Patents Assigned to UNIVERSITE PIERRE ET MARIE CURIE—PARIS 6 (UPMC)
  • Compounds for treating cystic fibrosis
    Patent number: 10414768
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable enantiomers, salts, solvates or prodrugs thereof. The invention further relates to the use of the compounds of Formula (I) for the treatment of cystic fibrosis. The invention also relates to a process for manufacturing compounds of Formula (I).
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 17, 2019
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie—Paris 6 (UPMC)
    Inventors: Isabelle Callebaut, Jean-Paul Mornon, Jean-Luc Decout, Frederic Becq, Pierre Lehn, Brice Hoffman, Benjamin Boucherle, Romain Haudecoeur, Antoine Fortune, Clement Boinot, Julien Alliot
  • Fluorogen activating and shifting tag (FAST)
    Patent number: 10138278
    Abstract: Disclosed is a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labelling particles, e.g. proteins, or surfaces, which is capable of binding reversibly a fluorogenic chromophore of formula (I), and which is capable of enhancing the brightness of the fluorogenic chromophore upon complexation thereto; and of inducing the spectral shift of the fluorogenic chromophore through the ionization of an auxochromic group thereof.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: November 27, 2018
    Assignees: PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS), UNIVERSITE PIERRE ET MARIE CURIE—PARIS 6 (UPMC)
    Inventors: Arnaud Gautier, Ludovic Jullien