Patents Assigned to Universite de Reims Champagne-Ardenne
  • Patent number: 10829581
    Abstract: The invention relates to a curable resin that represents an excellent substitute for phenolic resins and is therefore able to replace phenolic resins in all applications in which they are used. Said resin is characterised in that it comprises: (1) at least one prepolymer resulting from the prepolymerisation of a compound A comprising at least one aromatic or heteroaromatic ring, a first group —O—CH2-C?CH and at least one second group selected from the groups —O—CH2-C?CH2 and —CH2-CH?CH2, said groups being carried by the at least one aromatic or heteroaromatic ring; and (2) a compound B comprising at least two thiol groups (—SH). The invention also relates to a material obtained by curing said curable resin, and in particular to an ablative composite material. The invention further relates to a material obtained by curing said curable resin.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: November 10, 2020
    Assignees: ARIANEGROUP SAS, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Bastien Rivieres, Brigitte Defoort, Cécile Lesamber, Xavier Coqueret
  • Patent number: 10745530
    Abstract: A sizing composition for reinforcing fibres is provided which makes it possible to improve the adhesion of these fibres with respect to an organic matrix that forms, with them, a part made of a composite material and that results from the chain transfer polymerization of a curable resin. The sizing composition includes a polybutadiene prepolymer comprising at least two epoxide functions, a cross-linking agent comprising at least two reactive functions, at least one of which is a thiol function; and a catalyst comprising at least one tertiary amine function.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: August 18, 2020
    Assignees: AIRBUS SAFRAN LAUNCHERS SAS, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Arnaud Martin, Brigitte Defoort, Xavier Coqueret
  • Patent number: 10673633
    Abstract: Method for retrieving data entered during a server connection, the server having access to a memory including a generated hashed word of a first input data, which corresponds to the data modified by a processing function, the capacity of the hashed word being lower than a predefined capacity, a generated security key of a second input data, which corresponds to the data modified by a processing function, the capacity of the security key being equal to the difference between the predefined capacity and the hashed word capacity, the security key not being stored, method wherein: —after a request to retrieve the data, the hashed word and the security key are concatenated in order to reach the predefined capacity, and —an inverse hash function, using an algebraic solving of the hash function, is applied to the concatenation of the hashed word and security key, to retrieve the data.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: June 2, 2020
    Assignees: UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITE DE PICARDIE JULES VERNE
    Inventors: Gilles Dequen, Florian Legendre, Michaël Krajecki
  • Publication number: 20190382458
    Abstract: The present invention is situated in the field of multimers used for targeted therapies. More particularly, the invention relates to methods for preparing multifunctional heteromultimeric protein complexes with a defined ratio of functional components and to multifunctional heteromultimeric protein complexes for directing complement-dependent cytolysis, optionally comprising a scaffold, which display three or more different functional components present in a defined relative ratio, of which one is a tracking component.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 19, 2019
    Applicants: Luxembourg Institute of Health (LIH), Université de Reims Champagne Ardenne URCA
    Inventors: Xavier Dervillez, Carole Devaux, Jacques H.M. Cohen
  • Patent number: 10155065
    Abstract: The subject matter of the present invention is a photopolymerizable liquid composition comprising at least one epoxidized polybutadiene prepolymer, at least one cationic photoinitiator, and at least one thioxanthone-derived photosensitizer, which can, for example, be in the form of a liquid dressing. The subject matter of the invention is also a process for obtaining a polymerized film from said photopolymerizable liquid composition, characterized in that said composition is applied to tissues such as the skin, the skin appendages or the mucous membranes so as to form a uniform liquid film, and the film thus obtained is subjected to ultraviolet radiation, preferably ultraviolet-visible radiation having a wavelength of between 380 and 405 nm, preferably between 385 and 395 nm.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: December 18, 2018
    Assignees: LABORATORIES URGO, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Xavier Coqueret, Sadananda Das, Stéphane Auguste
  • Patent number: 9810625
    Abstract: A method for detecting and quantifying fibrosis, which involves at least; positioning a non-colored fixed tissue sample on a support; carrying out infrared acquisition, by scanning, of points of the sample; converting the infrared spectrum produced by each acquired point into at least one spectral image; carrying out a digital processing operation on the spectral image by distinguishing between at least physiological collagen and pathological collagen from fibrosis, attributing, to each point, a spectral class defined by an algorithm classifying the spectra according to the spectral similarities % thereof, then attributing a status to each class by statistically comparing with a digital model of spectra; quantifying the relative surface area occupied by the points of each status; and recording the result.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE
    Inventors: Vincent Vuiblet, Olivier Piot, Philippe Rieu, Michael Fere, Cyril Gobinet
  • Patent number: 9682929
    Abstract: The invention relates to new ?-vinyl carbonylated compounds corresponding to general formula (I), wherein R1, R2,R3, R4, R5 and Y are as defined in claim 1, their isomers, their diastereoisomers and acid addition salts or a pharmaceutically acceptable base. The invention also relates to a method for producing said compounds (I). It further relates to the use of said compound (I) as selective metalloprotease inhibitors, especially matrix metalloproteases 12 (MMP-12) and/or 9 (MMP-9). The compounds (I) are particularly useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD), particularly emphysema induced by cigarette smoke.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: June 20, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE
    Inventors: Samir Bouzbouz, Xavier Pannecoucke, Azzaq Belaaouaj, Laurette Malleret, Clement Denhez, Dominique Guillaume
  • Patent number: 9675628
    Abstract: The method for producing a mixture of neutral oligosaccharides extracted from flaxseed includes oligosaccharides having high molar masses generated by fractionation by ultrafiltration at a cut-off of between 15,000 and 50,000 Da and between 5,000 and 15,000 Da. The mixture of oligosaccharides produced as a result of the implementation of the method, and to the applications of the mixture can be used for skin repair and skin aging control.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: June 13, 2017
    Assignees: UNIVERSITE DE REIMS CHAMPAGNE ARDENNE, CENTRE VALORISATION GLUCIDES PROD NAT, UNIVERSITE DE ROUEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Francois Maquart, Georges Bellon, Claire Marchal, Helene Ducatel, Olivier Dupuis, Luc Picton, Didier Lecerf, Renauld Forbice
  • Patent number: 9644033
    Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 9, 2017
    Assignee: Universite De Reims Champagne Ardenne
    Inventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez
  • Patent number: 9605025
    Abstract: Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: March 28, 2017
    Assignee: Universite de Reims Champagne Ardenne
    Inventors: Stéphane Dedieu, Nicolas Floquet, Laurent Martiny, Christophe Schneider, Albin Jeanne, Emilie Sick, Manuel Dauchez
  • Patent number: 9551829
    Abstract: A photoacoustic detection device including a nanophotonic circuit including a first chip on which is formed at least one optical waveguide and in which is formed a set of cavities defining a Helmholtz resonator; at least one optical source capable of emitting an optical signal in a given wavelength range, capable of being modulated at an acoustic modulation frequency, this source being attached to the first chip; a second chip forming a cap for said cavities and including acoustic sensors; and electronic circuits for processing the output of the acoustic sensors formed in the first or the second chip.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: January 24, 2017
    Assignees: Commissariat a l'energie atomique et aux energies alternatives, Universite De Reims Champagne Ardenne
    Inventors: Mickaël Brun, Sergio Nicoletti, Bertrand Parvitte, Virginie Zeninari
  • Publication number: 20170014544
    Abstract: The subject matter of the present invention is a photopolymerizable liquid composition comprising at least one epoxidized polybutadiene prepolymer, at least one cationic photoinitiator, and at least one thioxanthone-derived photosensitizer, which can, for example, be in the form of a liquid dressing. The subject matter of the invention is also a process for obtaining a polymerized film from said photopolymerizable liquid composition, characterized in that said composition is applied to tissues such as the skin, the skin appendages or the mucous membranes so as to form a uniform liquid film, and the film thus obtained is subjected to ultraviolet radiation, preferably ultraviolet-visible radiation having a wavelength of between 380 and 405 nm, preferably between 385 and 395 nm.
    Type: Application
    Filed: December 12, 2014
    Publication date: January 19, 2017
    Applicants: Laboratoires Urgo, Universite de Reims Champagne-Ardenne, Centre National de la Recherche Scientifique
    Inventors: Xavier Coqueret, Sadananda Das, Stéphane Auguste
  • Patent number: 9447093
    Abstract: The present invention discloses compositions of novel DYRK1A protein inhibitors based on a 3,5-diarylazaindole motif and their preparation and use as medications in the treatment of cognitive disorders associated with dysfunction of DYRK1A protein, with Down's syndrome and with Alzheimer's disease.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 20, 2016
    Assignees: Centre National De La Recherche Scientifique (CNRS), Universite de Reims Champagne-Ardenne, Universite Paris Diderot Paris 7
    Inventors: Robert Dobb, Kevin Cariou, Stephanie Gourdain, Jean Maurice Delabar, Nathalie Janel, Fernando Rodrigues Lima, Julien Dairou, Clement Denhez
  • Publication number: 20160263858
    Abstract: A structural part (10) for a motor vehicle includes first (12A) and second (12B) mats, each mat comprising fibers and a resin bonding the fibers, and a separator (14) inserted between the first (12A) and second (12B) mats, the first (12A) and second (12B) mats being fixed on opposite faces of the separator (14). At least one of the first (12A) and second (12B) mats includes at least one continuous web of fibers (16), said web (16) comprising a plurality of parallel fibers bonded together by a thermosetting resin, at least part of the fibers of each web (16) having a length greater than 20 cm, in particular greater than 50 cm.
    Type: Application
    Filed: October 17, 2014
    Publication date: September 15, 2016
    Applicants: Faurecia Automotive Industrie, Lineo NV, Peugeot Citroen Automobiles SA, Universite de Reim Champagne-Ardenne
    Inventors: Frédéric ROUSSEAU, Moussa KHALFALLAH, François VANFLETEREN, Boussad ABBES, Valérie MARCEL
  • Publication number: 20160200676
    Abstract: The invention relates to new ?-vinyl carbonylated compounds corresponding to general formula (I), wherein R1, R2, R3, R4, R5 and Y are as defined in claim 1, their isomers, their diastereoisomers and acid addition salts or a pharmaceutically acceptable base. The invention also relates to a method for producing said compounds (I). It further relates to the use of said compounds (I) as selective metalloprotease inhibitors, especially matrix metalloproteases 12 (MMP-12) and/or 9 (MMP-9). The compounds (I) are particularly useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD), particularly emphysema induced by cigarette smoke.
    Type: Application
    Filed: September 2, 2014
    Publication date: July 14, 2016
    Applicant: Universite de Reims Champagne-Ardenne
    Inventors: Samir Bouzbouz, Xavier Pannecoucke, Azzaq Belaaouaj, Laurette Malleret, Clement Denhez, Dominique Guillaume
  • Publication number: 20160038569
    Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.
    Type: Application
    Filed: October 21, 2015
    Publication date: February 11, 2016
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE ROUEN, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE
    Inventors: Ebba BRAKENHIELM, Sébastien BANQUET, Florence EDWARDS-LEVY, Christian THUILLEZ
  • Patent number: 9238008
    Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: January 19, 2016
    Assignees: Institut National de la Sante et da la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Universite de Rouen, Universite de Reims Champagne-Ardennes, Centre Hospitalier Universitaire de Rouen
    Inventors: Ebba Brakenhielm, Sébastien Banquet, Florence Edwards-Levy, Christian Thuillez
  • Patent number: 9115212
    Abstract: The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts A, B and C. The first peptide part A corresponds to a hexapeptide repeated at least three times, the part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis. The second peptide part B corresponds to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease. The third peptide part C corresponds to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to enable inhibition of the proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: August 25, 2015
    Assignees: REGENTIS INTERNATIONAL, UNIVERSITE DE REIMS CHAMPAGNE ARDENNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: William Hornebeck, Joan Attia, Sandrine Lorimier, Frank Antonicelli
  • Patent number: 9051408
    Abstract: A curable composition, and a material obtained by curing the composition, in which the curable composition includes a vinylester polymerisable compound, jointly with a sulphonated polyaromatic thermoplastic polymer, and an N-vinyl lactam, and which is characterised in that it further includes, a first non-vinylester polymerisable compound which includes at least one isocyanurate group bearing at least two (meth)acrylate groups; and a second non-vinylester polymerisable compound which includes at least one carbopolycyclic or heteropolycyclic group bearing at least two (meth)acrylate groups.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: June 9, 2015
    Assignees: Astrium SAS, Universite De Reims Champagne-Ardenne, Centre National De La Recherche Scientifique
    Inventors: Xavier Coqueret, Mickael Krzeminski, Brigitte Defoort
  • Patent number: 8900592
    Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.
    Type: Grant
    Filed: November 23, 2006
    Date of Patent: December 2, 2014
    Assignee: Universite de Reims Champagne Ardenne
    Inventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez