Patents Assigned to Universite Pierre et Marie Curie (Paris 6)
  • Patent number: 10947152
    Abstract: The invention relates to a process for permanently electrostatically doping a layer of a conductive or non-conductive material that is deposited on a solid substrate, to the doped material obtained according to this process, and to the use of such a material.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: March 16, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIC, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Abhay Shukla, Johan Biscaras, Andrea Paradisi
  • Patent number: 10939838
    Abstract: The invention relates to a method for detecting a physiological state of a patient deviating from a reference physiological state, in which, after having determined, in each of Q frequency bands, R reference matrices PRq,r with qe[1 . . . Q] and r?[1 . . . R] which correspond to the reference physiological state, the following steps are repeated in a loop: carrying out measurements, in M time segments, of an electroencephalographic signal; filtering and centering the measurements in Q frequency bands to obtain and determine M×Q scaled matrices of spatial covariance; for each time segment m, calculating a deviation from the reference physiological state, and comparing each of the deviations from the reference physiological state to a predefined threshold. The invention also relates to a monitoring device applying said method.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: March 9, 2021
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FONDATION ICM—INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Thomas Similowski, Mathieu Raux, Mario Chavez, Jacques Martinerie, Pierre Pouget
  • Patent number: 10869705
    Abstract: An implant and guide are described, together with methods for configuring the same. The implant and guide are for maxillofacial osteosynthesis and may be provided as a kit. Three-dimensional models of the pre- and post-operative anatomy are used to define attachment points. These attachment points are used to define a structure for the implant and the guide.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: December 22, 2020
    Assignees: OBL S.A., Université Pierre et Marie Curie (Paris 6), Assistance Publique—Hôpitaux de Paris (Paris)
    Inventors: Guillaume Dubois, Patrick Goudot, Thomas Schouman
  • Patent number: 10765412
    Abstract: The invention relates to an endoscopic instrument (1) having an elongate body with a distal end (4) designed to be introduced into the body of the patient so as to come into proximity with an internal organ, the distal end carrying a tool (7) for intervention on the internal organ. The endoscopic instrument has a fool (10) rigidly connected to the distal end and designed to bear on the internal organ, and also controllable means (13) for conferring movements on the tool, at least in directions transverse to a longitudinal axis (X) of the distal end of the endoscopic instrument, when the foot is bearing against the internal organ.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: September 8, 2020
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MAUNA KEA TECHNOLOGIES, ENDOCONTROL
    Inventors: Benoît Rosa, Benoît Herman, Jérôme Szewczyk, Guillaume Morel, Clément Vidal, Patrick Henri, François Lacombe, Jérôme Lopez
  • Patent number: 10680241
    Abstract: The present application describes a process for the preparation of titanium-based compounds having an anatase type structure with cationic vacancies arising from a partial substitution of oxygen atoms by fluorine atoms and hydroxyl groups. Electrochemically active materials comprising the titanium-based compounds for use in lithium-ion battery electrodes are also described.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: June 9, 2020
    Assignees: HYDRO-QUEBEC, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Damien Dambournet, Wei Li, Henri Groult, Sandrine Leclerc, Christian Julien, Karim Zaghib
  • Patent number: 10519039
    Abstract: The present invention relates to a process for the preparation of a boron phosphide, more specifically BP and/or B12P2, comprising the mechanochemical reaction of boron phosphate (BPO4) with at least one alkaline earth metal (EA). In particular, the process of the invention allows for the selective preparation of either BP or B12P2 with more than 95% purity, through the reduction of boron phosphate (BPO4) with at least one alkaline earth metal (EA) according to reaction (1) for BP and according to reaction (2) for B12P2: BPO4+4 EA?BP+4 EA(O) (1) 2BPO4+5 (EA)B2+3 EA?B12P2+8 EA(O) (2). The present invention further relates to boron phosphide powders, in particular BP or B12P2 powders, of nanometric or micrometric size.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: December 31, 2019
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIV PARIS XII-NORD VILLETANEUSE
    Inventors: Yann Le Godec, Vladimir A. Mukhanov, Vladimir L. Solozhenko, Petr S. Sokolov, Dominique Vrel
  • Publication number: 20190353590
    Abstract: The invention relates to a portable device (1) for estimating at least one parameter characteristic of a polymer material, characterized in that the device comprises at least one infrared source (101), each infrared source (101) being capable of emitting towards the polymer material a spectral line, representing maximum emission energy, selected in one of the wavelengths 10 ?m, 9.5 ?m, 7.2 ?m, 6 ?m, 3.5 ?m, 2.7 ?m or in one of the wave numbers 1000 cm?1, 1050 cm?1, 1350 cm?1, 1700 cm?1, 2900 cm?1, 3700 cm?1, at least one infrared detector (102), capable of receiving infrared radiation (112), which is reflected by the polymer material (M) in response to the spectral line, a unit for determining the parameter characteristic of the polymer material (M) as a function of the energy present in said spectral line in the infrared radiation (112), having been reflected by the polymer material (M) and having been received by the infrared detector (102).
    Type: Application
    Filed: November 17, 2017
    Publication date: November 21, 2019
    Applicants: Electricite de France, Universite Pierre Et Marie Curie (Paris 6)
    Inventors: Alejandro Ribes Cortes, Mohamed Ben Chouikha
  • Publication number: 20190338423
    Abstract: A sol-gel method for producing an anti-corrosion coating consisting of at least one layer of an oxide on a metal substrate. A non-aqueous solution of a precursor of the oxide is prepared and deposited on one surface at least of the metal substrate in order to cover said surface at least partially with a film comprising the precursor of the oxide. Hydrolysis-condensation of the precursor of the oxide is carried out by exposing the film to a humid atmosphere in order to form an oxide network in the film. Then, a treatment for stabilizing the film on the surface of the substrate is carried out, followed by a heat treatment of the surface of the metal substrate in order to crystallize the network of oxide and form the anti-corrosion coating.
    Type: Application
    Filed: December 20, 2017
    Publication date: November 7, 2019
    Applicants: ELECTRICITE DE FRANCE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS-, COLLEGE DE FRANCE
    Inventors: Adele Astorg, Xavier Crozes, Lionel Nicole, Clement Sanchez
  • Patent number: 10440296
    Abstract: Disclosed is a method for processing an asynchronous signal produced by a light sensor, the sensor having a pixel matrix disposed opposite a scene, the method including: receiving from the light sensor the asynchronous signal including, for each pixel of the matrix, successive events from the pixel; analysing the asynchronous signal using activity profiles as events are received in the asynchronous signal. The activity profile includes at least, for each pixel of the sensor, an activity value that decreases as a function of the time that has passed since the most recent event among the successive events from the pixel.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: October 8, 2019
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Ieng Sio-Hoi, Benosman Ryad, Shi Bertram
  • Patent number: 10371774
    Abstract: A method for carrying out two-field nuclear magnetic resonance (=2FNMR) measurements involves preparing a sample (9a) in a first working volume (5) of a highly homogeneous magnetic field with a first field strength; transferring the sample (9a) to a second working volume (7) with a magnetic field having lower homogeneity and having a second field strength, wherein the first field strength is at least 2 Tesla larger than the second field strength; manipulating the sample (9a) at the second working volume (7) by applying a sequence of radio-frequency (=RF) and/or field gradient pulses; transferring the sample (9a) back to the first working volume (5); and detecting an NMR signal of the sample (9a) in the first working volume (5). The method allows for NMR experiments with which more and/or improved quality information about an investigated sample can be obtained.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: August 6, 2019
    Assignees: Bruker S.A.S, Ecole normale supérieur, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie (Paris 6)
    Inventors: Samuel Cousin, Cyril Charlier, Fabien Ferrage, Jean-Max Tyburn, Thorsten Marquardsen
  • Patent number: 10365246
    Abstract: Device for the representation, in a frequency-wave number reference frame f-k, of the propagation of an ultrasound wave in a dihedral guide (1), which comprises ultrasound emitters (2) referenced by “Ej” with j an integer varying between 1 and N, N a strictly positive integer and ultrasound receivers (3) referenced by “Ri” with i an integer varying between 1 and M, M a strictly positive integer, the receivers being disposed spatially over a first segment of a straight line according to a regular pitch “A”, which comprises means for processing the signal received by the receivers, originating from the emitters, and in which the processing means comprise means for calculating a modified discrete spatial Fourier transform, for a spatial integration variable “x”, centered in the middle of said first segment and running through the receivers in the direction of increasing x, and for a wave vector k(x) equal to a product k.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: July 30, 2019
    Assignees: Azalée, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie - Paris 6
    Inventors: Ludovic Moreau, Jean-Gabriel Minonzio, Maryline Talmant, Pascal Laugier
  • Publication number: 20190125723
    Abstract: The present invention relates to compounds of the following general formula (I) or (II) or a pharmaceutically acceptable salt and/or solvate thereof, for use in the prevention and/or the treatment of disorders associated to gammaherpesvirinae, in particular to the human herpesvirus 8 (HHV8) or the human herpes virus 4 (HHV4), and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: June 28, 2017
    Publication date: May 2, 2019
    Applicants: Assistance Publique - Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Pierre et Marie Curie (Paris 6), Universite Paris Descartes, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Nicolas Dupin, Anne-Geneviève Marcelin, Vincent Calvez, Philippe Grange
  • Publication number: 20190083776
    Abstract: The invention relates to a process for manufacturing at least one implant for focal electrical stimulation of a nervous structure, said implant being of the type including in a supporting structure a network of cavities at the bottom of which are placed microelectrodes, the cavities being bounded by walls erected and located around the microelectrodes, the supporting structure being produced beforehand by implementing the following steps: deposition and etching, in a planar manner, on an insulating substrate, of electrical contacts, of electrical tracks and of microelectrodes, first tracks electrically connecting the microelectrodes and the electrical contacts, second electrical tracks being electrically connected to a ground.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 21, 2019
    Applicants: Chambre de Commerce et D'Industrie de Region Paris Ile de France (ESIEE Paris), Universite Pierre Et Marie Curie (Paris 6), Centre National de la Recherche Scientifique (CNRS ), Institut National de la Sante et de la Recherche M edicale (INSERM)
    Inventors: Lionel Rousseau, Gaëlle Lissorgues, Myline Cottance, Serge Picaud, Julie Degardin
  • Patent number: 10227653
    Abstract: The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, the polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions containing the same. The invention is also directed to the use of the polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: March 12, 2019
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Christophe Prehaud, Monique Lafon, Nicolas Wolff, Zakir Khan, Elouan Terrien, Sandrine Vitry
  • Publication number: 20190018230
    Abstract: The present disclosure concerns a broadband hyperspectral imaging spectrophotometer configured to analyze an object and includes an illumination assembly having a source for emitting a light beam and configured so that the light beam scans line by line the object to be analyzed, a focusing mirror, a first mirror folding, and a planar scanning mirror movable in rotation. The illumination assembly, the focusing mirror, the first folding mirror and the planar mirror are arranged to bring the light beam to the object along a line which will be displaced on the object via the scanning mirror. The imaging spectrophotometer further includes two measuring sensors by a distance between the object and the scanning mirror. The focusing mirror is movable in translation to adapt the imager to the measured distance by the measuring sensors.
    Type: Application
    Filed: July 6, 2018
    Publication date: January 17, 2019
    Applicants: Centre National d'Études Spatiales, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Frédéric BOURCIER, Philippe WALTER
  • Patent number: 10179921
    Abstract: The present invention relates to a method for producing polyphenol compounds, i.e. phloroglucinol or one of its derivatives, with a polyketide synthase of type III (PKSIII) from a brown marine alga. The invention also relates to recombinant nucleic acids coding for a polyketide synthase of type III (PKSIII) from the brown alga Ectocarpus siliculosus (E. siliculosus), to recombinant vectors comprising these nucleic acids, as well as to host cells comprising these vectors. Finally, the invention relates to a method for preparing of various compounds by means of polyphenol compounds produced according to the aforementioned method.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: January 15, 2019
    Assignees: UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
    Inventors: Ludovic Delage, Laurence Meslet-Cladiere, Philippe Potin, Sophie Goulitquer
  • Publication number: 20190011317
    Abstract: Disclosed is a force sensor, including: at least one measurement cell, each measurement cell being filled with a filling material in which at least one inclusion of a substance is embedded; for each cell, at least one light source arranged in order to illuminate the inclusion embedded in this cell; for each cell, a measurement system including at least one optical measurement point arranged in order to capture light originating from the inclusion embedded in this cell; for each cell, a unit arranged in order to convert optical signals originating from the measurement system of this cell to a signal representative of a force exerted on this cell, this signal being dependent on a movement of the inclusion embedded within the filling material of this cell.
    Type: Application
    Filed: August 11, 2016
    Publication date: January 10, 2019
    Applicants: MUSEUM NATIONAL D'HISTOIRE NATURELLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT - PARIS 7
    Inventors: Séverine TOUSSAINT, Artémis LLAMOSI
  • Patent number: 10159684
    Abstract: The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention also relates to a topical pharmaceutical composition comprising an amount of at least one glucocorticoid and an amount of at least one mineralocorticoid receptor antagonist or inhibitor of MR expression for use in a method for treating an inflammatory skin disease or an inflammatory disease of the cornea or of the anterior segment of the eye in a subject in need thereof.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: December 25, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DESCARTES, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP)
    Inventors: Nicolette Farman, Frederic Jaisser, Francine Behar-Cohen, Selin Aractingi, Van Tuan Nguyen
  • Publication number: 20180361378
    Abstract: The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.
    Type: Application
    Filed: May 6, 2016
    Publication date: December 20, 2018
    Applicants: Paris Sciences Et Lettres - Quartier Latin, Centre National de la Recherche Scientifique (CNRS ), Universite Pierre Et Marie Curie (Paris 6), Universite Paris Diderot Paris 7
    Inventors: Vincent Croquette, David Bensimon, Jimmy Ouellet, Jean-François Allemand, Charles Andre, Gordon Hamilton
  • Patent number: 10154235
    Abstract: A device for displaying an image sequence in the form of a pixel matrix, includes a control unit coupled to a projector. The control unit includes an input interface designed to receive asynchronous information representing, for each pixel of the matrix, events concerning the pixel, and a processor designed to control the activation of each pixel of the matrix at moments determined by the respective events indicated by the asynchronous information for the pixel. The projector is disposed on a support so as to illuminate the light receptors of the eye when the device is in use and is designed to project a light flux corresponding to the pixels activated by the control unit.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: December 11, 2018
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Ryad Benosman, Guillaume Chenegros, Serge Picaud, Siohoi Ieng, Jose-Alain Sahel