Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. 5 Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
Type:
Application
Filed:
October 28, 2010
Publication date:
December 27, 2012
Applicant:
Univeristy of Pittsburgh of the Commonwealth System of Highter Education
Inventors:
Mohammed El-Kurdi, J. Christopher Flaherty, Yi Hong, Jonathan McGrath, Lorenzo Soletti, John Stankus, David Vorp, William Wagner