Patents Assigned to Trustees of the University of Pennsylvania
  • Publication number: 20200236945
    Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.
    Type: Application
    Filed: April 13, 2020
    Publication date: July 30, 2020
    Applicants: Colgate-Palmolive Company, The Trustees of the University of Pennsylvania
    Inventors: Carl MYERS, Carlo DAEP, Lynette ZAIDEL, James MASTERS, Russell COMPOSTO, Hyun-Su LEE
  • Patent number: 10722598
    Abstract: Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: July 28, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Guangping Gao, Mauricio R. Alvira, Luc H. Vandenberghe
  • Patent number: 10724006
    Abstract: The invention provides lentiviral preparations containing a sulfonic acid buffer, such as 1,4-piperazinediethanesulfonic acid (PIPES), 2-(N-morpholino)ethanesulfonic acid (MES), and 3-morpholinopropane-1-sulfonic acid (MOPS), a sodium citrate buffer, or a phosphate buffer. The invention additionally encompasses methods of lentiviral purification as well as methods of transducing human cells.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: July 28, 2020
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Amitabha Deb, Eugene Nebelitsky, Vladimir Slepushkin
  • Patent number: 10725778
    Abstract: A method includes receiving, for metadata processing, a current instruction with a associated metadata tags. The metadata processing is performed in a metadata processing domain isolated from a code execution domain including the current instruction. Each respective associated metadata tag representing a respective policy of the composite policy. The associated metadata tags further including pointers to tags of a component policy of the composite policy. For each respective metadata tag, the method includes determining, in the metadata processing domain and in accordance with the metadata tag and the current instruction, whether a rule exists in a rule cache for the current instruction. The rule cache including rules on metadata used by said metadata processing to define allowed instructions. The determination of whether a rule exists resulting in a respective output.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: July 28, 2020
    Assignees: The Charles Stark Draper Laboratory, Inc., The Trustees of the University of Pennsylvania Penn Center for Innovation
    Inventors: Andre′ DeHon, Udit Dhawan
  • Patent number: 10719630
    Abstract: A system and method for metadata processing that can be used to encode an arbitrary number of security policies for code running on a stored-program processor. This disclosure adds metadata to every word in the system and adds a metadata processing unit that works in parallel with data flow to enforce an arbitrary set of policies, such that metadata is unbounded and software programmable to be applicable to a wide range of metadata processing policies. This instant disclosure is applicable to a wide range of uses including safety, security, and synchronization.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: July 21, 2020
    Assignees: BAE Systems Information and Electronic Systems Integration Inc., The Trustees of the University of Pennsylvania
    Inventors: Silviu S Chiricescu, Andre DeHon, Udit Dhawan
  • Publication number: 20200223871
    Abstract: The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
    Type: Application
    Filed: August 22, 2019
    Publication date: July 16, 2020
    Applicants: AstraZeneca AB, The Trustees of the University of Pennsylvania
    Inventors: David W. Christianson, Bruce Edward Tomczuk, Richard Scott Pottorf, Andrew Vargha Colasanti, Gary Lee Olson
  • Patent number: 10711282
    Abstract: The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell. The lentiviral transfer vector may be characterized by the following features: (a) including a cytomegalovirus (CMV) promoter; (b) including a polynucleotide encoding a partial gag protein that includes a mutated INS1 inhibitory sequence that reduces restriction of nuclear export of RNA; (c) not including a polynucleotide encoding the INS2, INS3, and INS4 inhibitory sequences of gag; (d) not including an SV40 origin of replication and/or an f1 origin of replication; (e) including a cPPT sequence that contains splice site; (f) including an EF1 alpha promoter with intact splice donor and acceptor sites; and (g) including hepatitis B PRE with mutation in start codon of X protein ORF.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: July 14, 2020
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Vladimir Slepushkin, Dmitriy Lukashev
  • Publication number: 20200216841
    Abstract: Provided herein are compositions and methods to assess the genomic landscape of fixed cells using light activated oligonucleotides that can be directed to the nucleus, mitochondria, or cytoplasm of fixed cells and that, upon activation, can be extended for in situ copying of nuclear single-stranded DNA (i.e., open chromatin), open mitochondrial DNA, and/or cytoplasmic RNA into barcoded complementary DNA. These methods also provide for gene specific 3D chromatin structural niche analysis.
    Type: Application
    Filed: January 7, 2020
    Publication date: July 9, 2020
    Applicants: Agilent Technologies, Inc., The Trustees of the University of Pennsylvania
    Inventors: James EBERWINE, Jae-Hee LEE, Jifen LI, Stephen FISHER, Youtao LU, Junhyong KIM, Jai-Yoon SUL, Jinchun WANG, Mimi HEALY
  • Publication number: 20200215313
    Abstract: The presently disclosed subject matter relates to methods and devices for decompressing the lymphatic system. In particular, the present disclosure provides devices for actively or passively decompressing the lymphatic system and methods of their use and deployment within a subject. In certain non-limiting embodiments, a device of the present disclosure can include a pump for actively transferring lymph fluid from the lymphatic fluid into the venous system.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 9, 2020
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Maxim Itkin, Yoav Dori
  • Patent number: 10704122
    Abstract: A method is provided for separating mixtures of different rare earth metals using a ligand having a size-sensitive molecular aperture. The present invention meets the needs in the field by providing method of separating and purifying rare earth metals. The object of this invention is to separate and purify rare earth metals, e.g., the more valuable Dy away from Nd, in mixtures containing such metals using a simple chemical process without the need for countercurrent liquid-liquid separations.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: July 7, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Eric J. Schelter, Justin A. Bogart
  • Patent number: 10703819
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: July 7, 2020
    Assignees: The Trustees of the University of Pennsylvania, Novartis AG
    Inventors: Jennifer Brogdon, Saar Gill, David Jonathan Glass, Saad Kenderian, Andreas Loew, Joan Mannick, Michael Milone, Leon Murphy, David L. Porter, Marco Ruella, Yongqiang Wang, Qilong Wu, Jiquan Zhang
  • Patent number: 10700492
    Abstract: A laser frequency control apparatus comprising: (a) a laser; (b) an oscillator configured to receive an output of the laser and to output a modulated signal; (c) a frequency reference configured to receive the modulated signal and to provide an output signal; and (d) a mixer configured to mix at least a portion of the output signal with an output of the oscillator to generate a mixer output, wherein the mixer output is injected to a section of the laser.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: June 30, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mohamad Hossein Idjadi, Firooz Aflatouni
  • Patent number: 10695410
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: June 30, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Patent number: 10695421
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HBV core protein, as well as genetic constructs/vectors and vaccines that express said protein sequences. Also provided herein are methods for generating an immune response against HBV using the nucleic acid sequences that are provided.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: June 30, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David Weiner, Jian Yan, Nyamekye Obeng-Adjei
  • Patent number: 10695441
    Abstract: Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: June 30, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Guangping Gao, Mauricio R. Alvira, Luc H. Vandenberghe
  • Patent number: 10696983
    Abstract: This invention provides methods for transducing a ciliated cell with a recombinant serotype 2 adeno-associated virus (AAV) vector. Additionally, the invention provides methods of treating diseases associated with a mutated gene by transducing a ciliated cell with a recombinant serotype 2 AAV vector containing a corrective transgene.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: June 30, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Jean Bennett, Joshua Lipschutz
  • Patent number: 10696749
    Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 30, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Yangbing Zhao, Xiaojun Liu
  • Publication number: 20200199511
    Abstract: The presently disclosed subject matter provides a microfluidic device that can simulate capillary blood flow on a fetal side of the device and pooled blood on a maternal side of the device (i.e., intervillous space). The microfluidic device can reconstitute the maternal-fetal interface, can expand the capabilities of cell culture models, and can provide an alternative to current maternal-fetal transfer models.
    Type: Application
    Filed: January 17, 2020
    Publication date: June 25, 2020
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Dongeun Huh, Cassidy Blundell
  • Publication number: 20200197488
    Abstract: The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
    Type: Application
    Filed: January 28, 2019
    Publication date: June 25, 2020
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: George COTSARELIS, Oh Sang Kwon
  • Patent number: 10690653
    Abstract: The present disclosure provides devices and methods using separating a fluid—e.g., plasma or serum—from whole blood. In some embodiments, the devices and methods use hydrophobic or superhydrophobic surfaces to encourage whole blood to contact a selective membrane that extracts the desired fluid component from the blood.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: June 23, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Changchun Liu, Haim H. Bau, Michael G. Mauk