Patents Assigned to Universita' Degli Studi di Bari
  • Publication number: 20210148854
    Abstract: Described herein is a field effect transistor sensor including: a substrate, a source electrode, a drain electrode, a gate electrode functionalized with a layer of biological recognition elements, a source-drain channel and a semiconductor layer. The layer of biological recognition elements of the gate electrode is patterned into a plurality of uncoupled domains.
    Type: Application
    Filed: May 22, 2018
    Publication date: May 20, 2021
    Applicant: UNIVERSITA' DEGLI STUDI DI BARI ALDO MORO
    Inventors: Luisa TORSI, Gerardo PALAZZO, Gaetano SCAMARCIO
  • Publication number: 20200410706
    Abstract: A process and device for the plenoptic capture of photographic or cinematographic images are described, both based on the correlation measure or “Correlation Plenoptic Imaging” (CPI), comprising the steps of splitting a primary light beam (6) coming from at least one light source in at least two distinct light beams (7, 8), directing said distinct light beams towards two image capturing sensors to capture images, so that the first light beam is directed towards at least one first capturing sensor to capture a spatial measure of a scene and the second light beam is directed towards a second capturing sensor to capture an angular measure of said scene, said angular measure being adapted to provide the propagation direction of the light beam coming from the scene, said spatial measure being adapted to provide the conventional two-dimensional capture of the image of the scene.
    Type: Application
    Filed: September 26, 2017
    Publication date: December 31, 2020
    Applicant: Universita' Degli Studi Di Bari Aldo Moro
    Inventors: Milena D'ANGELO, Augusto GARUCCIO, Francesco Vincenzo PEPE, Ornella VACCARELLI
  • Patent number: 10576127
    Abstract: An object of the present invention is the use of Irisin for the treatment and/or prevention of osteoporosis. In particular, the present invention refers to the use of recombinant irisin for the treatment and/or prevention of osteoporosis. A method for preventing and/or treating osteoporosis by administering an effective amount of irisin to a subject, is provided.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: March 3, 2020
    Assignees: UNIVERSITA' DEGLI STUDI DI BARI, UNIVERSITA' POLITECNICA DELLE MARCHE
    Inventors: Maria Grano, Graziana Colaianni, Concetta Cuscito, Giacomina Brunetti, Silvia Colucci, Saverio Cinti, Giorgio Mori
  • Publication number: 20190331673
    Abstract: A method of functionalization of a gate electrode of a field-effect transistor sensor includes forming a layer of biological recognition elements on a surface of said gate electrode, wherein said layer of biological recognition elements includes a self-assembled structure of one or more specific-binding-pair-forming substances (anti-hIg, anti-IgG, anti-IgM). The layer of biological recognition elements is treated with a solution containing a blocking agent to fill vacancies and prevent nonspecific binding in the self-assembled structure. One or more specific-binding-pair-forming substances immobilized in said layer of biological recognition elements are packed at a density of 0.1×104 ?m?2 and 10×104 ?m?2, preferably between 1×104 ?m?2 and 2×104 ?m?2.
    Type: Application
    Filed: December 18, 2017
    Publication date: October 31, 2019
    Applicant: UNIVERSITA' DEGLI STUDI DI BARI ALDO MORO
    Inventors: Luisa TORSI, Gerardo PALAZZO, Gaetano SCAMARCIO
  • Patent number: 10413596
    Abstract: Object of the present invention is the use of a known protein, irisin, for preservation of the functionality and survival of the cells of the pancreatic islets.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: September 17, 2019
    Assignee: UNIVERSITA' DEGLI STUDI DI BARI
    Inventors: Francesco Giorgino, Annalisa Natalicchio, Nicola Marrano
  • Patent number: 10149837
    Abstract: Object of the present invention is the use of selective agonists of beta-adrenergic type 3 receptors (BAR3) in the treatment of nephrogenic diabetes insipidus (NDI), in particular of X-linked nephrogenic diabetes insipidus (X-NDI).
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: December 11, 2018
    Assignees: UNIVERSITA' DEGLI STUDI DI BARI, UNIVERSITA' DEGLI STUDI DELLA BASILICATA, UNIVERSITA' DEGLI STUDI DI PISA
    Inventors: Maria Svelto, Giuseppe Procino, Monica Carmosino, Massimo Dal Monte, Paola Bagnoli
  • Patent number: 9575029
    Abstract: A transistor includes at least one conductive layer, at least one gate dielectric layer and at least one semiconducting film deposited on top of a receptor molecule layer previously deposited or covalently linked to the surface of the gate dielectric. The layer of biological material includes single or double layers of phospholipids, layers made of proteins such as receptors, antibodies, ionic channels and enzymes, single or double layers of phospholipids with inclusion or anchoring of proteins such as: receptors, antibodies, ionic channels and enzymes, layers made of oligonucleotide (DNA, RNA, PNA) probes, layers made of cells or viruses, layers made of synthetic receptors for example molecules or macromolecules similar to biological receptors for properties, reactivity or steric aspects.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: February 21, 2017
    Assignees: UNIVERSITA DEGLI STUDI DI BARI, CONSIGLIO NAZIONALE DELLE RICERCHE ISTITUTO PROCESSI CHIMICO FISICI-IPCF, SEDE DI BARI
    Inventors: Luisa Torsi, Gerardo Palazzo, Nicola Cioffi, Maria Daniela Angione, Maria Magliulo, Serafina Cotrone, Gaetano Scamarcio, Luigia Sabbatini, Antonia Mallardi
  • Patent number: 9283206
    Abstract: The invention relates to the use of 4,6,4?-trimethylangelicin (TMA) and structural analogs thereof to prepare a medicament for the treatment of cystic fibrosis with the primary objective of correcting the defective CFTR in a sub-group of cystic fibrosis patients consisting of patients carrying the F508del-CFTR mutation.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: March 15, 2016
    Assignees: Azienda Ospedaliera Universitaria Integrata di Verona, Universita' degli Studi di Ferrara, Universita' degli Studi di Bari, Rare Partners S.r.l.
    Inventors: Giulio Cabrini, Valeria Casavola, Roberto Gambari
  • Patent number: 9260400
    Abstract: The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor and having the following formula IV: wherein W is O; K, L, M and Q is CH or nitrogen; R1 is hydrogen; R2 is hydrogen; and Ar is an aromatic ring with the following formula: wherein X, Y and Z is CH; and R3 is a five- or six-membered ring selected from the group consisting of:
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: February 16, 2016
    Assignee: UNIVERSITA' DEGLI STUDI DI BARI “ALDO MORO”
    Inventors: Marcello Leopoldo, Enza Lacivita, Nicola Antonio Colabufo, Paola De Giorgio, Francesco Berardi, Roberto Perrone
  • Publication number: 20150290167
    Abstract: The invention relates to the use of 4,6,4?-trimethylangelicin (TMA) and structural analogues thereof to prepare a medicament for the treatment of cystic fibrosis with the primary objective of correcting the defective CFTR in a sub-group of cystic fibrosis patients consisting of patients carrying the F508de1-CFTR mutation.
    Type: Application
    Filed: June 13, 2012
    Publication date: October 15, 2015
    Applicants: AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA DI VERONA, RARE PARTNERS S.R.L., UNIVERSITA' DEGLI STUDI DI BARI, UNIVERSITA' DEGLI STUDI DI FERRARA
    Inventors: Giulio Cabrini, Valeria Casavola, Roberto Gambari
  • Patent number: 9095631
    Abstract: The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: August 4, 2015
    Assignee: UNIVERSITA DEGLI STUDI DI BARI “ALDO MORO”
    Inventors: Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, Marialessandra Contino, Marcello Leopoldo, Roberto Perrone
  • Publication number: 20140312879
    Abstract: A transistor includes at least one conductive layer, at least one gate dielectric layer and at least one semiconducting film deposited on top of a receptor molecule layer previously deposited or covalently linked to the surface of the gate dielectric. The layer of biological material includes single or double layers of phospholipids, layers made of proteins such as receptors, antibodies, ionic channels and enzymes, single or double layers of phospholipids with inclusion or anchoring of proteins such as: receptors, antibodies, ionic channels and enzymes, layers made of oligonucleotide (DNA, RNA, PNA) probes, layers made of cells or viruses, layers made of synthetic receptors for example molecules or macromolecules similar to biological receptors for properties, reactivity or steric aspects.
    Type: Application
    Filed: October 31, 2011
    Publication date: October 23, 2014
    Applicants: UNIVERSITÁ DEGLI STUDI DI BARI, Consiglio Nazionale delle Ricerche Istituto Pro- cessi Chimico Fisici-IPCF
    Inventors: Luisa Torsi, Gerardo Palazzo, Nicola Cioffi, Maria Daniela Angione, Maria Magliulo, Serafina Cotrone, Gaetano Scamarcio, Luigia Sabbatini, Antonia Malllardi
  • Patent number: 8716250
    Abstract: A pharmaceutical preparation treats Friedreich's ataxia and treats or prevents pathologies related thereto. In particular, the pharaceutical preparation concerns the use of diazoxide or 7-chloro-3-methyl-4H-1,2,4 benzothiadiazine 1,1-dioxide, in combination with glucose and/or leucine, for the treatment of Friedreich's ataxia (FRDA) and for the treatment or prevention of pathologies related thereto.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: May 6, 2014
    Assignee: Universita' Degli Studi di Bari
    Inventors: Carlo Marya Thomas Marobbio, Luigi Palmeri, Ferdinando Palmeri, Antonella Santoro
  • Publication number: 20140112868
    Abstract: The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.
    Type: Application
    Filed: May 24, 2011
    Publication date: April 24, 2014
    Applicant: UNIVERSITA' DEGLI STUDI DI BARI "ALDO MORO"
    Inventors: Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, Marialessandra Contino, Marcello Leopoldo, Roberto Perrone
  • Publication number: 20140086834
    Abstract: The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention of 5-HT7 receptor relating disorders of the central nervous system. The invention also relates to the isotopically labeled compounds for use in vivo diagnosis or imaging of a 5-HT7 condition.
    Type: Application
    Filed: May 24, 2011
    Publication date: March 27, 2014
    Applicant: UNIVERSITA' DEGLI STUDI DI BARI ''ALDO MORO''
    Inventors: Marcello Leopoldo, Enza Lacivita, Nicola Colabufo, Paola De Giorgio, Francesco Berardi, Roberto Perrone
  • Patent number: 8518606
    Abstract: The catalyst thin layer consists of electronically conductive catalyst nano-particles embedded in a polymeric matrix. The ratio number of catalyst atoms/total number of atoms in the catalyst layer is comprised between 40% and 90%, more preferably between 50% and 60%.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: August 27, 2013
    Assignees: Commissariat a l'energie Atomique et aux Energies Alternatives, Universita Degli Studi di Bari
    Inventors: Steve Martin, Riccardo D'agostino, Antoine Latour, Antonella Milella, Fabio Palumbo, Jessica Thery
  • Patent number: 8461354
    Abstract: This invention pertains to gaseous analytes sensor devices comprising organic thin film transistor and, in particular, sensors able to perform the enantiomeric discrimination of gaseous analytes.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: June 11, 2013
    Assignee: Universita' Degli Studi di Bari
    Inventors: Francesco Babudri, Gianluca Maria Farinola, Francesco Naso, Francesco Palmisano, Luisa Torsi, Maria Cristina Tanese, Pier Giorgio Zambonin, Omar Hassan Omar, Ludovico Valli
  • Patent number: 8354412
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: January 15, 2013
    Assignee: Universita' Degli Studi di Bari
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
  • Patent number: 8318771
    Abstract: Nephrogenic diabetes insipidus is treated with statins.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: November 27, 2012
    Assignee: Universita' Degli Studi di Bari
    Inventors: Giuseppe Procino, Maria Svelto, Giovanna Valenti, Monica Carmosino
  • Patent number: 8234081
    Abstract: A system measures the strain of an object. The system includes a laser source for generating an output radiation, a strainable optical fiber having first and second facets, and means for calculating a measure of a strain of the optical fiber. The first facet is coupled to the laser source to receive the output radiation and transmit a guided radiation over the optical fiber towards the second facet. The second facet is adapted to receive the guided radiation and to reflect a corresponding reflected radiation towards the first facet. The laser source is a self-mixing type adapted to receive at least part of the reflected radiation and to mix the output radiation with the received radiation. The calculating means calculate the measure of the strain of the optical fiber based on a self-mixing effect in the laser source that is caused by the linear displacement of the second section.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: July 31, 2012
    Assignee: Universita degli Studi di Bari
    Inventors: Maurizio Dabbicco, Gaetano Scamarcio, Simona Ottonelli, Angela Intermite, Branimir Radisavljevic