Patents Assigned to UNIVERSITÉ PIERRE ET MARIE CURIE
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Patent number: 10323078Abstract: A present invention relates to isolated peptides obtained from human fibrinogen for their use as drug, particularly for the prevention and/or the treatment of inflammatory skin diseases, more particularly acne. The present invention also relates to fragments of these polypeptides, nucleic acid molecules encoding them, expression vectors, host cells, a pharmaceutical composition and a combination product containing them, and their use for treating and/or preventing inflammatory skin diseases, particularly acne.Type: GrantFiled: March 21, 2016Date of Patent: June 18, 2019Assignees: Universite Paris Descartes, Assistance Publique—Hopitaux De Paris, Universite Paris—Sud, Universite Pierre et Marie Curie (Paris 6), Institut National De La Sante et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Institut Gustave-RoussyInventors: Nicolas Dupin, Philippe Grange, Vincent Calvez, Joël Raingeaud
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Publication number: 20190125723Abstract: The present invention relates to compounds of the following general formula (I) or (II) or a pharmaceutically acceptable salt and/or solvate thereof, for use in the prevention and/or the treatment of disorders associated to gammaherpesvirinae, in particular to the human herpesvirus 8 (HHV8) or the human herpes virus 4 (HHV4), and pharmaceutical compositions containing such compounds.Type: ApplicationFiled: June 28, 2017Publication date: May 2, 2019Applicants: Assistance Publique - Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Pierre et Marie Curie (Paris 6), Universite Paris Descartes, Centre National de la Recherche Scientifique (CNRS)Inventors: Nicolas Dupin, Anne-Geneviève Marcelin, Vincent Calvez, Philippe Grange
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Patent number: 10267732Abstract: A method for detection of at least one reversibly photo-convertible fluorescent species, comprises the following steps: a) illumination of a sample comprising said or at least one of the reversibly photo-convertible fluorescent species by a periodically modulated illuminating light; and b) detection of fluorescent emission emitted by the sample thus illuminated; wherein the method further comprises the following step: c) extraction of the amplitude of the intensity component of the fluorescent emission exhibiting the same periodicity as the periodically modulated illuminating light and a phase quadrature with respect to the same; and wherein the mean intensity of the illuminating light and the modulation frequency of the same are chosen to maximize the amplitude of the intensity component of the fluorescent emission.Type: GrantFiled: November 21, 2014Date of Patent: April 23, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, ECOLE NORMALE SUPERIEURE DE PARIS, UNIVERSITE PIERRE ET MARIE CURIEInventors: Ludovic Jullien, Thomas Le Saux, Arnaud Gautier, Vincent Croquette, Nath Sarang, Pencheng Wang, Jérôme Querard, Samantha Albright
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Publication number: 20190083776Abstract: The invention relates to a process for manufacturing at least one implant for focal electrical stimulation of a nervous structure, said implant being of the type including in a supporting structure a network of cavities at the bottom of which are placed microelectrodes, the cavities being bounded by walls erected and located around the microelectrodes, the supporting structure being produced beforehand by implementing the following steps: deposition and etching, in a planar manner, on an insulating substrate, of electrical contacts, of electrical tracks and of microelectrodes, first tracks electrically connecting the microelectrodes and the electrical contacts, second electrical tracks being electrically connected to a ground.Type: ApplicationFiled: November 19, 2015Publication date: March 21, 2019Applicants: Chambre de Commerce et D'Industrie de Region Paris Ile de France (ESIEE Paris), Universite Pierre Et Marie Curie (Paris 6), Centre National de la Recherche Scientifique (CNRS ), Institut National de la Sante et de la Recherche M edicale (INSERM)Inventors: Lionel Rousseau, Gaëlle Lissorgues, Myline Cottance, Serge Picaud, Julie Degardin
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Patent number: 10227653Abstract: The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, the polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions containing the same. The invention is also directed to the use of the polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.Type: GrantFiled: September 14, 2016Date of Patent: March 12, 2019Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)Inventors: Christophe Prehaud, Monique Lafon, Nicolas Wolff, Zakir Khan, Elouan Terrien, Sandrine Vitry
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Publication number: 20190018230Abstract: The present disclosure concerns a broadband hyperspectral imaging spectrophotometer configured to analyze an object and includes an illumination assembly having a source for emitting a light beam and configured so that the light beam scans line by line the object to be analyzed, a focusing mirror, a first mirror folding, and a planar scanning mirror movable in rotation. The illumination assembly, the focusing mirror, the first folding mirror and the planar mirror are arranged to bring the light beam to the object along a line which will be displaced on the object via the scanning mirror. The imaging spectrophotometer further includes two measuring sensors by a distance between the object and the scanning mirror. The focusing mirror is movable in translation to adapt the imager to the measured distance by the measuring sensors.Type: ApplicationFiled: July 6, 2018Publication date: January 17, 2019Applicants: Centre National d'Études Spatiales, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)Inventors: Frédéric BOURCIER, Philippe WALTER
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Patent number: 10179921Abstract: The present invention relates to a method for producing polyphenol compounds, i.e. phloroglucinol or one of its derivatives, with a polyketide synthase of type III (PKSIII) from a brown marine alga. The invention also relates to recombinant nucleic acids coding for a polyketide synthase of type III (PKSIII) from the brown alga Ectocarpus siliculosus (E. siliculosus), to recombinant vectors comprising these nucleic acids, as well as to host cells comprising these vectors. Finally, the invention relates to a method for preparing of various compounds by means of polyphenol compounds produced according to the aforementioned method.Type: GrantFiled: September 26, 2012Date of Patent: January 15, 2019Assignees: UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)Inventors: Ludovic Delage, Laurence Meslet-Cladiere, Philippe Potin, Sophie Goulitquer
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Publication number: 20190011317Abstract: Disclosed is a force sensor, including: at least one measurement cell, each measurement cell being filled with a filling material in which at least one inclusion of a substance is embedded; for each cell, at least one light source arranged in order to illuminate the inclusion embedded in this cell; for each cell, a measurement system including at least one optical measurement point arranged in order to capture light originating from the inclusion embedded in this cell; for each cell, a unit arranged in order to convert optical signals originating from the measurement system of this cell to a signal representative of a force exerted on this cell, this signal being dependent on a movement of the inclusion embedded within the filling material of this cell.Type: ApplicationFiled: August 11, 2016Publication date: January 10, 2019Applicants: MUSEUM NATIONAL D'HISTOIRE NATURELLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT - PARIS 7Inventors: Séverine TOUSSAINT, Artémis LLAMOSI
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Patent number: 10159684Abstract: The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention also relates to a topical pharmaceutical composition comprising an amount of at least one glucocorticoid and an amount of at least one mineralocorticoid receptor antagonist or inhibitor of MR expression for use in a method for treating an inflammatory skin disease or an inflammatory disease of the cornea or of the anterior segment of the eye in a subject in need thereof.Type: GrantFiled: June 8, 2017Date of Patent: December 25, 2018Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DESCARTES, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP)Inventors: Nicolette Farman, Frederic Jaisser, Francine Behar-Cohen, Selin Aractingi, Van Tuan Nguyen
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Publication number: 20180361378Abstract: The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.Type: ApplicationFiled: May 6, 2016Publication date: December 20, 2018Applicants: Paris Sciences Et Lettres - Quartier Latin, Centre National de la Recherche Scientifique (CNRS ), Universite Pierre Et Marie Curie (Paris 6), Universite Paris Diderot Paris 7Inventors: Vincent Croquette, David Bensimon, Jimmy Ouellet, Jean-François Allemand, Charles Andre, Gordon Hamilton
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Patent number: 10154235Abstract: A device for displaying an image sequence in the form of a pixel matrix, includes a control unit coupled to a projector. The control unit includes an input interface designed to receive asynchronous information representing, for each pixel of the matrix, events concerning the pixel, and a processor designed to control the activation of each pixel of the matrix at moments determined by the respective events indicated by the asynchronous information for the pixel. The projector is disposed on a support so as to illuminate the light receptors of the eye when the device is in use and is designed to project a light flux corresponding to the pixels activated by the control unit.Type: GrantFiled: March 12, 2015Date of Patent: December 11, 2018Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventors: Ryad Benosman, Guillaume Chenegros, Serge Picaud, Siohoi Ieng, Jose-Alain Sahel
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Patent number: 10109057Abstract: Asynchronous information is provided by a sensor having a matrix of pixels disposed opposite the scene. The asynchronous information includes, for each pixel of the matrix, successive events originating from this pixel, that may depend on variations of light in the scene. A model representing the tracked shape of an object is updated after detecting events attributed to this object in the asynchronous information. Following detection, the updating of the model includes an association of a point of the model with the event detected by minimizing a criterion of distance with respect to the pixel of the matrix from which the detected event originates. The updated model is then determined as a function of the pixel of the matrix from which the detected event originates and attributed to the object and of the associated point in the model, independently of the associations performed before the detection of this event.Type: GrantFiled: April 24, 2015Date of Patent: October 23, 2018Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)Inventors: Ryad Benosman, Siohoi Ieng, Stephane Regnier, Ni Zhenjiang
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Patent number: 10106765Abstract: The invention relates to a method for producing microalgae on a support (14) that is movably mounted essentially in an aqueous medium contained in a tank (12), said method comprising a succession of phases in which the microalgae developing on the support (14) are exposed to sunlight and phases in the shade, the light intensity received in the shade being less than 50% of the average light intensity received during the sunlight exposure phases. The total length of the shade phases is more than 50% longer than the total length of the sunlight exposure phases.Type: GrantFiled: July 15, 2014Date of Patent: October 23, 2018Assignees: Inria Institut National De Recherche En Informatique Et En Automatique, Centre National De La Recherche Scientifique (C.N.R.S), Ecole Centrale Paris, Universite Pierre Et Marie Curie (Paris 6)Inventors: Olivier Bernard, Filipa Lopes, Eric Pruvost, Antoine Sciandra
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Patent number: 10107745Abstract: A method and a device allow optical properties of a sample to be estimated. The method includes the illumination of the sample by a first light source, and the formation of an image of the sample thus illuminated, on the basis of which a first optical property is estimated, at various points on a surface of the sample. The method also includes measuring an auxiliary optical property of the sample and estimating the first optical property, taking account of the auxiliary optical property measured on the sample.Type: GrantFiled: April 21, 2017Date of Patent: October 23, 2018Assignees: Commissariat à l'énergie atomique et aux énergies alternatives, Centre National De la Recherche Scientifique, Université Pierre et Marie Curie (Paris 6)Inventors: Veronica Sorgato, Michel Berger, Anne Planat-Chretien, Christine Vever-Bizet, Genevieve Bourg-Heckly, Charlotte Emain
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Publication number: 20180277840Abstract: The present application describes a process for the preparation of titanium-based compounds having an anatase type structure with cationic vacancies arising from a partial substitution of oxygen atoms by fluorine atoms and hydroxyl groups. Electrochemically active materials comprising the titanium-based compounds for use in lithium-ion battery electrodes are also described.Type: ApplicationFiled: November 20, 2015Publication date: September 27, 2018Applicants: HYDRO-QUÉBEC, UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Damien DAMBOURNET, Wei LI, Henri GROULT, Sandrine LECLERC, Christian JULIEN, Karim ZAGHIB
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Patent number: 10077294Abstract: The invention relates to an isolated peptide inhibitor of the interaction between the TEAD and YAP or TAZ proteins and a derived chimeric peptide linked to a cell-penetrating peptide. These peptides which have a cytotoxic activity are useful, in particular for the treatment of hyperproliferative disorders such as cancer.Type: GrantFiled: November 4, 2014Date of Patent: September 18, 2018Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), INSTITUT CURIEInventors: Angelita Rebollo Garcia, Fariba Nemati, Didier Decaudin
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Publication number: 20180251523Abstract: The invention relates to a peptide comprising the following amino acid sequence useful as a CCR2 non competitive antagonist peptide.Type: ApplicationFiled: May 1, 2018Publication date: September 6, 2018Applicant: UNIVERSITE PIERRE ET MARIE CURIE (Paris 6)Inventors: Christophe Combadiere, Florian Sennlaub, Constance Auvynet, Sylvian Chemtob, Christiane Quiniou
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Patent number: 10059748Abstract: The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.Type: GrantFiled: June 8, 2015Date of Patent: August 28, 2018Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE)Inventors: Daniel Dunia, Marion Szelechowski, Alexandre Betourne, Stephane Hunot
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Patent number: 10042052Abstract: A method for determining a location of a reflecting scatterer (S) in a medium (M) including a transmitting step in which a transducer (4) emits a transmit wave (T), a receiving step in which a receive array (3) provide transducer signals in response to a reflected wave (R), a beam forming step in which beam formed signals are computed, an interferometric processing step during which a complex interferometric signal is determined as a function of products of beam formed signals and conjugate of beam formed signals and a location determining step in which interferometric beam samples are selected from the complex interferometric signal, based on their complex arguments. The selected interferometric beam samples are indicatives of the location of the reflecting scatterer (S).Type: GrantFiled: August 1, 2014Date of Patent: August 7, 2018Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventor: Pierre Cervenka
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Publication number: 20180207423Abstract: Disclosed is a method for processing asynchronous signals generated by a light sensor, the sensor having a matrix of pixels, the method including: —receiving the asynchronous signals, each signal being associated with a pixel in a group of pixels in the matrix, each signal including successive events issued by the associated pixel; —upon an occurrence of an event in one of the asynchronous signals, updating an integration value associated to the group by adding an additive value to the integration value; —if the integration value is greater than a predetermined threshold, generating an event in an outputted asynchronous signal.Type: ApplicationFiled: July 18, 2016Publication date: July 26, 2018Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Ryad BENOSMAN, Francesco GALLUPI, Guillaume CHENEGROS, Xavier LAGORCE, Christoph POSCH