Patents Assigned to UAB Research Foundation
  • Patent number: 10729200
    Abstract: In one embodiment, a tether system for use with a protective helmet worn by a user includes multiple tethers, each tether having a first end adapted to attach to a shell of the protective helmet and a second end adapted to attach to an article worn by the user, wherein the tethers limit movement of the helmet.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: August 4, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Dean Sicking, Blake Feltman, James T. Houston
  • Patent number: 10653747
    Abstract: Disclosed are synthetic apolipoprotein E-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein E-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 19, 2020
    Assignees: UAB RESEARCH FOUNDATION, LIPIMETIX DEVELOPMENT, LLC
    Inventors: Gattadahalli M. Anantharamaiah, Dennis Goldberg
  • Patent number: 10653682
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 19, 2020
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Patent number: 10634685
    Abstract: Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {?2) glucose 1 (1?3) glucose 2 (1?3) rhamnose (1?3) ribitol (5?phosphate}. This new serotype may be included in pneumococcal vaccines.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: April 28, 2020
    Assignees: The UAB Research Foundation, Fundacao Oswaldo Cruz
    Inventors: Moon H. Nahm, Jisheng Lin, Angela P. Brandao, Maria Cristina Brandileone
  • Patent number: 10617729
    Abstract: To increase the therapeutic potential of these oncolytic viruses based on a 24 base pair deletion in the viral E1 A gene (D24), a conditionally replicating adenovirus targeting multiple receptors upregulated on tumors was generated by incorporating an Ad5/3 fiber with a carboxyl terminus RGD ligand. The virus displayed full cytopathic effect in tumor lines assayed at low titers with improved cytotoxicity over Ad5-RGD D24, Ad5/3 D24 and an HSV oncolytic virus. The virus was further engineered to deliver immunotherapeutic agents such as GMCSF while maintaining enhanced heterogenic oncolysis.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: April 14, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventor: George Clement Dobbins
  • Patent number: 10576101
    Abstract: The present invention relates to roneparstat for use in a combined therapy for the treatment of multiple myeloma. In particular it has unexpectedly been found that the combined use of roneparstat with a proteasome inhibitor, in particular selected between bortezomib and carfilzomib or with melphalan improve efficacy in decreasing the overall tumor burden, especially showing synergism, with respect to the administration of each active ingredient alone.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: March 3, 2020
    Assignees: Leadiant Biosciences SA, The UAB Research Foundation
    Inventors: Ralph D. Sanderson, Vishnu Prakash C. Ramani, Alessandro Noseda, Paola Barbieri
  • Patent number: 10578702
    Abstract: An imaging phantom having a housing and a dynamic perfusion assembly positioned within the housing. The dynamic perfusion assembly permits the flow of at least one contrast agent into a non-contrast solution at a desired rate. The dynamic perfusion assembly includes a first chamber that receives at least one contrast agent and a second chamber that receives a non-contrast solution. The second chamber receives the at least one contrast agent from the first chamber at the desired rate.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 3, 2020
    Assignees: UAB Research Foundation, Southern Research Institute
    Inventor: Harrison Kim
  • Patent number: 10562844
    Abstract: Provided herein are compounds of Formula (I), Formula (II), and Formula (III), and compositions comprising the same, as well as methods of use thereof for controlling or inhibiting the formation of calcium oxalate kidney stones, inhibiting the production of glyoxylate and/or oxalate, and/or inhibiting hydroxyproline dehydrogenase (HYPDH).
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: February 18, 2020
    Assignees: Wake Forest University Health Sciences, UAB Research Foundation
    Inventors: W. Todd Lowther, Ross P. Holmes, Daniel Yohannes
  • Patent number: 10543233
    Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: January 28, 2020
    Assignees: Emory University, The UAB Research Foundation, Children's Healthcare of Atlanta, Inc.
    Inventors: Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb
  • Patent number: 10534004
    Abstract: The present invention provides a method of identifying meningitis as either bacterial meningitis or aseptic meningitis in a subject, comprising: a) measuring the amount of complement C3, complement factor B, complement membrane attack complex (MAC) protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 in a cerebrospinal fluid (CSF) sample obtained from the subject; and b) comparing the amount of complement C3, complement factor B, complement MAC protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 measured in (a) with the amount of complement C3, complement factor B, complement MAC protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 measured in a control sample, wherein an amount of complement C3, complement factor B, complement MAC protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 measured in (a) that is greater than the amount of complement C3, complement
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: January 14, 2020
    Assignee: UAB Research Foundation
    Inventors: Scott R. Barnum, Theresa N. Schein, James M. Johnston
  • Patent number: 10522998
    Abstract: A method for detecting an open-phase condition of a transformer having a grounded-wye high voltage side connection including monitoring current flowing in a neutral connection on the high voltage side of the transformer in real time by voltage relaying and current relaying to identify an open phase condition signature in a signal capable of characterizing change of current magnitude. A current signal may be injected onto the neutral terminal and the zero-sequence mode of the transformer monitored to detect an open-phase condition indicated by an increase in network impedance and decrease or elimination of the injection current.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: December 31, 2019
    Assignee: The UAB Research Foundation
    Inventors: Robert F. Arritt, Roger C. Dugan, Wayne E. Johnson, Gregory A. Franklin
  • Publication number: 20190351043
    Abstract: The present embodiments provide compositions and methods related to novel recombinant protein immunogens, comprising specific portions of alpha helical domains (aHD) and proline rich regions (PRD) of pneumococcal surface protein A (PspA), which portions are linked to provide aHD-PRD constructs. The aHD and PRD proteins constituting the aHD-PRD constructs are selected to maximize cross-reactivity and provide protection against a broad spectrum of pneumococcal serotypes. Immunogenic compositions, including vaccines, comprising at least one aHD PRD construct may also include a non-linked aHD portion. Also provided are recombinant nucleic acid molecules that encode aHD-PRD constructs, vectors and recombinant host cells containing such molecules, aHD-PRD expression products, use of such nucleic acid molecules to express aHD-PRD constructs by recombinant techniques, and use of the expression products to elicit an immune or protective response against pneumococcal disease in a suitable host.
    Type: Application
    Filed: December 1, 2017
    Publication date: November 21, 2019
    Applicants: The UAB Research Foundation, The University of Tokyo
    Inventors: David E. BRILES, Hiroshi KIYONO, Robert KNELLER, Reshmi MUKERJI, Kristopher GENSCHMER, Yoshikazu YUKI
  • Patent number: 10456624
    Abstract: Disclosed are various approaches for determining the maximum oxygen consumption of a person, also known as maximum aerobic capacity or VO2 Max. A person is positioned on a treadmill. Attached to the person is a harness configured to apply a horizontal force to the person. A work rate for the person can be calculated based at least in part on the magnitude of the horizontal force applied by the harness and the velocity of the belt. The maximum oxygen consumption for the person can then be calculated based at least in part on the previously calculated work rate.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: October 29, 2019
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: David A. Brown, Christopher Hurt, Marcas Bamman
  • Patent number: 10444099
    Abstract: In one embodiment, a helmet testing system includes a sled adapted to support a bullet dummy, a track along which the sled can travel, a target dummy support apparatus adapted to support a target dummy at a point near an end of the track, and an impact cushion positioned at the end of the track that is adapted to halt forward motion of the sled along the track to enable the bullet dummy to be launched from the sled and into the target dummy.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: October 15, 2019
    Assignee: UAB Research Foundation
    Inventor: Dean Sicking
  • Patent number: 10426677
    Abstract: A transport chair is provided that includes a base frame, a seat assembly pivotally mounted to the base, and a footrest assembly pivotally mounted to the base frame, the footrest assembly being associated with the seat assembly so as to pivot in unison with the seat assembly until the seat assembly is pivoted forward to an extent at which the footrest assembly contacts the floor or ground, at which point the footrest assembly does not pivot further upon further forward pivoting of the seat assembly. Further embodiments of the transport chair allow the seat assembly to recline, alone or in unison with a leg rest assembly, while the footrest remains in position.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: October 1, 2019
    Assignees: The UAB Research Foundation, MOVI Medical, LLC
    Inventors: William Ferniany, Lloyd Cooper
  • Patent number: 10391183
    Abstract: A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to specific promoter control or mutations in E1a or E1b genes.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: August 27, 2019
    Assignees: The UAB Research Foundation, The Board of Regents of the University of Texas System
    Inventors: Juan Fueyo-Margareto, Candelaria Gomez-Manzano, David Curiel
  • Patent number: 10351532
    Abstract: Provided is a compound of formula (I), in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: July 16, 2019
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, VANDERBILT UNIVERSITY, THE UAB RESEARCH FOUNDATION, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David J. Maloney, Alex Gregory Waterson, Ganesh Rai Bantukallu, Kyle Ryan Brimacombe, Plamen Christov, Chi V. Dang, Victor Darley-Usmar, Xin Hu, Ajit Jadhav, Somnath Jana, Kwangho Kim, Jennifer L. Kouznetsova, William J. Moore, Bryan T. Mott, Leonard M. Neckers, Anton Simeonov, Gary Allen Sulikowski, Daniel Jason Urban, Shyh Ming Yang
  • Patent number: 10352059
    Abstract: In some embodiments, a shelter includes an impact-resistant panel having an energy-absorbing core positioned between two outer layers, wherein the energy-absorbing core includes a syntactic foam material that has a plurality of hollow microspheres compounded with a polymeric resin.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 16, 2019
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Uday Vaidya, Selvum Pillay, Haibin Ning, Krishnan Balaji Thattai Parthasarathy
  • Patent number: 10335448
    Abstract: Provided herein are compositions and methods for treating or preventing fibrosis.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 2, 2019
    Assignee: The UAB Research Foundation
    Inventors: Philip J. O'Reilly, Edwin J. Blalock
  • Patent number: 10322145
    Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: June 18, 2019
    Assignees: Emory University, The UAB Research Foundation, Children's Healthcare of Atlanta, Inc.
    Inventors: Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb