Patents Assigned to Universidade de Santiago de Compostela
  • Publication number: 20210002245
    Abstract: Gracilin A congeners and methods for their use as immunosuppressive and neuroprotective agents.
    Type: Application
    Filed: March 5, 2019
    Publication date: January 7, 2021
    Applicants: THE TEXAS A&M UNIVERSITY SYSTEM, UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Daniel Romo, Mikail E. Abbasov, Eva Lopez Alonso, Maria Amparo Alfonso Rancano, Miguel Luis Botana Lopez
  • Patent number: 10471020
    Abstract: The present invention generally relates to particles, including nanoparticles, for example, for drug delivery or other applications. Certain aspects of the present invention are generally directed to particles, such as nanoparticles, comprising an inner portion and a coating. The inner portion may contain insulin or other therapeutic molecules for delivery to a living organism. In some cases, the molecules may be electrostatically complexed with an oppositely-charged peptide, such as an oligoarginine, or other species. The therapeutic molecules may also be water soluble. In some cases, the peptide may be conjugated to a hydrophobic portion, such as cholesterol, lauric acid, or a fatty acid chain. This hydrophobic modification may facilitate complex formation with the therapeutic molecule and the stability of the resulting complex. The complex typically is surrounded by a coating, which may protect the complex. For example, the coating may include polymers such as poly(glutamic acid) and poly(ethylene glycol).
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: November 12, 2019
    Assignee: Universidade de Santiago de Compostela
    Inventors: Maria Josefa Alonso Fernandez, Zhigao Niu, Manuel Jesus Santander Ortega
  • Patent number: 10464047
    Abstract: The present invention discloses the use of a metal nanoparticle which comprises at least one semiconductor attached to it, wherein the at least one semiconductor is an atomic quantum cluster (AQC) consisting of between 2 and 55 zero-valent transition metal atoms, as photocatalysts in photocatalytic processes and applications thereof.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: November 5, 2019
    Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Manuel Arturo Lopez Quintela, Jose Rivas Rey
  • Patent number: 10351884
    Abstract: Process for enriching microalgal biomass, in particular of the genus Nannochloropsis, with different polyunsaturated fatty acids, primarily docosahexaenoic acid (22:6 n-3, DHA), using oils that are rich in these fatty acids. The process comprises the following steps: Preparing a solution or an emulsion of lipids+emulsifying agent (BSA), Preparing the biomass concentrate to obtain a final concentration of mg/ml or greater, Enriching the biomass concentrate by adding the lipids or the emulsion thereof to the microalgal concentrate, Allowing the mixture to rest under constant stirring for at least 24 hours under lighting conditions. The process allows for the simultaneous enrichment of microalgal biomass of the genus Nannochloropsis with eicosapentaenoic acid (20:5 n-3) (EPA) and docosahexaenoic acid (22:6 n-3) (DHA), to obtain a minimum EPA:DHA weight ratio of 10:1, with an EPA content of at least 10% of the total fatty acid content.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: July 16, 2019
    Assignees: ALGAENERGY, S.A., UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Ana María Otero Casal, Isabel Freire Fontáns, Hugo Alexandre Milhazes Da Cunha, María Segura Fornieles, Juan Pablo Jiménez Martín
  • Patent number: 10316302
    Abstract: The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS) signals of the Tenacibaculum sp. strain 20J (CECT7426). Said gene encodes a peptide having at least lactonase activity with a percentage of identity less than 38% with the lactonases described up until now for other species, as well as the sequences of the homologous genes present in other species of the genus Tenacibaculum. Said peptide shows a broad spectrum of activity degrading optionally substituted N-acyl-homoserine lactones (AHLs) of 4-14 carbon atoms in the side chain thereof, is active at pH comprised between 3 and 9, proteinase K- and chymotrypsin-resistant and does not interact with ?-lactam antibiotics.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: June 11, 2019
    Assignees: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA
    Inventors: Ana María Otero Casal, Manuel Romero Bernárdez, Celia Mayer Mayer
  • Publication number: 20190144636
    Abstract: Mixtures of salts to dissolve cellulose. The present invention refers to a composition based in a eutectic mixture of imidazolium salts and natural biopolymers, in particular cellulose, its manufacturing process and method of use to obtain foils or films. The composition is based in a eutectic mixture of imidazolium salts with 0.1 to 50 wt % of biomass.
    Type: Application
    Filed: June 29, 2017
    Publication date: May 16, 2019
    Applicants: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, ADAM MICKIEWICZ UNIVERSITY FOUNDATION
    Inventors: Hector RODRIGUEZ MARTINEZ, Ana Maria SOTO CAMPOS, Olga STOLARSKA, Marcin SMIGLAK, Anna PAWLOWSKA
  • Publication number: 20190111002
    Abstract: The invention relates to a nanoparticle comprising: (i) between 60 wt.-% and 99 wt.-% sorbitan ester, relative to the total weight of the nanoparticle; (ii) a positively charged substance; and (iii) a miRNA. The invention also relates to the methods for producing same and to the uses thereof, particularly for therapeutic uses, such as cancer treatment.
    Type: Application
    Filed: April 4, 2017
    Publication date: April 18, 2019
    Applicant: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Alejandro SÁNCHEZ BARREIRO, Inés FERNÁNDEZ PIÑEIRO, Iker BADIOLA, Joana MÁRQUEZ
  • Patent number: 10253000
    Abstract: The present invention refers to pyridazin-3(2H)-one derivatives of general structure I, II and III, which are selective MAO-B inhibitors, and to the use thereof for preparing medicaments intended to treat disorders derived from MAO-B hyperactivity, particularly degenerative disorders of the central nervous system (CNS), such as Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. These are pyridazin-3(2H)-one derivatives having dithiocarbamate moieties bonded to position 4, 5 or 6 through an alkyl chain of variable length (n=1, 2, 3). This invention is also directed to the preparation of said compounds.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: April 9, 2019
    Assignees: UNIVERSIDADE DE VIGO, UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Ma del Carmen Terán Moldes, Pedro Besada Pereira, Tamara Costas Caamaño, Ma del Carmen Costas Lago, Noemí Vila Molares, Dolores Viña Castelao
  • Publication number: 20180371138
    Abstract: The present invention refers to a novel screening method for transfection employing novel acryloyl based amphiphilic polymers.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 27, 2018
    Applicants: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, UNIVERSITY OF BIRMINGHAM
    Inventors: Javier MONTENEGRO GARCIA, Francisco FERNANDEZ-TRILLO
  • Patent number: 10059745
    Abstract: The invention is based on the identification of the minimum region of the avian Orthoreovirus muNS protein which is capable of forming inclusions as well as on the identification of specific regions of the muNS protein showing capacity to associate with the inclusions formed by muNS. The identification of said regions allows developing methods for purifying recombinant polypeptides as well as methods for detecting the interaction between two polypeptides of interest.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: August 28, 2018
    Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Alberto Brandariz Nunez, Rebeca Menaya Vargas, Francisco Javier Benavente Martinez, Jose Manuel Martinez Costas
  • Publication number: 20180236086
    Abstract: A system for administering biologically active substances produced by foaming techniques using compressed gases or supercritical fluids relates to a porous system containing biologically active substances. The system includes a polymer matrix of poly(D,L-lactic-co-glycolic acid) or a polymer mixture containing poly(D,L-lactic-co-glycolic acid) of an intrinsic viscosity of less than 0.5 dL/g with other biodegradable synthetic or semisynthetic polyesters, a release-regulating component (starch and derivatives), and at least one biologically active substance. The matrix is biodegradable with a solid or semisolid consistency and a homogeneous appearance. A method for producing these systems using foaming with compressed fluids, and the use for the production of implants and scaffolds having this system are also disclosed. Optionally, a porogenic agent can be used for the formation of macropores by thermal decomposition.
    Type: Application
    Filed: July 12, 2016
    Publication date: August 23, 2018
    Applicant: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Carlos GARCIA GONZALEZ, Luis A DIAZ GOMEZ, Carmen ALVAREZ LORENZO, Angel J CONCHEIRO NINE
  • Publication number: 20180215718
    Abstract: The present invention refers to pyridazin-3(2H)-one derivatives of general structure I, II and III, which are selective MAO-B inhibitors, and to the use thereof for preparing medicaments intended to treat disorders derived from MAO-B hyperactivity, particularly degenerative disorders of the central nervous system (CNS), such as Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. These are pyridazin-3(2H)-one derivatives having dithiocarbamate moieties bonded to position 4, 5 or 6 through an alkyl chain of variable length (n=1, 2, 3). This invention is also directed to the preparation of said compounds.
    Type: Application
    Filed: March 3, 2015
    Publication date: August 2, 2018
    Applicants: UNIVERSIDADE DE VIGO, UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Mª del Carmen TERÁN MOLDES, Pedro BESADA PEREIRA, Tamara COSTAS CAAMAÑO, Mª del Carmen COSTAS LAGO, Noemí VILA MOLARES, Dolores VIÑA CASTELAO
  • Publication number: 20180078510
    Abstract: The present invention generally relates to particles, including nanoparticles, for example, for drug delivery or other applications. Certain aspects of the present invention are generally directed to particles, such as nanoparticles, comprising an inner portion and a coating. The inner portion may contain insulin or other therapeutic molecules for delivery to a living organism. In some cases, the molecules may be electrostatically complexed with an oppositely-charged peptide, such as an oligoarginine, or other species. The therapeutic molecules may also be water soluble. In some cases, the peptide may be conjugated to a hydrophobic portion, such as cholesterol, lauric acid, or a fatty acid chain. This hydrophobic modification may facilitate complex formation with the therapeutic molecule and the stability of the resulting complex. The complex typically is surrounded by a coating, which may protect the complex. For example, the coating may include polymers such as poly(glutamic acid) and poly(ethylene glycol).
    Type: Application
    Filed: November 14, 2016
    Publication date: March 22, 2018
    Applicant: Universidade de Santiago de Compostela
    Inventors: Maria Josefa Alonso Fernandez, Zhigao Niu, Manuel Jesus Santander Ortega
  • Patent number: 9861588
    Abstract: The invention relates to systems comprising homogenous nanoparticles having an average size of less than 1 micrometer and containing at least a sorbitan ester, a macrogol ester, a macrogol ether or a derivative of same and, optionally, at least one component derived from oxyethylene and/or at least one component having an electric charge (positive or negative). According to the invention, the components are incorporated in a single step consisting in mixing two solutions. The invention also relates to the use of said systems as medicines or medical devices, in tissue engineering or regenerative medicine, for cosmetic, hygienic or nutritional uses, and in surface coatings. The invention further relates to methods for preparing same.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: January 9, 2018
    Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Alejandro Sanchez Barreiro, Begoña Seijo Rey, Giovanni Konat Zorzi, Edison Luis Santana Carvalho, Andrea Pensado Lopez
  • Patent number: 9784680
    Abstract: The present invention relates to nanosystems comprising metal atomic quantum clusters (AQCs) of at least two different sizes encapsulated in a cavity with an inner diameter less than or equal to 10 nm for the use thereof as luminescent nanosystems, particularly for the use thereof as fluorescent nanosystems; as well as the method for obtaining and detecting them. The invention also relates to the use of said luminescent nanosystems as a fluorescent probe, biomarker or contrasting agent.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: October 10, 2017
    Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventor: Manuel Arturo Lopez Quintela
  • Patent number: 9725345
    Abstract: Integrated methanogenic anaerobic reactor and membrane bioreactor, and method for eliminating organic matter and nitrogen in urban or industrial wastewater, preferably with COD concentrations between 150 and 5000 mg/L and where the eliminations of total nitrogen that occur are between 15 and 50 mg/L, at temperatures above 15° C. The wastewater treatment takes place thanks to three stages of treatment: methanogenic anaerobic stage, anoxic stage with biofilms and suspended biomass and aerobic filtration stage with biofilms and suspended biomass.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: August 8, 2017
    Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Juan Manuel Garrido Fernandez, Dagmara Buntner, Alberto Sanchez Sanchez, Juan Manuel Lema Rodicio
  • Patent number: 9663429
    Abstract: The present invention relates to compounds of pharmaceutical interest. More particularly, it relates to compounds of formula (I), to processes for obtaining thereof, to the intermediates of their synthesis and processes for obtaining the latter. The compounds of formula (I) have a certain affinity with the vitamin D receptor, they are active in a similar order to 1,25?-dihydroxyvitamin D3 (1,25D), with the advantage of producing less or no hypercalcemia.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: May 30, 2017
    Assignees: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, UNIVERSIDADE DA CORUNA, SERVIZO GALEGO DE SAUDE (SERGAS)
    Inventors: Roman Perez Fernandez, Samuel Seoane Ruzo, Antonio Mouriño Mosquera, Miguel Maestro Saavedra, Jose Esteban Castelao Fernandez, Pranjal Gogoi
  • Patent number: 9642816
    Abstract: The present invention relates to the design and development of nanocapsule systems for the administration of active substances, wherein the nanocapsules of the system have a mean diameter less than 1 ?m and are characterized by comprising (a) a protamine shell, (b) an oily core, and one or more surfactants characterized by having a hydrophilic-lipophilic ratio greater than 8, provided that said surfactant is not a phospholipid.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: May 9, 2017
    Assignee: Universidade de Santiago de Compostela
    Inventors: María José Alonso Fernández, Noemi Csaba, José Vicente González Aramundiz
  • Patent number: 9421610
    Abstract: Stable atomic quantum clusters, AQCs, characterized by being composed of at least 500 metal atoms, its production process characterized by having a kinetic control and by maintaining a low concentration of reagents in the reaction medium, as well as the uses of these clusters as sensors (fluorescent, magnetic or chemical), electrocatalysts and as cytostatics and/or cytotoxics.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: August 23, 2016
    Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Manuel Arturo Lopez Quintela, Jose Rivas Rey
  • Patent number: 9415019
    Abstract: The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: August 16, 2016
    Assignee: Universidade de Santiago de Compostela
    Inventors: María José Alonso Fernández, Dolores Torres Lopez, Gustavo Rivera Rodriguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo, Teresa Gonzalo Lázaro, Marcos García Fuentes