Patents Assigned to Universite Claude Bernard Lyon 1
  • Publication number: 20220259661
    Abstract: A kit for in vitro measurement of a at least one IL7R gene transcript in a blood sample, including specific reagents for measuring the transcript, and a control sample calibrated to contain the IL7R gene transcript corresponding to the mean quantity measured in a pool of reference blood samples from human patients in a state of septic shock when reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and who were known to have survived, and/or a calibrated to contain the quantity of an IL7R gene transcript corresponding to the mean quantity measured in reference blood samples from patients in a state of septic shock when the reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and not to have survived.
    Type: Application
    Filed: April 26, 2022
    Publication date: August 18, 2022
    Applicants: BIOMERIEUX, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Elisabeth CERRATO, Benjamin DELWARDE, Guillaume MONNERET, Estelle PERONNET, Julien TEXTORIS, Fabienne VENET
  • Patent number: 11390643
    Abstract: The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: July 19, 2022
    Assignees: ETABLISSEMENT FRANÇAIS DU SANG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE MONTPELLIER, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Chantal Fournier-Wirth, Myriam Lereau, Jean-François Cantaloube, Jean-Jacques Vasseur, François Morvan, Albert Meyer, Julie Mayen, Carole Chaix, Carole Farre
  • Publication number: 20220220027
    Abstract: The invention relates to a method for depositing metal particles on a textile support, which comprises: placing at least one textile sheet (1) made of side-emitting optical fibers (2) in contact with a solution containing at least one ionic precursor of a metal to be deposited, the textile sheet (1) being formed from optical fibers (2) woven in warp and/or weft with binding threads in warp and/or weft, each of the optical fibers (2) having invasive alterations (5) along the fiber and allowing the emission of light propagating in the fiber at these alterations (5), the textile sheet (1) being coated on all or part of the surfaces thereof with a layer of semiconductor particles (4) having photocatalytic properties, the textile sheet (1) and the solution being contained in a space of a reactor (9), the space being free of oxygen; illuminating the textile sheet (1) by at least one light source (7) connected to all or part of the free ends (6) of the optical fibers (2), the light source generating light radiati
    Type: Application
    Filed: May 5, 2020
    Publication date: July 14, 2022
    Applicants: Brochier Technologies, Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1
    Inventors: Eric PUZENAT, Cédric BROCHIER, Davide LORITO, Lina LAMAA, Laure PERUCHON
  • Patent number: 11384081
    Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 12, 2022
    Assignees: CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Toufic Renno, Isabelle Coste-Invernizzi, Stéphane Giraud, Serge Lebecque
  • Patent number: 11383053
    Abstract: The invention relates to a device for olfactory stimulation of a patient with a plurality of scents, said device comprising: —a source (2) of a carrier gas (G); —a plurality of scent odorization circuits, each odorization circuit (4) comprising: —a container (18) containing an odorous volatile substance (V), —a container inlet line (26), provided with a container inlet valve (28), connecting an inlet (30) of said container with said source of carrier gas, and —a container outlet line (36), provided with a container outlet valve (38), connecting an outlet (40) of said container with an exit line (12); —a control unit (8), configured to control said container inlet valve and container outlet valve according to a medical protocol.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: July 12, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE JEAN MONNET SAINT ETIENNE
    Inventors: Marc Thevenet, Patricia Viret
  • Publication number: 20220186321
    Abstract: A method of prognosis of patient outcome and of the resistance to a chemotherapy treatment of an individual afflicted by a tumor. The method involves determining the amount of the product of each of at least 21 genes belonging to the group of 160 genes as set forth in SEQ ID NO: 1 to SEQ ID NO: 160.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 16, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE LÉON BERARD, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ CLAUDE BERNARD LYON 1
    Inventors: Véronique MAGUER-SATTA, Boris GUYOT, Flora CLÉMENT, Pierre SAINTIGNY, Jean-Philippe FOY, Emmanuel DELAY
  • Publication number: 20220178949
    Abstract: The invention relates to a process in vitro for diagnosing a paraneoplastic neurological syndrome (PNS) associated with a tumor in an individual, comprising the detection of at least one antibody chosen among antibodies against TRIM9 and antibodies against TRIM67, in a biological fluid of said individual.
    Type: Application
    Filed: May 2, 2019
    Publication date: June 9, 2022
    Applicants: HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Le Duy DO, Jérôme HONNORAT, Véronique ROGEMOND
  • Patent number: 11351180
    Abstract: The present invention relates to a pharmaceutical or veterinary composition for the use thereof in preventing and/or treating infection by the influenza viruses. Said composition is characterized in that it contains, in an appropriate pharmaceutical carrier, at least one compound selected from among Etilefrine and Diltiazem.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: June 7, 2022
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), HOSPICES CIVILS DE LYON, UNIVERSITE LAVAL
    Inventors: Manuel Rosa-Calatrava, Olivier Terrier, Julien Textoris, Guy Boivin, Mario Pizzorno
  • Publication number: 20220146402
    Abstract: A particle detector includes at least one resonant cavity partially formed at least by a first reflector, a second reflector disposed at a distance from the first reflector and a channel located between the first and second reflectors, the channel being intended to receive at least one fluid comprising particles and to receive at least one light radiation; and at least one detection system having at least one photodetector. The particle detector is configured so that a portion of the light radiation present in the channel escapes from the cavity throughout the second reflector and reaches the detection system, thereby enabling the at least one photodetector to detect leakage of the cavity. The second reflector is a photonic crystal membranes PCM based reflector.
    Type: Application
    Filed: December 23, 2019
    Publication date: May 12, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Gabriel JOBERT, Salim BOUTAMI, Maryse FOURNIER, Christian SEASSAL
  • Patent number: 11313800
    Abstract: A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: April 26, 2022
    Assignees: TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Mattéo Martini, Olivier Tillement, Arthur Marais, Christian Hurtevent, Stéphane Jouenne
  • Publication number: 20220119893
    Abstract: The invention relates to an in vitro process for classifying a glioma, comprising the following steps: a. Measuring at least, from a glioma patient biological sample, the Alternative Lengthening of Telomeres (ALT) status of said glioma; b. Optionally, determining the isocitrate dehydrogenase genes mutation status (IDH status) of said glioma; c. Based on the data obtained in steps (a) and optionally (b) and, if available, on the histological grade of said glioma, classifying said glioma in one of the five following classes: oligodendroglioma-like, glioblastoma IDHwt-like, glioblastoma IDHmt-like, low-grade astrocytoma-like, and other gliomas.
    Type: Application
    Filed: February 19, 2020
    Publication date: April 21, 2022
    Applicants: HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventor: Delphine PONCET
  • Patent number: 11286557
    Abstract: A method of preparing a crystalline thin film having a formula MY2 includes (1) preparing an MYx amorphous film by atomic layer deposition on a surface of a substrate, and (2) annealing the amorphous MYx film at 350° C. or more to provide the crystalline MY2 film. The amorphous MYx film is formed from at least one metal M precursor and at least one element Y precursor, wherein x is 1.5 to 3.1, M is tungsten or molybdenum, and Y is sulfur or selenium. Step (1) includes a) introducing a first metal M precursor or element Y precursor into a deposition chamber, b) purging with inert gas, c) introducing a second metal M precursor when the first precursor is element Y, or element Y precursor when the first precursor is metal M, d) purging with inert gas, e) repeating steps a) to d), and f) obtaining the amorphous MYx film.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: March 29, 2022
    Assignees: Commissariat A L'Energie Atomique Et Aux Engergies Alternatives, Centre National De La Recherche Scientifique, Universite Claude Bernard Lyon 1, CPE Lyon Formation Continue et Recherche
    Inventors: Stéphane Cadot, Francois Martin, Elsje Quadrelli, Chloé Thieuleux
  • Patent number: 11287397
    Abstract: This gaseous elementary-particle detector is equipped with a readout plate comprising: conductive tiles (80) that are all identical to one another and all located at the same distance from an exterior face (39), these conductive tiles being distributed over the front face of a dielectric layer (72) and being mechanically separated from one another by a dielectric material (76), the smallest dimension of each tile being larger than 300 ?m, and electrical connections (88), which are located under the dielectric layer (72) and which electrically connect the conductive tiles in series so as to form conductive strips, these electrical connections being arranged so that each conductive tile belongs to a single conductive strip and each side of one tile is adjacent to the side of another tile belonging to another conductive strip.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: March 29, 2022
    Assignees: Université Claude Bernard Lyon 1, Centre National De La Recherche Scientifique
    Inventor: Imad Laktineh
  • Publication number: 20220091018
    Abstract: An optical particle detector including at least one channel intended to receive a fluid carrying at least one particle, and across which light rays are intended to pass such that the light rays are partially scattered by the at least one particle, a plurality of photodetectors capable of receiving said scattered light rays, wherein the detector includes at least one optical waveguide configured to collect, at least at one entrance of the waveguide, light rays that were not scattered by the at least one particle and having crossed the channel, and to reinject the unscattered light rays into the channel through at least one exit of the waveguide.
    Type: Application
    Filed: September 21, 2021
    Publication date: March 24, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON FORMATION CONTINUE ET RECHERCHE, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Salim BOUTAMI, Maryse FOURNIER, Gabriel JOBERT, Christian SEASSAL, Cécile JAMOIS
  • Publication number: 20220089966
    Abstract: The present invention relates to a dinuclear molybdenum complex with ligands selected from fatty tertiary amines of formula (I): R—N[(CH2)nR2][(CH2)nR3]??(I) wherein R represents a linear or branched alkyl comprising 3 to 30 carbon atoms, preferably 3 to 20, advantageously 7 to 17 carbon atoms; n, identical or different, represents 2 or 3; R2 and R3, identical or different, represent an O, OR, NR?2, COOR?, or COO group, where R?, identical or different, represents a hydrogen atom or an alkaline or alkaline earth metal, preferably R? is H, preferably R2 and R3, identical or different, represent an OH or NH2 group.
    Type: Application
    Filed: January 21, 2020
    Publication date: March 24, 2022
    Applicants: TOTAL MARKETING SERVICES, Centre national de la recherche scientifique, ECOLE CENTRALE DE LYON, Université Claude Bernard Lyon 1
    Inventors: Benoît THIEBAUT, Catherine CHARRIN, Camella OUMAHI, Maria Isabel DE BARROS BOUCHET, Pavel AFANASIEV
  • Patent number: 11267947
    Abstract: A method for modifying a cellular polymer foam with apparent porosity, which includes providing a cellular polymer foam with apparent porosity, placing the cellular polymer foam in contact with at least one compound in order to obtain a cellular polymer foam including on the surface thereof an intermediate phase formed from the compound having at least one catechol unit. The foam may be used as a catalyst substrate.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: March 8, 2022
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: David Edouard, Vincent Ritleng, Loïc Jierry, Nguyet Trang Thanh Chau Dalencon
  • Publication number: 20220028574
    Abstract: The invention relates to an electrically insulating composite material (1) comprising a polyepoxide matrix (2) of cycloaliphatic type or of diglycidyl ether type in a content of less than 40% by mass, from 20 to 75% by mass of one or several micrometric and/or mesometric filler(s) (3), and from 0.1 to 20% by mass of at least one ionic liquid (4), the masses being expressed relative to the total mass of the electrically insulating composite material (1). The invention also relates to a method for manufacturing such an electrically insulating composite material (1), as well as its use for an electrically insulating support (9) in a metal-enclosed substation (5).
    Type: Application
    Filed: December 27, 2019
    Publication date: January 27, 2022
    Applicants: SUPERGRID INSTITUTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE JEAN MONNET SAINT ETIENNE
    Inventors: Thibaut LEFORT, Damien BACHELLERIE, Sébastien PRUVOST, Jannick DUCHET, Sébastien LIVI
  • Patent number: 11229597
    Abstract: The present invention relates to a novel pharmaceutical composition comprising doxycycline for topical application, in particular to the eye and eyelids. The invention also relates to this topical composition for use in the treatment of bacterial infections of the skin and mucous membranes.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: January 25, 2022
    Assignees: HORUS PHARMA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Marion Dubald, Sandrine Bourgeois, Hatem Fessi, Martine Claret
  • Publication number: 20220007620
    Abstract: The present invention relates to an avian model enabling the amplification of human or animal circulating tumour cells (CTC) and to the use thereof for monitoring and determining the sensitivity of a patient or an animal suffering from cancer to one or more therapeutic agent(s), as well as for screening novel therapeutic agents intended for the treatment of cancer.
    Type: Application
    Filed: October 29, 2019
    Publication date: January 13, 2022
    Applicants: INOVOTION, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Xavier ROUSSET, Emilien DOSDA, Jean VIALLET, Léa PAYEN-GAY, Denis MAILLET
  • Publication number: 20210364660
    Abstract: A multilayer scintillation detector, includes at least three layers superposed on one another, and each extending parallel to a plane, called the detection plane, wherein each layer is formed by a first material, called a scintillation material, capable of interacting with an ionizing radiation and of forming, following the interaction, a scintillation light in a scintillation spectral band; each layer has a plurality of light guides, respectively extending parallel to the detection plane, according to a length, the light guides being disposed, over all or part of their length, parallel to an axis of orientation; the axis of orientation of the light guides of each layer is oriented, in the detection plane, according to an orientation, the orientations of the respective axes of orientation of at least three layers being different from one another, such that each layer has an associated orientation; and the scintillation material has a first refractive index.
    Type: Application
    Filed: March 20, 2019
    Publication date: November 25, 2021
    Applicants: UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, HOSPICES CIVILS DE LYON, CPE LYON FORMATION CONTINUE ET RECHERCHE, ECOLE CENTRALE DE LYON
    Inventors: Patrick PITTET, Guo-Neng LU, Patrice JALADE, Jean-Marc GALVAN