Patents Assigned to Universite de Rennes 1
  • Patent number: 10454173
    Abstract: A Frequency-tunable and slot-fed planar antenna is proposed. The antenna includes resonant patch, a first dielectric layer, a ground plane having a first slot for each linear polarization, a second dielectric layer and a transmission line having, for each first slot, an end strand extending beneath the first slot. The antenna is frequency tunable for each linear polarization through at least one variable capacitance element. The matching of the antenna varies, for each linear polarization, as a function of a bias voltage applied to the variable capacitance element(s). The antenna includes, for each linear polarization, at least one second slot extending along the first slot. The end strand of the transmission line extends between the first slot and second slots. The at least one second slot creates an additional resonance.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: October 22, 2019
    Assignees: UNIVERSITE DE RENNES 1, CNRS—CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Yaakoub Taachouche, Mohamed Himdi
  • Patent number: 10310044
    Abstract: A computer-implemented method of characterizing molecular diffusion within a body from a set of diffusion-weighted magnetic resonance signals by computing a weighted average of a plurality of multi-compartment diffusion models comprises a same number of compartments, fitted to a set of diffusion-weighted magnetic resonance signals, the weighted average being computed using weights representative of a performance criterion of each of the models; wherein each of the multi-compartment diffusion models comprises a different number of subsets of compartments, the compartments of a same subset being identical to each other.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: June 4, 2019
    Assignees: UNIVERSITE DE RENNES 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE (INRIA), INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Patrick Perez, Olivier Commowick, Christian Barillot, Aymeric Stamm
  • Publication number: 20190165477
    Abstract: The invention relates to an antenna designed to emit and/or receive surface waves with a decametric, hectometric or kilometric central wavelength ?0, characterised in that it comprises at least one horizontal wire aerial element of between 0.5?0 and ?0 in length, and at least three vertical wire aerial elements of the same length between 0.03?0 and 0.1?0, arranged in a same plane and each comprising an upper end and a lower end, said upper ends being connected to the horizontal wire aerial element, said lower ends being designed to be connected to a conducting medium having a substantially horizontal surface. The invention also relates to an antenna, an antenna array and a use of an antenna or of an antenna array.
    Type: Application
    Filed: July 22, 2016
    Publication date: May 30, 2019
    Applicants: TDF, UNIVERSITE DE RENNES 1
    Inventors: Mathilde BELLEC, Jean-Yves LAURENT, Sébastien M. PALUD, Pierre-Yves JEZEQUEL, Franck COLOMBEL, Stéphane AVRILLON
  • Patent number: 10292897
    Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 21, 2019
    Assignees: SORIN CRM SAS, INSERM—INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1
    Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
  • Patent number: 10287633
    Abstract: The present invention relates to methods and reagents for the treatment of melanoma and/or of metastatic melanoma that directly or indirectly target TYRP1 RNA transcript. The invention also relates to methods for predicting if a melanoma patient will be therapeutically responsive to such methods of treatment and reagents, and to methods for assessing the effectiveness of such methods of treatment and reagents. The invention further relates to a combination of biological markers that allows the prediction of melanoma patients' survival irrespective of the treatment administered.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: May 14, 2019
    Assignees: UNIVERSITE DE RENNES 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER UNIVERSITAIRE PONTCHAILLOU
    Inventors: David Gilot, Marie-Dominique Galibert, Ghanem Ghanem, Fabrice Journe
  • Publication number: 20190126048
    Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 2, 2019
    Applicants: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
  • Patent number: 10251809
    Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: April 9, 2019
    Assignees: Sorin CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ DE RENNES 1, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1
    Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
  • Patent number: 10220112
    Abstract: The present invention provides cyclic antimicrobial pseudopeptides that are useful in a variety of applications. Also provided are pharmaceutical compositions, products and kits comprising such cyclic antimicrobial peptides and methods of using these antimicrobial peptides for modifying infectivity, killing microorganisms or inhibiting microbial growth or function and for preventing and/or treating an infection or contamination caused by such microorganisms.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: March 5, 2019
    Assignees: Universite de Rennes 1, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale
    Inventors: Olivia Solecki, Amor Mosbah, Michèle Baudy-Floch, Brice Felden
  • Patent number: 10166393
    Abstract: The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: January 1, 2019
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1
    Inventors: Jean-Luc Bonnet, Mélanie Mullemeester, Alfredo Hernandez, Guy Carrault
  • Patent number: 10159840
    Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 25, 2018
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM-INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
  • Patent number: 10135150
    Abstract: A beamformer comprises a transmission line fed by at least one input feed source, the transmission line comprising two stacked metal plates extending, along two directions, longitudinal X and transverse Y. The transmission line further comprises at least one protuberance extending in the directions X, Y, and in a direction Z orthogonal to the plane XY, the protuberance comprising a metal insert extending in the directions X and Y and extending height-wise in the direction Z, the insert comprising a base fastened to one of the two metal plates and a free end and having a contour of variable length between the two lateral edges of the transmission line. In the protuberance, the transmission line is adjoining the insert and forms, in the direction Z, a circumvolution around the insert.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: November 20, 2018
    Assignees: THALES, UNIVERSITE DE RENNES 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Hervé Legay, Ségolène Tubau, Jean-Philippe Fraysse, Etienne Girard, Mauro Ettorre, Ronan Sauleau, Nelson Fonseca
  • Patent number: 10124173
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: November 13, 2018
    Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM- INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Patent number: 10099056
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: October 16, 2018
    Assignees: Sorin CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Patent number: 10092756
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: October 9, 2018
    Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Patent number: 10088534
    Abstract: A measurement device for magnetic resonance applications includes, in a measurement case: a first sensor for measuring radiofrequency magnetic fields; a second sensor for measuring magnetic field gradients; and a third sensor for measuring the radiofrequency electric field; and a stage for converting the electric signals delivered by the different measurement sensors into light signals. The device also in a controller for controlling and processing the signals, connected to the stage for conditioning the measurement case via a beam for transmitting light signals. The controller includes a stage for converting light signals into electric signals delivered by the sensors.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: October 2, 2018
    Assignees: UNIVERSITE CLAUDE BERNARD LYON I, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1
    Inventors: Hervé Saint-Jalmes, Olivier Beuf
  • Patent number: 10084548
    Abstract: A method is provided for transmitting a sequence of data symbols including at least two data symbols of distinct values, delivering an electromagnetic wave carrying an orbital angular momentum. The method includes, for at least one data symbol to be transmitted: a bijective selection of an order of orbital angular momentum associating, with each distinct value of a data symbol, a distinct order of orbital angular momentum, and delivering a selected order of orbital angular momentum that is representative, by bijection, of the value of the at least one data symbol to be transmitted; and transmitting the electromagnetic wave carrying an orbital angular momentum, the order of orbital angular momentum of which corresponds to the selected order of orbital angular momentum.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: September 25, 2018
    Assignees: Institut National des Sciences Appliquees de Rennes, Universite de Rennes 1, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Philippe Mary, Adbullah Haskou, Christian Brousseau
  • Publication number: 20180214509
    Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.
    Type: Application
    Filed: March 27, 2018
    Publication date: August 2, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE RENNES 1, UNIVERSITE DE BRETAGNE OCCIDENTALE
    Inventors: Florie DESRIAC, Yannick FLEURY, Patrick LE CHEVALIER, Delphine DESTOUMIEUX, Matthieu SIMON
  • Patent number: 9981132
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: May 29, 2018
    Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Publication number: 20180136299
    Abstract: The invention relates to a module (6) for producing an MRI and/or MRS reference signal (S0), characterized in that the module comprises: a first receiving input (621) for receiving of an MRI and/or MRS synchronization signal (S3), a second receiving input (612) for receiving of a time signal (S8) of external stimulation, supply means (62) for supplying of a prescribed signal (RV) representing an MRI and/or MRS virtual object (RVV), generating means for generating of the MRI and/or MRS reference signal (S0), for temporally varying the MRI and/or MRS reference signal (S0) in the same way as a time characteristic determined from the time signal (S8) of external stimulation and in synchronization with the MRI and/or MRS synchronization signal (S3), a supply output (632) for supplying of the MRI and/or MRS reference signal (S0).
    Type: Application
    Filed: April 1, 2016
    Publication date: May 17, 2018
    Applicants: Universite De Rennes 1, Institut National de la Sante et de la Recherche Medicale (INSERM), Fondat Region Ouest Ligue Cancer
    Inventors: Hervé Saint-Jalmes, Giulio Gambarota
  • Patent number: 9956262
    Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: May 1, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE RENNES 1, UNIVERSITE DE BRETAGNE OCCIDENTALE
    Inventors: Florie Desriac, Yannick Fleury, Patrick Le Chevalier, Delphine Destoumieux, Matthieu Simon