Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.

Abstract: A device and method for carrying out dialysis and stimulation of a patient at the same time, in which an inflatable/deflatable cuff applies the stimulation.

Abstract: The invention relates to a system for estimating the spatial position (pose) of a tool (2) within an object (1), particularly in the form of a human bone that is to be machined with said tool, comprising: a sensor (21) being designed to be coupled to said tool (2), which sensor (21) is further designed to generate an sensor output signal (31) upon machining of said object (1) along an actual trajectory (30), which sensor output signal (31) depends on a material property of said object along said actual trajectory (30), an analyzing means being designed to determine a correlation between said sensor output signal (31) upon machining said object (1) and a plurality of pre-determined candidate output signals (42), each candidate output signal (42) being generated in beforehand using said material property along an associated model trajectory (40) in a model of said object (1), and wherein said analyzing means is designed to estimate a spatial position of the tool (2) within the object (1) using the model traject

Abstract: The present invention provides fluorine substituted tricyclic nucleosides of formula (I) wherein: the substituents are as defined in the claims. The present invention further provides oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound enhances one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions.

Abstract: The invention relates to a system for estimating the spatial position (pose) of a tool (2) within an object (1), particularly in the form of a human bone that is to be machined with said tool, comprising: a sensor (21) being designed to be coupled to said tool (2), which sensor (21) is further designed to generate an sensor output signal (31) upon machining of said object (1) along an actual trajectory (30), which sensor output signal (31) depends on a material property of said object along said actual trajectory (30), an analyzing means being designed to determine a correlation between said sensor output signal (31) upon machining said object (1) and a plurality of pre-determined candidate output signals (42), each candidate output signal (42) being generated in beforehand using said material property along an associated model trajectory (40) in a model of said object (1), and wherein said analyzing means is designed to estimate a spatial position of the tool (2) within the object (1) using the model traject

Abstract: The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.

Abstract: The present invention relates to a cardioplegic preparation. According to a preferred embodiment of the invention, the preparation is made of two solutions, the first containing magnesium sulfate, potassium and xylitol, and the other containing procaine.

Abstract: The invention relates to a method for detecting a phantom, comprising the steps of: arranging a phantom with respect to an object, acquiring at least one image of said object by means of an x-ray apparatus, such that the image contains projections of the object and projections of at least three first calibration fiducials of the phantom, detecting the projections of the at least three first calibration fiducials in said at least one image, and establishing a correspondence between the 2D image coordinates of said projections of the at least three first calibration fiducials and the 3D coordinates of said at least three first calibration fiducials in a local coordinate system of the phantom for computing the projection matrix at least up to a scale factor.

Abstract: The invention related to a device (1) for spraying charged droplets of a liquid towards a target along a spraying direction, comprising: a reservoir (10) for storing the liquid (L), a first electrode (100) being arranged at an outlet (11) of said reservoir (10), a second electrode (200) forming a counter electrode to the first electrode (100) for accelerating said droplets (D) along the spraying direction (S), and a housing (30) holding the reservoir (10) as well as said electrodes (100, 200).

Abstract: The invention relates to a compound comprising the following general formula (1) and said compound for use as a medicament, in particular for use in the treatment psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (formula 1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl.

Abstract: The invention relates to the use of CD89 activating molecules, in particular Fc alpha comprising molecules, and more particularly, IgA, for inducing apoptosis in neutrophils. Anti-CD89 antibodies can alternatively be used. The CD89 activation is beneficial in the treatment of various disorders associated with increases in neutrophils, such as autoimmune disorders, inflammatory disorders, NETosis, or cystic fibrosis.

Abstract: The invention relates to a peptide dendrimer described by a general formula X—(B2—[Y2]S-D1)2-B1—Z, wherein X is (D2)4 or (D3)8-(B3—[Y3]r-D2)4 or a higher analogue, Y is a linkage moiety, Z is a central moiety; each B denotes a diaminoalkylcarboxylic acid moiety; each D is a hydrophobic or cationic amino acid, or a di- or tripeptide composed of hydrophobic and cationic amino acids, for use as a pharmaceutical.

Abstract: The present invention provides a substance comprising a preparation of at least one chemotherapeutic or cytotoxic substance for the use in treatment of a disease of a mammalian patient, especially in the treatment of cancer. The invention suggests a symbiotic or synergistic combination of radiotherapy and chemotherapeutic or cytotoxic drug delivery.

Abstract: The invention relates to the use of CD89 activating molecules, in particular Fc alpha comprising molecules, and more particularly, IgA, for inducing apoptosis in neutrophils. Anti-CD89 antibodies can alternatively be used. The CD89 activation is beneficial in the treatment of various disorders associated with increases in neutrophils, such as autoimmune disorders, inflammatory disorders, NETosis, or cystic fibrosis.

Abstract: The invention relates to a method for determining and particularly imaging sound speed in an object by means of pulse-echo ultrasound, comprising the steps of: transmitting by means of an ultrasound probe (1) at least a first ultrasound pulse (10) in a first direction (?0) and a second ultrasound pulse (20) in a different second direction (?) into an object (O) to be imaged, so that said first ultrasound pulse (10) is backscattered in said object towards said ultrasound probe in the form of first ultrasound pulse echoes (11), and so that said second ultrasound pulse (20) is backscattered in said object towards said ultrasound probe in the form of second ultrasound pulse echoes (21), detecting said backscattered first ultrasound pulse echoes (11) and said backscattered second ultrasound pulse echoes (21) with said ultrasound probe (1), reconstructing from said detected backscattered first ultrasound pulse echoes (11) a first image of first local echoes (5) and from said detected backscattered second ultrasound

Abstract: The present invention provides a substance comprising a preparation of at least one chemotherapeutic or cytotoxic substance for the use in treatment of a disease of a mammalian patient, especially in the treatment of cancer. The invention suggests a symbiotic or synergistic combination of radiotherapy and chemotherapeutic or cytotoxic drug delivery.

Abstract: The invention relates to a device for examining an eye, particularly a human eye, comprising: an optical unit that is designed to generate a current image of a current intermediate image, wherein the optical unit comprises an objective, an additional lens that is designed to be arranged in front of an eye along an optical axis of the optical unit in order to generate said current intermediate image of a posterior structure of said eye, and wherein said additional lens is designed to be movable relative to said optical unit so as to generate a sharp and particularly reflection-free current image of said posterior structure with help of said optical unit. According to the invention, the device comprises a first actuator means that is designed to move the additional lens and which is controlled depending on the current image. Furthermore, the invention relates to a method for examining an eye.

Abstract: The present invention relates to a cap device for closing a hole, particularly a burr hole, in a bone, particularly a skull, of a human or an animal, comprising a frame member for fastening the cap device to the bone, and a cap member for covering the hole. According to the invention, the cap member is integrally connected to the frame member, so that the cap member can be bent away from the frame member, particularly for allowing passage of a catheter through said hole.

Abstract: To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an Integer from 1 to 3 and n is an integer from 1 to 6.

Abstract: The invention related to a device (1) for spraying charged droplets of a liquid towards a target along a spraying direction, comprising: a reservoir (10) for storing the liquid (L), a first electrode (100) being arranged at an outlet (11) of said reservoir (10), a second electrode (200) forming a counter electrode to the first electrode (100) for accelerating said droplets (D) along the spraying direction (S), and a housing (30) holding the reservoir (10) as well as said electrodes (100, 200).