Patents Assigned to Université Louis Pasteur
  • Patent number: 9073837
    Abstract: A process for the preparation of dimethyl ether by catalytic dehydration of methanol, in which there is used a catalyst based on a zeolite immobilized on a silicon carbide support, for example a zeolite of type ZSM-5 supported on silicon carbide extrudates or on a silicon carbide cellular foam.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: July 7, 2015
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE LOUIS PASTEUR
    Inventors: Svetlana Ivanova, Estelle Vanhaecke, Suzanne Libs, Benoit Louis, Cuong Pham-Huu, Marc Jacques Marie Ledoux
  • Patent number: 8603388
    Abstract: The invention concerns a method for obtaining a metal implant for open porosity tissue support and/or replacement, characterized in that it comprises the following steps: (i) selecting a mould, (ii) arranging in the mould a solid metal core (7), (iii) filling the volume of the mould (1) still available with a powder of microspheres (3), (iv) consolidating the microspheres (3) with each other as well as with said at least one solid core (7) by electrical discharge sintering.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: December 10, 2013
    Assignees: Protip SAS, Universite Louis Pasteur (ULP), Hopitaux Universitaires de Strasbourg (HUS)
    Inventors: Christian Debry, André Walder
  • Patent number: 8551168
    Abstract: The present invention relates to a valve device designed to be implanted in a dysfunctional larynx or in a prosthetic larynx. The valve device has a distal portion forming an annular support structure and a central portion forming an obturator. The obturator includes i) a peripheral part forming a first valve integral with the annular support structure in a first hinge region, and ii) a central part forming a second valve integral with the first valve in a second hinge region.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: October 8, 2013
    Assignees: Protip SAS, Universite Louis Pasteur (ULP), Hopitaux Universitaires de Strasbourg (HUS)
    Inventors: Christian Debry, André Walder, Roland Duffait, Sylvain Lefebvre, Claudia Blank
  • Patent number: 8404216
    Abstract: The invention relates to dendritic chelated compounds, to methods for producing the same and to pharmaceutical compositions containing the same. The dendritic chelated complexes of the present invention have the following formula (I): [[MC]En-[D]m-X1p1X2p2X3p3X4p4]z?zB+ (I), where m is a magnetic or scintigraphic marker, C is a chelating agent of the marker M, E is a spacer, n=0 or 1, D is compound capable of forming a dendritic structure, m is an integer equal to 1 or 2 or 4, X1 is a group increasing the complex lipophily, p1 is an integer from 0 to 12, X2 is a group increasing the complex specificity for a particular organ, p2 is an integer equal to 1 or 2 or 4, X3 is a group having a therapeutic activity, p3 is an integer equal to 0, 1, 2 or 4, X4 is a CH3 group, p4 is an integer from 0 to 12, B is a counter-ion, z is an integer equal to 0, 1, 2, 3 or 4. The invention can be used in the field of pharmacy, more precisely in medical imaging.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: March 26, 2013
    Assignees: Centre National de la Recherche Scientifique, Universite Louis Pasteur
    Inventors: Delphine Felder-Flesch, Jérôme Steibel, Annabelle Bertin
  • Patent number: 8389940
    Abstract: The invention relates to a novel discriminating molecule family for neutron and gamma radiation, and to the preparation method thereof. Said molecules are also useful for detecting radiation (X, gamma, electrons, protons, ions), and thus for manufacturing radar, and industrial or medical dosimetry instruments.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: March 5, 2013
    Assignee: Universite Louis Pasteur de Strasbourg
    Inventors: Remi Barillon, Ezeddine Bouajila, Laurent Douce, Jean-Marc Jung, Louise Stuttge
  • Patent number: 8158135
    Abstract: The present invention relates to a delivery system based on a film of an imine forming liquid crystalline phase, mixed with at least with one biologically active substance, to which a constant or variable electric field can be applied. The delivery system can be used as a delivery system for biologically active substances such as flavors, fragrances, bactericides, fungicides, insecticides, insect attractants or repellents, agrochemicals or pharmaceuticals.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: April 17, 2012
    Assignees: Firmenich SA, Universite Louis Pasteur, Centre National de la Recherche Scientifique
    Inventors: Jean-Marie Lehn, Nicolas Giuseppone, Andreas Herrmann
  • Patent number: 8124578
    Abstract: The present invention relates to a delivery system in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one hydrazine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide or fungicide aldehyde or ketone. The inventive mixture is capable of releasing in a controlled and prolonged manner the aldehyde or ketone in the surrounding environment. Furthermore, the present invention concerns also the use of these dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles that include such mixtures.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: February 28, 2012
    Assignees: Firmenich SA, Universite Louis Pasteur, Centre National de la Recherche Scientifique
    Inventors: Jean-Marie Lehn, Andreas Herrmann
  • Publication number: 20110303850
    Abstract: The invention relates to a novel discriminating molecule family for neutron and gamma radiation, and to the preparation method thereof. Said molecules are also useful for detecting radiation (X, gamma, electrons, protons, ions), and thus for manufacturing radar, and industrial or medical dosimetry instruments.
    Type: Application
    Filed: July 10, 2009
    Publication date: December 15, 2011
    Applicants: Universite Louis Pasteur De Strasbourg, Centre National De La Receherche Scientifique (C.N.R.S.)
    Inventors: Remi Barillon, Ezeddine Bouajila, Laurent Douce, Jean-Marc Jung, Louise Stuttgé
  • Patent number: 7991730
    Abstract: A computer-based method for identifying at least one pair of similar chemical reactions between a plurality of reactions each related to preparation of at least one product from at least one reagent may include generating for each reaction a structural representation involving dynamic and conventional bonds and, based on the this structural representation, generating for each reaction a set of fragment descriptors of a predetermined length comprising the dynamical bonds and a corresponding descriptor vector. The method may further include calculating similarity indices between descriptor vectors of the plurality of reactions and comparing the similarity indices to identify at least one pair of similar reactions.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: August 2, 2011
    Assignees: Novalyst Discovery, Universite Louis Pasteur
    Inventors: Alain Wagner, Frank Hoonakker, Alexandre Varnek
  • Patent number: 7988861
    Abstract: A method of preparing a solid material based on tangled nanotubes and/or nanofibers, includes a step of growing carbon nanofibers and/or nanotubes with restraint in a contained reactor; and the materials thus obtained. The different uses of the materials are also disclosed.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: August 2, 2011
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite Louis Pasteur
    Inventors: Cuong Pham-Huu, Marc-Jacques Ledoux, Dominique Begin, Patrick Nguyen, Julien Amadou, Jean-Philippe Tessonnier
  • Patent number: 7981436
    Abstract: The present invention relates to the formation of hydrogels based on guanosine hydrazide derivatives in the presence of cations. The hydrogels can be used as a carrier/delivery system for biologically active substances such as flavors, fragrances, insect attractants or repellents, bactericides, fungicides, pharmaceuticals or agrochemicals.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: July 19, 2011
    Assignees: Firmenich SA, Universite Louis Pasteur, Centre National de la Recherche Scientifique
    Inventors: Jean-Marie Lehn, Nampally Sreenivasachary, Andreas Herrmann
  • Publication number: 20110106251
    Abstract: The present invention relates to a valve device designed to be implanted in a dysfunctional larynx or in a prosthetic larynx, said device comprising a distal portion forming an annular support structure and a central portion forming an obturator, characterized in that said obturator comprises i) a peripheral part forming a first valve integral with the annular support structure in a first hinge region, and ii) a central part forming a second valve integral with the first valve in a second hinge region.
    Type: Application
    Filed: December 2, 2008
    Publication date: May 5, 2011
    Applicants: PROTIP SAS, UNIVERSITE LOUIS PASTEUR (ULP), HOPITAUX UNIVERSITAIRES DE STRASBOURG (HUS)
    Inventors: Christian Debry, André Walder, Roland Duffait, Sylvain Lefebvre, Claudia Blank
  • Patent number: 7897786
    Abstract: The invention relates to unsaturated dipyrromethene-boron borocarbons of formula (I) and the use thereof for fluorescence or electroluminescent analysis. The fluorescent properties are provided by the central ring of six atoms comprising the —N—B—N— sequence, R1 to R7 permitting the modification of the compound properties (fluorescence emission wavelength, quantitative fluorescent yield), at least one of the substituents S1 and S2 has a chromophore end group which permits an excitation of the molecule at wavelengths close to those of the substituent chromophore. A preferably selected from the chromophore substituents with a wavelength close to the ultraviolet which significantly increases the Stokes displacement.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: March 1, 2011
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite Louis Pasteur de Strasbourg
    Inventors: Gilles Ulrich, Raymond Ziessel, Christine Goze
  • Patent number: 7881823
    Abstract: The invention relates to a robotic device for the positioning and orientation of a platform that is connected thereto by means of articulated support structures forming parallel mechanical links, each in the form of a serial kinematic chain of articulations that are interconnected by support segments. The inventive device (1) is characterized in that it comprises three articulated parallel mechanical links comprising: (i) two opposing, symmetrical and co-planar support structures (4 and 5), and (ii) a third support structure (6) which is located in a plane that is perpendicular to the plane containing the support structures (4 and 5). According to the invention, the articulated links formed by the three supports structures (4, 5 and 6) enable the controlled movement of points belonging to the platform (2) on a surface corresponding to a spherical or ellipsoidal cap and, preferably, essentially to a half-sphere, thereby providing at least five degrees of freedom.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: February 1, 2011
    Assignees: Institut National des Sciences Appliquees, Institut de Recherche sur les Cancers de l'Appareil Digestif - IRCAD, Universite Louis Pasteur, Centre National de la Recherche Scientifique
    Inventors: Michel Demathelin, Benjamin Maurin, Bernard Bayle, Jacques Gangloff, Olivier Piccin
  • Patent number: 7880021
    Abstract: 3-hydroxyflavone derivatives are useful in the detection and the quantification of cell apoptosis. Such derivatives are also useful as fluorescent probes in studying lipid asymmetry of cell plasma membrane and in detecting apopoptic cells. The derivatives can be used to monitor the evolution of diseases involving cell apoptosis.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: February 1, 2011
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Louis Pasteur (Strasbourg I)
    Inventors: Yves Mely, Andrey Klymchenko, Oleksandr Demchenko, Vasyl Shynkar
  • Publication number: 20110019511
    Abstract: The invention concerns a optical data memory, said memory comprising at least one layer of supporting material, said supporting material including molecules having, in a local zone, a collective state of molecules from at least one first collective state of molecules, and a second collective state of molecules. The invention is characterized in that only molecules having the first collective state of molecules in said local zone are capable of generating a second-harmonic signal when they are excited in said local zone by a reading electromagnetic radiation.
    Type: Application
    Filed: May 4, 2007
    Publication date: January 27, 2011
    Applicants: Centre National De La Recherche Scientifique -CNRS-, Universite Louis Pasteur Industrie
    Inventors: Alain Fort, Kokou Dorkenoo, Denis Gindre, Alberto Barsella
  • Patent number: 7838299
    Abstract: The invention relates to compounds, to the complexes they form with a lanthanide, and to the use of the complexes for fluorescence marking or NMR imaging. The complex consists of an Ln ion and a ligand R2—C(X—R1)(R3)—NR4R5. R1 is a functional group, X is a single bond or a hydrocarbon-based chain consisting of at least one alkylene or alkenylene group optionally comprising at least one hetero atom or an arylene. R2 is an anionic group A2 or a C1-C4 alkylene or alkenylene group bearing at least one such group A2 and optionally comprising at least one hetero atom. R3 is H or a C1-C5 alkylene or alkenylene group optionally containing at least one hetero atom, and optionally bearing at least one anionic group A3. R4 is a substituent with light-absorbing properties that forms chelate rings with Ln. R5 is a substituent that forms chelate rings with Ln.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: November 23, 2010
    Assignees: Centre National de la Recherche Scientifique, Universite Louis Pasteur de Strasbourg
    Inventors: Loïc Charbonniere, Raymond Ziessel, Nicolas Weibel, Aldo Roda, Massimo Guardigli
  • Patent number: 7784329
    Abstract: The invention relates to a piezo-rheometric measuring cell for shear or compression measurement, essentially comprising two sample holder plates, with the sample for analysis between the same in solid, liquid or intermediate form, piezoelectric ceramic elements on the faces of the plates opposite to the faces in contact with the sample and a construction forming the housing and compressing the arrangement of plates and ceramic elements, one or more ceramics called emitter, being connected to one of the two plates or the emitter plate and subjecting the same to shear or compression vibrations by means of an excitation signal and one or more ceramics, called receiver, being connected to the other plate or receiver plate and converting the forces to which the same is subject into a measured signal.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: August 31, 2010
    Assignee: Universite Louis Pasteur (Etablissement Public a Caractere Scientifique, Culturel et Professionnel)
    Inventors: Philippe Martinoty, Dominique Collin
  • Patent number: 7745413
    Abstract: The use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; R1 and R?1 represent in particular a hydrogen atom; R2 represents an amino acid side chain or an amino acid derivative; R3 represents a group derived from a carboxylic acid, bearing a basic entity; R4 represents in particular an alkyl group containing 1 to 10 carbon atoms; and A represents a hydrogen atom, a protecting group or a tracing group, in particular a fluorophor, a coloring agent or a quencher, for determining, through binding studies, ligands of receptors whose ligand is unknown or whose ligand useful for carrying out specific affinity binding assays is unknown.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: June 29, 2010
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Louis Pasteur
    Inventors: Marcel Francois Louis Hibert, Christel Anne Franchet, Jean-Luc Galzi, Franc Emile Jean Pattus, Fabrice Yves Guillier
  • Patent number: 7727526
    Abstract: The present invention concerns the use of a PTHrP antagonist for preparing a pharmaceutical composition for treating renal cell carcinoma (RCC) in a mammal and in particular in a human subject. Advantageously, the invention is of particular interest for inhibiting or reducing tumour growth and/or metastasis formation in kidney cancer and its metastatic developments, in particular in the lung and the liver.
    Type: Grant
    Filed: July 4, 2003
    Date of Patent: June 1, 2010
    Assignees: Universite Louis Pasteur, Institut National de la Sante et de la Recherche Medicale (INSERM), Hopitaux Universitaires de Strasbourg
    Inventors: Thierry Massfelder, Herve Lang, Eric Schordan, Jean-Jacques Helwig