Patents Assigned to Universite Paris Descartes
  • Patent number: 11820813
    Abstract: The present invention relates to a neutralising antibody which is capable of binding to neurotensin with high affinity. The antibody of the present invention neutralises the activity of neurotensin, in particular the oncogenic activities of neurotensin. In particular, the present invention relates to a neutralising antibody which binds to the human neurotensin long fragment, and having a heavy chain variable region which comprises a H-CDR1 region having at least 90% of identity with SEQ ID NO:2, a H-CDR2 region having at least 90% of identify with SEQ ID NO:3 and a H-CDR3 region having at least 90% of identity with SEQ ID NO:4; and a light chain variable region comprising a L-CDR1 region having at least 90% of identity with SEQ ID NO:6, a L-CDR2 having at least 90% of identity with SEQ ID NO:7 and a L-CDR3 region having at least 90% of identity with SEQ ID NO:8. The present invention also provides the use of such antibodies in the treatment of cancer.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: November 21, 2023
    Assignees: INSERM (INSITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DESCARTES
    Inventor: Patricia Forgez
  • Patent number: 11752131
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of obesity. In particular, the present invention relates to a method of treating obesity in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an indoleamine 2-3 dioxygenase (IDO) inhibitor.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: September 12, 2023
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DESCARTES
    Inventors: Fatima-Soraya Taleb, Ziad Mallat, Alain Tedgui
  • Patent number: 11679179
    Abstract: The invention relates to a method for predicting or diagnosing a risk of bioprosthetic valve degeneration. Further, the invention relates to a medical device, in particular a bioprosthetic valve coated with EPCR less prone to degeneration and/or calcification once implanted.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: June 20, 2023
    Assignees: UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: David Smadja, Nicolas Gendron, Richard Chocron
  • Patent number: 11607166
    Abstract: A method for quantifying the balance of an individual recording, on a memory, at least one statokinesigram of the individual obtained from a platform comprising pressure and/or force sensors; extracting, by a processor and from the at least one statokinesigram of the individual recorded on the memory, values of at least one position trajectory parameter of the pressure center and values of at least one stability trajectory parameter of the pressure center; determining, by the processor, the value of a plurality of quantifiers, from the values of the trajectory parameters extracted; comparing, by the processor, said values of the plurality of quantifiers with the values of the same quantifiers obtained from reference statokinesigrams; and determining, by the processor, said value representative of the balance of the individual at the end of the comparison.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: March 21, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE PARIS-SACLAY, UNIVERSITE PARIS DESCARTES, ETAT FRANCAIS—MINISTERE DE LA DEFENSE—DIRECTION CENTRALE DU SERVICE DE SANTE DES ARMEES
    Inventors: Nicolas Vayatis, Pierre Paul Vidal, Nikolaos Promponas Kefalas, Julien Audiffren, Alain Yelnik, Catherine De Waele Vidal, Damien Ricard
  • Patent number: 11492621
    Abstract: The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c. 2991+1655 A>G CEP290 mRNA.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: November 8, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), GENETHON, UNIVERSITE PARIS DESCARTES, ENSCP—CHIMIE PARISTECH—ECOLE NATIONALE SUPERIEURE DE CHIME DE PARIS, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Jean-Michel Rozet, Antoine Kichler, Isabelle Perrault, Josseline Kaplan, Xavier Gerard, Daniel Scherman, M. Arnold Munnich
  • Patent number: 11487094
    Abstract: The present invention concerns an optical system for spatiotemporally shaping the wavefront of the electric field of a light beam (1) to be projected into a target volume (5), where the propagation axis is axis z, to create 3D patterned illumination in the target volume (5), comprising a pulsed laser source, configured to have an illumination pattern whose transversal surface at the target volume being superior to the diffraction limit of the optical system, at least one intermediate optical element (4) which is a dispersive grating for performing temporal focusing of the light beam (1), located, on the propagation axis (z), where an image of the illumination pattern is formed, for modulating the phase and/or the amplitude of the electric field of the light beam, and a second optical element (3) which is a spatiallight modulator for modulating the phase of the electric field of the input light beam, and for realizing spatiotemporal multiplexing to create 3D patterned illumination in the target volume (5) by r
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: November 1, 2022
    Assignees: UNIVERSITE PARIS DESCARTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Emiliano Ronzitti, Nicolò Accanto, Valentina Emiliani, Eirini Papagiakoumou, Dimitrii Tanese
  • Patent number: 11406686
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of tissue lesions. The inventors showed that CCR2 is expressed on FMCs, especially on a subpopulation of progenitor cells, that they call “fetal myeloid progenitor cells” (FMPCs), and mediates the recruitment of these cells to maternal wound tissue. Moreover, the inventors reported that recruited FMCs/FMPCs improve maternal skin wound healing by organizing blood vessel endothelium and secreting pro-angiogenesis peptides, particularly chemokine CXCL1, to enhance angiogenesis in wound. In particular, the present invention relates to CCR2 agonists for use in the treatment of tissue lesions in a subject in need thereof.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: August 9, 2022
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Sorbonne Université, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (APHP)
    Inventors: Selim Aractingi, Mathieu Catela, Dany Nassar, Zhe Wang
  • Patent number: 11389434
    Abstract: The inventors demonstrate for the first time the activation of the Hedgehog (HH) signaling pathway in normal and abnormal human mast cells (MCs). These results prompt the inventors to explore the consequence of the inhibition of the HH pathway, especially the canonical pathway, on MC proliferation. They demonstrate that Hedgehog inhibitors inhibit proliferation and induces apoptosis of mast cells. Accordingly the present invention relates to a method of treating a mast cell disease in a patient in need there of comprising administering to the patient a therapeutically effective amount of a Hedgehog inhibitor.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: July 19, 2022
    Assignees: INSERM, FONDATION IMAGINE, UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Leila Maouche-Chretien, Christine Bodemer, Olivier Hermine, Laura Polivka
  • Patent number: 11344515
    Abstract: The present invention relates to the field of muscle regeneration, and more particularly to the replenishment of the in vivo muscle stem cells pool. It more specifically relates to a 5-hydroxytryptamine B1 receptor-stimulating agent, and to a composition comprising said agent, for use as i) a promoter of satellite cells self-renewal and/or differentiation, and/or ii) an agent preventing and/or inhibiting the satellite cells pool exhaustion. The invention further encompasses therapeutic and screening methods.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: May 31, 2022
    Assignees: INSTITUT PASTEUR, UNIVERSITE PARIS DESCARTES, CENTRE HOSPITALIER SAINTE ANNE PARIS, INISTITI IT GI ISTAV/E Dm ICCV
    Inventors: Fabrice Bruno Chretien, Raphael Gaillard, Pierre Rocheteau, Olivier Mir
  • Patent number: 11300569
    Abstract: The present invention relates to the prognosis of the outcome of a cancer in a patient, which prognosis is based on the quantification of one or several biological markers that are indicative of the presence of, or alternatively the level of, the adaptive immune response of said patient against said cancer.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: April 12, 2022
    Assignees: ISERM (Institut National de la Santé et de la Recherche Médicale), Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (APHP)
    Inventors: Jerome Galon, Franck Pages, Wolf-Herman Fridman
  • Patent number: 11231422
    Abstract: Plasma levels of different sub-populations of microvesicles (endothelial, leukocyte, platelet and hepatocyte) were measured by flow cytometry or ELISA/filtration on blood samples from 125 patients with cirrhosis, for which 36 of them were diagnosed with HCC at inclusion. The inventors show that the levels of microvesicles of endothelial origin (CD62E+) could predict the occurrence of HCC in patients with cirrhosis. Therefore the present invention relates to a method for determining whether a patient suffering from cirrhosis is at risk of having or developing hepatocellular carcinoma comprising determining the level of endothelial-derived microvesicles (e.g. by flow cytometry) in a blood sample obtained from the patient.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: January 25, 2022
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paris Descartes, Assistance Publique Hôpitaux de Paris (APHP), UniversitéParis Diderot—Paris 7
    Inventors: Pierre-Emmanuel Rautou, Chantal Boulanger-Robert
  • Patent number: 11203753
    Abstract: The present invention relates to a hepcidin antagonist for use in the treatment of inflammatory diseases.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: December 21, 2021
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes, Université Paris Diderot—Paris 7
    Inventors: Carole Peyssonnaux, Jacques Mathieu, Sara Zumerle
  • Patent number: 11160471
    Abstract: A device for being ingested by a patient, which includes a disintegration matrix designed to disintegrate in a digestive segment and a plurality of independent passive RFID markers that are housed together in the disintegration matrix. The disintegration matrix isshaped so that when it disintegrates, the RFID markers separate from one another and are no longer mechanically connected, so that each RFID marker is able to move independently of the other RFID markers in several segments of the digestive system of the patient. The RFID markers each being, in the disintegration matrix, protected by a hermetic encapsulation in a biocompatible material.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: November 2, 2021
    Assignees: UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventor: Michel Bouchoucha
  • Patent number: 11110133
    Abstract: The invention relates to a lyophilized composition comprising a microbiota in its ecosystem, in particular stools, and a mixture of cryoprotectant agents comprising maltodextrin and trehalose, a capsule comprising said lyophilized composition, the use thereof, and methods for the production thereof.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: September 7, 2021
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITE PARIS DESCARTES, UNIVERSITE PARIS DIDEROT—PARIS 7, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Nathalie Kapel, Anne-Judith Waligora-Dupriet, Muriel Thomas, Christine Charrueau, Francisca Joly, Camille Mayeur, Véronique Robert, Johanne Delannoy
  • Patent number: 11078251
    Abstract: The present invention relates to T-cell receptors (TCR) that recognize pancreatic betacell epitopes and uses thereof for the diagnosis and treatment of diabetes.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 3, 2021
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paris Descartes, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Roberto Mallone, Georgia Afonso, Ana Ines Lalanne, Slobodan Culina
  • Patent number: 11065230
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of systemic mastocytosis. The inventors showed the effect of KPT-251 treatment on SCF-dependent human Mast cell (MC) line without KIT mutation (WT ROSA) and on two factor-independent MC lines with KIT mutations : ROSA ? 417-419 insY and ROSA D816V. KPT is a Selective Inhibitor of Nuclear Export (SINE) that specifically inhibits the activity of the exportin-1 (XPO1). KPT-251 treatment induces minimal toxicity in non-cancerous hematopoietic cells both in vitro and in vivo. In particular, the present invention relates a method of treating systemic mastocytosis in patient in need thereof comprising administering to the patient a therapeutically effective amount of a XPO1 inhibitor.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: July 20, 2021
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), FONDATION IMAGINE, UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE CAEN NORMANDIE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE CAEN
    Inventors: Olivier Hermine, Flavia Guillem, Gandhi Damaj, Sophia Ladraa
  • Patent number: 11067585
    Abstract: The present Inventors demonstrated that the RelB subunit of NF?B plays a crucial role in promoting cell migration. More precisely, they identified that this pro-migratory activity is mediated by the activation of the NF?B pathway through RelB phosphorylation at serine 472. In a first aspect, the present invention proposes to monitor the activation of the NF?B pathway by following the phosphorylation status of said serine. Also, the present invention discloses methods and kits for prognosing the evolution of a disease involving cell migration in a subject—treated or not—suffering thereof, based on the detection of said RelB-S472 phosphorylation.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 20, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS DESCARTES, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Veronique Baud, Katy Billot
  • Patent number: 11013830
    Abstract: The present invention relates to the field of regenerative medicine, and more particularly to the improvement of the in vivo engraftment potential of biological material to be administered to a subject in need thereof.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: May 25, 2021
    Assignees: INSTITUT PASTEUR, UNIVERSITE PARIS DESCARTES, CENTRE HOSPITALIER SAINTE ANNE PARIS
    Inventors: Fabrice Bruno Chretien, Raphael Gaillard, Pierre Rocheteau
  • Patent number: 10986821
    Abstract: The present invention relates to a vector comprising a nucleic acid sequence that encodes the APP protein and/or the PS1 protein or variants thereof. The invention also relates to a method for inducing the Alzheimer's disease in an animal using the vector of the invention and to animal model having the Alzheimer's disease obtained by said method.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: April 27, 2021
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université de Paris—Sud, Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes
    Inventors: Nathalie Cartier-Lacave, Jerome Braudeau, Nicole Deglon, Philippe Hantraye, Mickael Audrain
  • Patent number: 10874637
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of neurodegeneration in with brain iron accumulation (NBIA). Studying two novel genes, namely, CRAT encoding the carnitine acetyltransferase and REPS1 involved in endocytosis and vesicle transport, and a series of known NBIA genes, the inventors reported on iron overload related to increased levels and abnormal recycling of transferrin receptor as a common feature in NBIA. They ascribe this anomaly, at least in part, to impaired palmitoylation of the receptor as a common consequence of the various disease causing mutations. Finally, the inventors show that Artesunate improved TfR1 palmitoylation in NBIA fibroblasts. In particular, the present invention relates to a method of treating neurodegeneration with brain iron accumulation in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a drug increasing TfR1 palmitoylation.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: December 29, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS DESCARTES, FONDATION IMAGING, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Anne Agnès Rötig, Anthony Drecourt