Patents Assigned to University of Cape Town
  • Patent number: 11124574
    Abstract: The technology provided herein generally relates to novel specific photoimmuno-theranostics for the use in detection and elimination of skin cancer cells. The technology also relates to novel methods which generate homogeneous and specific photoimmuno-theranostics reagents in a simple, controlled and efficient way. This method combines molecular optical imaging, photodynamic therapy and immunotherapy using SNAP-tag technology.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: September 21, 2021
    Assignee: UNIVERSITY OF CAPE TOWN
    Inventors: Stefan Barth, Ahmad Fawzi Hussain, Rainer Fischer
  • Publication number: 20210212588
    Abstract: A wireless radio frequency triggered signal acquisition device includes three orthogonal pick up coils in which voltages will be induced by a time varying, spatially varying magnetic field inside a chamber of an MRI scanner. A radio frequency detection circuit detects radio frequency pulses emitted by an MRI scanner and a wireless transmission circuit transmits data from the device, A 3-axis magnetometer is used for measuring magnetic flux in the chamber of the MRI scanner. A processor uses the detected radio frequency pulses to synchronize measurements taken by the magnetometer and pick-up coils to a time frame of a gradient driver hardware, thereby matching the measurements to a pulse sequence waveform. The processor further combines measurements of induced voltages in the orthogonal pick up coils and the magnetic flux with the pulse sequence waveform in order to solve for the instantaneous position and orientation of the device.
    Type: Application
    Filed: June 5, 2019
    Publication date: July 15, 2021
    Applicant: University of Cape Town
    Inventor: Adam Marthinus Johannes van Niekerk
  • Publication number: 20210205551
    Abstract: An assistive device for a metered dose inhaler decreases the force required to operate the inhaler. The assistive device has a body with a passage for receiving a replaceable conventional metered dose inhaler assembly that has a canister and a transverse mouthpiece with an axis of the canister aligning approximately with that of the passage. At least two symmetrically arranged levers extend in a direction away from the body and parallel to an axis thereof. A proximal end of each lever is attached to the body such that the free opposite ends of the levers may be moved towards and away from each other. An inwardly directed cam surface on each of the levers engages a closed end of a canister in use to move the canister longitudinally to cause a dose of medicament to be dispensed from the canister. An optional dose counter may form part of the device.
    Type: Application
    Filed: March 14, 2017
    Publication date: July 8, 2021
    Applicant: University of Cape Town
    Inventors: Sudesh SIVARASU, Giancarlo Lanfranci BEUKES, Jason Dirk VOORNEVELD, Michael LEVIN
  • Patent number: 11053509
    Abstract: This invention relates to a second generation, plant-produced synthetic Orbivirus candidate vaccine. The vaccine comprises a plant produced chimaeric Orbivirus virus like particle (VLP) comprising at least one structural protein from one Orbivirus serotype and at least one structural protein selected from another serotype of the Orbivirus, wherein both structural capsid proteins are from the same Orbivirus species. In particular the invention relates to a vaccine against an Orbivirus, a method of producing chimaeric Orbivirus virus-like particles (VLPs) for use in a method of prevention and/or treatment of an Orbivirus infection, the use of the chimaeric Orbivirus VLPs in the manufacture of a vaccine for an Orbivirus, and a method of preventing and/or treating an Orbivirus infection.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: July 6, 2021
    Assignees: CSIR, UNIVERSITY OF CAPE TOWN, ONDERSTEPOORT BIOLOGICAL PRODUCTS SOC LTD
    Inventors: Albertha René Van Zyl, Ann Elizabeth Meyers, Daria Anna Rutkowska, Edward Peter Rybicki, Hester Catharina Stark, Martha Magaretha O'Kennedy, Nobalanda Betty Mokoena
  • Publication number: 20210190848
    Abstract: A sensor for monitoring utility poles includes a sensing module to detect a physical quantity from a utility pole or a conductor supported by a utility pole to which the sensor is attached in use. A power supply supplies power to the device and a memory for storing sensor data. A communications module is used for transmitting and receiving sensor data to and from one or more sensors which are attached to other utility poles located adjacent to or nearby the utility pole. A processor uses the detected sensor data together with received sensor data to calculate if the utility pole to which the sensor is attached has changed its physical condition, and wherein if the processor calculates that the utility pole to which the sensor is attached has changed its physical condition, a message is transmitted via the communications module to a remote server.
    Type: Application
    Filed: June 5, 2019
    Publication date: June 24, 2021
    Applicant: University of Cape Town
    Inventors: Edward Sidney Boje, Jason Andrew Hardy
  • Patent number: 11021547
    Abstract: The invention provides an improved method of synthesising derivatives of ?-D-glucopyranoside-containing polymers, such as chitin, chitosan, cellulose, amylose, pullulan, curdlan, inulin, guar gum or cyclodextrin. The method includes reacting a polymer of formula (III) with a cyclic imide to form a polymer of formula (I) thereby introducing a nitrogen functionality at the 6-position and providing access to 6-deoxy-6-amino-?-D-glucopyranoside-containing polymers.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: June 1, 2021
    Assignee: University of Cape Town
    Inventors: Moegamat Anwar Jardine, Shakeela Sayed
  • Patent number: 10899801
    Abstract: The present invention relates to a method for producing a recombinant HIV glycoprotein polypeptide in a plant and to trimeric complexes of the recombinant, plant-produced HIV glycoprotein polypeptide which mimic the native HIV Env complex. The invention also relates to nucleic acids encoding the recombinant polypeptides, expression vectors containing the aforementioned nucleic acids and to pharmaceutical compositions, uses and methods of eliciting an immune response against HIV in a subject using the recombinant polypeptides and trimeric complexes.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: January 26, 2021
    Assignee: University of Cape Town
    Inventors: Ann Elizabeth Meyers, Anna-Lise Williamson, Edward Peter Rybicki, Emmanuel Aubrey Margolin, Rosamund Chapman
  • Patent number: 10897048
    Abstract: A method of coating a membrane having a first side and an opposite second side and carried with its second side adhering to a backer film is provided. The method includes coating the first side of the membrane with a catalyst ink or slurry with the second side adhering to the backer film and curing the coating on the first side. The backer film is then removed to expose the second side of the membrane which is fed onto a vacuum conveyor with the coated first side facing the conveyor. The second side of the membrane is then coated with a catalyst ink or slurry and the coating on the second side cured after which the membrane is removed from the vacuum conveyor.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: January 19, 2021
    Assignee: University of Cape Town
    Inventors: Duarte Rui Sousa, Nabeel Hussain
  • Publication number: 20210003717
    Abstract: A motion capture system and method are provided. In a motion capture method, a plurality of motion datasets are accessed. Each motion dataset is associated with a motion sensing unit at which timestamped motion data points of that motion dataset are generated, each motion sensing unit is configured to be in physical contact with a different part of a body of interest. Each timestamped motion data point is timestamped at the motion sensing unit at which it is generated using a clock time that is synchronized across the plurality of motion sensing units. The timestamped motion data points are processed to generate a kinematic model which describes motion of the respective parts of the body of interest.
    Type: Application
    Filed: March 14, 2019
    Publication date: January 7, 2021
    Applicant: University of Cape Town
    Inventors: Amir PATEL, Do KU
  • Patent number: 10874753
    Abstract: This invention relates new radiopharmaceutical conjugates for use in improved methods of diagnosis and treatment of cancer. The radiopharmaceutical conjugate comprises, in sequence: a metabolite that targets tumour cells, bound to a chelating agent capable of containing a radionuclide, bound to a linker capable of binding with an EPR agent in vitro or in vivo; or a chelating agent capable of containing a radionuclide, bound to a metabolite that targets tumour cells, bound to a linker capable of binding with an EPR agent in vitro or in vivo. The radiopharmaceutical conjugates of the present invention provide active and passive targeted radio nuclide delivery systems that can help to improve the biodistribution and pharmacological toxicity of the radiopharmaceuticals used for the diagnosis and therapy of cancer.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: December 29, 2020
    Assignees: The South African Nuclear Energy Corporation Limited, University of Cape Town
    Inventors: Cathryn Helena Stanford Driver, Jan Rijn Zeevaart, Mohamed Iqbal Parker, Roger Hunter
  • Publication number: 20200339963
    Abstract: The present invention relates to a fusion protein consisting of a scFv linked to a horseradish peroxidase enzyme or to an alkaline phosphatase enzyme by a peptide linker. The fusion protein also includes a histidine tag and optionally an endoplasmic reticulum retention signal. The invention also includes nucleic acids encoding the fusion protein, expression vectors containing the nucleic acids, plant cells transformed with the expression vectors and methods of producing the fusion proteins of the invention.
    Type: Application
    Filed: May 23, 2017
    Publication date: October 29, 2020
    Applicant: University of Cape Town
    Inventors: Ann Elizabeth Meyers, Edward Peter Rybicki, Inga Isabel Hitzeroth
  • Publication number: 20200325250
    Abstract: The invention provides an improved method of synthesising derivatives of ?-D-glucopyranoside-containing polymers, such as chitin, chitosan, cellulose, amylose, pullulan, curdlan, inulin, guar gum or cyclodextrin. The method includes reacting a polymer of formula (III) with a cyclic imide to form a polymer of formula (I) thereby introducing a nitrogen functionality at the 6-position and providing access to 6-deoxy-6-amino-?-D-glucopyranoside-containing polymers.
    Type: Application
    Filed: November 21, 2018
    Publication date: October 15, 2020
    Applicant: University of Cape Town
    Inventors: Moegamat Anwar JARDINE, Shakeela SAYED
  • Publication number: 20200305859
    Abstract: An implantable device for aiding in generating connective tissue between a pair of anatomical structures in a mammalian body is provided. The device includes an elongate, flexible tether which can be secured between the anatomical structures and which carries a scaffold which is generally porous so as to be capable of promoting tissue ingrowth and collagen deposition along its length. The scaffold extends along the tether for a sufficient distance so that it is securable in at least close proximity to an anatomical structure at either end. The pores in the scaffold extend through the scaffold and each has a diameter in the range of about 10 ?m to about 200 ?m. The length of the tether is selected to be a desirable maximum distance between the anatomical structures along a desired path when secured therebetween.
    Type: Application
    Filed: June 9, 2017
    Publication date: October 1, 2020
    Applicant: UNIVERSITY OF CAPE TOWN
    Inventors: Mogamat Rushdie Hendricks, Deon Bezuidenhout
  • Patent number: 10674932
    Abstract: An orientation tracking device includes a memory for storing data including magnetic reference data relating to the direction of a static magnetic field of a magnetic imaging scanner in a selected principle co-ordinate frame and earth gravitational reference data relating to the direction of the gravitational field of the earth in the principle co-ordinate frame. The device also includes an accelerometer, magnetometer and communication module. A processor is adapted for receiving from the magnetometer measured magnetic field vector and from the accelerometer a measured acceleration vector. These vectors are in a co-ordinate frame of the orientation tracking device, within the magnetic imaging scanner in which the orientation tracking device is placed in use.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 9, 2020
    Assignee: University of Cape Town
    Inventor: Adam Marthinus Johannes van Niekerk
  • Patent number: 10591380
    Abstract: A method of estimating characteristics of new leaks formed in an isolated section of a water distribution system supplied through a pressure reducing valve. The pressure reducing valve is used to vary the pressure in the isolated section to at least two different pressure settings during a minimum night flow period at which the measured pressure and flow rate into the system are taken at each pressure setting. The leak characteristics are estimated by subtracting an estimated user consumption from the measured flow rate in each instance. The same measurements are repeated one or more days later. The estimated leak characteristics derived on a later date are compared with those derived on an earlier date to establish a difference in the estimated leak characteristics to determine if there is a new leak or leaks in the isolated section.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: March 17, 2020
    Assignee: University of Cape Town
    Inventor: Jakobus Ernst Van Zyl
  • Publication number: 20200080104
    Abstract: The present invention relates to a polygenic DNA construct consisting of three abiotic stress tolerance genes, separated by nucleic acids encoding FMDV 2A peptides under the control of a stress inducible promoter. The stable insertion of the construct into plants confers drought tolerance to the plants. The invention also provides for vectors, host cells, transgenic plants and transgenic seeds containing the construct.
    Type: Application
    Filed: June 5, 2017
    Publication date: March 12, 2020
    Applicant: University of Cape Town
    Inventors: Bronwyn Lynn ARENDZE-BAILEY, Jennifer Ann THOMSON, Kershini IYER, Mohamed Suhail RAFUDEEN, Revel IYER, Tamaryn Lorean ELLICK
  • Patent number: 10524807
    Abstract: An accessory is provided for use in the conduct of patella reconstruction surgery. The accessory comprises an elongate datum limb for abutment in use with the superior pole of a patella preferably through the skin. An elongate guide limb for abutment by a side edge of a patella extends transversely relative to the datum limb has guide holes passing through it or an insert carried by it at positions selected to direct a drill or other surgical tool at an edge of the patella to enable holes or tunnels to be formed in the patella at required positions for the attachment or reception of reconstructive ligaments to the patella. Attachment limbs enable the accessory to be secured in an operative position relative to a patella. There may be slots formed by anchor bars integral with the guide limb and attachment limb to strap the accessory to a patient's knee.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: January 7, 2020
    Assignees: University of Cape Town
    Inventors: Sarthak Patnaik, Sudesh Sivarasu
  • Patent number: 10454126
    Abstract: A clamp assembly for securing a fuel cell stack arrangement in a compressed condition. The stack includes an electrode assembly interposed between upper and lower current collectors, supportable between upper and lower endpiate structures. It comprises at least one rigid clamping device comprising spaced apart transversely disposed elongate clamp members for engaging outer surfaces of the upper and lower endplates respectively along peripheral edges, the clamp members being interposed by vertically disposed support members having a length greater than the height of the stack in a compressed condition thereof. The endpiate structures define docking formations along peripheral edges for engaging the damp members under compression of the stack. The docking formations define spaces between the endpiate structures and the compressing means within which the clamp members are receivable during compression.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: October 22, 2019
    Assignee: UNIVERSITY OF CAPE TOWN
    Inventor: Shiro Tanaka
  • Patent number: 10403916
    Abstract: An apparatus and method for determining the condition of an electricity-producing cell such as a fuel cell is disclosed. A signal is injected into an electricity-producing cell, a voltage and/or current response is measured, and the impedance response of the electricity-producing cell is calculated using the injected signal and the response. The injected signal is a broadband signal that includes a plurality of superimposed waveforms at different frequency set points across a frequency range. The distribution of the waveform frequency set points is linear at either or both of a lower portion and an upper portion of the frequency range, and is logarithmic at a mid-range of the frequency range. The response at each of the frequency set points are simultaneously obtained and the impedance response across the frequency range is calculated and used to determine a condition of the electricity-producing cell.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: September 3, 2019
    Assignee: University of Cape Town
    Inventor: Chris De Beer
  • Publication number: 20190249228
    Abstract: This invention relates to a prognostic method for determining the risk of an asymptomatic human subject with latent tuberculosis (TB) infection or apparent latent TB infection and/or after suspected exposure to TB progressing to active tuberculosis disease comprising the steps of quantifying and computationally analysing relative abundances of a collection of pairs of gene products (“TB biomarkers”) derived from a sample obtained from the subject. The invention further relates to a collection of TB biomarkers that generates a transcriptomic signature of risk for prediction of the likelihood of an asymptomatic human subject with latent TB infection and/or after suspected exposure to TB progressing to active tuberculosis disease. Furthermore, a kit comprising gene-specific primers or oligonucleotide probes for the detection of pairs of TB biomarkers that generates a prognostic signature of risk for use with the method of the invention is described.
    Type: Application
    Filed: November 9, 2016
    Publication date: August 15, 2019
    Applicants: UNIVERSITY OF CAPE TOWN, CENTER FOR INFECTIOUS DISEASE RESEARCH
    Inventors: Adam Garth PENN-NICHOLSON, Thomas Jens SCRIBA, Alan Arnold ADEREM, Daniel Edward ZAK, Ethan Greene THOMPSON, Willem Albert HANEKOM