characterized in that a specific organophosphorus compound is copolymerized in the resin. Activity of the polymerization catalyst contained in the aliphatic polyester resin of the present invention after the polymerization is well lowered and a lactide is hardly produced even by heating after the polymerization or after the manufacture.Type: GrantFiled: October 4, 2012Date of Patent: February 4, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Tomokazu Kusunoki, Toshifumi Unrinin, Osamu Morimoto
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Patent number: 8632844Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.Type: GrantFiled: December 4, 2008Date of Patent: January 21, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
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Publication number: 20130323814Abstract: The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid sequence of amino acid SEQ ID NO: 1 and a second fusion protein comprising the second protein fused with a peptide having an amino acid sequence selected from the group consisting of amino acid SEQ ID NOS: 2 to 6, and allowing the first fusion protein to bind with the second fusion protein to form a complex, and detecting luminescence emitted from the complex.Type: ApplicationFiled: May 31, 2013Publication date: December 5, 2013Applicants: The University of Tokyo, Toyo Boseki Kabushiki Kaisha, ProbeX Inc.Inventors: The University of Tokyo, ProbeX Inc., Toyo Boseki Kabushiki Kaisha
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Patent number: 8580380Abstract: To provide fibers which retain the excellent heat resistance and flame retardancy inherent in polybenzazole fibers and pyridobisimidazole fibers, have improved post-processability and neither necessitate considerable change in production process conditions nor require a high-temperature and long-time heating treatment. With respect to the polybenzazole fiber and pyridobisimidazole fiber, in an electron diffraction diagram of a surface layer part (from the surface to 1 ?m) of the fibers, the fibers containing a crystal present in a state satisfying that S2/S1 is in a prescribed range, wherein S1 is a diffraction peak area derived from a crystal (200) plane and S2 is a diffraction peak area derived from a plurality of other crystal planes along an equatorial direction profile.Type: GrantFiled: August 22, 2007Date of Patent: November 12, 2013Assignee: Toyo Boseki Kabushiki KaishaInventors: Tooru Kitagawa, Kohei Kiriyama, Seiji Watanuki, Yoshihiko Teramoto, Yusuke Shimizu
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Patent number: 8569004Abstract: The invention relates to a method for improving the heat stability of glucose dehydrogenase (GDH). The invention provides a method for preparing a glucose sensor with soluble flavin-bound GDH by providing a composition comprising soluble flavin-bound GDH at an acidic pH and heat drying the composition onto a glucose sensor.Type: GrantFiled: October 5, 2009Date of Patent: October 29, 2013Assignee: Toyo Boseki Kabushiki KaishaInventor: Masao Kitabayashi
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Patent number: 8557472Abstract: There are provided a novel proton-conducting polymer membrane that shows good workability in a fuel cell assembling process and good proton conductivity and durability even under high-temperature, non-humidified conditions, a method for production thereof, and a fuel cell therewith. The proton-conducting polymer membrane includes: a polymer membrane containing a polybenzimidazole compound having a sulfonic acid group and/or a phosphonic acid group; and vinylphosphonic acid contained in the polymer membrane. The fuel cell uses the proton-conducting polymer membrane. The polybenzimidazole compound preferably includes a sulfonic and/or phosphonic acid group-containing component represented by Structural Formula (1): wherein n represents an integer of 1 to 4, R1 represents a tetravalent aromatic linking unit capable of forming an imidazole ring, R2 represents a bivalent aromatic linking unit, and Z represents a sulfonic acid group and/or a phosphonic acid group.Type: GrantFiled: May 31, 2006Date of Patent: October 15, 2013Assignee: Toyo Boseki Kabushiki KaishaInventors: Fusaki Fujibayashi, Yoshimitsu Sakaguchi, Satoshi Takase
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Patent number: 8552170Abstract: The present invention provides an expression vector which is effective in an efficient establishment of transformed cells which express the aimed protein gene in a high level. An expression vector which has a cassette for expressing the drug selective marker gene containing mRNA destabilizing sequence, at least one element for stabilizing the gene expression and a cassette for expressing the gene of the aimed protein. Preferably, the mRNA destabilizing sequence is derived from AT-rich sequence existing in the 3?-untranslated region of cytokine, interleukin or proto-oncogene, and the element for stabilizing the gene expression is derived from Chinese hamster genome.Type: GrantFiled: June 4, 2010Date of Patent: October 8, 2013Assignee: Toyo Boseki Kabushiki KaishaInventors: Tomomi Yamazaki, Kenji Masuda, Shigeaki Nishii, Bunsei Kawakami
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Patent number: 8541321Abstract: A copolymerized polyether polyamide resin for coating on or for impregnation to a woven or knitted fabric, wherein elongation and elastic modulus of the copolymerized polyether polyamide resin are not less than 1000% and not more than 15 MPa, respectively. The copolymerized polyether polyamide resin has a constitution wherein said copolymerized polyether polyamide resin is such that a soft segment comprising a polyether polyamide constituted from a polyether diamine compound and a dicarboxylic acid compound is bonded to a hard segment comprising a polyamide constituted from an aminocarboxylic acid compound and/or a lactam compound.Type: GrantFiled: October 16, 2008Date of Patent: September 24, 2013Assignee: Toyo Boseki Kabushiki KaishaInventors: Hiroaki Hagiwara, Kenichiro Kano, Gaku Maruyama, Takahiro Hattori, Takashi Tsuruta
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Patent number: 8512852Abstract: Provided is a polylactic acid resin composition useful as a molding material and a packaging material. The polylactic acid resin composition comprises a resin composition (l) comprising poly-L-lactic acid having an L-isomer content of 90-100 mol % as the main component and a resin composition (d) comprising poly-D-lactic acid having a D-isomer content of 90-100 mol % as the main component, the resin compositions (l) and (d) having been alternately stacked so that each layer has a thickness of 0.01-2.5 ?m. The polylactic acid resin composition has specific thermal properties, can be used at high temperatures even after high-temperature melt molding, and can give molded polylactic acid articles having excellent suitability for various kinds of processing, such as printing, and having excellent transparency, etc. Also provided is a stretched polylactic acid resin film obtained by heating the polylactic acid resin composition to 280° C.Type: GrantFiled: May 12, 2010Date of Patent: August 20, 2013Assignee: Toyo Boseki Kabushiki KaishaInventors: Toshiyuki Shimizu, Toshifumi Unrinin