Patents Assigned to Universite d'Aix-Marseille
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Patent number: 11004220Abstract: This method (100) for automatic propagation into an (N+1)-th dimension of an image segmentation initialized in dimension N, N?2, comprises the acquisition (102) of an ordered series of image representations of dimension N and an initial segmentation (104) in dimension N of a region of interest in the first and last image representations of the series, to obtain first and last initial segmentation masks (M0, Mn) of the region of interest. It further comprises an estimation (106) of registration parameters (La, Ld) between the first and last initial segmentation masks, and upward and downward automatic propagations (108) of the initial segmentation, from the first and last image representations, to all the other image representations of the series by step-by-step registration up to the last and first image representations.Type: GrantFiled: July 10, 2018Date of Patent: May 11, 2021Assignees: Universite d'Aix Marseille, Centre National de la Recherche ScientifiqueInventors: Arnaud Le Troter, David Ben Dahan, Augustin Ogier
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Patent number: 11006228Abstract: An implantable microphone for a middle ear prosthesis, includes an attachment system for fixing to a fixation bone close to an individual's middle ear; a cylindrical holding sheath, the sheath to be fixed to the fixation bone by the attachment system and having a suitable shape for extending from the fixation bone towards the ear ossicles of the individual; a coupler including a rod and an end piece of a suitable shape for bringing into contact with a point of the ear ossicles of the individual in a reversible manner; a sensor for converting a mechanical signal into an electrical signal, the sensor being secured to the coupler, supported by the cylindrical holding sheath and placed substantially in the extension of the axis of the cylinder; and a translation system for translation of the coupler along the axis of the cylinder, the translation system being housed in the sheath.Type: GrantFiled: December 23, 2016Date of Patent: May 11, 2021Assignees: UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE DES HÔPITAUX DE MARSEILLE, INSTITUT FRANAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS, DE L'AMÉNAGEMENT ET DES RÉSEAUXInventors: Laurent Badih, Arnaud Philippe Deveze
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Publication number: 20210123916Abstract: The invention relates to a method for diagnosing a cancer in a mammal in a need thereof. The method comprises the following steps: collecting a biological sample from said mammal; determining, from said biological sample, if the ADAMTSL5 gene is overexpressed; diagnosing a cancer from the determination of the overexpression of said gene. It also relates to a kit for determining an overexpression of the ADAMTSL5 gene in a biological sample obtained from a mammal, to a pharmaceutical composition comprising an agent targeting ADAMTSL5 or the ADAMTSL5 pathway as well as a pharmaceutically acceptable carrier for use in the treatment of a cancer, and to a use of an ADAMTSL5 mRNA or protein as a biomarker of cancer.Type: ApplicationFiled: March 29, 2019Publication date: April 29, 2021Applicants: UNIVERSITE D'AIX-MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Flavio Maina, Maria Arechederra, Rosanna Dono, Timothy Mead, Suneel Apte
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Publication number: 20210093881Abstract: This magnetic emission device includes an antenna and further includes means designed to select one of a plurality of predefined portions of the antenna and to connect the selected portion to a current-generating device in order both to cause the current to pass through the selected portion of the antenna so as to radiate a magnetic field, and to prevent the current from passing outside of the selected portion of the antenna.Type: ApplicationFiled: April 16, 2019Publication date: April 1, 2021Applicants: Université d'Aix Marseille, Centre National de la Recherche Scientifique, Ecole Centrale de Marseille, Assistance Publique - Hôpitaux de Marseille, Multiwave Technologies AGInventors: Stefan ENOCH, Redha ABDEDDAIM, Éric, Émile, David GUEDJ, Raphaëlle Richieri LE ROUZIC, Megdouda BENAMARA, Marie Coralie BULTOT, Michael KEFEDER, Tryfon ANTONAKAKIS, Elodie GEORGET-PARIS, Fouad FEZARI
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Patent number: 10940425Abstract: A subject of the present invention is the use of a compound having the general formula (I): (I) wherein V, W, X4, X5, X6, X7, X?4, X?5, X?6, X?7, Y, Y?, R3, R?3, R4 and R?4 are as defined in any one of claims 1 to 11, for the detection, capture and/or separation of polluting gases, in particular those selected from the group comprising carbon dioxide, methane, sulfur dioxide, nitrogen oxides, carbon monoxide, linear hydrocarbons, linear mono-olefins and their mixtures, and preferably carbon dioxide. Another subject of the invention is a compound of formula (I) wherein V, W, X4, X5, X6, X7, X?4, X?5, X?6, X?7, Y, Y?, R3, R?3, R4 and R?4 are as defined in any one of claims 12 to 21.Type: GrantFiled: December 23, 2016Date of Patent: March 9, 2021Assignees: Centre National de la Recherche Scientifique, Universite d'Aix-MarseilleInventors: Jean-Manuel Raimundo, Vinicius Demétrio da Silva, Philip Leslie Llewellyn, Julien Rodriguez, Olivier Yves Claude Siri
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Publication number: 20210063511Abstract: The invention relates to a material for use as a pad in high field and/or very high field magnetic resonance imaging instrument, comprising at least one polar solvent having a melting point of 14° C. to 50° C., a dispersant and a dielectric charge. The invention relates also to a pad used in field of high field and/or very high field magnetic resonance imaging made of at least such a material.Type: ApplicationFiled: March 27, 2019Publication date: March 4, 2021Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ECOLE CENTRALE DE MARSEILLE, UNIVERSITE D'AIX-MARSEILLE (AMU)Inventors: Abdeddaim Redha, Anne-Lise Adenot-Engelvin, Marc Dubois, Stefan Enoch, Nicolas Mallejac, Zo Raolison, Pierre Sabouroux, Alexandre Vignaud
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Publication number: 20210038682Abstract: The invention relates to a modulator of small conductance calcium activated K+ channels of the vestibular nuclei cells for use in the treatment of a lesional vestibular disorder in a patient in need thereof, and to a pharmaceutical composition comprising such modulator, for such a use.Type: ApplicationFiled: March 13, 2019Publication date: February 11, 2021Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE (AMU)Inventors: Brahim Tighilet, Christian Chabbert, Christiane Mourre, David Pericat, Jacques Léonard
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Patent number: 10899610Abstract: The disclosure relates to a method for producing hydrogen gas and/or magnetite comprising the steps of reacting a wüstite-containing material, such as steel slags, with H2O at a temperature ranging from 150° C. to 500° C., cooling down the gaseous reaction product to separate hydrogen gas from water steam and collecting hydrogen gas, and recovering magnetite from the solid reaction product.Type: GrantFiled: April 18, 2017Date of Patent: January 26, 2021Assignees: Centre National De La Recherche Scientifique, Universite d'Aix MarseilleInventors: Fabrice Brunet, Benjamin Malvoisin, Olivier Vidal, Bruno Goffe, Camille Crouzet
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Publication number: 20210018744Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.Type: ApplicationFiled: April 4, 2017Publication date: January 21, 2021Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Universite d'Aix-Marseille (AMU), Ecole Centrale de Marseille (ECM)Inventors: Hervé Rigneault, Esben Ravn Andresen, Siddarth Sivankutty
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Publication number: 20200407779Abstract: The present invention relates to an in vitro diagnostic method with regard to the presence of bacterial vaginosis, characterized in that the presence of bacterial vaginosis is determined if the archaea Methanobrevibacter smithii is present in a patient vaginal secretion sample by detecting therein the presence of at least one nucleic acid sequence specific to said methanogenic archaea Methanobrevibacter smithii.Type: ApplicationFiled: September 14, 2018Publication date: December 31, 2020Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLEInventors: Didier RAOULT, Michel DRANCOURT, Florence FENOLLAR, Ghiles GRINE
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Patent number: 10872429Abstract: This characterizing method comprises: estimating (28) the scalar coefficients ?m of an even function ?(?) defined in [0; 2?] that minimizes the following criterion C: C = ? j = 1 n i ? ( ? j - ? * ? ? ( ? j ) ) 2 where: ?j are terms estimated from an acquired digital image, ?(?) is a ?-periodic function defined in the interval [0; 2?], ?(?) is the function defined by the following relationship: ? ? ( ? ) = ? ? + ? ? v ^ ? ( ? ? ? ? ) ? 2 ? ? - 2 ? H - 1 ? d ? ? ? where: {circumflex over (V)} is the discrete Fourier transform of a convolution kernel v, H is an estimated Hurst exponent of the acquired image, f) then, calculating (30), depending on the estimate of the scalar coefficients ?m, an anisotropy index that characterizes the anisotropy of the image, this index varying monotonically as a function of the statistical dispersion of the values of the function ?(?) for ? varying between 0 and ?.Type: GrantFiled: November 23, 2017Date of Patent: December 22, 2020Assignees: UNIVERSITÉ D'AIX-MARSEILLE, Centre National de la Recherche ScientifiqueInventor: Frédéric Richard
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Publication number: 20200376104Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.Type: ApplicationFiled: June 9, 2020Publication date: December 3, 2020Applicants: Institut National de la Santé et de la Recherche Médicale (INSERM), UNIVERSITE D'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE NANTESInventors: Daniel OLIVE, Marc BONNEVILLE, Emmanuel SCOTET, Christelle HARLY, Yves GUILLAUME
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Patent number: 10843935Abstract: The application relates to a method for preparing magnetite, comprising steps of: a) reaction at a temperature of 100° to 500° C. of a material containing wüstite with water, in order to obtain a solid comprising magnetite, and then b) recovery of the magnetite in the form of particles wherein more than 25% by weight are of nanometric size.Type: GrantFiled: June 6, 2017Date of Patent: November 24, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLEInventors: Fabrice Brunet, Camille Crouzet, Bruno Goffe
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Publication number: 20200360889Abstract: A method for manufacturing microcapsules containing an active substance, the method including: providing an aqueous solution of a surfactant, an oily phase comprising the active substance and a first monomer, and a polar phase comprising a second monomer; preparing an oil-in-water emulsion by adding the oily phase to the aqueous solution of the surfactant; adding the polar phase to the oil-in-water emulsion, in order to obtain a polymer in a reaction mixture, by polymerization of the first monomer and the second monomer; isolating the microcapsules, including a wall formed by the polymer and containing the active substance, from the reaction mixture; wherein the polymer is a poly(beta-amino ester). Microcapsules obtained by the method.Type: ApplicationFiled: May 16, 2020Publication date: November 19, 2020Applicants: GEM INNOV, UNIVERSITÉ D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Yves ORTAIS, Thierry RIBEIRO, Kaouthar OUDOUA, The Hien HO, Didier GIGMES, Catherine GUILLANEUF, Yohann GUILLANEUF
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Publication number: 20200360334Abstract: The present invention relates to compound of formula (I): wherein R is O—R3 or R1 and R2 are identical or different and are each independently H, (C1-C6)alkyl, —CO—(C1-C21)alkyl or —CO—(C11-C21)alkenyl group, provided that at least one of R1 or R2 is H or (C1-C6)alkyl, R3 is a —CO—(C11-C21)alkyl or —CO—(C11-C21)alkenyl group, or its pharmaceutically acceptable salts, racemates, diastereoisomers, enantiomers, or mixtures thereof, for use in prevention and/or treatment of a disease or disorder linked to an exacerbated vascular, lymphatic or mucosal permeability.Type: ApplicationFiled: November 12, 2018Publication date: November 19, 2020Applicants: Universite De Montpellier, Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Superieure de Chimie, Institut de Recherche Pour le Developpement (IRD), Universite D'Aix-Marseille, Communaute Universites et Etablissements Universite Cote D AzurInventors: Céline Crauste, Joseph Vercauteren, Fransisco Veas, Thierry Durand, Nicolas Blondeau
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Patent number: 10837044Abstract: The present invention relates to a method of interpreting different antibiogram images in which it is possible to recognize a phenotype of bacterial resistance relative to antibiotics by comparing photographs using a photographic image bank of the reference antibiogram without any need to interpret them using the EUCAST or CA-SFM interpretation data; providing that for a given phenotype, there is available a collection of photographs of a plurality of bacteria of the same species and of the same phenotype.Type: GrantFiled: October 5, 2015Date of Patent: November 17, 2020Assignees: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Jean-Marc Rolain, Didier Raoult, Stéphanie Le Page, Sylvain Buffet
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Patent number: 10837981Abstract: A method of operating an atomic force microscope, comprising a probe, the probe being moved forth and back during respective trace and retrace times of a scan line, the method comprising: a) during trace time, oscillating the probe, b) generating a z feedback signal to keep an amplitude of oscillation of the probe constant at a setpoint value, the z feedback signal being generated by a first feedback loop, c) during retrace time, placing the probe in a drift compensation state by changing the setpoint value to a different value so that the z feedback signal being generated by the first feedback loop causes the probe to move away from the sample and oscillate free, d) detecting an amplitude of free oscillation of the probe and adjusting with a second feedback loop its excitation signal to maintain the amplitude of free oscillation of the probe close to a set value.Type: GrantFiled: April 26, 2017Date of Patent: November 17, 2020Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE D'AIX-MARSEILLEInventors: Simon Scheuring, Atsushi Miyagi
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Publication number: 20200345275Abstract: The invention relates to a method for automatic and continuous measurement of a sedation state of a patient in an intensive care unit. The method according to the invention comprises the following steps: providing signals representative of the condition of the patient, said signals comprising cardio-circulatory signals, signals representative of the respiratory activity and signals representative of the motor activity of the patient; and determining a global index representative of the sedation state of the patient.Type: ApplicationFiled: January 25, 2019Publication date: November 5, 2020Applicants: UNIVERSITE D'AIX-MARSEILLE (AMU), ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (AP-HM), INSTITUT FRANCAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS DE L'AMENAGEMENT ET DES RESEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Harold Noble Ibouanga-Kipoutou, Salah Boussen, Kouider Nacer M'Sirdi, Pierre-Jean Arnoux, Nicolas Bruder, Michel Behr
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Patent number: 10823805Abstract: In a method and magnetic resonance (MR) apparatus for MR image reconstruction, an image reconstruction algorithm is used that operates on one calibration matrix that is formed by reorganizing a number of individual, undersampled k-space data sets respectively acquired by multiple reception coils in a parallel MR data acquisition from a subject exhibiting motion. The motion causes the k-space data sets to exhibit errors. In order to use the calibration matrix in the reconstruction algorithm, it is subjected to an iterative rank reduction procedure in which, in each iteration, a residual is calculated for each data point that represents how poorly, due to motion-induced corruptions, that data point satisfies the low rank constraint, and non-satisfying data points are removed from the data point for the next iteration. The resulting low rank matrix at the end of the iterations is then used to produce images with fewer motion-induced errors.Type: GrantFiled: September 21, 2017Date of Patent: November 3, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ D'AIX-MARSEILLEInventors: Mark Bydder, Olivier Girard, Stanislas Rapacchi
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Publication number: 20200338062Abstract: The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the of treatment an immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.Type: ApplicationFiled: May 14, 2020Publication date: October 29, 2020Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite d'Aix-MarseilleInventor: Philippe Pierre