Patents Assigned to University of Hawaii
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Patent number: 9244074Abstract: Several embodiments provided herein relate to methods of diagnosing asbestos exposure or mesothelioma. Several embodiments also relate to methods of differentiating whether a tumor of the lung is lung cancer or mesothelioma.Type: GrantFiled: June 7, 2012Date of Patent: January 26, 2016Assignees: University of Hawaii, New York UniversityInventors: Haining Yang, Michele Carbone, Harvey I. Pass
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Patent number: 9138175Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: April 28, 2015Date of Patent: September 22, 2015Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 9120908Abstract: Provided are nanomaterial-reinforced resin compositions and related methods. The compositions include a reinforcing material, such as graphene, polyamic acid, carbon nanotubes, or dimethylacetamide that is dispersed into a resin. The reinforcing material is present in the resin at from about 0.001 to about 10 wt %. Also provided are methods of fabricating these compositions and methods of tailoring a composition to achieve a particular set of mechanical properties.Type: GrantFiled: March 28, 2011Date of Patent: September 1, 2015Assignee: UNIVERSITY OF HAWAIIInventors: Richard Russ, Mehrdad Ghasemi-Nejhad, Atul Tiwari, Anupama Chaturvedi, David A. Hummer, Vamshi Gudapati
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Patent number: 9109251Abstract: The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.Type: GrantFiled: January 3, 2013Date of Patent: August 18, 2015Assignee: University of HawaiiInventor: James Holm-Kennedy
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Patent number: 9084786Abstract: Methods are provided of treating cardiac hypertrophy in a mammalian subject comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TR-PV1 inhibitor. The methods include treatment of a symptom of cardiac hypertrophy in the subject comprises cardiac remodeling, cardiac fibrosis, apoptosis, hypertension, or heart failure.Type: GrantFiled: November 2, 2011Date of Patent: July 21, 2015Assignee: University of HawaiiInventor: Alexander Stokes
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Patent number: 9072778Abstract: The present invention relates to methods and compositions for treating diseases. More specifically, the present invention relates to the administration of multiple drugs as part of a treatment of disease. Specific embodiments of the invention relate to a treatment regimen for neuroblastomas and other N-MYC, c-MYC, and L-MYC amplified and overexpressed tumors, comprising administering multiple therapeutic compounds like DFMO, SAM486A, a verinoid and a cytotoxic drug and placing the patient on a low polyamine diet and/or providing the patient with a polyamine limiting dietary supplement.Type: GrantFiled: December 20, 2006Date of Patent: July 7, 2015Assignee: UNIVERSITY OF HAWAIIInventor: Andre S. Bachmann
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Patent number: 9076212Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: September 23, 2013Date of Patent: July 7, 2015Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 9064091Abstract: The present invention provides systems and methods for coupled dynamical systems for chaos computing. For example, a system for the coupled dynamical system comprises a first, second, and third circuit. The first circuit comprising a plurality of single dynamical systems forms a coupled dynamical system that reduces local noises in the plurality of single dynamical systems by diffusing the local noises across the coupled dynamical system. The second circuit, connected to the first circuit, receives the data and control inputs and builds an encoding map that translates the data and control inputs to an initial condition on an unstable manifold of the plurality of single dynamical systems in the coupled dynamical system. After the coupled dynamical system evolves, a third circuit, connected to the first circuit, samples a state of one of the plurality of single dynamical systems in the coupled dynamical system and builds a decoding map.Type: GrantFiled: March 21, 2014Date of Patent: June 23, 2015Assignee: University of HawaiiInventors: William Ditto, Behnam Kia, Sarvenaz Kia
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Patent number: 8945876Abstract: Embodiments herein include methods and constructs that can be used to co-express two or more polypeptides of interest from a single polynucleotide encoding a precursor polypeptide. Within this precursor polypeptide can reside at least one autonomous processing unit, which can mediate release of flanking polypeptides of interest in cis. The processing unit can include an N-terminal autocatalytic cleavage domain and a C-terminal cleavage domain. Some embodiments include constructs and methods for co-expressing polypeptides without N- or C-terminal overhangs, in any cellular or extracellular location, and/or in stoichiometric ratios.Type: GrantFiled: November 21, 2012Date of Patent: February 3, 2015Assignee: University of HawaiiInventors: Wei Wen Su, Bei Zhang
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Patent number: 8901372Abstract: This invention relates to a nucleic acid construct. The construct includes a nucleic acid molecule configured to silence Banana bunchy top virus (BBTV), a 5? DNA promoter sequence, and a 3? terminator sequence. The nucleic acid molecule, the promoter, and the terminator are operatively coupled to permit transcription of the nucleic acid molecule. The present invention also relates to expression vectors, host cells, and transgenic plants containing the nucleic acid construct of the present invention. Also disclosed are methods of imparting BBTV resistance to plants.Type: GrantFiled: February 25, 2010Date of Patent: December 2, 2014Assignee: University of HawaiiInventors: John Hu, Wayne Borth, Eden A. Perez, Kheng Cheah
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Publication number: 20140323823Abstract: A microwave stethoscope measurement method and sensor design employ a microwave transmission sensor and a microwave reception sensor placed on a patient's chest in spaced-apart side-by-side configuration for monitoring patient vital signs, lung water content and other critical measurements. The side-by-side sensors are spaced apart a separation distance of about 1-3 cm in lateral chest orientation. The sensors may be formed with a textile fabric for wearer comfort and to improve contact with the patient's skin. The microwave sensor measurements are digitally processed using a modified short time Fourier Transform (STFT) spectrum windowed-averaged algorithm. Output data extracted from the microwave sensor measurements may be transmitted wirelessly to a mobile device such as a smartphone for remote monitoring of the patient's medical condition.Type: ApplicationFiled: April 25, 2014Publication date: October 30, 2014Applicant: UNIVERSITY OF HAWAIIInventors: Magdy F. Iskander, Nuri Celik, Ruthsenne Gagarin, Gui Chao Huang, Darcy Alan Bibb
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Patent number: 8846266Abstract: Abiotic fuel cell and battery designs employing chemical dyes in alkaline solutions are disclosed. The fuel cells and batteries are capable of harnessing electrical power from various carbohydrates, including, but not limited to, glucose; in an anode design that does not require catalysts or membranes to separate half-cell reaction chambers. In certain embodiments, the abiotic fuel cell or battery designs may further employ electrodes, such as high surface area carbon materials and commercial air breathing electrodes, without the use of catalysts for glucose oxidation (i.e., precious metals or biocatalytic species). In further embodiments, organic dyes, including but not limited to, methyl viologen (MV), methylene blue, methylene green, Meldola's blue, indigo carmine, safranin O, and the like, may serve as the electron mediators. In some embodiments, the fuel cells or batteries are capable of generating power on the order of about tens of mW/cm2 from glucose and/or other types of sugars.Type: GrantFiled: April 28, 2010Date of Patent: September 30, 2014Assignee: University of HawaiiInventors: Daniel Marin Scott, BorYann Liaw
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Publication number: 20140248374Abstract: Embodiments of the invention relate to a composition containing zinc and copper and methods of using the same in treatment of exposure to a pore-forming toxin (PFT) in a subject or membrane perturbant (MP).Type: ApplicationFiled: February 21, 2012Publication date: September 4, 2014Applicant: UNIVERSITY OF HAWAIIInventor: Angel Anne YANAGIHARA
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Patent number: 8736844Abstract: A Sagnac interferometer can include a beamsplitter arranged to receive an input beam of light of a design wavelength, to split the input beam of light into first and second beams that counter propagate around an optical path, and to recombine the first and second beams into an output beam of light. The optical path can include at least one diffraction grating that is arranged to satisfy an effective Littrow geometry.Type: GrantFiled: June 6, 2011Date of Patent: May 27, 2014Assignee: University of HawaiiInventors: Eric Szarmes, Huan Ma
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Publication number: 20140037174Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: ApplicationFiled: September 23, 2013Publication date: February 6, 2014Applicants: THE QUEEN'S MEDICAL CENTER, UWM RESEARCH FOUNDATION, INC., THE MEDICAL COLLEGE OF WISCONSIN, INC., THE UNIVERSITY OF HAWAIIInventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 8632780Abstract: A modified human complement C3 protein (C3) is disclosed comprising a substitution of a portion of a human C3 protein, with a corresponding portion of a Cobra Venom Factor protein (CVF) which results in a human C3 protein with CVF functions, but with substantially reduced immunogenicity. Advantageously, the C3 protein can be manipulated to contain at least one of the following CVF functions: increased stability of the C3 convertase and increased resistance to the actions of factors H and/or I. A large number of hybrid C3 proteins containing substitutions in the C-terminal portion of the alpha chain of C3 are presented and tested for the above functions. Methods of treatment of diseases such as reperfusion injury, autoimmune diseases, and other diseases of increased complement activation are presented as well as methods of increasing the effectiveness of gene therapeutics and other therapeutics.Type: GrantFiled: April 29, 2005Date of Patent: January 21, 2014Assignee: University of HawaiiInventors: Carl-Wilhelm Vogel, David C. Fritzinger
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Publication number: 20140010802Abstract: Systems, methods, and computer readable media for diagnosing or characterizing a genetic predisposition to develop cancer, including cancers of the BAP1 cancer syndrome, are provided. Nucleic acids comprising a germline nucleic acid sequence encoding the BRCA1 associated protein 1 (BAP1) are sequenced or probed to determine if the nucleic acid sequence includes alterations that predispose a subject to develop cancer.Type: ApplicationFiled: August 19, 2013Publication date: January 9, 2014Applicants: University of Hawaii, Office of Technology Transfer and Economic Development, Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center ("Fox Chase CInventors: Joseph R. Testa, Michele Carbone, Mitchell Cheung, Jianming Pei
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Publication number: 20140005175Abstract: Compounds of formula II are described: wherein D, n, Ra, Rb, and Rc are as herein defined, along with pharmaceutical compositions and methods of using compounds of formula II for treating or reducing the risk of peritoneal carcinomatosis in a patient.Type: ApplicationFiled: August 26, 2013Publication date: January 2, 2014Applicants: Cephalon, Inc., University of Utah Research Foundation, University of HawaiiInventors: Bruce D. Dorsey, Scott K. Kuwada, Jay P. Theroff, Craig A. Zificsak
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Patent number: PP24482Abstract: A new cultivar of cultivar of Colocasia plant named ‘MAUI GOLD’ that is characterized by a combination of large sagittate-shaped chartreuse colored leaves with a glossy finish, bluish-purple colored piko, and petioles that are white to light yellow-green in color that turn light burgundy in color where they join the leaf ‘Maui Gold’ grows with a compact and clumping habit. In combination these characteristics distinguish ‘MAUI GOLD’ from all other varieties of Colocasia known to the inventor.Type: GrantFiled: March 16, 2013Date of Patent: May 20, 2014Assignee: University of HawaiiInventor: John J. Cho
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Patent number: PP24596Abstract: A new cultivar of Colocasia plant named ‘HAWAIIAN PUNCH’ that is characterized by large sagittate leaves which are semi-glossy mid green in color, with prominent burgundy-red veins on both surfaces. The leaves of ‘HAWAIIAN PUNCH’ are borne on glossy burgundy-red petioles. ‘HAWAIIAN PUNCH’ grows with a compact and clumping plant habit. In combination these characteristics distinguish ‘HAWAIIAN PUNCH’ from all other varieties of Colocasia known to the inventor.Type: GrantFiled: March 16, 2013Date of Patent: July 1, 2014Assignee: University of HawaiiInventor: John J. Cho