Patents Assigned to University of Guelph
  • SYNTHETIC LUNG SURFACTANT AND USE THEREOF
    Publication number: 20140044775
    Abstract: The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
    Type: Application
    Filed: September 18, 2013
    Publication date: February 13, 2014
    Applicants: University of Rochester, The Los Angles Biomedical Research Institute at Harbor-UCLA Medical Center, University of Guelph
    Inventors: Robert H. Notter, Zhengdong Wang, Adrian L. Schwan, Zhongyi Wang, Jason A. Davy, Alan J Waring, Frans Walther, Larry M. Gordon
  • NON-PATHOGENIC SEROTYPE 4 FOWL ADENOVIRUS (FADV-4) AND VIRAL VECTOR THEREOF
    Publication number: 20140010834
    Abstract: A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.
    Type: Application
    Filed: March 16, 2012
    Publication date: January 9, 2014
    Applicant: University of Guelph
    Inventors: Éva Nagy, Bryan Griffin, Helena Grgic, Davor Ojkic
  • Polysaccharide immunogens from
    Patent number: 8597663
    Abstract: The application relates to Clostridium difficile cell surface polysaccharides, compositions comprising Clostridium difficile cell surface polysaccharides, and includes kits, methods and uses thereof.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: December 3, 2013
    Assignee: University of Guelph
    Inventors: Mario Artur Monteiro, Nagalingham Ganeshapilla, Mononmanydevi Ganeshapilla
  • Nitrogen-regulated sugar sensing gene and protein and modulation thereof
    Patent number: 8586825
    Abstract: The present invention relates to a nitrogen-regulated GATA transcription factor gene required for sugar sensing and the modulation of the expression of this gene to modulate a characteristic in a plant. The GATA transcription factor of the present invention is involved in regulating sugar sensing in plants and its expression is influenced by nitrogen status. Increased expression of this or substantially similar genes can produce plants with improved nitrogen utilization and increased yield.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: November 19, 2013
    Assignee: The University of Guelph
    Inventors: Steven Rothstein, Yong-Mei Bi
  • VACCINES FOR INCLUSION BODY HEPATITIS
    Publication number: 20130295126
    Abstract: A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its progeny.
    Type: Application
    Filed: July 17, 2013
    Publication date: November 7, 2013
    Applicants: UNIVERSITY OF GUELPH, UNIVERSITY OF SASKATCHEWAN
    Inventors: Susantha Gomis, Suresh Kumar Tikoo, Davor Ojkic
  • Synthetic lung surfactant and use thereof
    Patent number: 8563683
    Abstract: The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: October 22, 2013
    Assignees: University of Rochester, The Los Angeles BioMedical Research Institute at Harbor—UCLA Medical Center, University of Guelph
    Inventors: Robert H. Notter, Zhengdong Wang, Adrian L. Schwan, Zhongyi Wang, Jason A. Davy, Alan J. Waring, Frans J. Walther, Larry M. Gordon
  • DETECTION OF FUSOBACTERIUM IN A GASTROINTESTINAL SAMPLE TO DIAGNOSE GASTROINTESTINAL CANCER
    Publication number: 20130259899
    Abstract: Fusobacterium is a genus of gram-negative, filamentous, anaerobic bacteria found as normal flora in the mouth and large bowel, and often in necrotic tissue. A comparison of microbial ribonucleic acids (RNA) between colorectal carcinoma (CRC) tissue and adjacent normal control tissue found the over-representation of F. nucleatum in CRC tissue. RNA abundance was measured by polymerase chain reaction (PCR)-amplifying RNA from the tissue, constructing libraries, sequencing the RNA in the libraries, pairing sequences from CRC and normal tissue, and quantifying RNA abundance. Detection of Fusobacterium in a gastrointestinal sample is indicative of gastrointestinal cancer.
    Type: Application
    Filed: October 4, 2011
    Publication date: October 3, 2013
    Applicants: ALLEN-VERCOE, EMMA MOLECULAR AND CELLULAR BIOLOGY UNIVERSITY OF GUELPH, BRITISH COLOMBIA CANCER AGENCY BRANCH
    Inventors: Emma Allen-Vercoe, Robert Holt, Richard Moore, Rene Warren
  • Vaccines for inclusion body hepatitis
    Patent number: 8524249
    Abstract: A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its progeny.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: September 3, 2013
    Assignees: University of Saskatchewan, University of Guelph
    Inventors: Susantha Gomis, Suresh Kumar Tikoo, Davor Ojkic
  • Stabilized Edible Emulsions, Acidification Methods of Preparation, and Beverages
    Publication number: 20130224335
    Abstract: Stable, edible delivery systems for water miscible or water soluble materials, and aqueous food products such as beverages incorporating such delivery systems are provided. The disclosed delivery systems may be used to isolate a substance otherwise having an unacceptable taste in the food product or to protect a sensitive material in the food, e.g., an ingredient prone to degradation. Methods for producing the delivery systems and aqueous dispersions are also disclosed, wherein an acidification agent lowers the pH of the emulsion particles core during and/or after emulsification.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 29, 2013
    Applicants: UNIVERSITY OF GUELPH, PEPSICO, INC.
    Inventors: PEPSICO, INC., UNIVERSITY OF GUELPH
  • Vaccine against
    Patent number: 8501190
    Abstract: There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: August 6, 2013
    Assignee: The University of Guelph
    Inventors: John Prescott, Raveendra Kulkarni, Valeria Parreira, Shayan Sharif
  • Single Nucleotide Polymorphisms (SNPs) in Genes Associated With Inflammatory Diseases
    Publication number: 20130189692
    Abstract: The present disclosure describes the identification of single nucleotide polymorphisms (SNPs) in inflammatory diseases and uses thereof, and methods of screening for, diagnosing, identifying susceptibility to or detecting a risk of developing an inflammatory disease comprising detecting the presence or absence of at least one SNP identified in a gene associated with inflammatory disease.
    Type: Application
    Filed: March 18, 2013
    Publication date: July 25, 2013
    Applicant: UNIVERSITY OF GUELPH
    Inventor: UNIVERSITY OF GUELPH
  • Embryo culture media containing thyroid hormone
    Patent number: 8492080
    Abstract: The disclosure relates to the use of culture media containing thyroid hormones or analogs thereof, and includes methods and uses thereof for embryo culture, embryo production, embryo maturation, improved survival of embryos and improved viability of embryos post cryopreservation.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: July 23, 2013
    Assignee: University of Guelph
    Inventors: William Allan King, Fazl A. Ashkar
  • Anti-cobra toxin antibody fragments and method of producing a VH library
    Patent number: 8465742
    Abstract: A method of constructing a VHH library from an immunized camelid, using whole venom or an extract thereof There is also provided VHH antibody fragments isolated from a library produced in hyperimmunized llama These VHH antibody fragments were sequenced, and specifically bind ?-cobratoxin.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: June 18, 2013
    Assignee: University of Guelph
    Inventors: J. Christopher Hall, Gabrielle Richard, Michael D. McLean
  • Protein Precipitate Comprising Minerals and Method for the Manufacture Thereof
    Publication number: 20130129868
    Abstract: Edible precipitate is disclosed binding one or more minerals that are stable in acidic aqueous systems. The precipitate may be utilized in acidic food products. The precipitate comprises at least one mineral and a layer around the at least one mineral wherein the layer comprises protein precipitate. Methods of producing the precipitate are also disclosed.
    Type: Application
    Filed: November 22, 2011
    Publication date: May 23, 2013
    Applicants: University of Guelph, PepsiCo., Inc.
    Inventors: Ibrahim Gülseren, Melina Corredig, Peter S. Given, JR., Yuan Fang
  • Single nucleotide polymorphisms (SNPs) in genes associated with inflammatory diseases
    Patent number: 8445656
    Abstract: The present disclosure describes the identification of single nucleotide polymorphisms (SNPs) in inflammatory diseases and uses thereof, and methods of screening for, diagnosing, identifying susceptibility to or detecting a risk of developing an inflammatory disease comprising detecting the presence or absence of at least one SNP identified in a gene associated with inflammatory disease.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: May 21, 2013
    Assignee: University of Guelph
    Inventors: Chris P. Verschoor, Niel A. Karrow
  • Stabilized Edible Emulsions, Methods of Preparation, and Beverages
    Publication number: 20130078336
    Abstract: Stable, edible delivery systems for water miscible or water soluble materials, and aqueous food products such as beverages incorporating such delivery systems are provided. The disclosed delivery systems may be used to isolate a substance otherwise having an unacceptable taste in the food product or to protect a sensitive material in the food, e.g., an ingredient prone to degradation. Methods for producing the delivery systems and aqueous dispersions are also disclosed.
    Type: Application
    Filed: September 28, 2012
    Publication date: March 28, 2013
    Applicants: UNIVERSITY OF GUELPH, PEPSICO, INC.
    Inventors: PepsiCo, Inc., University of Guelph
  • Nitrogen Responsive Early Nodulin Gene
    Publication number: 20130074214
    Abstract: Isolated nucleic acids and proteins and plants expressing the same for improved nitrogen utilization, increased yield, and increased stress tolerance.
    Type: Application
    Filed: September 25, 2009
    Publication date: March 21, 2013
    Applicants: University Of Guelph, Syngenta Participations
    Inventors: Surya Kant, Steven Rothstein, Yong-Mei Bi, Joseph Clarke
  • ANTIVIRULENCE COMPOUNDS INHIBITING BACTERIAL MONO-ADP-RIBOSYLTRANSFERASE TOXINS
    Publication number: 20120142682
    Abstract: Compounds that inhibit bacterial virulence factors from the mono-ADP-ribosyltransferase (mART) family of toxins have been identified that are not toxic to cells or the producing bacterial pathogen. These compounds have great potential as antivirulence agents for treating many bacterial infections and disease states.
    Type: Application
    Filed: December 2, 2011
    Publication date: June 7, 2012
    Applicant: UNIVERSITY OF GUELPH
    Inventor: Allen Rod Merrill
  • GENETIC MARKERS FOR BOAR TAINT
    Publication number: 20110263435
    Abstract: Genetic markers are disclosed with a useful association with boar taint that can be used for screening and selection of pigs for those with more favorable boar taint characteristics associated with androstenone/skatole metabolism. Specific polymorphic alleles of the 3?HSD, 3?HSD, CYP17A1, CYP2A, CYP2E1, CYTB5, BAC-CT and/or SULT1A1 genes are disclosed for tests to screen pigs to determine those more likely to produce desired boar taint traits.
    Type: Application
    Filed: January 12, 2007
    Publication date: October 27, 2011
    Applicant: UNIVERSITY OF GUELPH
    Inventors: E. James Squires, Dominique Rocha, John Peacock, Zhihong Lin, Nader Deeb
  • PROBIOTIC BACTERIAL MOLECULES AND THEIR USE IN METHODS TO TREAT/PREVENT INFECTION BY HARMFUL BACTERIA AND TO PROVIDE NUTRITIONAL HEALTH
    Publication number: 20110262400
    Abstract: This invention provides isolated and characterized secreted molecules from probiotic bacteria for use in compositions and methods for the treatment and/or prevention of infection by harmful pathogenic bacteria. The isolated secreted molecules can also be used in nutritional or medical food products which provide probiotics to the gastrointestinal tract of a mammal.
    Type: Application
    Filed: June 26, 2009
    Publication date: October 27, 2011
    Applicant: UNIVERSITY OF GUELPH
    Inventors: Mansel Griffiths, Maira Medellin-Pena, Veronique Delcenserie