Abstract: The invention relates to compounds, to the complexes they form with a lanthanide, and to the use of the complexes for fluorescence marking or NMR imaging. The complex consists of an Ln ion and a ligand R2—C(X—R1)(R3)—NR4R5. R1 is a functional group, X is a single bond or a hydrocarbon-based chain consisting of at least one alkylene or alkenylene group optionally comprising at least one hetero atom or an arylene. R2 is an anionic group A2 or a C1-C4 alkylene or alkenylene group bearing at least one such group A2 and optionally comprising at least one hetero atom. R3 is H or a C1-C5 alkylene or alkenylene group optionally containing at least one hetero atom, and optionally bearing at least one anionic group A3. R4 is a substituent with light-absorbing properties that forms chelate rings with Ln. R5 is a substituent that forms chelate rings with Ln.

Abstract: A compound of the general formula (I) as an active principle for treating cancer, specifically tumors, in particular diseases involving inhibition of metalloproteases, such as Aminopeptidase-N. Pharmaceutical compositions comprising the compound of general formula (I). Methods of treatment using the compound of general formula (I).

Abstract: An implant being urged to be positioned between the thyroid cartilage (22) and a vocal cord (20) so as to displace the latter in order to restore the speech to a patient, characterized in that it comprises: i) a “prosthesis” (3) being urged to rest on the muscle of the vocal cord (20), ii) a “counterplate” (5) resting on the internal wall of the thyroid cartilage (22), and iii) a liking element (7) of the prosthesis (3) and the counterplate (5), said counterplate (5) being mobile on said at least one linking element (7), thus enabling the adjustment of the distance D between the prosthesis (3) and the counterplate (5) to maintain the implant (1) in place.

Abstract: A process for the preparation of dimethyl ether by catalytic dehydration of methanol, in which there is used a catalyst based on a zeolite immobilized on a silicon carbide support, for example a zeolite of type ZSM-5 supported on silicon carbide extrudates or on a silicon carbide cellular foam.

Abstract: The present invention relates to a delivery system based on a film of an imine forming liquid crystalline phase, mixed with at least with one biologically active substance, to which a constant or variable electric field can be applied. The delivery system can be used as a delivery system for biologically active substances such as flavors, fragrances, bactericides, fungicides, insecticides, insect attractants or repellents, agrochemicals or pharmaceuticals.

Abstract: The invention concerns a method for obtaining a metal implant for open porosity tissue support and/or replacement, characterized in that it comprises the following steps: (i) selecting a mould, (ii) arranging in the mould a solid metal core (7), (iii) filling the volume of the mould (1) still available with a powder of microspheres (3), (iv) consolidating the microspheres (3) with each other as well as with said at least one solid core (7) by electrical discharge sintering.

Abstract: A monolithic active pixel dosimeter, provided with at least a sensing cell, having at least a junction sensing element. The junction sensing element includes a sensing region, having a first type of conductivity, and a charge collecting region, contiguous to the sensing region and having a second type of conductivity. The sensing cell further includes an ohmic region at least partially overlapping and extending laterally outside the charge collecting region, and an annular insulating region, abutting the ohmic region, so as to form an insulating junction surrounding both the ohmic region and the charge collection region.

Abstract: The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.

Abstract: The invention relates to vitamin D derivatives and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having different interesting biological properties, including vitamin D nuclear receptor (VDR) agonist activity, as well as therapeutics methods by administering said compounds, in particular for treating cancer, psoriasis, autoimmune diseases, osteodistrophy and osteoporosis. It further relates to pharmaceutical compositions comprising said compounds and methods for preparing the same.

Abstract: The invention relates to a system for inducible expression in cyanobacteria, which enables the expression of recombinant proteins, and to the vectors and cyanobacteria containing said expression system.

Abstract: The invention relates to macromolecules auto-assembled and photopolymerised around carbon nanotubes. Said macromolecules are essentially formed from rings of lipid compounds, polymerised about the nanotubes, said polymerised compounds being obtained from lipid molecules with one or two chains A, bonded to a group Z where A is a chain, CH3—(CH2)m—C?C—C?C—(CH2)n—, where n and m, independently=whole numbers from 1 to 16 and Z is a polar head group embodied by a —COOH, —CO—NH—Y, —NH2 or N+(R)3, where R is an alkyl with C1, to C4 and Y is a —(CH2)4—C(R1)—N(CH2—COOH)2 group with R=H, or a COOH group, where A is a single lipid chain or a group of structure (I) or (II), where R2=a COOH, or —CO—NH—Y1 group with Y1=a —(CH2)4—C (R3)—N(CH2COOH)2 group with R3=H or a COOH group, where Z and R2 can also be neutral polar head groups of the sugar or polysaccharide type.

Abstract: The invention concerns a phonatory implant (1) consisting of a central portion (3) forming a hollow cylindrical body having at each of its ends a lateral portion (5, 7) forming a shoulder or flange, said implant (1) being urged to be positioned in an opening or fistula running through the tracheoesophageal wall (9), each lateral portion (5, 7) abutting respectively at the inner surfaces of the walls of the trachea (13) and of the esophagus (11) so as to maintain the implant (1) in position, said phonatory implant (1) consisting of at least two parts (A, B), at least one of the two parts being called mobile part (B), and each lateral portion (5, 7) being arranged on a different part of the implant (1) so as to enable the implant to be inserted through an opening of reduced size corresponding to the diameter of the central portion.

Abstract: This invention relates to ?-SiC foam parts with a specific surface area preferably equal to at least 5 m2/g and with at least two zones A and B with a different cellular porosity distribution, wherein the parts were made by chemical transformation of a porous precursor medium comprising at least two blocks A? and B?, each having a different cellular porosity distribution, and in that the at least two zones A and B are derived from the chemical transformation of the two blocks A? and B?. This foam, optionally after deposition of an active layer, may be used as a filter medium in cartridges designed for the purification of exhaust gases. The invention also relates to manufacturing processes for preparing such a filter medium.

Abstract: The photocatalyst based on a composite WO3—SiC/TiO2 semiconductor and subjected to radiation whose wavelength is at least partly less than 400 nm gives1 photocatalytic oxidation of volatile organic compounds and leads to their total mineralisation into CO2 and H2O. The process for the photocatalytic purification of industrial, agricultural or domestic gaseous effluent may be conducted at room pressure and temperature. Its conversion rate is high and stable.

Abstract: The invention relates to a piezo-rheometric measuring cell for shear or compression measurement, essentially comprising two sample holder plates, with the sample for analysis between the same in solid, liquid or intermediate form, piezoelectric ceramic elements on the faces of the plates opposite to the faces in contact with the sample and a construction forming the housing and compressing the arrangement of plates and ceramic elements, one or more ceramics called emitter, being connected to one of the two plates or the emitter plate and subjecting the same to shear or compression vibrations by means of an excitation signal and one or more ceramics, called receiver, being connected to the other plate or receiver plate and converting the forces to which the same is subject into a measured signal.

Abstract: The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine.

Abstract: A device for supporting and controlling the translational movement of an elongated body, the body extending along the longitudinal axis thereof in the form of a rod, such as a needle intended for a percutaneous medical procedure. The device is designed to be mounted to a support that can be controlled in terms of position and orientation, and includes: (i) a first member for gripping the body, whose movement can be controlled in the translation direction with a pre-determined maximum stroke; and (ii) a second fixed member which can guide the elongated body when the body is moved by the first mobile gripping member and which can maintain the body in position when the body is not engaged with the first member.

Abstract: A method of preparing a solid material based on tangled nanotubes and/or nanofibres, includes a step of growing carbon nanofibres and/or nanotubes with restraint in a contained reactor; and the materials thus obtained. The different uses of the materials are also disclosed.

Abstract: A method for inactivating biological agents dispersed within a gaseous medium includes a step which consists in treating the gas flow with a photoactivated semiconductor, in particular with photoactivated titanium oxide. The invention also concerns a device for implementing the method, as well as the method for decontaminating gaseous medium containing harmful, toxic or pathogenic biological agents, such as bacteria.

Abstract: The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.