Abstract: A lipid nanoparticle that includes at least one antibiotic from the polymyxin family, a lipid fraction, and one or more surfactants. The lipid nanoparticle is useful in the prevention and/or treatment of respiratory tree infections.

Abstract: A method for the accurate quantification of a virus in a sample, by reverse transcription polymerase chain reaction (RT-PCR), includes: adding a known concentration of a Mengo virus to the sample as control for the nucleic acids extraction step, the Mengo virus being a mutant strain with the same growth properties than those of the wild-type Mengo virus, and with non-pathogenic capacity; performing a nucleic acids extraction to obtain a nucleic acids suspension; analyzing the nucleic acids suspension by RT-PCR with primers and probes; quantifying the amplimers resulting from the RT-PCR; determining the concentration of the virus in the sample by comparison of the value obtained with an appropriate standard curve; and determining the concentration of the Mengo virus by comparison of the value obtained with an appropriate standard curve.

Abstract: The present invention relates to a method of production of plants having improved resistance to low-temperature stress, comprising a stage of conversion of the cells of a plant with a sequence of exogenous arginine decarboxylase gene ADC1 under control of a promoter capable of functioning in the plant. Plants thus obtained show resistance to low-temperature stress without the phenotype being affected when compared with the phenotype of plants of the wild type.

Abstract: Method for fully adaptive calibration of a prediction error coder, comprising a first step of initialization; a second step of reception and accumulation of block-size data samples wherein for each received value, it is added one to the histogram bin associated to that value; a third step of analysis of the histogram and determination of the coding option; a fourth step of analysis of the histogram and determination of a coding table; a fifth step of output a header with the prediction error coder coding table determined; and wherein previous steps are repeated if more samples need to be compressed. It is useful as a data compression technique, with the advantage of being faster and more robust than the current CCSDS lossless compression standard.

Abstract: The present invention relates to a compound of formula (I): wherein: R1 and R2 are selected from among H and C1-C10 alkyl; R3 is selected from among H, —OR4, N, —CN, —C(O)R4, —C(O)OR4, —C(O)NR4R5, —C?NR4, —OC(O)R4, —NR4R5, —NR4C(O)R5, —NO2, —N?CR4R5, halogen and C1-C10 alkyl, wherein R4 and R5 are selected from among H, alkyl, alkenyl, cycloalkyl and aryl; X, Y, Z1, Z2 and Z3 are selected independently from among CH and N; A is selected from among (CH2)n, NH, O and CO, wherein n is an integer between 1 and 6, to the procedure for the obtainment of said compounds, to a pharmaceutical composition comprising said compound, and to the use thereof in the treatment of a neurodegenerative disease, more particularly treatment of Alzheimer's or Parkinson's disease.

Abstract: High performance thin-film, transistors are entirely processed at temperatures not exceeding 150° C., using amorphous multi component dielectrics based on the mixture of high band gap and high dielectric constant (K) materials. The sputtered or ink jet printed mixed dielectric materials such as Ta2O5 with SiO2 or Al2O3 or HfO2 with SiO2 or Al2O3 are used. These multicomponent dielectrics allow producing amorphous dielectrics to be introduced in high stable electronic devices with low leakage currents, while preserving a high dielectric constant. This results in producing thin film transistors with remarkable electrical properties, such as the ones produced based on Ga—In—Zn oxide as channel layers and where the dielectric was the combination of the mixture Ta2O5:SiO2, exhibiting field-effect mobility exceeding 35 cm2 V?1 s?1, close to 0 V turn-on voltage, on/off ratio higher than 106 and subthreshold slope below 0.24 V dec?1.

Abstract: It is provided an improved aqueous solution for the preservation of tissues and organs comprising carvedilol, tacrolimus, and trimetazidine. A synergistic effect is observed for this preservation solution which is particularly effective in marginal organs, such as steatotic livers.

Abstract: The present invention provides a standardized method and a kit for an accurate quantification of HAV in clinical and food samples. The general approach is based on the use of several controls to measure the efficiency of those critical steps of the quantification: the nucleic acids extraction and the RT-PCR reactions. The kit comprises: a Mengo virus mutant strain with the same growth properties than those of the wild-type Mengo virus and with no pathogenic capacity; a single stranded RNA molecule corresponding to a fragment of the HAV genome; primers that specifically bind to regions of the 5? non coding region of the HAV genome; a detectable labeled probe that specifically binds to the amplimer resulting from the RT-PCR; and an appropriate molecule to generate an standard curve for the quantification of HAV.

Abstract: The inventors have found that CD6, a member of the Scavenger Receptor Cysteine-Rich (SRSR) superfamily expressed on human lymphocytes binds to Gram-positive and Gram-negative bacteria, as well as to other microbial structures. Thus, a CD6 product is useful for the manufacture of a medicament for therapeutic and/or preventive treatment of an infectious disease or of an inflammatory condition related to an infectious disease or to the presence of a product derived from an infectious agent in a mammal including a human. Examples of such inflammatory conditions are systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock.

Abstract: This invention describes a device for the generation of electric energy from small movements which comprises: a magnet with the shape of a solid of revolution which comprises at least a couple of poles (N, S) placed around an axis of revolution; a tube whose transversal section is complementary to the shape of the magnet, and which comprises a winding rolled transversally around it, with the magnet placed in the interior of the tube so that an inclination of the tube causes the magnet to roll, traveling along the interior of the tube and inducing tension on the winding.

Abstract: The invention relates to a method for obtaining formulations which improve the binding capacity of siRNAs in relation to plasma components, which promote the transport of siRNA in the blood, which increase the passage of siRNA through the cell membrane and, consequently, which increase the inhibitory activity of siRNA. The invention also relates to a method for obtaining a formulation comprising siRNA associated with plasma components, characterised in that the method includes a step in which the plasma components are dispersed in an aqueous medium.

Abstract: The present invention relates to a specific aqueous separation liquid and to a process for removing paint overspray from a paint spray booth comprising: i) directing a gas stream through a paint spray booth; ii) contacting paint overspray with the gas stream flowing through the paint booth thereby forming a paint loaded gas stream containing paint particles or droplets dispersed therein, iii) forming a flowing substantially continuous liquid film of the aqueous separation liquid on a surface positioned within the flow path of the gas stream; iv) directing the paint loaded gas stream to said surface, in order to bring the gas stream in contact with the flowing substantially continuous film of the aqueous separation liquid, thereby transferring paint particles or droplets from the gas stream into the separation liquid to form a first paint loaded separation liquid; and v) removing the first paint loaded separation liquid and the gas stream having a reduced paint load.

Abstract: It is provided an improved aqueous solution for the preservation of tissues and organs comprising carvedilol, tacrolimus, and trimetazidine. A synergistic effect is observed for this preservation solution which is particularly effective in marginal organs, such as steatotic livers.

Abstract: Compounds of formula (I), where: R0 is (C8-C11)-branched alkyl, CH3—(CH2)m—, CH3—O—(CH2CH2O)2CH2—, or phenyl-(CH2)x—; m=6-10; x=1-3; R1, R3, R4, R7, and R8 are independently selected from the formula GF-(CH2)n—; with n=1-4; and GF=—NH2 or —NH—C(?NH)—NH2; R2 is —CH(CH3)(OH), —CH(CH3)2, —CH2NH2 o —CH2OH; R5 and R6 are independently selected among H, —(C1-C4)— linear or branched alkyl, —(CH2)—R10, —CH2—CH2—S—CH3 and —CH—(CH3)—OH; R9 is CONH2, —CH(CH3)(OH) or CONHR11; R10 is phenyl, 3-indolyl, 4-imidazolyl, 4-hydroyiphenyl, ? o ?-naphtyl or 2-, 3- or 4-pyridyl; R11 is a specific peptide sequence; u is CH2 or S; v is NH o S; w is CH2 or CO; with the condition that when R9 is CONH2, then (a) R5 or R6 is —CH(CH3)(OH), or (b) R5 and R6 are H; or (c) the configuration of the C bound to R9 is S or (d) the configuration of the C bound to R5 is R; and with the condition that when R9 is —CH(CH3)OH, then R8 is GF(CH2)n where n is 3 and GF is —NH—C(?NH)—NH2, and R7 is GF(CH2)n where n is 2 and GF is NH2, have been found to

Abstract: The present invention relates to a compound of formula (I) wherein: R1 and R2 are selected from among H and C1-C10 alkyl; R3 is selected from among H, —OR4, N, —CN, —C(O)R4, —C(O)OR4, —C(O)N4R5, —C?NR4, —OC(O)R4, —NR4R5, —NR4C(O)R5, —NO2, —N?CR4R5, halogen and C1-C10 alkyl, wherein R4 and R5 are selected from among H, alkyl, alkenyl, cycloalkyl and aryl; X, Y, Z1, Z2 and Z3 are selected independently from among CH and N; A is selected from among (CH2)n, NH, O and CO, wherein n is an integer between 1 and 6, to the procedure for the obtainment of said compounds, to a pharmaceutical composition comprising said compound, and to the use thereof in the treatment of a neurodegenerative disease, more particularly treatment of Alzheimer's or Parkinson's disease.

Abstract: A monopolar electrosurgical instrument includes a hollow cylindrical metallic electrode which is connected to one pole of a radio frequency generator via a first end of the electrode, and a handle connected to and partially covering the electrode. The electrode includes at least one lumen to permit liquid supply of cooling liquid to the hollow electrode, a part covered with an insulative material, and a coagulating and cutting uninsulated tip. The tip includes a round ending part, a part attached to the cutting metal blade near the round ending part, and a part non-attached to the cutting metal blade. It is useful for precisely cutting the tissue that it is previously coagulated, using a single instrument, and avoiding risk of bleeding.

Abstract: High performance thin-film, transistors are entirely processed at temperatures not exceeding 150° C., using amorphous multi component dielectrics based on the mixture of high band gap and high dielectric constant (K) materials. The sputtered or ink jet printed mixed dielectric materials such as Ta2O5 with SiO2 or Al2O3 or HfO2 with SiO2 or Al2O3 are used. These multicomponent dielectrics allow producing amorphous dielectrics to be introduced in high stable electronic devices with low leakage currents, while preserving a high dielectric constant. This results in producing thin film transistors with remarkable electrical properties, such as the ones produced based on Ga—In—Zn oxide as channel layers and where the dielectric was the combination of the mixture Ta2O5:SiO2, exhibiting field-effect mobility exceeding 35 cm2 V?1 s?1, close to 0 V turn-on voltage, on/off ratio higher than 106 and subthreshold slope below 0.24 V dec?1.

Abstract: Method for fully adaptive calibration of a prediction error coder, comprising a first step of initialization; a second step of reception and accumulation of block-size data samples wherein for each received value, it is added one to the histogram bin associated to that value; a third step of analysis of the histogram and determination of the coding option; a fourth step of analysis of the histogram and determination of a coding table; a fifth step of output a header with the prediction error coder coding table determined; and wherein previous steps are repeated if more samples need to be compressed. It is useful as a data compression technique, with the advantage of being faster and more robust than the current CCSDS lossless compression standard.

Abstract: This invention describes a device for the generation of electric energy from small movements which comprises: a magnet with the shape of a solid of revolution which comprises at least a couple of poles (N, S) placed around an axis of revolution; a tube whose transversal section is complementary to the shape of the magnet, and which comprises a winding rolled transversally around it, with the magnet placed in the interior of the tube so that an inclination of the tube causes the magnet to roll, traveling along the interior of the tube and inducing tension on the winding.

Abstract: The present invention provides a standardized method and a kit for an accurate quantification of HAV in clinical and food samples. The general approach is based on the use of several controls to measure the efficiency of those critical steps of the quantification: the nucleic acids extraction and the RT-PCR reactions. The kit comprises: a Mengo virus mutant strain with the same growth properties than those of the wild-type Mengo virus and with no pathogenic capacity; a single stranded RNA molecule corresponding to a fragment of the HAV genome; primers that specifically bind to regions of the 5? non coding region of the HAV genome; a detectable labeled probe that specifically binds to the amplimer resulting from the RT-PCR; and an appropriate molecule to generate an standard curve for the quantification of HAV.