Patents Assigned to UAB Research Foundation
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Publication number: 20230159542Abstract: This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation.Type: ApplicationFiled: April 21, 2021Publication date: May 25, 2023Applicants: THE UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTE, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Louis B. Nabors, Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Vibha Pathak, Peter King
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Publication number: 20230154004Abstract: Relationships between morphological changes to an eye due to intraocular pressure changes and blood perfusion and nerve function changes in the retina are determined by colocalizing retinal perfusion data, optic nerve head (ONH) mechanical deformation data, visual field data and nerve fiber data. Perfusion and nerve function changes from intraocular pressure (IOP) changes are determined by colocalizing retinal perfusion data with ONH mechanical deformation data, visual field data and nerve fiber data. Optical coherence tomography-angiography (OCT-A) can be used to generate retinal perfusion data, mechanical deformation data for an imaged volume, and nerve fiber data. A three-dimensional model (e.g., connectivity map or connectivity model) of the vasculature and nerve fibers can be generated from the OCT-A imaging data and used to predict changes in blood perfusion and nerve function in various areas of the retina due to IOP-induced mechanical deformations.Type: ApplicationFiled: February 5, 2021Publication date: May 18, 2023Applicant: THE UAB RESEARCH FOUNDATIONInventors: Massimo Antonio Fazio, Christopher Anthony Girkin, Andrea Ramazzotti
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Patent number: 11643668Abstract: Provided herein are CRISPR/Cas9 complexes and method of using same.Type: GrantFiled: June 17, 2016Date of Patent: May 9, 2023Assignee: THE UAB RESEARCH FOUNDATIONInventors: Tim Townes, Lei Ding, Chia-Wei Chang
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Patent number: 11634764Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.Type: GrantFiled: December 14, 2020Date of Patent: April 25, 2023Assignees: University of Washington, The UAB Research FoundationInventors: Jens H. Gundlach, Michael Niederweis, Thomas Z. Butler, Mikhail Pavlenok, Mark A. Troll, Suja Sukumaran
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Patent number: 11623918Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: November 17, 2021Date of Patent: April 11, 2023Assignees: Southern Research Institute, UAB Research Foundation, The United States Government as Represented by the Department of Veterans AffairsInventors: Mark J. Suto, Bini Mathew, Anupam Agarwal, Amie M. Traylor
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Patent number: 11589219Abstract: The present disclosure relates exposure notification, and in particular to techniques for verification of positive test results from public health authorities where individuals submit notice using public health approved mobile applications for exposure notification and/or contact tracing. When an individual attempts to submit a positive test result notification in a mobile application, the associated device's mobile number will be requested. This mobile number will then be sent a verification code to be entered in the application. At this point, these codes shall be stored digitally in escrow. A regular data feed from a health authority shall be provided that shall include an agreed encryption (irreversibly encrypted or reversibly encrypted) of the mobile numbers associated with any reported test. Any results submitted in the application that have a matching encryption of the mobile numbers shall be released from the escrow for subsequent notification.Type: GrantFiled: August 16, 2021Date of Patent: February 21, 2023Assignee: THE UAB RESEARCH FOUNDATIONInventors: Claude B. Rivers, Rajesh B. Pillai, Zekai Demirezen, Jaret A. Langston
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Patent number: 11587232Abstract: A method for preventing wrong-patient errors includes receiving a selection of a current imaging subject. The current imaging subject is selected for a current image acquisition session comprising capturing one or more current images of the current imaging subject utilizing at least a first image sensor system of a first imaging modality. The method includes accessing one or more previous images of a previous imaging subject. The one or more previous images depict the previous imaging subject according to at least a second imaging modality that is different from the first imaging modality. The method includes presenting the one or more previous images on a display system and, in response to determining that the previous imaging subject matches the current imaging subject based upon the one or more previous images, performing the current image acquisition session.Type: GrantFiled: May 6, 2022Date of Patent: February 21, 2023Assignees: CAMERAD TECHNOLOGIES, THE UAB RESEARCH FOUNDATIONInventors: Carson Arthur Wick, Srini Tridandapani
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Patent number: 11560413Abstract: The present invention is directed to modified CFTR proteins or fragments thereof that contain single or multiple amino acid mutations to improve the structural stability of such CFTR proteins and/or fragments. Specifically, the modified CFTR proteins or fragment thereof differ from the wild-type human CFTR protein or fragment thereof by the presence of four or more mutations selected from V150D, M470V, S492P, F494N, S495P, A534P, I539T, G550E, G551D, R553Q, R555K, Q637R, S1255L, K1334G, S1359A, E1371Q, H1402S, Q1411D, and any combination thereof, such that the stability of the polypeptide is increased relative to that of the wild-type human CFTR polypeptide or fragment thereof.Type: GrantFiled: February 15, 2019Date of Patent: January 24, 2023Assignees: UAB Research Foundation, Texas Tech University SystemInventors: John C. Kappes, Zhengrong Yang, Christie G. Brouillette, Ina L. Urbatsch
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Patent number: 11555207Abstract: Provided herein are CRIS-PR/Cas9 complexes and methods of using same.Type: GrantFiled: June 17, 2016Date of Patent: January 17, 2023Assignee: THE UAB RESEARCH FOUNDATIONInventors: Tim Townes, Lei Ding, Chia-Wei Chang
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Patent number: 11547691Abstract: Described herein are Dendrilla membranosa compounds and derivatives thereof. Also described herein are formulations that can contain an amount of one or more Dendrilla membranosa compounds or derivatives thereof and a carrier. Also described herein are methods of administering one or more Dendrilla membranosa compound and/or derivative thereof or a formulation thereof to a subject in need thereof.Type: GrantFiled: December 16, 2019Date of Patent: January 10, 2023Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UAB RESEARCH FOUNDATIONInventors: Bill J. Baker, Lindsey N. Shaw, Andrew Jason Shilling, Alexandre Jean Bory, Jessie Allen (Adams), Charles Dunkle Amsler, Jr., James Bruce McClintock
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Patent number: 11529291Abstract: A feeding bottle includes a bottle enclosure defining a hollow bottle chamber, wherein the enclosure defines a feeding outlet at a first end and an attachment structure 26 at a second end. A bottom housing defines an instrument compartment extending between a closed exterior portion of the bottom housing and a separation surface within the bottom housing, wherein the bottom housing is configured for detachable connection to the attachment structure 26 of the bottle enclosure. A relief valve is positioned within the separation surface of the bottom housing. A pressure sensor is positioned adjacent the separation surface of the bottom housing and connected by a passageway to the instrument compartment in the bottom housing, wherein the pressure sensor is configured to detect changes of pressure in the bottle enclosure.Type: GrantFiled: October 25, 2019Date of Patent: December 20, 2022Assignees: The Board of Trustees of the University of Alabama, The UAB Research FoundationInventors: Eduard S. Sazonov, Ariel A. Salas, Paula Catherine Chandler-Laney
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Patent number: 11524010Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: July 13, 2021Date of Patent: December 13, 2022Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATIONInventors: Corinne E. Augelli-Szafran, Omar Moukha-Chafiq, Mark J. Suto, Anath Shalev, Lance Thielen, Junqin Chen, Gu Jing
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Patent number: 11505531Abstract: The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: August 5, 2019Date of Patent: November 22, 2022Assignees: UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTEInventors: Mark J. Suto, Vandana V. Gupta, Wei Zhang, Joanne Murphy-Ullrich
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Publication number: 20220342233Abstract: A method of improving emmetropization or slowing myopia development in an eye is provided that involves adjusting the vision in the eye to achieve one or both of increase the distance between the long-wavelength focal plane and the short wavelength focal plane; and position the short wavelength focal plane closer to the cornea than it would normally be located. Multi-spectral devices (e.g., lenses and spectacles) are provided that are useful to improve emmetropization or preventing or reducing the development of myopia, which are optionally multi-focal as well.Type: ApplicationFiled: August 31, 2020Publication date: October 27, 2022Applicant: THE UAB RESEARCH FOUNDATIONInventors: Timothy Jerner GAWNE, Thomas Tolles NORTON
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Patent number: 11471063Abstract: A computerized information processing method for evaluating blood vessels is provided. The method includes acquiring a series of sequences of measurements, each at different time points in at least one cardiac cycle and at a different point along a blood vessel segment of a subject, generating corresponding profiles, calculating a transfer function for a subsegment between two selected points along a blood flow direction, and based thereon determining the physiological property of the subsegment. The measurements can contain information of blood velocity or blood pressure. A processing device and system implementing the information processing method are also provided. This approach can be used to evaluate arteries or veins and can be applied in screening, diagnosis, or prognosis of a variety of vascular diseases. For example, when combined with MRI scan, this approach can be used for non-invasively diagnosing pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), etc.Type: GrantFiled: June 12, 2020Date of Patent: October 18, 2022Assignees: Auburn University, Areus-Med, LLC, The UAB Research FoundationInventors: Thomas S. Denney, Jr., Himanshu Gupta, Ankur Gupta
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Patent number: 11461442Abstract: A user input system comprising a vibration motor, a sensor and a processor in communication with the sensor. The vibration motor is in contact with a surface and generates vibrations in the surface. The vibrations can be altered by a user touching the surface to create altered vibrations. The sensor is in contact with the surface and detects the altered vibrations. The processor receives and analyzes data corresponding to the altered vibrations. The processor determines, based on the analyzed data, whether a user's touch on the surface matches a stored vibration profile of the user.Type: GrantFiled: June 5, 2019Date of Patent: October 4, 2022Assignees: Rutgers, The State University of New Jersey, The UAB Research FoundationInventors: Yingying Chen, Jian Liu, Chen Wang, Nitesh Saxena
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Publication number: 20220305051Abstract: Methods for the treatment of lung injury caused by chemical inhalation, smoke inhalation or microbial infection are described. The methods include administering a therapeutically effective amount of nitrite or a nitrite formulation. Nitrite formulations that include a nitrite salt and an anti-caking agent, such as sodium bicarbonate, and the use of such formulations, is also described.Type: ApplicationFiled: September 4, 2020Publication date: September 29, 2022Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The UAB Research FoundationInventors: Jason Joseph Rose, Mark Thomas Gladwin, Rakesh P. Patel, Sadis Matalon
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Publication number: 20220267383Abstract: Adeno associated viral (AAV) particles are emerging as a useful vehicle for gene delivery to various organs and tissues, one of them being the retina. Provided here are variant AAV (e.g., variant serotype 2 (AAV2)) capsid proteins and variant capsid protein containing particles with enhanced ability to transduce retinal cells.Type: ApplicationFiled: March 8, 2022Publication date: August 25, 2022Applicants: University of Florida Research Foundation, Incorporated, The UAB Research FoundationInventors: Sergei Zolotukhin, Sanford L. Boye, Shannon E. Boye, Damien Marsic, Paul D. Gamlin
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Patent number: 11421005Abstract: The invention provides chimeric antigen receptor(s) (CAR(s)) that comprise a fusion protein of CTX or any functional variant thereof or a CTX-like peptide or any functional variant thereof as the extracellular antigen recognition moiety of the CAR. CAR(s) comprising CTX, a CTX-like peptide or functional variants of the foregoing are collectively referred to herein as “CTX-CAR(s).” Such CTX-CAR(s) may further comprise additional moieties or domains in the extracellular domain, a transmembrane domain and at least one intracellular! signaling domain. Such CTX-CAR(s) may be expressed in a host cell, such as, but not limited to, an immune effector cell. The present invention also provides methods of treatment (such as, for example, methods for treating cancer) by providing to the patient in need thereof immune effector cells that are engineered to express a CTX-CAR described herein.Type: GrantFiled: December 9, 2017Date of Patent: August 23, 2022Assignee: The UAB Research FoundationInventors: Lawrence S. Lamb, Jr., Antonio Di Stasi, G. Yancey Gillespie, Larisa Pereboeva
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Publication number: 20220169683Abstract: Provided herein are mutant single-chain Mycobacterium smegmatis porin (Msp) and uses thereof.Type: ApplicationFiled: February 17, 2022Publication date: June 2, 2022Applicant: THE UAB RESEARCH FOUNDATIONInventors: Michael Niederweis, Mikhail Pavlenok